Increase In Basal Metabolic Rate Research Articles

AKTIVITAS FISIK DAN PENINGKATAN BASAL METABOLISME RATE PADA PASIEN DIABETES MELITUS

Diabetes mellitus basically occurs due to insulin intolerance which causes high blood glucose and if not controlled can cause complications and even death. One of the efforts to overcome Diabetes Mellitus is to change lifestyle by increasing physical activity. This study aimed to determine the relationship between physical activity and an increase in basal metabolic rate in diabetes mellitus patients in the working area of UPT Puskesmas Perumnas 2. This research was quantitative research with cross-sectional. Using the Pearson correlation test. Basal Metabolism Rate is measured using formula provisions and physical activity scores using the GPAQ questionnaire sheet. with a total of 100 respondents obtained using a purposive sampling technique. The research results showed Hypothesis testing uses the Pearson correlation statistical test with a p-value of 0.000 which was less than <0.05, so it can be concluded that Ho is rejected, meaning that there is a relationship between physical activity and an increase in basal metabolic rate in diabetes mellitus patients. This research shows that there is a relationship between physical activity and an increase in basal metabolic rate in diabetes mellitus patients in the working area of the UPT Puskesmas Perumnas 2.

Early-life sodium deprivation programs long-term changes in ingestive behaviors and energy expenditure in C57BL/6J mice.

Postnatal growth failure remains a significant problem for infants born prematurely, despite aggressive efforts to improve perinatal nutrition. Though often dysregulated in early life when children are born preterm, sodium (Na) homeostasis is vital to achieve optimal growth. We hypothesize that insufficient Na supply in this critical period contributes to growth restriction and programmed risks for cardiometabolic disease in later adulthood. Thus, we sought to ascertain the effects of prolonged versus early-life Na depletion on weight gain, body composition, food and water intake behaviors, and energy expenditure in C57BL/6J mice. In one study, mice were provided a low (0.04%)- or normal/high (0.30%)-Na diet between 3 and 18 wk of age. Na-restricted mice demonstrated delayed growth and elevated basal metabolic rate. In a second study, mice were provided 0.04% or 0.30% Na diet between 3 and 6 wk of age and then returned to standard (0.15%)-Na diet through the end of the study. Na-restricted mice exhibited growth delays that quickly caught up on return to standard diet. Between 6 and 18 wk of age, previously restricted mice exhibited sustained, programmed changes in feeding behaviors, reductions in total food intake, and increases in water intake and aerobic energy expenditure while maintaining normal body composition. Although having no effect in control mice, administration of the ganglionic blocker hexamethonium abolished the programmed increase in basal metabolic rate in previously restricted mice. Together these data indicate that early-life Na restriction can cause programmed changes in ingestive behaviors, autonomic function, and energy expenditure that persist well into adulthood.

Factors Involved in the Evolution of the Basal Metabolic Rate over 30 Months After Roux-en-Y Gastric Bypass.

After Roux-en-Y gastric bypass (RYGB), the basal metabolic rate (BMR) falls. However, it is important to know how BMR per kilogram of body weight (BMR/kg) varies in the postoperative period. The present study evaluated the changes in the BMR/kg and its correlates over 30 months after RYGB. Eighty adult patients of both genders who underwent RYGB agreed to participate in the study. The following evaluations were performed before surgery (n=48) and 6 (n=27), 12 (n=28), 24 (n=40), and 30 months (n=29) after surgery: anthropometry, body composition (bioelectrical impedance), metabolic analysis (indirect calorimetry), and diet (food recall). Statistical analysis was performed (p = 0.05). Although BMR decreased after surgery, BMR/kg increased significantly as compared to baseline from 12 months onward, peaking at 24 months and not significantly dipping at 30 months, suggesting stabilization of BMR/kg 2 years after surgery (pre, 10.68 ± 2.33 kcal/kg; 12 months, 12.46 ± 2.85 kcal/kg; 24 months, 18.78 ± 4.81 kcal/kg; 30 months, 18.12 ± 3.69 kcal/kg; p <0.001). Regarding the variables that influenced the BMR/kg, at 12 months, they were %LBM and intake of calcium-source foods (34%); at 24 months, it was protein intake (16%); and at 30 months, it was the intake of calcium-source foods (26.7%). RYGB is associated with a significant increase in BMR when it is adjusted to body weight from 12 to 24 months postoperatively. Among the factors involved in the increase in BMR/kg are body composition and intake of protein-rich foods.

Back to the Womb: A Perinatal Perspective on Mammalian Hibernation.

AbstractThe idea of putting astronauts into a hibernation-like state during interplanetary spaceflights has sparked new interest in the evolutionary roots of hibernation and torpor. In this context, it should be noted that mammalian fetuses and neonates respond to the environmental challenges in the perinatal period with a number of physiological mechanisms that bear striking similarity to hibernation and torpor. These include three main points: first, prenatal deviation from the overall metabolic size relationship, which adapts the fetus to the low-oxygen conditions in the womb and corresponds to the metabolic reduction during hibernation and estivation; second, intranatal diving bradycardia in response to shortened O2 supply during birth, comparable to the decrease in heart rate preceding the drop in body temperature upon entry into torpor; and third, postnatal onset of nonshivering thermogenesis in the brown adipose tissue, along with the increase in basal metabolic rate up to the level expected from body size, such as during arousal from hibernation. The appearance of hibernation-like adaptations in the perinatal period suggests that, conversely, hibernation and torpor may be composed of mechanisms shared by all mammals around birth. This hypothesis sheds new light on the origins of hibernation and supports its potential accessibility to nonhibernating species, including humans.

A multi-isotope approach reveals seasonal variation in the reliance on marine resources, production of metabolic water, and ingestion of seawater by two species of coastal passerine to maintain water balance

Tracing how free-ranging organisms interact with their environment to maintain water balance is a difficult topic to study for logistical and methodological reasons. We use a novel combination of triple-oxygen stable isotope analyses of water extracted from plasma (δ16O, δ17O, δ18O) and bulk tissue carbon (δ13C) and nitrogen (δ15N) isotopes of feathers and blood to estimate the proportional contribution of marine resources, seawater, and metabolic water used by two species of unique songbirds (genus Cinclodes) to maintain their water balance in a seasonal coastal environment. We also assessed the physiological adjustments that these birds use to maintain their water balance. In agreement with previous work on these species, δ13C and δ15N data show that the coastal resident and invertivore C. nigrofumosus consumes a diet rich in marine resources, while the diet of migratory C. oustaleti shifts seasonally between marine (winter) to freshwater aquatic resources (summer). Triple-oxygen isotope analysis (Δ17O) of blood plasma, basal metabolic rate (BMR), and total evaporative water loss (TEWL) revealed that ~25% of the body water pool of both species originated from metabolic water, while the rest originated from a mix of seawater and fresh water. Δ17O measurements suggest that the contribution of metabolic water tends to increase in summer in C. nigrofumosus, which is coupled with a significant increase in BMR and TEWL. The two species had similar BMR and TEWL during the austral winter when they occur sympatrically in coastal environments. We also found a positive and significant association between the use of marine resources as measured by δ13C and δ15N values and the estimated δ18O values of ingested (pre-formed) water in both species, which indicates that Cinclodes do not directly drink seawater but rather passively ingest when consuming marine invertebrates. Finally, results obtained from physiological parameters and the isotope-based estimates of marine (food and water) resource use are consistent, supporting the use of the triple-oxygen isotopes to quantify the contribution of water sources to the total water balance of free-ranging birds.

Effect of Thyroid Hormones and Trace Elements (Zn, Mg) on Obesity

Background: Obesity is characterized by abnormal or excessive fat accumulation that is the result of a chronic imbalance between energy intake and energy expenditure. Thyroid hormones have profound effect on many physiological processes, such as development, growth in children and metabolism. Thyroid hormones stimulate diverse metabolic activates in most tissues, leading to an increase in basal metabolic rate. Trace elements are essential nutrients with regulatory, immunologic, and antioxidant functions resulting from their action as essential components or cofactors of enzymes throughout metabolism.&#x0D; Methods: In this study conducted on 176 individuals in the age group from (20-55) years, from Tikrit and Kirkuk Governorates. Blood samples were divided into three groups according to BMI: Group One: Control group (Normal Weight): 66 individual BMI (18.5 - 24.9 kg/m2). Group Two: Overweight group: 50 individual BMI (25.0 – 29.9 kg/m2).Group Three: Obese group: 60 individual BMI (≥ 30 kg/m2).&#x0D; Results: The results showed a high significant increase (p&lt;0.0001) in the BMI level in obese and overweight groups comparison with normal weight group. The results showed a significant decrease (p&lt;0.001) in (T3 and T4) hormones levels in obese and overweight groups comparison with normal weight group. While the results showed a high significant increase (p&lt;0.0001) in the TSH levels in obese and overweight groups comparison with normal weight group, the results showed a significant decrease (p&lt;0.001) in the Zn concentration in obese and overweight groups comparison with normal weight group, the results showed a high significant decrease (p&lt;0.0001) in the Mg concentration in obese and overweight groups comparison with normal weight group. There is a high significant increase in the (cholesterol, TG, VLDL-c and LDL-c) levels in obese and overweight groups comparison with normal weight group (p&lt;0.0001), while the results showed a high significant decrease (p&lt;0.0001) in the HDL-c level in obese and overweight groups comparison with normal weight group. The results showed that there was a significant positive correlation between T3 and T4.While there was a significant negative correlation between T3 and LDL. There was a positive correlation between T4 and HDL. Whereas the there was a significant negative correlation between T4 and LDL. There was a significant positive correlation between TSH with Cholesterol, Triglyceride, LDL and VLDL. There was a significant negative correlation between TSH with HDL, and Mg. Conclusions: The results of (thyroid hormones and lipid profile) indicated highly associated with trace elements (Zn, Mg) levels and these correlations may be caused a risk of the obesity

Effects of a Combined Intradialytic Exercise Training Program on Functional Capacity and Body Composition in Kidney Transplant Candidates.

Chronic kidney disease (CKD) leads to gradual muscle mass loss, which is strongly associated with lower functional capacity, which limits a patient’s daily activities. The aim of the present study is to examine the effects of a 4-month intradialytic exercise program on the functional capacity and body composition of kidney transplant (KT) candidates. Twenty-nine male patients on hemodialysis (HD) waiting for a kidney transplant, with a mean age of 53.86 ± 9.56 years old and BMI 27.11 ± 5.55 kg/m2, were randomly assigned into the following two groups: A (nA = 15 HD patients), who followed a 4-month intradialytic exercise program combining aerobic and resistance training, with a supervised, progressively increasing workload, and B (nB = 14 HD patients), who continued to receive usual care. At baseline and the end of the study, the KT candidates underwent a 6-min walking distance (6-MWD), and a 10-repetition sit-to-stand test (10-STS) to access physical function, a handgrip strength (HGS) test to evaluate the muscle strength of the non-fistula hand. Moreover, the bioelectrical impedance analysis (BIA) was performed to assess body composition indices, such as body fat (BF), body fat mass index (BFMI), fat-free mass index (FFMI), body cell mass (BCM), basal metabolic rate (BMR), extracellular water (ECW), intracellular water (ICW), total body water (TBW) and phase angle (PhA). Following the exercise program, group A showed favorable improvements in HGS (from 26.59 ± 9.23 to 28.61 ± 9.58 kg, p < 0.05) and 6-MWD (from 427.07 ± 7.66 to 468.16 ± 11.39 m, p < 0.05). Intergroup results from 6-MWD showed a statistically significant difference (Δp = 0.04), at the end of the study. Moreover, group A results from BIA revealed a significant increase of BMR by 2.4% (p < 0.05), ECW by 3.6% (p = 0.01), ICW by 3.8% (p = 0.01), TBW by 4.1% (p = 0.01), lean mass by 2.7% (p = 0.01), and PhA by 13.3% (p = 0.04), while a reduction in BF by 5.0% (p = 0.01) and BFMI by 6.6% (p = 0.03) was also noticed. At the end of the study, group A showed statistical differences in BMR (Δp = 0.01), BMR/BW (Δp = 0.01), dry lean (Δp = 0.01), and PhA (Δp = 0.03), compared to the group B. Linear regression analysis in group A after training showed positive correlations between HGS and both PhA (r = 0.52, p = 0.04) and FFMI (r = 0.64, p = 0.01), and a strong negative correlation between 6-MWT and BF (r = −0.61, p = 0.01). In conclusion, a 4-month intradialytic exercise program can enhance body composition and some physical parameters in HD patients awaiting kidney transplantation.

Оценка основного обмена у несовершеннолетних спортсменов

Objective. To assess the intensity of basal metabolism in adolescent elite athletes. Patients and methods. This study included 154 adolescent athletes (42 boys, 112 girls) aged 13–18 years (mean age: 15.3 ± 2.5 years). Basal metabolic rate (BMR) was measured in all participants using respiratory indirect calorimetry and the Harris–Benedict equation. Study design: single-center, cross-sectional, randomized, uncontrolled. Results. An increase in BMR was revealed in 79 (51%) participants, normal BMR – in 50 (33%) participants, and a decrease in BMR – in 25 (16%) participants. Increased BMR was statistically significantly more common in boys compared to girls (83% and 39% respectively, p = 0,01), whereas decreased BMR was more characteristic of girls compared to boys (20% and 4%, respectively, p = 0.001). Conclusion. Most adolescent athletes show an increase in BMR, which reflects an adaptation of the organism to high physical exertion. A decrease in BMR may indicate the presence of relative energy deficiency in athletes. The Harris–Benedict equation significantly underestimates the value of BMR in adolescent athletes and is not an alternative to respiratory indirect calorimetry when individual assessment of energy expenditure is necessary as part of biomedical support. Key words: children, high-performance sport, basal metabolic rate, indirect calorimetry

Deficiency of Irx5 protects mice from obesity and associated metabolic abnormalities.

Obesity, a leading cause of several metabolic abnormalities, is mainly caused by imbalanced energy homeostasis. IRX3 and IRX5 have been suggested as genetic determinants of obesity in connection with the intronic variants of the FTO gene, the strongest genetic risk factor of polygenic obesity in humans. Although the causal effects of Irx3 and its cooperation with Irx5 in obesity and associated metabolic abnormalities have been demonstrated in vivo, the function of Irx5 in energy homeostasis remains unclear. Here we aim to decipher the actions of Irx5 in the regulation of obesity and metabolic abnormalities. We employed a mouse model homozygous for an Irx5-knockout (Irx5KO) allele and determined its metabolic phenotype in the presence or absence of a high-fat diet challenge. To investigate the function of Irx5 in the regulation of energy homeostasis, adipose thermogenesis and hypothalamic leptin response were assessed, and single-cell RNA sequencing (scRNA-seq) in the hypothalamic arcuate-median eminence (ARC-ME) was conducted. Irx5KO mice were leaner and resistant to diet-induced obesity as well as associated metabolic abnormalities, primarily through loss of adiposity. Assessments of energy expenditure and long-term dietary intake revealed that an increase in basal metabolic rate with adipose thermogenesis and a reduction of food intake with improved hypothalamic leptin response in Irx5KO mice may contribute to the anti-obesity effects. Utilizing scRNA-seq and marker gene analyses, we demonstrated the number of ARC-ME neurons was elevated in Irx5KO mice, suggesting a direct role for Irx5 in hypothalamic feeding control. Our study demonstrates that Irx5 is a genetic factor determining body mass/composition and obesity and regulates both energy expenditure and intake.

Obligatory homeothermy of mesic habitat-adapted African striped mice, Rhabdomys pumilio, is governed by seasonal basal metabolism and year-round 'thermogenic readiness' of brown adipose tissue.

Small mammals undergo thermoregulatory adjustments in response to changing environmental conditions. Whereas small heterothermic mammals can employ torpor to save energy in the cold, homeothermic species must increase heat production to defend normothermia through the recruitment of brown adipose tissue (BAT). Here, we studied thermoregulatory adaptation in an obligate homeotherm, the African striped mouse (Rhabdomys pumilio), captured from a subpopulation living in a mesic, temperate climate with marked seasonal differences. Basal metabolic rate (BMR), non-shivering thermogenesis (NST) and summit metabolic rate (Msum) increased from summer to winter, with NST and Msum already reaching maximal rates in autumn, suggesting seasonal preparation for the cold. Typical of rodents, cold-induced metabolic rates were positively correlated with BAT mass. Analysis of cytochrome c oxidase (COX) activity and UCP1 content, however, demonstrated that thermogenic capacity declined with BAT mass. This resulted in seasonal differences in NST being driven by changes in BMR. The increase in BMR was supported by a comprehensive anatomical analysis of metabolically active organs, revealing increased mass proportions in the cold season. The thermoregulatory response of R. pumilio was associated with the maintenance of body mass throughout the year (48.3±1.4 g), contrasting large summer-winter mass reductions often observed in Holarctic rodents. Collectively, bioenergetic adaptation of this Afrotropical rodent involves seasonal organ adjustments influencing BMR, combined with a constant thermogenic capacity dictated by trade-offs in the thermogenic properties of BAT. Arguably, this high degree of plasticity was a response to unpredictable cold spells throughout the year. Consequently, the reliance on such a resource-intensive thermoregulatory strategy may expose more energetic vulnerability in changing environments of food scarcity and extreme weather conditions due to climate change, with major ramifications for survival of the species.

The Influence of Organic Vanadium Complexes on an Antioxidant Profile in Adipose Tissue in Wistar Rats.

One of the aspects of biological activity of vanadium is its influence on carbohydrate metabolism. For more than 30 years, various vanadium complexes have been tested as antidiabetic agents. This study researched organic vanadium complexes with bipyridinium ligands and their influences on metabolic rate, as well as on the antioxidant activity of adipose tissue. The effects of sodium (2,2′-bipyridine) oxidobisperoxovanadate (V) octahydrate (known as the V complex), bis(2,2′-bipyridine) oxidovanadium (IV) sulfate dehydrate (known as the B complex), and bis(4.4′-dimethyl-2,2′-bipyridine) oxidovanadium (IV) sulfate dihydrate (labelled as the BM complex) were assessed. Solutions of the tested complexes were introduced intraperitoneally with a probe to animals fed with either a control diet or a high-fat diet. The BM complex had a significant influence on the increase in ferric reducing antioxidant power, as well as on the concentration of glutathione in the adipose tissue of rats fed with a high-fat diet. The V complex increased the concentration of glutathione in the adipose tissue of rats fed with control fodder, as well as significantly reduced the relative change in rat weight for the high-fat diet. Furthermore, the presence of each tested vanadium complex had an impact of statistically significant increase in basal metabolic rate, regardless of applied diet. Further research on these organic vanadium complexes is necessary to understand the mechanisms responsible for their ability to affect adipose tissue.

The Effect of A Weight-Loss Diet in Women Doing Reformer Pilates: A 12-Week Evaluation

Aim: This study aims to define the effect of a weight-loss diet on body composition in women doing reformer pilates for 12 weeks. It compares dietary habits in subject groups with and without a weight-loss diet and macro and micronutrient intakes at the beginning and end of the study. Method: A total of 49 women (≥18 age) were randomly allocated to either a control (CG: reformer pilates; n=23) or a study (SG: reformer pilates+weight-loss diet; n=26) group. In both groups, subjects did pilates for 45 minutes a day three times a week for a total of 12 weeks. Their body weight (kg), waist circumference (cm), hip circumference (cm), neck circumference (cm), mid-upper arm circumference (cm), body composition, waist/height ratio, and body mass index (BMI; kg/m2) were evaluated at the beginning and the third month of the study. Dietary habits of all subjects were questioned, their 24-hour retrospective food consumption was taken, and their physical activity levels were evaluated through the International Physical Activity Questionnaire (Short Form). Results: The use of vitamin and mineral supplements in SG was lower than CG (p=0.003). The twelve-week evaluation showed a significantly higher increase in dietary protein and calcium levels in SG than CG (p&amp;lt;0.05). In SG, a significantly higher decrease was determined in body weight, BMI, waist circumference, hip circumference, and waist/height ratio, and a higher increase in Basal Metabolic Rate, body muscle, and body water, compared to CG (p&amp;lt;0.05). Conclusion: Pilates combined with a weight-loss diet has more positive effects on body composition than pilates alone. Providing dietary training and counseling for women who practice reformer pilates will increase the health benefits of exercise.

Phenotypic plasticity to chronic cold exposure in two species of Peromyscus from different environments.

Effective thermoregulation is important for mammals, particularly those that remain winter-active. Adjustments in thermoregulatory capacity in response to chronic cold can improve capacities for metabolic heat production (cold-induced maximal oxygen consumption, [Formula: see text]), minimize rates of heat loss (thermal conductance), or both. This can be challenging for animals living in chronically colder habitats where necessary resources (i.e., food, O2) for metabolic heat production are limited. Here we used lowland native white-footed mice (Peromyscus leucopus) and highland deer mice (P. maniculatus) native to 4300m, to test the hypothesis that small winter-active mammals have evolved distinct cold acclimation responses to tailor their thermal physiology based on the energetic demands of their environment. We found that both species increased their [Formula: see text] after cold acclimation, associated with increases in brown adipose tissue mass and expression of uncoupling protein 1. They also broadened their thermoneutral zone to include lower ambient temperatures. This was accompanied by an increase in basal metabolic rate but only in white-footed mice, and neither species adjusted thermal conductance. Unique to highland deer mice was a mild hypothermia as ambient temperatures decreased, which reduced the gradient for heat loss, possibly to save energy in the chronically cold high alpine. These results highlight that thermal acclimation involves coordinated plasticity of numerous traits and suggest that small, winter-active mammals may adjust different aspects of their physiology in response to changing temperatures to best suit their energetic and thermoregulatory needs.

CARDIOHEMODYNAMIC RESPONSE TO LOCAL COLD EXPOSURE AMONG MEN FROM COASTAL- AND INLAND ZONES OF THE MAGADAN REGION

Aim: To study the changes in cardiodynamics experienced by humans under local cold exposure in coastal- and inland areas of the Magadan region, North-Eastern Russia. Methods: In total, 124 residents from the coastal area (Magadan) and 62 residents from the inland area (Susuman) took part in the experiment. Parameters of heart rate and hemodynamics at rest and at the peak of a cold test were estimated using "Varicard" device and a tonometer. Results: At rest the examinees from the continental zone demonstrated a less economical mode of the circulatory system functioning with a simultaneous decrease in sympathetic activity and the transition of the autonomic balance towards parasympathetic predominance. That is considered a regional-related feature of the functional status of the cardiovascular system when adapting to more extreme environmental factors. Such features of cardiohemodynamics could be observed against the background of an increase in basal metabolic rate by 17 % in subjects from Magadan and 31 % in those from Susuman. The short-term cold exposure caused a hypertensive response in both groups. The subjects from the continental area showed a more pronounced vasoconstriction, which was combined with a decrease in the activity of the parasympathetic link in the heart rhythm regulation, while the Magadan subjects demonstrated the opposite reaction to the cold test which led to the activation of the parasympathetic link of the ANS. Conclusion: The results that the residents of the coastal areas develop the reaction of getting used to the influence of the cold factor, with a slightly pronounced metabolic adaptation Young residents of the continental zone, in response to the effects of cold, develop an isolation type of cold adaptation with sufficient activation of metabolic adaptation.

ОСОБЕННОСТИ КОМПОЗИЦИОННОГО СОСТАВА ТЕЛА И ОСНОВНОГО ОБМЕНА У ПОДРОСТКОВ С МОРБИДНЫМ ОЖИРЕНИЕМ

Objective of the study: to compare the values of basal metabolic rate and body composition in children with morbid and non-morbid obesity. Materials and methods of research: 87 adolescents with constitutionally exogenous obesity (CEO) were included in a prospective open-label observational single-center selective non-randomized uncontrolled study. The participants were divided into 2 groups: 43 with morbid obesity – mean age 15,7 years [14,9; 16,9], 20 boys (46%) and 23 girls (54%) and 44 with non-morbid obesity – the control group, mean age 15,3 years [10,1; 15,6], 19 boys (43%) and 25 girls (57%). All children underwent an assessment of body composition and basal metabolic rate. Results: adolescents with morbid obesity showed a statistically significantly greater amount of adipose tissue (51,5% [48,3; 56,2] vs 39,5% [35,4; 42,8], p&lt;0,0001) and lean mass (65,8% [56,3; 72,3] vs 51,0% [45,2; 59,8], p&lt;0,0001) compared with the group of non-morbid obesity. When assessing the amount of skeletal muscles, an increase in its absolute values was demonstrated in adolescents with severe obesity compared to the control group. The percentage of skeletal muscle mass in lean mass with severe obesity was statistically significantly higher compared to the group of non-morbid obesity (50,4% [45,1; 53,6] vs 41,8% [40,8; 43,3], p&lt;0,0001). There was a statistically significant increase in basal metabolic rate in the group of morbid obesity compared with the group of non-morbid obesity (2489 [2313; 2802] and 1829 [1525; 2117] kcal/day, respectively, p&lt;0,0001). These differences between the study groups persisted after the introduction of lean mass correction. Conclusion: the development of morbid obesity in adolescents is accompanied by an increase in basal metabolism, an increase in the amount of fat and lean mass. The increase in lean mass occurs mainly due to an increase in skeletal muscle.

Energetics of whiskered bats in comparison to other bats of the family Vespertilionidae.

ABSTRACTBats inhabit a variety of climate types, ranging from tropical to temperate zones, and environmental differences may therefore affect the basal metabolic rate (BMR) of bats from different populations. In the present study, we provide novel data on the energetics of whiskered bats (Myotis mystacinus), which is the smallest species within Chiroptera measured to date. We investigated the thermoregulatory strategies of M. mystacinus close to the northern limits of this species’ distribution range and compared these data to other vespertilionid bats living in different climates. As mammals living in colder areas experience elevated thermoregulatory costs, often leading to an increase in BMR, we hypothesised that BMR of this northern population of whiskered bats would be higher than that of bats from climates with warm environmental temperatures. From a systematic literature search we obtained BMR estimates (N=47) from 24 species within Vespertilionidae. Our metabolic measurements of M. mystacinus in Norway (body mass of 4.4 g; BMR of 1.48 ml O2 g−1 h−1) were not different from other vespertilionid bats, based on the allometric equation obtained from the systematic literature search. Further, there was no effect of environmental temperature on BMR within Vespertilionidae. How these tiny bats adapt metabolically to high latitude living is thus still an open question. Bats do have a suite of physiological strategies used to cope with the varying climates which they inhabit, and one possible factor could be that instead of adjusting BMR they could express more torpor. This article has an associated First Person interview with the first author of the paper.

P566 Impact of induction therapy and clinical remission on resting energy expenditure in children with Crohn’s Disease

Abstract Background Crohn’s Disease (CD) is known to affect nutritional status and linear growth in affected children. Patients with CD often have decreased oral intake, malabsorption, and increased intestinal losses. Basal metabolic rate may be affected by chronic inflammation and states of anorexia or malnutrition in these patients. In this study, our aim was to compare the effect of different induction regimens in children with CD on resting energy expenditure (REE) and nutritional status. Methods We recruited patients under 18 years old with new-onset CD or relapse, diagnosed at our centre over a three-year period from July 2016. Patients included had one of the following induction regimens: corticosteroids, exclusive enteral nutrition (EEN), or anti-TNF therapy (Infliximab). REE was assessed at baseline and 6 to 8 weeks after induction. REE (kcal/d) was measured using an open-circuit indirect calorimeter with computerized metabolic cart (Vmax Encore, Vyaire Medical). Secondary outcomes included anthropometrics and clinical and biochemical response, defined by improved wPCDAI and negative inflammatory markers and fecal calprotectin, respectively. Results 17 patients were enrolled and 8 patients excluded (loss to follow-up (n=3), therapeutic change (n=3), revised diagnosis (n=2)). 9 patients completed REE assessments (44.4% anti-TNF (n=4), 44.4% EEN (n=4), 11.1% corticosteroid (n=1)). 3 out of 4 patients on anti-TNF had clinical and biochemical response, while only 1 of 4 patients responded to EEN. For patients in the EEN group, mean BMI change was +0.9 (SD 0.4), compared to +0.4 (SD 1.1) in the anti-TNF group. There was no difference in REE change between treatment groups. Data was then pooled based on response to treatment. 100% of non-responders had increased per cent of predicted REE (REEPP), while 75% of responders decreased their REEPP. Mean REEPP change in non-responders was +12.5% (1, 22) vs. -4.3% (-10, 6) in responders. Figure I. Relationship between REE and weight at baseline and on follow-up in non-responders. Figure II. Relationship between REE and weight at baseline and on follow-up in responders. Conclusion Our results suggest that induction regimen did not impact REE change on follow-up. In our patients, clinical response to therapy was related to a tendency to decrease REE. Patients who did not achieve remission after induction therapy increased their REE. We suspect that this increase in basal metabolic rate is related to persistent inflammation despite improved nutritional status. Further studies with larger patient populations are needed to infer significance and compare subgroups based on body composition.

Dirençli Egzersiz Eğitiminin Obez Bireylerde Vücut Kas ve Yağ Parametreleri Üzerine Etkisi

Obesity is a multifactorial disease with an increasing prevalence worldwide and is characterized by an increase in body weight. It poses a risk for diseases such as hypertension and diabetes, especially by causing an increase in fat in the abdominal area. Obesity can be managed through behavioral changes in energy intake or expenditure. Various nutrition and exercise strategies are used for this purpose. Exercise causes an increase in energy expenditure and contributes to a decrease in body weight, loss of fat mass and the maintenance of these effects. Exercise has the potential to mitigate the adverse health consequences of obesity even without weight loss in the body. Studies suggest that resistance exercise training can promote a negative energy balance, play a role in weight management by changing body fat mass. Increase in muscle mass with resistance exercise training provides a better metabolic control in the body. From the perspective of weight loss and control, recent exercise guidelines include resistance exercise training as part of an exercise prescription. Resistance exercise training can play an important role in body fat management, with an increase in energy expended during physical activity and an acute increase in basal metabolic rate. Resistance exercise training can increase lean body mass and cause changes in body composition by reducing visceral and total body fat. However, the effects of resistance exercise training on body fat composition still do not give definitive results. In this respect, this review aims to examine the effects of resistance exercise training on body fat mass and muscle.

Global deletion of NTPDase3 protects against diet-induced obesity by increasing basal energy metabolism

BackgroundEcto-nucleoside triphosphate diphosphohydrolase 3 (NTPDase3), also known as CD39L3, is the dominant ectonucleotidase expressed by beta cells in the islet of Langerhans and on nerves. NTPDase3 catalyzes the conversion of extracellular ATP and ADP to AMP and modulates purinergic signaling. Previous studies have shown that NTPDase3 decreases insulin release from beta-cells in vitro. This study aims to determine the impact of NTPDase3 in diet-induced obesity (DIO) and metabolism in vivo. MethodsWe developed global NTPDase3 deficient (Entpd3−/−) and islet beta-cell-specific NTPDase-3 deficient mice (Entpd3flox/flox,InsCre) using Ins1-Cre targeted gene editing to compare metabolic phenotypes with wildtype (WT) mice on a high-fat diet (HFD). ResultsEntpd3−/− mice exhibited similar growth rates compared to WT on chow diet. When fed HFD, Entpd3−/− mice demonstrated significant resistance to DIO. Entpd3−/− mice consumed more calories daily and exhibited less fecal calorie loss. Although Entpd3−/− mice had no increases in locomotor activity, the mice exhibited a significant increase in basal metabolic rate when on the HFD. This beneficial phenotype was associated with improved glucose tolerance, but not higher insulin secretion. In fact, Entpd3flox/flox,InsCre mice demonstrated similar metabolic phenotypes and insulin secretion compared to matched controls, suggesting that the expression of NTPDase3 in beta-cells was not the primary protective factor. Instead, we observed a higher expression of uncoupling protein 1 (UCP-1) in brown adipose tissue and an augmented browning in inguinal white adipose tissue with upregulation of UCP-1 and related genes involved in thermogenesis in Entpd3−/− mice. ConclusionsGlobal NTPDase3 deletion in mice is associated with resistance to DIO and obesity-associated glucose intolerance. This outcome is not driven by the expression of NTPDase3 in pancreatic beta-cells, but rather likely mediated through metabolic changes in adipocytes.

How to get rid of visceral fat: a randomised double-blind clinical trial

Inflammation and oxidative damage are immanent in visceral adiposity that is characterised by excess lipids and lipoproteins, viewed as the core components of arterial plaques, ultimately obstructing blood flow and lymphatic drainage. Accumulated toxicity dysregulates the orexigenic hormone ghrelin and anorexic hormone leptin, which are part of a reciprocal network controlling appetite. Weight gain promotes hormonal imbalance, expressed in disturbances in free T3 and an inverse low testosterone/high cortisol incongruity that provokes stress-eating behaviours. The author explored a number of interventions designed to reduce visceral adipose tissue (VAT), including radiofrequency, lasers and exercise, as well as exercise alone. Short-term gymnastics evidenced a modest advantage in VAT decrease, but there were no changes in body mass index (BMI) or physical appearance. Overtraining appeared to negate the benefits of exercise by increasing inflammation and cortisol, while suppressing testosterone and leptin that inevitably instigated hunger and weight gain. The blood samples of 10 overweight, healthy adults who underwent 12 treatments during the course of 1 month were examined. Results demonstrated a statistically significant decline in very-low-density lipoprotein, triglycerides and VAT, accompanied by a substantial increase in basal metabolic rate and skeletal muscle mass. Importantly, free T3, insulin-like growth factor 1, leptin, and testosterone were elevated towards the top of the normal range, while cortisol and ghrelin gravitated towards the low end of the normal range, without ever spiking outside the limits of hormonal balance.