Subsurface (or tile) drainage offers a valuable solution for enhancing crop productivity in poorly drained soils. However, this practice is also associated with significant nutrient leaching, which can contribute to water quality problems at the regional scale. This research presents the findings from a 4-year tile depth and spacing study in central Illinois that included three drain spacings (12.2, 18.3, and 24.4 m) and two drain depths (0.8 and 1.1 m) implemented in six plots under the corn and soybean rotation system (plots CS-1 and CS-3: 12.2 m spacing and 1.1 m depth, plots CS-2 and CS-4: 24.4 m spacing and 1.1 m depth, and plots CS-5 and CS-6 18.3 m spacing and 0.8 m depth). Our observations indicate that drain flow and NO3-N losses were higher in plots with narrower drain spacings, while plots with wider drain spacing showed reduced drain flow and NO3-N losses. Specifically, plots set up with drain spacings of 18.3 m and 24.4 m showed significant reductions in drain flow compared to plots featuring a 12.2 m drain spacing. Likewise, plots characterized by 18.3 m and 24.4 m drain spacings (except CS-4) showed better NO3-N retention and lower leaching losses than those with 12.2 m spacing (CS-1 and CS-3). Crop yield results over a 3-year period indicated that CS-2 (wider spacing plot) showed the highest productivity, with up to 13.6% higher yield compared to other plots. Furthermore, when comparing plots with the same drainage designs, CS-2 and CS-4 showed 5.1% to 2.6% higher corn yield (3-year average) compared to CS-1 and CS-3, and CS-5 and CS-6, respectively. Overall, a wider drainage system showed the capacity to export lower nutrient levels while concurrently enhancing productivity. These findings represent that optimizing tile drainage systems can effectively reduce nitrate losses while increasing crop productivity.