Increase In High-density Lipoprotein Research Articles

Dietary assessment of type 2 diabetic patients using healthful plant-based diet score in the Eastern Province of Saudi Arabia

BackgroundDiabetes mellitus is a chronic disease characterized by a wide range of metabolic problems. The current study sought to assess nutritional habits of Saudi patients with type 2 diabetes (T2D) and to propose recommendations to improve these patients’ dietary habits and delay possible disease complications.MethodsOver a period of three years, (2017–2019) 577 patients with T2D attending the outpatient’s diabetic clinics at King Fahd Hospital of the University, Al Khobar, Saudi Arabia were invited to participate in this study. Data of dietary intake were collected by trained nurses using a pretested structured validated semi quantitative food frequency questionnaire. The dietary data were collected using 7-day dietary recall questionnaire. A modified score system that associates dietary habits with glycemic control and lipid profile was used.ResultsOverall, a high healthful plant-based diet score was associated with a significant (P = 0.018) reduction in triglycerides (TG) level (mean difference − 3.78%; 95% CI, -0.65% to -6.81%) and a statistically non-significant (P = 0.06) increase in high density lipoprotein (HDL) levels (mean difference 1.87%; 95% CI -0.06–3.84%) in T2D patients from the Eastern Province of Saudi Arabia. Additionally, in our patient group, the prevalence of coronary artery disease, stroke, peripheral artery disease, and chronic kidney disease in T2D patients was 11.3%, 6.2%, 3.3%, and 8.4%, respectively and were higher when compared to the prevalence in the general population.ConclusionThe present study showed that adherence to a healthful plant-based diet, when compared to high glycemic index diet, is associated with a favorable outcome in glycemic control and lipid profile in T2D patients. Prior assessment of total diet quality may be beneficial when giving nutritional advice to T2D patients with the possibility of improving glycemic control and lipid profile.

Effect of Ethanol Extract from Kersen Leaves (Muntingia calabura L.) on Changes in Blood Factors Total Cholesterol, Triglycerides, LDL and HDL in Hyperlipidemia Mice

Hyperlipidemia is a risk factor of cardiovascular disorder in diabetes mellitus. Lack of insulin in diabetes mellitus can increase lipolysis which leads to an increased free fatty acid that also increases total cholesterol level and LDL (Low-Density Lipoprotein). This study aims to determine the effect of Muntingia calabura leaf extract on the level of total cholesterol (TC), triglycerides (TG), LDL, and High Density Lipoproteins (HDL) of alloxan-induced male white mice. Thirty male mice were separated into five groups: negative control (NC) without alloxan and extract, diabetes control (DC) with only alloxan, treatment 1 (T1) with alloxan and 100mg/kgBW of M. calabura leaf extract, treatment 2 (T2) with alloxan and 300 mg/kgBW of M. calabura leaves extract, and positive control (PC) with alloxan and 600 µg/kgBW of glibenclamide. One-Way Anova demonstrated that the administration of glibenclamide and M. calabura effectively reduce TC, TG, LDL and increase HDL compared to the diabetes control group (P<0.05) and the most effective dose M. calabura to decrease TC, TG, LDL, and to increase HDL were 300 mg/kgBW. Extraction using 96% ethanol of M. calabura leaf affects the reduction of TC, TG, LDL, and the increase of HDL in the blood and it can be developed as alternative of antihyperlipidemia drugs.

The impact of oral sea-buckthorn oil on skin, blood markers, ocular, and vaginal health: A randomized control trial

Sea buckthorn have been used for centuries as food and traditional medicine in Asia and Europe. This study evaluated the effects of a nutraceutical consisting of sea buckthorn oil as a functional supplement (Omegia™ sea buckthorn oil). Subjects were randomly divided into two groups and were given capsules containing or without sea buckthorn oil. Skin elasticity, color, collagen, pore, and redness were measured using skin assessment instruments. Blood samples were taken to assess serum antioxidant levels by using ELISA (enzyme-linked immunosorbent assay) kit. Additionally, a questionnaire survey was conducted to gather information on subjects' experiences in eye discomfort and vaginal dryness issues. After 12 weeks, skin parameters showed improvement, and participants reported relief from dry eyes and vulvar issues. This study highlights the potential of Omegia™ supplements demonstrating the ability to delay skin aging, increase high-density lipoprotein cholesterol, and antioxidant enzyme activity when used continuously for a period of 12 weeks.

Effects of green tea catechin on the blood pressure and lipids in overweight and obese population-a meta-analysis

BackgroundOverweight and obesity as main health problems harm human beings worldwide. The number of people diagnosed with overweight and obese is gradually increasing. Green tea catechin has been reported to effectively help control body weight in overweight and obese population, and is protectively against the blood pressure and lipids in people with type 2 diabetes and metabolic syndrome. MethodsWe retrieved 4 English databases (PubMed, Web of science, Cochrane, Scoups) from inception to April 20, 2023. Two reviewers independently determined eligibility, assessed the reporting quality of included studies, and extracted the data. Data were extracted from eleven studies. The results were presented with the weighted mean differences (WMDs), and the confidence intervals (CIs) was 95 %. The random-effects or fixed-effects model was applied according to the heterogeneity. The subgroup analysis was used to identify the source of heterogeneity. Publication bias was evaluated using funnel plots, Egger's test, and Begg's test. ResultsEleven randomized controlled trials (RCTs) inclusion studies were screened from 3072 literature articles, involving 613 overweight and obese patients. After combining all studies, it was found that in overweight and obese people green tea catechin could reduce waist circumference (WC) (pooled WMD = −1.37 cm, 95 % CI: −2.52 to −0.22 cm, p = 0.019), and triglyceride (TG) (pooled WMD = −0.18 mmol/L, 95 % CI: −0.35 to −0.02 mmol/L, p = 0.032), and increase high density lipoprotein cholesterol (HDL-c) (pooled WMD = 0.07 mmol/L, 95 % CI: 0.01–0.14 mmol/L, p = 0.031). ConclusionGreen tea catechin supplement effectively reduced WC and TG levels and improved HDL-c levels. However, it did not show the significant effect on the blood pressure in overweight and obese people. The present meta-analysis showed a moderate benefit of green tea catechin supplementation on lipid profiles in overweight and obese people.

Antihyperlipidemic and Histopathological Pancreas Analysis of Muntingia calabura L. Fruit Extract on Alloxan-Induced Diabetic Mice

Hyperlipidemia is clinically manifested by high levels of Total Cholesterol (TC), Triglycerides (TG), Low Density Lipoprotein (LDL) and low levels of High Density Lipoprotein (HDL) in the blood. Antihyperlipidemic drugs available currently have adverse effects. One of the medicine plants with antihyperlipidemic properties with no side effects is Muntingia calabura fruit. The sample used for this research were 30 male mice were divided into 5 groups, i.e., a negative control, a diabetic control, a positive control group, and two treatment groups which were given 100 and 300mg/kg of M. calabura fruit extract every day for 14 days. Examination of TC, TG, HDL, LDL and histopathological pancreas were determined after administration of the extract orally for 14 days. The results demonstrated an administration of glibenclamide and M. calabura fruit could effectively reduce TC, TG and LDL and increase HDL compared to the diabetes control group (P<0.05). In the diabetes control group, the mice given alloxan 150mg/kg showed a decrease in Langerhans islet density, vascularity, and islet injury compared to the normal control group. Mice given M. calabura fruit extract showed a significant increase in pancreatic Langerhans cells granulation and cell density. The conclusion of this research is M. calabura fruit extract showed improvements in lipid profile and pancreatic Langerhans cell regeneration. Therefore, the fruit extract of M. calabura is a potential antihyperlipidemic drug.

Herbal Seeds for Lowering Low Density Lipoprotein Cholesterol and to Increase High Density Lipoprotein Cholesterol

Herbal Seeds for Lowering Low Density Lipoprotein Cholesterol and to Increase High Density Lipoprotein Cholesterol

ANTIHYPERLIPIDEMIC EFFECT OF CORN SILK ETHANOL EXTRACT (Stigma maydis) ON HIGH FAT DIET INDUCED WHITE RATS

Hyperlipidemia is a state when there is an elevation in total cholesterol, triglycerides, Low Density Lipoprotein (LDL) and a reduction in High Density Lipoprotein (HDL) levels. The aim of this research is to investigate the antihyperlipidaemic effects of corn silk and determine the effective dosage of corn silk for reducing cholesterol, triglycerides, LDL and increasing HDL levels in male rats induced by a high-fat diet and PTU. This experiment utilized 24 male Wistar rats divided into six groups, each consisting of individuals aged 2-3 months and weighing between 200 and 250 grams. The groups were labelled as follows: negative control (Na CMC0.5%), positive control, comparison (simvastatin), and treatment I, II, III (with extract doses of 50 mg/KgBW, 100 mg/KgBW, and 150 mg/KgBW). The rats were administered a high-fat diet and propylthiouracil for a period of seven days to induce an increase in cholesterol levels. For the subsequent seven days, the extract was administered. The study results demonstrate that corn silk extract can significantly decrease cholesterol by 46%, 49% and 51%, and LDL by 57%, 61% and 67%, and that corn hair extract can decrease triglycerides by 60%, 65% and 67%, and increase HDL by 21%, 24% and 28%. Thus, it can be concluded that corn silk extract possesses antihyperlipidemic activity with significant value (p<0.005), and the most effective dose for lipid reduction is 150 mg/Kg BB.

Effects of fabomatisol under lead intoxication in rat experiment

The conducted study indicates the priority use of the drug fabomatizole to protect living systems from the negative effects of lead acetate.Aim: To study the mechanisms of fabomatizole effect on the nature of changes in redox reactions, NO-forming function of the endothelium, cholesterol metabolism and functional parameters in rats with lead intoxication.Material and Methods. The study was carried out on 60 Wistar rats. Lead intoxication was induced by intramuscular administration of lead acetate at a dose of 5 mg/kg of animal weight for a month. At the end of the intoxication period, Fabomatizol was administered at a dose of 10 mg/kg for a month. Next, blood and tissue samples were taken from rats to determine the activity of oxidative, antioxidant, enzymatic systems, nitric oxide metabolism, and blood lipid spectrum.Results. The data obtained showed that intramuscular administration of fabomatisol in case of lead intoxication has an antioxidant effect and inhibits lipid peroxidation (LPO) activity. Under the influence of fabomatizol, nitric oxide metabolism andtotal nitric oxide metabolites (NOx) content significantly increased, and a negative correlation was found between the malondialdehyde level, superoxide dismutase activity and NOx. At the same time, the study found a decrease in the expression level of eNOS as the cause of a reduced concentration of NOx in the blood. L-arginine availability for eNOS was disturbed by atherogenic low density lipoprotein (LDL). Treatment with fabomatizol against the background of lead intoxication caused a decrease in total cholesterol, LDL cholesterol and an increase inhigh density lipoprotein cholesterol. By inhibiting lipid peroxidation in the cells of the renal and hepatic tissues, fabomatizol contributed to the restoration of lipid-protein interactions and the functional activity of Na and K-activated ATPase in the renal interstitium. Simultaneously, there is an activation of Na,K-ATP-ase in the hepatocyte and a decrease in the level of organ-specific enzymes in the blood plasma.Conclusion. The results obtained are evidence of the antioxidant properties of fabomatisol in lead intoxication, its ability to induce the activity of antioxidant system (AOS enzymes, stimulate the NO-forming function of the endothelium, NOx production and the activity of the membrane enzyme – Na,K-ATP-ase in the renal and hepatic tissues and reduce the level of organ-specific enzymes in blood plasma.

Fish consumption and its lipid modifying effects – A review of intervention studies

Fish is an important source of nutrients, particularly the long chain n-3 polyunsaturated fatty acids (n-3 PUFAs). The incorporation of fish into the diet has been shown to have several health benefits, including lowering the risk of cardiovascular disease (CVD). Elevated plasma lipids are one of the main modifiable risk factors contributing to CVD and may be partly mediated by n-3 PUFAs. Although n-3 PUFAs in the form of supplementation have been shown to exert lipid modifying effects, the effects of fish consumption on the lipid profile have not been well summarised to date. Therefore, the aim of the present review is to discuss the current evidence from intervention studies investigating the effect of fish consumption on the lipid profile in both apparently healthy and non-healthy populations. Existing evidence appears to support the role of fish in promoting a shift towards a less inflammatory lipid profile through raising n-3 PUFAs and potentially lowering n-6 PUFA and triglyceride concentrations in both healthy and non-healthy populations. Fish consumption has a negligible effect on cholesterol concentrations; however, fish consumption may promote a small increase in high density lipoprotein (HDL) cholesterol amongst people with lower HDL at baseline. Limited studies have shown fish consumption to result in shifts in phospholipid and sphingolipid species and structure, albeit it is not yet clear whether these alterations have any meaningful impact on CVD risk. Future well-designed studies that utilise NMR and/or lipidomics analysis are warranted to explore the effects of these shifts in lipid content and structure in the context of disease development. Public health guidance should emphasise the cardioprotective benefits of fish and encourage consumption particularly in the Global North where fish consumption remains low.

Hyperglycemia effect of Pinctada martensii hydrolysate in diabetic db/db mice

Ethnopharmacological relevancePinctada martensii (Dunker) and other marine shellfish flesh have been traditionally used in China as folk remedies regulate blood sugar. Aim of the studyTo investigate the main active constituents and the pharmacological mechanism of Pinctada martensii flesh enzymatic hydrolysate (PMH) against T2DM. Materials and methodsThe hypoglycemic activity of enzymolysis peptides from Pinctada martensii was evaluated by using db/db mice, through the influence of glycemic index, blood lipid and key protein expression of PI3K-Akt pathway. In addition, label-free quantitative proteomics was used to screen the key proteins for Pinctada martensii hydrolysate (PMH) to improve T2DM, and Western blot and qRT-PCR were used to verify the expression difference of differential proteins at protein and mRNA levels between different groups. ResultsPMH were prepared and characterized. In vivo investigations revealed that the PMH could regulate blood glucose and improve glucose tolerance and insulin tolerance, reduced serum total cholesterol, triglyceride, low-density lipoprotein cholesterol levels and increase high-density lipoprotein cholesterol levels in db/db mice. Western blot results showed that PMH could up-regulate IRS-1, P-PI3K/PI3K and P-Akt/Akt levels in db/db mice. Label-free quantitative proteomic approach was used to analyze the proteome in db/db mouse liver, 231 proteins were reversed significantly (p < 0.05), and these proteins were involved in oxidative phosphorylation, glycolysis/gluconeogenesis and other pathways. Further screened 15 proteins with FC > 1.2 could be enriched in the retinol metabolic pathway, and the proteins in this pathway were also verified. ConclusionsPMH has hypoglycemic effect and can be used as a potential natural T2DM intervener. The hypoglycemic activity of PMH is related to its regulation of the PI3K/AKT pathway. The PI3K/AKT pathway and the retinol pathway are considered as another potential pathway for PMH to exert hypoglycemic effects.

Meditation and Its Mental and Physical Health Benefits in 2023.

This article discusses the power of meditation and how beneficial it is for the body. Magnetic resonance imaging (MRI) has shown many positive brain changes and improved several brain functions. Meditation has several benefits improving the immune system andinflammatory processes by decreasing cytokine; appropriate telomere shortening also has helped healthy aging.Regarding physical health, meditation has been beneficial in various multi-factorial diseases like diabetes, hypertension, and fibromyalgia. It has also helped bring down blood cholesterol levels and increase high-density lipoproteins (HDL) levels. Improvement was also seen in systolic and diastolic blood pressure. Mental health is another aspect influenced by meditation, as positive emotion brought about by meditation helps addressvarious mental problems like social anxiety disorder, post-traumatic stress disorder (PTSD), anxiety, and depression. Overall, it seems to have some impact in all health areas. However, themagnitude of its effect is not known. More diverse and detailed studies should yield more beneficial clinical outcomes.

Evaluation of Glycemic Index, Hypolipidemic and Hypoglycemic Activities of “osu une” on Alloxan Induced Diabetic Rats

Background: The incidence of diabetes has been on the increase due to increase in sedentary lifestyle together with increase in life expectancy. “Osu une” is a native meal in Anambra State, Nigeria used in the management of diabetics. There is no scientific based study/data to ascertain the effect on blood glucose level.&#x0D; Objective: The study investigated the glycemic index, hypolipidemic and hypoglycemic activities of “osu une” on Alloxan induced rats.&#x0D; Methods: The “osu une” was prepared, dried and blended. Twenty adult male Albino rats were grouped into four of five rats each based on their body weight. Alloxan at a dose of 42mg/kg was induced intravenously through tails of group 2-4 rats. Blood samples were collected from the ocular vein and analyzed for blood glucose and lipid profile on day 7, 14 and 28 using standard method. Ten healthy subjects aged between 24 -40 participated in this study. They were fed with the standard food (50 g glucose) on day one and the test foods on day two, after an overnight fast. Blood samples were taken at 0, 30, 60, 120, and 180 min after the food had been eaten.&#x0D; Results: The result showed that rats that received ‘osu une’ extract showed an increase in body weight from 130.70mg/kg to 146.20mg/kg, while rats that received glucophage tablets also showed an increase in body weight from 126.01mg/kg to 158.81mg/kg after inducing diabetes. The rats fed ‘osu une’ extract had a decrease in fasting blood glucose level, total cholesterol (TC), triglycerides, Low Density Lipoprotein (LDLc) and increase in High Density Lipoprotein (HDLc). The test diet had a low glycemic index of 9.59.&#x0D; Conclusion: The study shows that “osu une” can play a key role in the management of Diabetes Mellitus.

Purification, identification and hypolipidemic activities of three novel hypolipidemic peptides from tea protein

In this study, hypolipidemic peptides were obtained from tea protein by enzymatic hydrolysis, ultrafiltration and high-performance liquid chromatography. Subsequently, the hypolipidemic peptides were identified by mass spectrometry and screened through molecular docking technology, and the hypolipidemic activities and mechanisms of the active peptides were explored. The results showed that the hydrolysate of hypolipidemic peptides obtained by pepsin hydrolysis for 3 h had good bile salt binding ability. After purification, identification and molecular docking screening, three novel hypolipidemic peptides FLF, IYF and QIF were obtained. FLF, IYF and QIF can interact with the receptor proteins 1LPB and 1F6W through hydrogen bonds, π-π bonds, hydrophobic interactions and van der Waals forces, thus exerting hypolipidemic activities. Activity studies showed that, compared with the positive controls, FLF, IYF and QIF had excellent sodium taurocholate binding abilities, pancreatic lipase inhibitory activities and cholesterol esterase inhibitory activities. Moreover, FLF, IYF and QIF can effectively inhibit lipogenic differentiation of 3T3-L1 preadipocytes, reduce intracellular lipid and low-density lipoprotein content and increase high-density lipoprotein content. These results indicated that the three novel hypolipidemic peptides screened in this study had excellent hypolipidemic activities and were expected to be used as natural-derived hypolipidemic active ingredients for the development and application in functional foods.

Chemical composition, glycaemic index, and antidiabetic property of analogue rice made from composite tubers, germinated legumes, and cereal flours

The dependence on rice as a source of carbohydrates in Indonesia is among the highest in Asia. Innovations to develop products that can be used as a carbohydrate source, and have functional values beneficial to health are currently needed. The present work thus aimed to determine the chemical composition, glycaemic index, and antidiabetic property of three analogue rice types. The formulation of three types of analogue rice was done by combining natural tuber flour, modified tuber flour, germinated cereals, and germinated legumes. The glycaemic index was assessed using experimental animal. The antidiabetic properties of three types of analogue rice were assessed by food efficiency ratio, glucose profile, lipid profile, and atherogenic index. Results showed that analogue rice had high dietary fibre, resistant starch, and protein, and low fat and carbohydrate. The three types of analogue rice were classified as low glycaemic index based on glycaemic response tests. The glycaemic index of analogue rice I, II, and III were 41.23 ± 3.39, 42.55 ± 3.21, and 40.19 ± 3.34, respectively. The ability of analogue rice to decrease glucose, triglycerides, total cholesterol, low-density lipoprotein, atherogenic index; and increase high-density lipoprotein in diabetic mice was affected by its low glycaemic index and chemical composition benefits. The ability to improve the characteristics of glucose and lipids should support the development of analogue rice as a functional food.

Jogging and weight training associated with increased high-density lipoprotein cholesterol levels in Taiwanese adults.

Although previous studies have shown that aerobic and resistance exercise increase high-density lipoprotein cholesterol (HDL-C) levels, the optimal type of exercise has not been determined. Therefore, the purpose of this study was to investigate the association of jogging (a type of aerobic exercise) and weight training (a type of resistance exercise) with HDL-C levels in Taiwanese adults. The data used in this cross-sectional study were obtained from the Taiwan Biobank (TWB), which is a national health resource that contains the genetic information of Taiwanese volunteers aged 30-70years. A total of 75,635 subjects (47,881 women and 27,754 men) were included in this study. The subjects were divided into four groups: jogging (n =2,278), weight training (n =522), mixed exercise (n =519), and no exercise (n =72,316). The TWB data were collected through questionnaires (e.g. basic characteristics, lifestyle factors, and disease history), biochemical tests, and anthropometric measurements. Compared with no exercise, jogging, weight training, and mixed exercise were all associated with higher HDL-C levels (β=2.5470, 2.6249, and 3.2117, respectively). As seen, the β value was highest for the mixed exercise group, followed by weight training and then jogging (p for trend <0.0001). In the current study, jogging and weight training were individually associated with higher levels of HDL-C. Engaging in both activities was associated with much higher levels of HDL-C. Our findings suggest that regular jogging and weight training might play an important role in increasing HDL-C levels.

Impaired Cardiometabolic Effects of Bromocriptine in Men With Early-Onset Androgenic Alopecia.

Both hyperprolactinemia and early-onset androgenic alopecia are associated with increased cardiometabolic risk. The aim of this study was to assess whether early-onset male-pattern baldness modifies cardiometabolic effects of bromocriptine in men with prolactin excess. The study included 2 groups of men with prolactin excess: individuals with early-onset androgenic alopecia (group1) and individuals with normal hair growth (group2). Both groups were matched for age, smoking habits, body mass index, blood pressure, and prolactin levels. Over the entire study period (4months), all participants were treated with bromocriptine (7.5mg daily). Plasma levels of hormones (prolactin, total testosterone, and bioavailable testosterone), glucose homeostasis markers, lipids, uric acid, high-sensitivity C-reactive protein (hsCRP), fibrinogen, homocysteine, and the urinary albumin-to-creatinine ratio (UACR) were measured at the beginning and at the end of the study period. The two groups differed in total testosterone, bioavailable testosterone, insulin sensitivity, high-density lipoprotein (HDL) cholesterol, triglycerides, uric acid, hsCRP, fibrinogen, homocysteine, and UACR. In both groups, bromocriptine reduced prolactin, increased total and bioavailable testosterone, improved insulin sensitivity, and decreased uric acid, hsCRP, and homocysteine. The impact on prolactin, insulin sensitivity, uric acid, hsCRP, and homocysteine was stronger in group2 than in group1. Only in group2 did the drug increase HDL cholesterol and decrease triglycerides, fibrinogen, and UACR. The impact on cardiometabolic risk factors correlated with a reduction in prolactin levels and an improvement in insulin sensitivity, and, in group1, inversely correlated with testosterone levels. The obtained results suggest that men with early-onset androgenic alopecia are partially resistant to the cardiometabolic effects of bromocriptine.

ODP156 A Case Report of Clomiphene induced Severe Hypertriglyceridemia

Abstract Background The effects of estrogen on lipids have been well studied whereby estrogen has been shown to decrease total cholesterol and low-density lipoprotein (LDL) cholesterol concentrations and increase high-density lipoprotein (HDL) cholesterol and triglyceride (TG) levels. On the other hand, the effects of clomiphene, a selective estrogen receptor modulator have not been well established. Clinical Case A 34-year-old woman with a significant history of type II diabetes who recently started taking self-prescribed clomiphene presented with epigastric pain, nausea, and vomiting. Abdominal examination revealed generalized abdominal tenderness. Laboratory testing revealed normal lipase (30 U/L, normal range 6-51 U/L), increased serum glucose (268 mg/dL, normal range 60-140 mg/dL), and significant elevated TG level (6576 mg/dL, normal range 0-149 mg/dL). Her TG level was 345 mg/dl five months prior to presentation. Abdominal ultrasonography was revealed with no evidence of gallstones and a heterogenous pancreas. She was treated with an insulin infusion and aggressive fluid resuscitation, and her TG level improved to 255 mg/dL after treatment. Given her recent clomiphene use, the patient was deemed to have developed clomiphene-induced severe hypertriglyceridemia. The patient was advised to stop further clomiphene indefinitely and was discharged with fenofibrate 145mg daily and fish oil i. e. omega-3 fatty acid 4g daily for her hypertriglyceridemia. She was asked to follow up with endocrinology outpatient after discharge; however, she was unfortunately lost to follow-up. Conclusion This is a rare case report of hypertriglyceridemia caused by using clomiphene citrate. Serum lipid levels should be measured and followed up closely for patients having risk factors predisposing to hyperlipidemia while using clomiphene citrate. Reference: Castro, M. R., T. T. Nguyen, and T. O'Brien, Clomiphene-induced severe hypertriglyceridemia and pancreatitis. Mayo Clin Proc, 1999. 74(11): p. 1125-8. Presentation: No date and time listed

Response of yield and quality of giant embryo rice to nitrogen application and analysis of lipid-lowering effect.

Giant embryo rice is known as a highly nutritious functional rice because it is rich in gamma-aminobutyric acid (GABA), which has various regulatory functions in the human body. To study the response of giant embryo rice yield and quality to nitrogen (N) application, and to verify the effect of giant embryo brown rice on alleviating hyperlipidemia in rats. In this study, field experiments were conducted in 2020 and 2021 using the giant embryo rice varietiers J20 (japonica) and Koshihikari (japonica) rice as experimental materials and five N levels, 0 (N0), 90 (N1), 135 (N2), 180 (N3) and 225 (N4) kg ha-1. The results showed that the yield of both varieties increased with increasing N and the maximum values were observed under the N2 treatment. As more N was gradually applied, the brown rice rate, milled rice rate, head rice rate and GABA content of both varieties first increased and then decreased, while the chalky grain rate and chalkiness showed the opposite trend. The optimal values of these indexes were observed under the N2 treatment. The peak viscosity and breakdown value of J20 decreased, while its setback value and pasting temperature increased with increasing N. In contrast, Koshihikari showed the opposite trend. The protein content and protein component contents of both varieties showed an increasing trend with increasing N, among which gliadin was the most sensitive protein component to N fertilizer. Animal experiments results showed that J20 brown rice could significantly slow the rate of weight gain of rats, reduce serum total cholesterol and triglyceride levels and increase high-density lipoprotein cholesterol levels. Therefore, increasing N could effectively enhance J20 yield and improve processing, appearance and nutritional quality but decrease cooking and eating quality. The brown rice J20 had the effect of slowing the rate of weight gain and reducing the hyperlipidemia level of rats, the optimal N application rate for achieving high yield, high quality and good functional characteristics in the giant embryo rice J20 was 135 kg ha-1. These findings will provide a theoretical and technical foundation for the popularization and application of giant embryo rice in the future.

Evaluation of anti-hyperlipidemic activity of Euphorbia Hirta bark against triton ® WR 1339 induced hyperlipidemia

Hyperlipidemia is the major risk factor causing many cardiovascular disorders like myocardial infarction and stroke, atherosclerosis. The world has complimented many herbal substances of therapeutic importance. There are many reports about the use of herbal medicine for reduction of lipid profile and reducing the cardiovascular risk in clinical subjects and experimental pharmacology. The plant Euphorbia hirta bark was evaluated for anti-hyperlipidemic activity by Triton (Superinone, Triton WR-1339), induced hyperlipidemia in rats. This study was carried out on the action of Euphorbia hirtabarkethanolic extracts, a known anti-hyperlipidemic drug, Simvostatin (10 mg/kg body wt.), was taken as a standard drug. The statistical parameters of mean± S.E were employed for the calculation of one way analysis of variance test (ANOVA) and Dunnet’s test for many comparison’s P &lt; 0.05 were considered as significant. The studies were shown. There was a significant (P&lt;0.01) reduction in serum levels in lipid profile experiments. It has reported a significant lower total cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipopreotein (VLDL) and an increase in high density lipoprotein (HDL).The study confirmed that ethanolic extract of Euphorbia hirta bark having significant anti-hyperlipidemic action proving a potential herbal medicine as an alternative to currenttreatment of hyperlipidemia.

Biometabolites of Tamarindus indica play a remarkable cardioprotective role as a functional food in doxorubicin-induced cardiotoxicity models

This research investigated the cardioprotective effects of Tamarindus indica extracts (TIEx) in doxorubicin (Dox)-induced cardiotoxicity model. TIEx was tested for phytochemical and antioxidative status followed by a randomized controlled intervention in Swiss albino models. The results were verified by in silico interactions of GC-MS characterized phytocompounds against AT1 (angiotensin II type 1) receptor antagonist complexed with PPARγ agonist. TIEx showed an excellent antioxidative effect and a significant (P < 0.05) decrease in C-reactive protein (CRP), Serum troponin I (STI), aspartate transaminase (AST), lactate dehydrogenase (LDH), and creatinine kinase-MB (CKMB), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and increase high-density lipoprotein (HDL) in treatment groups in comparison with standard drug valsartan. The selected bioactive compounds especially Thymine, 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl- showed the highest binding affinity with the human AT1 receptor antagonist complexed with PPARγ agonist. Results demonstrate that Tamarindus indica parts could be a food supplement for cardiac toxicity.