d t s t v u a t 2 n v a s v m c w i c Over the last decade, it has become widely accepted that achycardia-induced remodeling is an important pathophysologic mechanism that contributes to the initiation and aintenance of an arrhythmogenic substrate. In response o a sustained increase in activation rate, the heart undergoes emodeling, defined as an alteration in cardiac function or tructure induced by a disease process or external stimulus. hronic tachycardia induces lasting changes in electrohysiologic and structural properties of the myocardium hat increase susceptibility to cardiac arrhythmias. This iewpoint focuses on the effects of chronic rapid ventricular ates on ventricular electrophysiology, highlighting areas of ontroversy or uncertainty and potential implications of achycardia-induced electrical remodeling in the clinical etting. This brief review is not meant to be exhaustive; for his the reader is referred to several recent publications on he topic.