Increase In Blood Sugar Levels Research Articles

Reflexology On Blood Sugar Levels In Patients With Diabetes Mellitus: Literature Review

Background: Diabetes mellitus is a disease that often causes chronic complications if not handled properly and is characterized by an increase in blood sugar levels. This literature review aims to determine the effect of reflexology on blood sugar levels in patients with diabetes mellitus. Methods: The method used in this article is a literature review using a journal database from Science Direct and Google Scholar from 2020 to 2023 with the keywords "Reflexology" or "Reflexology," "Blood glucose" or "Blood sugar levels," and "Diabetes Mellitus" Results: obtained results of 1,070 articles. Articles were selected according to the criteria, and ten articles were ready to be reviewed. Reflexology affects lowering blood sugar levels in people with diabetes mellitus by doing it regularly for 20-30 minutes 12 times. Conclusion: Doing a physical activity, one of which is applying Reflexology 12 times in 3 sessions for four weeks, can control blood sugar levels

The level of compliance of type II diabetes mellitus patients in controlling blood sugar

Diabetes mellitus is a chronic disease in the form of a metabolic disorder characterised by increased blood sugar levels that exceed normal limits. The purpose of the study was to determine the characteristics of type DM patients based on their level of adherence to drug use. The study used analytical descriptive methods with a cross-sectional study approach. Research samples were determined using the accidental sampling method on subjects who encountered as many as 44 pieces that doctors have diagnosed in the Kalumata Health Centre work area and according to inclusion criteria. Variable measurement using the Morisky Medication Adherence Scale questionnaire and validity and reliability analysis using SPSS version 25. Further tests were performed using bivariate Pearson correlation analysis. The results of the statistical analysis obtained sig values. (2-tailed) between age and gender, BPJS users' compliance rates are 0.510, 0.109, and -0.192, respectively. This means that there is no correlation or relationship. The variables of education level and type of work are 0.005 and 0.014, which significantly influence the level of compliance. It can be concluded that the variables that substantially impact the level of adherence of type 2 DM patients are education level and type of work. It is essential to constantly monitor and evaluate the effectiveness of implementing these recommendations to ensure an increase in the compliance rate of type 2 DM patients.

Nano Drug Delivery System with Resveratrol as Promising Novel Adjuvant Therapy for Diabetic Non-Healing Wounds: A Literature Review

Diabetes mellitus (DM) is a metabolic disease characterized by increased blood sugar levels (hyperglycemia) and is associated with impaired function of β cells. The uncontrolled and prolonged hyperglycemia in DM can cause complications. One of the most common is diabetic non-healing wounds, the leading cause of disability in people with diabetes, therefore adjuvant therapy is needed. Compounds from natural ingredients are currently getting the spotlight in recent studies conducted to prove their effect on non-healing wounds, such as Resveratrol (RSV). This review aims to discuss the potential of RSV as a novel adjuvant therapy and its delivery system strategy in the case of diabetic non-healing wounds. We conducted an extensive search from three online scientific databases such as ScienceDirect, ResearchGate, and PubMed on February-March 2023. Keywords used are "resveratrol", "diabetic wound healing", and "diabetes mellitus". As a result, 86 studies were reviewed, and only 79 selected studies met all inclusion criteria. The formulation of RSV nanoparticles in oral drug delivery systems and topical administration has shown promise to overcome the limitations of RSV as adjuvant therapy in diabetic non-healing wounds. The best option that we found through this literature review is the nano-oral drug delivery system as it could minimize drug metabolism in the gastrointestinal tract, therefore the drug bioavailability and drug concentration on the target site could be maximized, even though the systemic side effects might occur.

Karakteristik Kesejahteraan Psikologis Dan Kadar Gula Darah Pada Penderita Diabetes Mellitus

Diabetes mellitus is a metabolic disorder disease characterized by increased blood sugar levels due to decreased insulin secretion by pancreatic beta cells and/or impaired insulin function (insulin resistance). This study aims to describe the psychological well-being and blood sugar levels in people with diabetes mellitus. This research is a quantitative research using descriptive method to make an objective picture of a situation. The sample of this study amounted to 74 respondents using the technique purposive sampling. This study used a standard psychological well-being questionnaire and used a glucometer to measure blood sugar levels. The data analysis used is a simple descriptive form of a frequency distribution table. The results of this study indicate that 31 respondents (41,9%) accept their own state, 8 respondents (10,8%) have positive relationships with other people, 6 respondents (8,1%) have independence, 25 respondents (33,8%) can manage the environment, 2 respondents (2,7%) have a purpose in life, and 2 respondents (2,7%) have personal growth. People with diabetes mellitus with high psychological well-being are able to accept their situation, like undergoing the process of diabetes mellitus treatment, and are able to master the environment.

Schizophyllum spp. in Covid-19- A Series of Ten Cases from a Tertiary Care Hospital of Central India.

Background: Schizophyllum species can cause diverse clinical infections like sinusitis, pulmonary disease, ulcerative lesions of the palate, atypical meningitis, cerebral abscess which can occur in both immunocompetent and immunocompromised individuals. Although it is one of the emerging fungi, data on clinical features and outcomes of fungal diseases caused by Schizophyllum spp. in India are currently not sufficient. A failure to exhibit morphological characteristics leads to difficulties in identification, incorrect therapy and decreased frequency of reporting. It is one of the underreported fungal species and the disease load is much higher than reported. Here, we report a series of ten cases where Schizophyllum is isolated as the causative fungal agent. Materials and methods: Nasal scrappings were taken from suspected mucormycosis patients and processed for KOH mount and fungal culture by standard methods. Results: Schizophyllum spp. were isolated from ten suspected patients and majority of them had history of Covid-19, increased blood sugar level and steroid therapy. One of them was a case of T-lymphoid leukaemia under chemotherapy. All the patients were discharged from the hospital after successful treatment. Conclusion: During the second wave of Covid-19 pandemic there was sudden rise of mucormycosis cases in India. This study shows that Schizophyllum spp. can also be a causative fungal agent in post covid patients showing similar signs and symptoms like mucormycosis and can easily be misdiagnosed

The Effect of a Combination of Brisk Walking Exercise and Bay Leaf Decoction on Changes in Blood Sugar Levels in Diabetes Mellitus Patients

Diabetes mellitus is a clinical condition of metabolic disease characterized by an increase in blood sugar levels or called hyperglycemia due to failure of insulin secretion, insulin performance or both. Management of diabetes mellitus can be helped non-pharmacologically in the form of brisk walking exercises and boiled bay leaves. This research aims to determine the effect of a combination of brisk walking exercise and boiled bay leaves on reducing blood sugar levels in people with type 2 diabetes mellitus. This type of research is quasi-experimental with pretest - posttest with control group. The instruments used were an observation sheet and a glucometer set. Sampling used probability sampling with purposive sampling consisting of 38 respondents for the intervention group and 38 respondents for the control group. The data analysis used was the Wilcoxon test and the Mann-Whitney test. The results showed a significant reduction in blood sugar levels in the intervention and control groups. However, there was a significant reduction in blood sugar levels in the intervention group with a p-value of 0.000. This study concluded that there was an effect of the combination of brisk walking exercise and boiled bay leaves on reducing blood sugar levels in people with type 2 diabetes mellitus.

Ageing-Related Alterations in Renal Epithelial Glucose Transport.

The kidney plays a crucial role in glucose homeostasis by regulating glucose transport. We aimed to investigate the impact of alterations in glucose transport on glucose metabolism during ageing. Adult male Sprague Dawley rats were divided into five groups: 3-month, 6-month, and 12-month control groups, and 6- and 12-month groups receiving the hydrogen sulfide donor molecule GYY4137. The study found that, as age increased, daily urinary uric acid and protein levels increased in the 12-month group. Blood sugar level and HOMA-IR index increased in the 12-month group, and were partially improved by GYY4137. The kidney tissue showed mild glomerulosclerosis in the 12-month group, which was diminished by GYY4137. Gene expression analysis showed decreased sirtuin and increased p21 expression in the aging groups. Increased SGLT1 and SGLT2 expression was observed in the 12-month group, which was reversed by GYY4137. Both GLUT1 and GLUT2 expression was increased in the 6- and 12-month groups, and reversed by GYY4137 in the 12-month group. The study concluded that aging was associated with increased blood sugar levels and the HOMA-IR index, and the abundance of renal glucose transporters increased as aging progressed. GYY4137 effectively reversed aging-related alterations in glucose homeostasis and renal epithelial transporters.

The Effect of Diabetic Gymnastics on Reducing Blood Sugar Levels, Stress, and Anxiety in Patients with Type II Diabetes Mellitus

Type II diabetes mellitus (DM) has increased significantly in developing countries, including Indonesia. Type II DM is caused by increasing blood sugar levels. There are various complications both physically and psychologically. Psychological disorders include stress and anxiety. One intervention to reduce blood sugar levels, stress and anxiety is diabetic gymnastics. The purpose of the study was to determine the effect of diabetic gymnastics on reducing blood sugar levels, stress, and anxiety. This type of research uses quasi experiment with pre-test and post-test control group design. The population was type II DM patients with a sample of 36 people divided into control and intervention groups of 18 respondents each using purposive sampling technique. The results of the validity and reliability test of the stress variable referring to the Diabetes Distress Scale-17 were declared valid with r 0.79-0.83 with Cronbach alpha's of 0.921, and the anxiety variable referring to the Depression Anxiety Stress Scales-42 instrument was declared valid with r 0.532 and Cronbach alpha's of 0.943. Data analysis using Paired Sample T-Test and Independent Sample T Test. The results showed that there was an effect of diabetes gymnastics on reducing blood sugar levels, stress and anxiety in the control group (p-value 0.000), (p-value 0.005), (p-value 0.020) and the intervention group (p-value 0.000), (p-value 0.000), (p-value 0.000) and there were differences in the value of reducing blood sugar levels, stress and anxiety in the control and intervention groups (p-value 0.000), (p-value 0.041), (p-value 0.038). Conclusion There is an effect of diabetic gymnastics on reducing blood sugar levels, stress, and anxiety in patients with type II diabetes mellitus. It is expected that diabetes exercises can be used as one of the interventions in dealing with complications of diabetes mellitus. Keywords: Diabetes mellitus, blood sugar level, anxiety, diabetes gymnastics, stress.

Type 1 Diabetes Mellitus in Children: Diagnosis and Management

Diabetes is a chronic metabolic disease characterized by increased blood sugar levels over time. This disease is caused by the presence of impaired insulin secretion, impaired insulin action, or both. The method used in writing this article is literature study. The literature study was carried out by searching published articles regarding the diagnosis and management of type 1 diabetes mellitus (T1DM) in children. Diagnosis is determined based on typical symptoms including polydipsia, polyuria, and decline body weight accompanied by blood sugar measurements. Components of managing T1DM (Type 1 Diabetes Mellitus) including (1) education; (2) insulin administration; (3) diet management; (4) physical activity; (5) self-monitoring; and (6) psychosocial therapy. Management of diabetes is necessary to achieve metabolic control optimally, preventing acute complications, microvascular or macrovascular complications, as well to improve the psychological aspects of patients and families.

Prediction of FKRTL Services Diagnosed with Type 2 Diabetes Mellitus Using the Hierarchical Agglomerative Clustering Time Series Method

Diabetes Mellitus (DM) is a disease characterized by hyperglycemia or increased blood sugar levels and metabolic disorders. DM is a disease with a high prevalence rate in Indonesia. DM is included in the 10 most frequent Advanced Referral Health Facility (FKRTL) visits diagnoses. This research aims to find out provincial groupings based on data from FKRTL visits of participants diagnosed with T2DM using the Hierarchical Agglomerative Clustering method (single linkage, complete linkage, average linkage) and to find out predictions of participants diagnosed with T2DM at FKRTL visits using the Autoregressive Integrated Moving Average (ARIMA) method. The method used is Hierarchical Agglomerative Clustering Time Series. This research shows that the best algorithm is average linkage with a number of clusters of two. Forecasting provides a pattern that tends to decline.

Ffectiveness of Resistance Exercise and Diabetic Foot SPA Interventions on Fasting Blood Sugar Levels and Peripheral Neuropathy in Type II Diabetes Mellitus Clients

Background: Diabetes mellitus is one disease that has a distinctive clinical sign, namely an increase in blood sugar levels beyond the normal range. DM can also cause complications such as peripheral neuropathy. Interventions that can be applied in dealing with the above problems are Resistance exercise and Diabetic Foot Spa. Objective: The purpose of this study was to determine the effectiveness of resistance exercise and diabetic foot spa on fasting blood sugar levels and peripheral neuropathy in Type II Diabetes Mellitus clients. Method: This study is a true experimental research using pre test and post test approach with control group design. Sampling was carried out using a simple random sampling technique and obtained 40 DM patients who sought treatment in the work area of the Srondol Health Center, which were divided into 2 groups (Intervention and Control). Statistical analysis Pre-Test Post-Test difference test using Paired T-Test difference test and Wilcoxon test then Inter-group difference test using Independent T-Test and Mann Whitney U-Test. Results: This study showed that there were significant differences before and after the combination treatment of Resistance exercise and Diabetic Foot Spa on fasting blood sugar levels values (p = 0.000), and peripheral sensory neuropathy responses (p = 0.031), Dorsiflexion (p = 0.003), Plantarflexion (p = 0.011), Inversion (p = 0.000), Eversion (p = 0.018), autonomic neuropathy (p = 0.108), while Resistance exercise and Diabetic Foot Spa did not have significant differences in motor neuropathy response foot deformity (p = 1,000) and autonomic neuropathy (p = 0.108). Conclusion: Resistance exercise and Diabetic foot spa interventions are effective against fasting blood sugar levels and peripheral sensory, motor neuropathy (joint area of motion) in type II diabetes mellitus clients.

The Influence of Diabetic Foot Exercise On Foot Sensitivity Of Diabetes Mellitus Patient Type 2

Introduction: Diabetes mellitus (DM), a chronic metabolic condition marked by elevated blood sugar levels (hyperglycemia), is brought on by an imbalance between the supply and demand for insulin. Decreased or missing insulin causes glucose to be retained in the circulation, increasing blood sugar levels while depleting the glucose that is required for cell survival and function. In type 2 DM patients, complaints of neuropathy are common.The aim of this study was to evaluate the impact of diabetic foot exercise on patients with Type 2 Diabetes Mellitus at the Selemadeg Timur II Health Center. Methods: Pre-experimental research is the type of study being conducted. During December 2022 to January 2023, the study was conducted at the Selemadeg Timur II Health Center. A total of 34 people were included in the sampling method with purposive sampling. The Wilcoxon Sign Rank test was used for analysis.Result: This study included 34 samples, and convenience or accidental sampling was used to choose the samples. The Wilcoxon test's asymp sign (2 tailed), which is 0.02 or 0.05, reveals the significance value. The results of the research show that before intervention the most sensitivity is moderate with 18 (61,2%) after treatment, data show that the most sensitivity is good with 16 (47%); p value 0,02<0,05. The sensitivity of the feet of Type II Diabetes Mellitus patients at the Selemadeg Timur II Health Center is influenced by diabetic foot exercise. Conclusion: Patients with Type II Diabetes Mellitus at the Selemadeg Timur II Health Center have sensitive feet, which is influenced by diabetic foot activity). It is important for families and communities to give motivation to the diabetes mellitus patients to do diabetic foot as one of alternative therapies to prevent foot complications such and increase foot sensitivity.Keywords: Diabetes Mellitus Type 2, Foot Sensitivity, and Diabetic Foot Exercise

Knowledge and Attitude of Medical Students about Insulin Resistance Symptoms, Effect, and Treatment

The inability of the target organs to react appropriately to the action of insulin is known as insulin resistance. Insulin resistance impairs insulin-mediated glucose absorption in the peripheral (skeletal muscle and adipose tissue), which results in increased blood sugar levels and increase insulin demand.
 Aim: This study aims to assess medical students' knowledge and attitudes on the signs, consequences, and treatments of insulin resistance.
 Patients and methods: There were 160 medical students at Tikrit University in all, male and female. The average age of students in the primary stages was 20 years, while that of students in the clinical stages was 23 years old. The current study, which was conducted in 2023 at Tikrit University College of Medicine (TUCOM), is cross-sectional in nature. All data presented statically as percentage.
 Results: There are three forms of diabetes mellitus, according to 43.75 percent of medical students. One of the complications of DM, according to (90.63 %) of them, is vision problems. Diet modification and exercise were preferable than oral hypoglycemic drugs and insulin therapy.
 Conclusions: The study found that (75%) of medical students recognized the link between type 2 DM and insulin resistance, with clinical students showed a higher level of awareness in comparison with preclinical students.

Microvascular Complications Associated with Advanced Glycation End Products in Diabetes

Diabetes is a frequent metabolic complaint associated with increasing blood sugar levels, it also has a connection to long- term vascular problems that can damage blood vessels, urinary tract, sight, and neurons. By adding amino acid breakdown and ultimately accumulating complex end products of glycation in the organs, hyperglycemia is a crucial factor in the progression of complications related to diabetes. The breakdown process, which entails free of enzymes couplings of polysaccharides to lipids, proteins, or inheritable material, produces miscellaneous motes known to be sophisticated glycation end products. The root cause of diabetes-related difficulties such as atherosclerosis, retinopathy, nephropathy, and nephropathy are greatly impacted by the development of complex end products of glycation and the glycation of proteins. Glycation of proteins hinders molecules from behaving as anticipated by altering the functioning of enzymes, altering the structure of molecules, and impeding sensory interaction. In order to aid in the development of diabetes problems. Recent research suggests that AGEs interact with RAGEs on the plasma membrane to change gene expression, intracellular signaling, and the release of free radicals and pro-inflammatory chemicals. The formation of several AGE types from the glycation of plasma proteins is covered in the current review. The pathogenesis of diabetes sequelae such as retinal degeneration, glaucoma nerve damage, kidney failure, and myocardium are also discussed in relation to AGEs. This study includes an update on the disease's vascular consequences, underlying causes, and available therapeutic options. A summary of illness management techniques is also provided in this article.

Pulmonary Aspergilloma Co-Existing with Pulmonary Tuberculosis: A Case Report in Type 1 Diabetes Mellitus (T1DM) Patient

Introduction: Pulmonary aspergilloma is a disease frequently found in immunocompromised patients. In Indonesia, around 18% of diabetes mellitus (DM) patients suffer from chronic pulmonary aspergilloma. However, data on type 1 DM (T1DM) are still limited. Case: We presented the case of a 22-year-old male admitted to the emergency room due to hemoptysis of approximately 200 ml within six hours before admission, nonspecific chest pain during cough, fever, night sweats, and weight loss of 3 kg over the last months. The patient had a history of T1DM and no prior history of respiratory diseases. Physical examination showed tachycardia, tachypnoea, subfebrile, normal body mass index, and rhonchi on the left thorax. Routine laboratory tests revealed increased blood sugar level (503 mg/dL) and HbA1c 16.4%. Chest X-ray and high-resolution computed tomography (HRCT) showed a cavity with an opaque lesion, crescent sign, consolidation, and reticulonodular infiltrate on the left lung. Rapid molecular tests, tuberculosis (TB), and serum galactomannan (GM) were negative. The patient was diagnosed with pulmonary aspergilloma, T1DM, and clinical TB. He was treated with fluconazole, insulin, and a fixed-dose combination of anti-TB. The patient refused the surgery procedure. Immediately, the hemoptysis stopped, blood glucose level was normal, and concomitant with weight gain. Conclusion: Due to innate and acquired immunity impairment, T1DM is a risk factor for pulmonary infections, including TB and pulmonary aspergilloma. Chest HRCT may help diagnose fungal balls. Though the patient refused to undergo surgery, administering antifungal, anti-TB drugs, and glucose control as initial treatment presented a good prognosis in the patient.

Nanotechnology and Nanocapsule-Based Approaches for the Diagnosis and Therapeutics of Diabetes Mellitus: A Concise Survey

A serious health concern of frightening proportions is diabetes mellitus, a common metabolic illness marked by increased blood sugar levels as a result of insufficient insulin production or response. Nanosensors and nanomaterials have recently shown tremendous promise for enhancing glucose detection for the treatment of diabetes. Significant improvements in glucose sensor sensitivity, specificity, and reversibility have been achieved through the incorporation of nanoscale carbon structures, nanocomposites, and other nanomaterials. The use of these tailored nanocarriers offers a viable technique to enhance patient compliance and diabetes management by addressing the difficulties associated with oral peptide medication delivery for the treatment of diabetes caused by adverse circumstances in the gastrointestinal system. Nanocapsules are a promising approach for effective medication transportation via biological barriers by protecting drug molecules from the biological environment. A workable solution to problems with oral peptide medicine distribution for treating diabetes, particularly when it comes to unfavorable gastrointestinal conditions, is the use of customized nanocarriers. These nanocarriers have a flexible design and special in vivo characteristics that make it possible to go beyond cellular and tissue absorption barriers while improving the stability and effectiveness of therapeutic peptides. The management of diabetes mellitus has a great deal of potential for targeted lipid-based nanoparticles, which operate as an efficient drug delivery technique for oral administration of therapeutic peptides. With these developments in nanotechnology and nanocapsule-based techniques, diabetes treatment might be improved, patient compliance could be increased, and drug administration frequency could be decreased, potentially changing the field. This article presents a comprehensive review of recent advances in nanotechnology for diabetes mellitus diagnosis and the utilization of nanocapsules in diabetes treatment
 Keywords: Nanotechnology, Nanocapsules, Diabetes Mellitus, Nanocarriers, Nanomaterial, Nanotube

Comparative Effects of Ethanolic Leaf Extracts of Gongronema latifolium Benth and Bryophyllum pinnatum (Lam.) Oken in The Management of Diabetes Mellitus in Albino Rats

Introduction: Diabetes is a multi-factorial metabolic disorder characterized by hyperglycemia, which is the primary factor in preventing glucose from achieving its desired levels in patients with the condition. Hyperglycemia results from a lack of insulin secretion, inadequate insulin action or both. Materials and Methods: The comparative effects of ethanolic leaf extracts of The comparative effects of ethanolic leaf extracts of Gongronema latifolium (G. latifolium) and Bryophyllum pinnatum (B. pinnatum) on some biochemical parameters in diabetic induced albino rats were investigated. Two different concentrations of ethanolic leaves extracts of both plants were used to treat alloxan-induced diabetic rats. Results: The study found that alloxan administration significantly increased blood sugar levels in diabetic rats, with the highest reduction in group 7 and the lowest in group 5. The ethanolic extracts of B. pinnatum and G. latifolium leaves showed potential hepatoprotective and renal protective activities, but mild urea level alteration was observed. The study suggests that these extracts may be beneficial for diabetic rats. Conclusion: The study reveals that alloxan monohydrate can induce diabetes in animals, and ethanolic extracts from B. pinnatum leaves and G. latifolium leaves may reduce blood sugar levels in diabetic rats. Glibenclamide showed better hypoglycaemic effects. Alloxan may cause hepatotoxicity and renal toxicity, but the extracts may also cause mild urea level alteration.

The Relationship between Anxiety Levels and Blood Sugar Levels in the Elderly

The increasing age, the more problems faced both physically and mentally such as loneliness, anxiety and depression. The prevalence of anxiety in the elderly is increasing. The increased release of the hormones cortisol and epinephrine in someone who is experiencing anxiety can affect an increase in gluconeogenesis and glycogenolysis which results in an increase in blood sugar levels. This study was to analyze the relationship between anxiety levels and blood sugar levels in the elderly. The research design uses a cross sectional approach. The sample for this research was 87 respondents who were taken by purposive sampling from 111 elderly people. The results of the Pearson correlations test showed that there was a relationship between anxiety and blood sugar levels in the elderly with a p value = 0.000 (<0.05). Therefore, the elderly can control their anxiety to reduce the risk of increasing blood sugar levels which have an impact on the health of the elderly

Effect of Chia Seed Extract (Salvia Hispanica L) On Current Blood Sugar Levels and MDA Levels

Hyperglycemia is a condition in which the body experiences an increase in blood sugar levels and is a clinical manifestation of type 2 DM which will increase ROS so that an antioxidant imbalance occurs which results in oxidative stress, one of the biomarkers, namely MDA. Chia seeds contain high antioxidants so that they are effective in reducing oxidative stress caused by hyperglycemia in type 2 diabetes. The research study was to prove the effect of chia seed extract on GDS and MDA levels in DMT2 rats with STZ injection. The metods is experimental research with Posttest Only Control Group Design. The number of samples was 25 male wistar rats aged 3-4 months with a weight of 180-200 grams and adapted for 7 days, divided into 5 groups randomly, namely the treatment group P0 as a control, P1 as a positive control, P2 as a negative control, and P3 as a control group. STZ injection and chia seed extract at a dose of 4.5 mg/KgBW/day, P4 for STZ injection and chia seed extract at a dose of 13.5 mg/KgBW/day. Treatment time is 7 days. Blood samples were taken from v. Ophtalmica on day 14. Examination of GDS levels using the ELISA method and examination of MDA levels using the TBARS method, the data were analyzed by the Anova test. The result Mean level of GDS P0: 127.6±2.8; P1: 204.6±6.1; P2: 76.2±1.3; P3: 45.6±2.07; P4: 40±1.58. Mean levels of MDA in nmol/ml P0: 0.93±0.04; P1: 1.20±0.01; P2: 0.73±0.04; P3: 0.44±0.03; P4: 0.22±0.20. The results of the ANOVA test obtained a P value of 0.000 and the results of the post hoc LSD test between groups obtained a P value of 0.000 (<0.05). conclusion is significant difference in reducing GDS and MDA levels between Chia seed extract doses of 4.5 mg/KgBW/day and 13.5 mg/kgBW/day. Keywords: chia seeds; MDA; GDS; DM Type 2

The Relationship between Diet Compliance and Physical Activity with Blood Sugar Levels in Patients with Type II Diabetes Mellitus in the Work Area of the Pasundan Health Center

Diabetes Mellitus is a disorder of the metabolic system with increased blood sugar levels (hyperglycemia), caused by the inability of the pancreas to produce insulin or lack of insulin sensitivity. Management of DM has four pillars, namely education, diet therapy, physical activity, and drug therapy. The purpose of this study was to determine the relationship between dietary adherence and physical activity with blood sugar levels in patients with Type II Diabetes Mellitus in the working area of ​​the Pasundan Health Center. This type of research is analytic observational with cross sectional design. Sampling using consecutive sampling technique and a total sample of 40 people. The data analysis used is the Spearman Rank Test. The results of the study showed a relationship between dietary compliance and GDS levels (p = 0.000) and there was a relationship between physical activity and GDS levels (p = 0.026).