PURPOSE:. Recent studies have reported that oxidative stress may play a key role in the pathogenesis of psoriasis. In fact, it has been proposed as a potential theraputic target. Accordingly, this study was conducted to determine the influence of aerobic training on antioxidant enzyme activity in adults with psoriasis. METHODS: A total of 100 sedentary, male-adults with moderate psoriasis, according to the PASI (psoriasis area and severity index) score, volunteered for this interventional study. Psoriatic arthritis was considered as exclusión criteria. Participants were randomly allocated to the intervention (n=50) or control group (n=50) using a concealed method. The intervention consisted of a supervised 12-week treadmill training program, 3 sessions/week. According to this protocol, they performed a warm-up, 40-50 min treadmill exercise (increasing 5-minutes each 4-weeks) at a work intensity of 55-65% of peak heart rate (increasing 5% each 4-weeks) and cooling-down. Erythrocyte glutathione reductase (GR, EC 1.6.4.2) activity was measured spectrophotometrically by following the decrease in absorbance due to the oxidation of NADPH. Lastly, the current protocol was approved by an Institutional Ethics Committee. RESULTS: When compared to baseline, aerobic training significantly increased erythrocyte GR activity (8.8±1.0vs10.2±1.3U/gHb;p=0.028) in the intervention group. On the contrary, no significant changes were found in the control group. CONCLUSION: A 12-week aerobic training programme increased antioxidant enzyme activity in adults with psoriasis. While current results are promising, future studies are still required to consolidate this approach in clinical application.