Increase In Number Of Alveoli Research Articles

Polyalveolar Lobe and Congenital Cystic Adenomatoid Malformation Type II: Are They Related?

A left lower polyalveolar lobe in a 28-day-old infant and a right lung with congenital cystic adenomatoid malformation type II in a 17-day-old infant are described. The adenomatoid malformation involved all lobes, but the lower lobe appeared to be mostly replaced by a polyalveolar area, a complication hitherto undescribed. The pronounced increase in number of alveoli in both cases was established by two different morphometric methods and was compared with three normal controls of the same age. The simultaneous occurrence of polyalveolar lobe and congenital cystic adenomatoid malformation type II in the same lung suggests a causal relation between both anomalies. In the grossly abnormal lung tissue of an adenomatoid malformation, polyalveolar areas can easily be overlooked.

27. MAMMARY GLAND DEVELOPMENT UNDER THE EFFECT OF A PLACENTAL PROTEIN

A protein from human placenta, the Uterotrophic Placental Protein (UTPH) was isolated in our lab(Beas & Flores, 1969). It evoked crop sac stimulation in pigeons, inhibited mammary growth produced by estradiol (E) and progesterone (P) in ovariectomized rats and increased DNA synthesis in 5 day organ cultures of mouse mammary gland. The objective of this work was to analyze the effect of UTPH on mammary gland development in intact virgin Balb/c mice injected during 8 days. There were four experimental groups: (I) Control: 0.3 ml saline sol., (II) E + P: 0.4 ug/0.3 ml and 0.8 mg/0.3 ml respectively, (III) E + P + UTPH: 200 ug/0.3 ml and (IV) UTPH. Results on who lemount mammary gland indicated that there was: a) not significant difference among groups vs control in the number of mammary gland ducts. b) a significant increase in number of terminal end buds (TEB) in group II vs I (p<0.0005) and III (p<0.0005) or II vs IV (p<0.0005). c) a significant increase in number of alveoli of group II(p< 0.0005) and III (p<0.0005) vs control. We can conclude from these studies that UTPH inhibited E + P action on TEB development while had no effect on ducts and alveoli.