Abstract
A protein from human placenta, the Uterotrophic Placental Protein (UTPH) was isolated in our lab(Beas & Flores, 1969). It evoked crop sac stimulation in pigeons, inhibited mammary growth produced by estradiol (E) and progesterone (P) in ovariectomized rats and increased DNA synthesis in 5 day organ cultures of mouse mammary gland. The objective of this work was to analyze the effect of UTPH on mammary gland development in intact virgin Balb/c mice injected during 8 days. There were four experimental groups: (I) Control: 0.3 ml saline sol., (II) E + P: 0.4 ug/0.3 ml and 0.8 mg/0.3 ml respectively, (III) E + P + UTPH: 200 ug/0.3 ml and (IV) UTPH. Results on who lemount mammary gland indicated that there was: a) not significant difference among groups vs control in the number of mammary gland ducts. b) a significant increase in number of terminal end buds (TEB) in group II vs I (p<0.0005) and III (p<0.0005) or II vs IV (p<0.0005). c) a significant increase in number of alveoli of group II(p< 0.0005) and III (p<0.0005) vs control. We can conclude from these studies that UTPH inhibited E + P action on TEB development while had no effect on ducts and alveoli.
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