Increase In Cycle Length Research Articles

Termination of reentry by lidocaine in the tricuspid ring in vitro. Role of cycle-length oscillation, fast use-dependent kinetics, and fixed block.

We hypothesized that drugs with rapid recovery kinetics from use-dependent sodium channel block could promote oscillatory termination of reentry by enhancing interval-dependent conduction. Mechanisms of termination were related to properties of the reentrant circuit. Nine adjustable reentrant preparations were used in which the canine atrial tricuspid ring was cut and then reconnected electronically by sensing activation on one side of the cut and pacing the other after an adjustable delay. The cycle length and diastolic interval during reentry were manipulated by changing this delay. Lidocaine (1.28 x 10(-5) mol/L) significantly increased refractoriness (94 +/- 39 ms) and the slope of the conduction curve (-0.12 +/- 0.07) at the site of block during pacing. Lidocaine terminated sustained reentry by two mechanisms. Early termination resulted from increased cycle length oscillation and refractoriness (reproducible in each experiment) but only at short delays with short initial diastolic intervals. The range of delays showing this mechanism of termination was 100 +/- 48 ms. Increased cycle-length oscillation resulted from an increased slope of the conduction curve. In eight experiments, lidocaine terminated reentry by causing fixed block after 50 minutes of drug superfusion, which prevented reentry at all delays. Fixed block occurred at one of two vulnerable sites and was transiently reversed by acetylcholine. Termination due to refractory block occurred only when the initial diastolic interval was short, and termination due to fixed block developed when there was a susceptible region with a low safety factor for propagation. Fast recovery from sodium channel block promotes oscillatory termination by increasing the slope of the conduction curve.

Amiodarone Instilled Into the Canine Pericardial Sac Migrates Transmurally to Produce Electrophysiologic Effects and Suppress Atrial Fibrillation

We investigated whether amiodarone delivered into the pericardial sac exerted an effect on atrial and ventricular refractoriness, impulse generation, and conduction and on induced atrial fibrillation. All animals were anesthetized with alpha-chloralose. After a sternotomy, the pericardium was opened and cradled to produce a "container" of approximately 75 mL. Part I experimental animals received amiodarone, 0.5, 1.0, or 5.0 mg/mL, dissolved in 3 mL polysorbate 80 and 5% dextrose in water (D5W) instilled into their pericardial sac for 3-hour intervals. Part II experimental animals received either 1.0 or 5.0 mg/mL of amiodarone. Control dogs received a pericardial solution of 3 mL polysorbate 80 in D5W. Pre- and postinstillation electrophysiologic studies were performed. In part I, the increase in sinus cycle length, 1:1 AV conduction, and effective refractory period (ERP) of atrium, right ventricular (RV) and left ventricular epicardium, and RV endocardium were significantly greater in animals receiving amiodarone compared with controls. Amiodarone concentrations in the tissue samples were highest in the superficial sites of the atria, sinoatrial node, and ventricular epicardial samples and lowest in the interventricular septum. Only trace concentrations of amiodarone and no desethylamiodarone were found in the blood samples. In part II, atrial ERP significantly increased in the animals receiving amiodarone, and the number of episodes of sustained atrial fibrillation that could be induced decreased. Amiodarone instilled into the pericardial sac migrates transmurally to produce significant electrophysiologic effects at superficial sites and appears to suppress electrically induced atrial fibrillation.

Effects of Azimilide Dihydrochloride on Circus Movement Atrial Flutter in the Canine Sterile Pericarditis Model

The effects of a Class III agent, azimilide dihydrochloride, on atrial flutter circuits were studies in a functional model of single loop reentrant atrial flutter using dogs, 3 to 5 days after production of sterile pericarditis. A computerized mapping system was used to construct activation maps from 138 to 222 epicardial sites in the right atrium. Doses of 3, 10, and 30 mg/kg i.v. azimilide dihydrochloride were analyzed in 8 dogs in which sustained atrial flutter lasting more than 30 minutes was induced by burst pacing. Atrial flutter was always due to single loop circus movement reentry in the lower right atrium. At 3 mg/kg, azimilide dihydrochloride terminated atrial flutter in 2 dogs; however, atrial flutter was reinduced. At 10 mg/kg, atrial flutter was terminated in all 8 dogs but was reinduced in 4 dogs with slower rate. At 30 mg/kg, atrial flutter was terminated in the remaining 4 dogs and could not be reinduced. Atrial flutter cycle length always increased prior to termination. Isochronal activation maps showed that the increase in cycle length was due to additional conduction delays in the slow zone of the reentrant circuit. The site of termination was always located within the slow conduction zone situated in the lower right atrium between the line of functional conduction block and the AV ring. Effective refractory periods (ERPs) were measured at selected sites in the slow zone and normal zone at twice diastolic threshold for the 10 mg/kg dose. Azimilide preferentially prolonged ERP in the slow zone (42.4 +/- 20.1 msec, mean +/- SD) compared with the normal zone (23.3 +/- 15.4 msec, P < 0.0001). The increase in cycle length corresponded with the increase in ERP in the slow zone. In a functional model of circus movement atrial flutter, azimilide dihydrochloride terminates and prevents reinduction of atrial flutter by a preferential increase in refractoriness leading to further conduction delay and conduction block in the slow zone of the functional reentrant circuit.

Conversion of atrial flutter by ibutilide is associated with increased atrial cycle length variability

This study was designed to test the hypothesis that conversion of atrial flutter in humans by ibutilide, a new class III antiarrhythmic agent, is characterized by an increase in atrial cycle length variability. Conversion of tachyarrhythmias has been associated with increased oscillations of cycle length. Electrograms and monophasic action potentials from the right atrium in 35 patients with spontaneous, sustained atrial flutter were recorded before, during and after intravenous ibutilide (0.005 to 0.025 mg/kg body weight, n = 25) or placebo (n = 10). Atrial cycle length, cycle length variability (coefficient of variation), diastolic interval and diastolic interval variability were measured from 10 consecutive cycles at baseline and 3 min before, 1 min before, 30 s before and immediately before conversion. Similar measurements were made in patients who received ibutilide or placebo but did not convert. Ibutilide converted atrial flutter in 14 of 25 patients 25 +/- 16 min (mean +/- SD) after initiation of the infusion, whereas placebo converted no patients. Atrial cycle length was prolonged to the same extent in ibutilide converters and nonconverters (36 +/- 19 vs. 38 +/- 21 ms, p = NS) and was not affected by placebo. Beat-to-beat variability in atrial cycle length (baseline 1.2 +/- 0.7 vs. preconversion 7.3 +/- 4.9, p < 0.01) and diastolic interval (baseline 11 +/- 8 vs. preconversion 33 +/- 23, p < 0.05) increased significantly just before atrial flutter conversion and remained unchanged in ibutilide nonconverters and placebo group patients. Ibutilide prolongs atrial cycle length, but conversion of atrial flutter by ibutilide is characterized by increased variability in atrial cycle length and diastolic interval.

Quantitative analysis of proliferation and cell cycle length during development of the rat retina.

The rat retina has been a useful model system for the study of the development of the central nervous system (CNS). In order to facilitate future studies on the mechanisms that control retinal growth, we have quantified the proliferation of retinal cells and the length of the cell cycle throughout development. For each day during development, the number of mitotic and postmitotic cells per retina, the proportion of cycling cells, S phase length, and cell cycle length were determined through quantification of cell numbers and 3H-thymidine labeling. As retinal development proceeds, the proportion of cycling cells decreases, and cell cycle length increases, in part due to an increase in S phase length.

Effect of hCG administration on day 7 of the estrous cycle on follicular dynamics and cycle length in cows

The use of hCG in cattle at breeding or at different times after breeding has been associated with extension in estrous cycle length among cows that do not become pregnant. The objective of this study was to determine whether the increase in estrous cycle length observed in hCG-treated cows that fail to become pregnant is due to changes in ovarian follicular dynamics. Twelve nonbred lactating cows were randomly assigned either to receive hCG on Day 7 of the cycle (Day 0 = day of estrus, n = 6) or to serve as controls (n = 6). Ultrasound scanning was conducted daily from Day 0 until the onset of the next ovulation to monitor follicular and corpus luteum (CL) dynamics. Blood samples were collected for progesterone analysis at each ultrasound session. Ovulation of the Day 7 follicle occurred in all 6 hCG-treated cows. The time of emergence of the second-wave of follicular growth was advanced in hCG-treated cows but was not statistically different (P > 0.05) from that of the control cows (10.8 ± 0.3 vs 12.7 ± 1.4 d). The mean diameter of the second-wave dominant follicle from Days 15 to 18 was not different (P > 0.05) between the treatment groups. However, the second-wave dominant follicle had a slower growth rate (0.8 vs 1.3 mm/d) among cows treated with hCG compared with that of the controls. The second-wave dominant follicle was the ovulatory follicle in 5 control cows, but only in 3 hCG-treated cows. The dominant follicle from the third wave ovulated in 1 control and in 3 hCG-treated cows. The lifespan of the spontaneous CL and the time to low progesterone levels (< 1 ng/ml) were not different between the control and hCG-treated cows. These results suggest an altered follicular dynamic but no extension in estrous cycle length when hCG is administered on Day 7 of the cycle in postpartum cows.

Effects of Sotalol on His-Purkinje Conduction and Refractoriness in Humans.

BACKGROUND: The effects of sotalol on refractoriness in human ventricular and atrial muscles have been well established, but the drug's effect on the electrical properties of the His-Purkinje system in humans is not known, especially whether sotalol's effect is due solely to its action on prolonging repolarization or in combination with its beta-blocking properties. We studied the electrophysiologic effects of intravenous sotalol and propranolol in patients undergoing electrophysiologic studies of cardiac arrhythmias. METHODS AND RESULTS: We studied 22 patients (19 men, 3 women; mean age, 60 +/- 6 years) who had coronary artery disease and assessable anterograde, retrograde, or both, His-Purkinje system function. Fifteen patients underwent electrophysiologic studies before and after intravenous sotalol (1.5 mg/kg), and 7 patients underwent electrophysiologic studies before and after intravenous propranolol (0.15 mg/kg). Both sotalol and propranolol had no significant effect on the H-V interval, but sotalol significantly increased ventricular refractoriness and His-Purkinje refractoriness, both in anterograde and retrograde conduction, whereas propranolol did not, Sotalol's effect on His-Purkinge refractoriness also caused atrioventricular block distal to the His bundle during atrial pacing at a moderately fast rate. Sotalol was not effective in preventing bundle branch re-entry tachycardia, nevertheless, it increased cycle length of bundle branch re-entry tachycardia by increasing refractoriness. CONCLUSIONS: Sotalol increased His-Purkinje refractoriness in humans but had no effect on His-Purkinje conduction. The drug must be used judiciously in patients with a diseased His-Purkinje system because it may cause atrioventricular block distal to His at fast heart rates. Sotalol had no effect on macrore-entry utilizing bundle branches.

Alterations in circulating ovarian steroids in hexachlorobenzene-exposed monkeys

Hexachlorobenzene (HCB) is a global pollutant that has been identified in human serum and ovarian follicular fluid, and its effect on ovarian function has not been adequately defined. Thus, the effects of HCB on ovarian steroidogenesis and menstrual cycle characteristics were investigated in cynomolgus monkeys ( n = 16) orally dosed by gelatin capsule (0.0, 0.1, 1.0, and 10.0 mg HCB/kg b.wt./d) for 90 d (approximately three menstrual cycles). Analysis of change in menstrual cycle length for each animal revealed a dose-dependent increase ( P = 0.02) in cycle length. Ovulatory levels of estradiol (E 2) were significantly reduced ( P = 0.02) in the highest treatment group. During ovulation induction, the area under the E 2 concentration curve (AUC) was significantly ( P = 0.03) suppressed in the highest treatment group. Our data demonstrate that HCB treatment, under the conditions of the present study, alters both ovarian function and menstrual cycle characteristics with a no observable adverse effect level of 1.0 mg/kg.

Average duration and performance of actuated signal phases

This paper describes an approach for evaluating alternative traffic detection designs for a signalized intersection. The models described in this paper can be used to determine the average phase duration and frequency of phase “max-out” as a function of the detector loop layout, detector unit timing, traffic demand, and approach speed. Layout and timing are described by the number of detectors on each approach served by the phase, detector location on each approach, detector length, and detector unit and controller time settings. The authors have used the concept of maximum allowable headway ( MAH) to combine the many possible combinations of layout and timing variables into one representative quantity, which greatly simplifies the modelling process. The performance models were used to examine the sensitivity of intersection performance to a range of design values. In general, both phase duration and cycle length increase with higher demands or larger MAHs. Multiloop (i.e. two or more detection zones per lane) detector designs typically have larger MAHs than designs with one detector loop per lane. Phase duration and cycle length also increase for very low demand levels. In terms of performance, the maximum green duration was found to have a contrary effect at higher flow conditions. Larger maximum greens were found to reduce delays to the phase in service by reducing the probability of max-out but they increased delays to drivers waiting for service.

Mechanisms of conduction time hysteresis in rabbit atrioventricular node.

The functional origin of atrioventricular nodal hysteresis was studied in isolated rabbit heart preparations. This hysteresis is characterized by asymmetric changes in nodal conduction time (NCT) occurring for symmetric changes in cycle length. The respective contribution of the nodal properties of recovery, facilitation, and fatigue to the beat-to-beat changes in NCT observed during paired symmetric ramps of decreasing and increasing cycle length was determined with specifically design stimulation protocols. Nodal hysteresis was found to be entirely accounted for by variations in the contribution of nodal recovery and fatigue properties observed at corresponding cycle lengths. The study establishes how this contribution varies on a beat-to-beat basis as a result of cycle length history. This holds true for the numerous changes in hysteresis observed in response to changes in the sequence and slope of the ramps. Facilitation clearly affected NCT during these responses but did not contribute to the hysteresis. Moreover, the study demonstrates that there is no inherent change in the characteristics of nodal function with the direction of the ramp that could account for the hysteresis. Thus nodal hysteresis arises from nodal functional properties of recovery and fatigue but does not constitute a distinct independent intrinsic property of the node.

Effect of Velocity on Cycle Rate and Length for Three Roller Skiing Techniques

This investigation examined the adjustments made in cycle rate and length to velocity changes during roller skiing with the double pole (DP), kick double pole (KD), and VI skate (VS) techniques. Eight cross-country ski racers roller skied with each technique on a flat track at submaximal and maximal velocities while being videotaped from a lateral view. Increases in submaximal velocities were associated with increases in cycle rate and cycle length for KD and VS but only with increases in cycle rate for DP. Maximal sprint velocities were approximately 7% lower (p &lt; .01) for KD than for DP and VS and were associated with increases (p &lt; .01) in cycle rate for each technique combined with decreases (p &lt; .01) in cycle length for DP and VS. The findings indicate that there are differences among techniques in the manner in which cycle rate and length are adjusted to change submaximal velocity, but each technique relies upon an increase in cycle rate to achieve maximal velocity.

Maturational changes in the respiratory rhythm generator of the mouse.

The changes in motor activity of the respiratory rhythm generator were quantitatively analysed in mice (from birth to at least 56 days old) in both awake and anaesthetized preparations, as well as in vitro to define the age at which the respiratory network is mature. In awake and anaesthetized spontaneously breathing mice respiratory-related thoracic movements were recorded and revealed an age-dependent increase in both inspiratory time (45%) and cycle length (22%) over the first 15 days of life. Similarly, the pattern of phrenic nerve activity recorded from anesthetized animals also changed from a short, rapid onset and offset burst, without a post-inspiratory phase (0-10 days old), to a discharge of longer duration which included both ramp and post-inspiratory components (> 15 days). This pattern was comparable to that seen in adult mice (> 56 days old). A recently developed tilted-sagittal brainstem slice preparation containing an isolated, but functionally intact, medullary respiratory network was employed in our in vitro studies. Since this preparation generates respiratory rhythmic activity spontaneously in both neonatal and mature mice (> 56 days old) it has permitted a direct comparison of the respiratory motor output pattern, recorded from the hypoglossal (XII) motor nucleus, during post-natal development in similar preparations. Consistent with our in vivo findings there was an age-dependent change in the motor pattern. The rhythmic burst of XII neurones recorded from slices of neonates (0-10 days old) was short in duration and decremented whereas a longer discharge (increase of 625% compared to neonate) containing a plateu component was seen in animals more than 15 days old. In addition, the cycle length of rhythmic XII neurones increased (143%) and, together with the changes in burst duration, reached a steady-state value over a similar time course to the maturational changes in phrenic nerve activity recorded in vivo.

Role of fast inhibitory synaptic mechanisms in respiratory rhythm generation in the maturing mouse.

1. The importance of glycinergic and GABAAergic synaptic mechanisms for respiratory rhythm generation in the maturing mouse were investigated in vivo and in an in vitro slice preparation generating respiratory rhythmic activity spontaneously at all postnatal ages. 2. The effect on respiration of topical application of strychnine or bicuculline to the surface of the ventrolateral medulla was assessed in spontaneously breathing anaesthetized mice of different ages (postnatal (P) days 0 to > 56). Glycine receptor antagonization with concentrations of strychnine up to 25 microM was ineffective in altering the breathing pattern in neonates (P1-P8). However, in mature mice (P > 15), low doses of strychnine (0.2-2 microM) abolished regular rhythmic discharge in the phrenic nerve. Bicuculline (0.5-50 microM) produced dose-dependent increases in inspiratory time, amplitude and cycle length of phrenic nerve discharge in anaesthetized neonatal mice whereas both cycle length and duration of inspiratory activity were reduced in mature animals. In addition, in both neonates and mature mice low concentrations of bicuculline (0.5-5 microM) abolished phrenic nerve discharge intermittently. 3. The response of respiratory-modulated hypoglossal (XII) neurones recorded in tilted sagittal slices from newborn and mature mice during blockade of glycine and GABAA receptors was similar to the phrenic nerve changes observed in vivo: in slices from neonates, the rhythmic activity of XII neurones was resistant to concentrations of strychnine up to 50 microM whereas low doses of strychnine (0.2-2 microM) abolished rhythmic activity in preparations from mature mice. Bicuculline (1-50 microM) produced a dose-dependent prolongation of burst duration and a slowing of rhythmic discharge in slices from neonatal mice whereas in mature mice rhythmic XII bursts were shortened and their frequency increased. At all maturational stages, bicuculline (1-50 microM) induced severe disruption of the regular rhythm of XII neurone activity causing maintained depolarizations and oscillations in membrane potential. 4. On-going inhibitory postsynaptic potentials of neurones located in the ventral respiratory group region of tilted sagittal slices from both immature and mature mice were sensitive to low concentrations of either bicuculline or strychnine (1-5 microM) indicating an absence of a maturational change in the sensitivity of GABAA and glycine receptors to their respective antagonists.(ABSTRACT TRUNCATED AT 250 WORDS)

Levonorgestrel intrauterine device in the treatment of menorrhagia in chinese women: Efficacy versus acceptability

Ten Chinese women who had menorrhagia without organic cause and suffered from anaemia were treated with levonorgestrel intrauterine device for a total of 129 woman-months. There was a 54%, 87% and 95% reduction in menstrual blood loss at the first, third and sixth month of treatment when compared with the pretreatment cycle. These percentages of reduction were statistically significant, with p values of 0.004, 0.03 and 0.008, respectively. There was a median increase in menstrual cycle length of 12 days in nine months. Fifteen percent of the menstrual cycles were longer than 60 days. The total bleeding days increased by 4 days at the third menstrual cycles, but reduced to a median of 6 days at 6 months. Seventy-six percent of the menstrual bleeding was in the form of spotting. These Chinese women accepted such menstrual alterations. There was no hormonal side effects. All women preferred the device to hysterectomy. Levonorgestrel intrauterine device appeared to be an effective and acceptable treatment for menorrhagia in perimenopausal Chinese women.

Effect of exercise on cycle length in atrial flutter.

To examine the effect of exercise on cycle length in atrial flutter. 15 patients with chronic atrial flutter. Seven patients were taking digoxin and six verapamil; two were not taking medication. All patients underwent bicycle ergometry. Flutter cycle length was measured at rest and at peak exercise. Mean flutter cycle length increased from 245 ms to 256 ms (P = 0.002). Six patients developed 1:1 atrioventricular conduction. Significant increases in flutter cycle length were observed irrespective of development of 1:1 atrioventricular conduction and use of digoxin and verapamil. Exercise prolongs flutter cycle length. This effect would promote development of 1:1 atrioventricular conduction during exercise, causing inordinately high ventricular rates.

The effect of nadolol on heart rate and the standard deviation of the RR intervals

The aim of this study was to evaluate the effect of nadolol in modifying the standard deviation of RR intervals (SDRR) and the coefficient of variance (CV) in 47 patients characterized by symptomatic, frequent (> 30 h-1) and reproducible premature ventricular contractions (PVCs). Sixteen patients had suffered a previous myocardial infarction (Group 1), 22 had various non-ischaemic cardiac diseases (Group 2) and nine had no heart disease (Group 3). All patients underwent two 24 h Holter recordings during the washout period, and a third Holter recording was taken 5 days after the administration of nadolol (80 mg.day-1). The RR cycle length (RR), SDRR and CV were evaluated for each 24 h period, as well as for six daytime (1000-1600h) and six night-time hours (0000-0600h). In all three groups, nadolol was highly effective in lengthening RR. However, the effect on SDRR was different in the three groups; 24-h SDRR tended to be reduced in all three groups (but the reduction was significant only in Group 1) due to a certain RR homogeneity. On the other hand, daytime SDRR tended to increase (but the increase was significant only in Group 3). CV is concomitantly affected by heart rate and SDRR, therefore it may be more sensitive in evaluating the effect of beta-blockers. The reduction in CV post-nadolol means that the bradycardia-induced effect is associated with an inadequate increase, or even a reduction in SDRR, whereas the absence of any CV changes (found only in Group 3) is the result of a concomitant increase in both RR cycle length and SDRR.(ABSTRACT TRUNCATED AT 250 WORDS)

N-olefin skeletal isomerization process

In a process for skeletal isomerization of linear olefins to iso-olefins, e.g., n-butenes to isobutylene, over a catalyst comprising medium pore zeolite, e.g., a zeolite selected from ZSM-22, ZSM-23, and ZSM-35, the zeolite is pretreated with a dicarboxylic acid, e.g., oxalic acid. The pretreatment significantly reduces aging rate and increases cycle length of the catalyst.

Atrial flutter can be terminated by a class III antiarrhythmic drug but not by a class IC drug

In atrial flutter, chemical conversion with class I drugs is often unsuccessful, whereas class III drugs seem more promising. The different electrophysiological effects of these drugs may explain this discrepancy. To date, only experimental data show the differential effects of these drugs on conversion rate and atrial flutter cycle length. This study evaluates the effects of the class IC antiarrhythmic drug flecainide, and of dofetilide, a new class III drug, on conversion rate and flutter cycle length in patients with atrial flutter. Flecainide (11 patients) was given as an intravenous bolus of 2 mg.kg-1 in 10 min and dofetilide (10 patients) as a maximum intravenous bolus of 8 micrograms.kg-1 in 15 min. Baseline characteristics were comparable between both groups. Only one patient treated with flecainide converted to sinus rhythm. This patient showed the largest flutter cycle length increase (280 to 420 ms). By contrast, seven of the 10 patients treated with dofetilide converted to sinus rhythm. Patients treated with flecainide showed a significantly larger increase in atrial flutter cycle length at the end of the infusion compared to the dofetilide-treated patients (from 226 +/- 28 to 317 +/- 52 ms vs from 221 +/- 26 to 239 +/- 39 ms, respectively). In conclusion, dofetilide is more effective than flecainide in the conversion of atrial flutter to sinus rhythm, despite the fact that flecainide produced a more prolonged flutter cycle length. Thus, action potential prolongation in the absence of conduction slowing seems more effective in terminating human atrial flutter than depression of the excitability.

Hormone replacement therapy in perimenopausal women with a low dose oral contraceptive preparation: Effects on bone mineral density and metabolism

In a 2-year longitudinal, calcium-controlled study we evaluated bone density and metabolism in perimenopausal women with initial ovarian failure, and the effects of hormone replacement with a low dose oral contraceptive preparation (OC). In perimenopausal oligomenorrhoic women ( n = 16) a significant ( P < 0.01) increase in cycle length and plasma FSH levels as well as a parallel decrease in plasma estradiol levels ( P < 0.01) were evident. In this group, despite the calcium supplementation (500 mg/day), a significant ( P < 0.001) increase in the biochemical markers of bone remodelling paralleled a significant ( P < 0.001) decrease (-3.4% after 24 months) in bone density. Conversely, in premenopausal oligomenorrhoic women treated with a low dose oral contraceptive (OC) formulation (30 mcg ethinyl estradiol plus 75 mcg gestodene, n = 16), bone markers showed a significant ( P < 0.01) decrease, that paralleled a slight but significant ( P < 0.01) increase (+1.71%) in bone density. These data suggest that premenopausal administration of OC can prevent the acceleration of bone turn-over and reverse the decrease in bone density that follows the premenopausal impairment of ovarian function.

Comparison of electrophysiologic effects of quinidine and amiodarone in sustained ventricular tachyarrhythmias associated with coronary artery disease

Fifteen patients with spontaneous ventricular tachyarrhythmias underwent electrophysiologic studies at baseline and during therapy with quinidine and amiodarone. In 9, ventricular tachycardia (VT) with a similar QRS morphology was induced with quinidine, amiodarone and under the control state. Both quinidine and amiodarone significantly increased QRS duration and the VT cycle length. Amiodarone increased the VT cycle length more than quinidine (85 vs 121 ms, p < 0.05). Amiodarone increased the percent QRS duration (during sinus rhythm, ventricular pacing and VT) significantly less than percent VT cycle length, whereas quinidine did so only at stow rates (at faster rates the percent increase in QRS duration is not different from the percent increase in VT cycle length). The percent increase in QRS duration produced by quinidine correlated significantly with the percent increase in VT cycle length (the best correlation was observed during pacing, r = 0.78). In contrast, no such significant correlations were obtained for amiodarone. Thus, amiodarone prolongs VT cycle length more than quinidine (at the doses used). The effects of quinidine on conduction in tissue mostly unrelated to tachycardia origin predict effects in the tachycardia cycle length. In contrast, the effects of amiodarone on the latter are more intense but not predicted by those on tissue unrelated to the tachycardia origin.