Abstract
This research investigated the cardioprotective effects of Tamarindus indica extracts (TIEx) in doxorubicin (Dox)-induced cardiotoxicity model. TIEx was tested for phytochemical and antioxidative status followed by a randomized controlled intervention in Swiss albino models. The results were verified by in silico interactions of GC-MS characterized phytocompounds against AT1 (angiotensin II type 1) receptor antagonist complexed with PPARγ agonist. TIEx showed an excellent antioxidative effect and a significant (P < 0.05) decrease in C-reactive protein (CRP), Serum troponin I (STI), aspartate transaminase (AST), lactate dehydrogenase (LDH), and creatinine kinase-MB (CKMB), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and increase high-density lipoprotein (HDL) in treatment groups in comparison with standard drug valsartan. The selected bioactive compounds especially Thymine, 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl- showed the highest binding affinity with the human AT1 receptor antagonist complexed with PPARγ agonist. Results demonstrate that Tamarindus indica parts could be a food supplement for cardiac toxicity.
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