Incorporation Of Chitosan Research Articles

Designing of pH-Sensitive Hydrogels for Colon Targeted Drug Delivery; Characterization and In Vitro Evaluation.

In the current research work, pH-sensitive hydrogels were prepared via a free radical polymerization technique for the targeted delivery of 5-aminosalicylic acid to the colon. Various proportions of chitosan, β-Cyclodextrin, and acrylic acid were cross-linked by ethylene glycol dimethacrylate. Ammonium persulfate was employed as an initiator. The development of a new polymeric network and the successful encapsulation of the drug were confirmed by Fourier transform infrared spectroscopy. Thermogravimetric analysis indicated high thermal stability of the hydrogel compared to pure chitosan and β-Cyclodextrin. A rough and hard surface was revealed by scanning electron microscopy. Similarly, the crystallinity of the chitosan, β-Cyclodextrin, and fabricated hydrogel was evaluated using powder X-ray diffraction. The swelling and drug release studies were performed in both acidic and basic medium (pH 1.2 and 7.4, respectively) at 37 °C. High swelling and drug release was observed at pH 7.4 as compared to pH 1.2. The increased incorporation of chitosan, β-Cyclodextrin, and acrylic acid led to an increase in porosity, swelling, loading, drug release, and gel fraction of the hydrogel, whereas a decrease in sol fraction was observed. Thus, we can conclude from the results that a developed pH-sensitive network of hydrogel could be employed as a promising carrier for targeted drug delivery systems.

Antimicrobial cotton gauzes modified with poly(acrylic acid-co-maltodextrin) hydrogel using chitosan as crosslinker.

Cotton gauzes were grafted with a hydrogel of maltodextrin (MD) and poly(acrylic acid) (PAAc) using N-maleyl chitosan as crosslinker to obtain materials with antimicrobial properties. Reaction parameters including monomer, crosslinker, and initiator concentrations were studied. The modification with the copolymer poly(acrylic acid)-co-maltodextrin (PAAc-co-MD) was corroborated by Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM). The grafted gauzes (gauze-g-(PAAc-co-MD)) were able to load vancomycin and inhibit the growth of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) bacteria. In addition, the incorporation of chitosan as crosslinker showed a synergistic effect against these bacteria. The prepared gauze-g-(PAAc-co-MD) materials could be used in the biomedical area particularly as antimicrobial wound dressings.

Novel chitosan-based nanocomposites as ecofriendly pesticide carriers: Synthesis, root rot inhibition and growth management of tomato plants

Novel bio-based nanocomposites were developed as carriers for loading and sustained-release of vanillin (Van.) and cinnamaldehyde (Cinn.) antioxidants. The composites were obtained by intercalation of chitosan (CS) into sodium montmorillonite (CS/Mt), incorporation of chitosan with polyaniline (CS/PANI) and chitosan/polyaniline/exfoliated montmorillonite (CS/PANI/Mt). The structure and morphology of composites were characterized by FTIR, XRD, SEM and TEM. The release data of Van. and Cinn. from CS and CS/Mt obeyed well zero-order equation. However, Higuchi and Korsmeyer-Peppas models fitted well the release data from CS/PANI and CS/Mt composites. Their antifungal activity was examined towards Fusarium oxysporum and Pythium debaryanum. In vitro assay, CS, Cinn., Van., CS/PANI and CS/PANI/Cinn., have a strong inhibitory effect on the linear growth of the target pathogens, even at lower concentrations. Greenhouse assay indicated that seedling treatment by the loaded CS/PANI/Cinn and CS/Mt/Cinn. reduced both disease index and disease incidence parameters of both pathogens and possessed seedlings growth promoting potential of tomato compared to untreated-infected controls.

A pulp foam with highly improved physical strength, fire-resistance and antibiosis by incorporation of chitosan and CPAM

Bio-inspired borate cross-linked pulp foam (PF) with high porosity and low density can be widely used in many fields. However, PF is flammable, and lack of mechanical strength and antibacterial activity. To solve these issues, an ultra-strong PF was prepared by incorporation of chitosan and cationic polyacrylamide (CPAM). Results showed that the obtained PF exhibited highly improved mechanical properties (the compressive strength (485 kPa at a strain of 50%) was over 6 times higher compared with the borate cross-linked PF without chitosan and CPAM, and it was even higher than most of the reported cellulose-based porous materials). Also, the prepared PF has good performance on fire-retardance (hard to light), thermal insulation, antibiosis and sound absorption, due to the synergistic actions of borate, chitosan and CPAM. Additionally, spent liquor in preparing PF could be fully recycled, and thus this sustainable approach has potential for large-scale production of high-performance PF.

Incorporation of Low Molecular Weight Chitosan in a Low-Fat Beef Burger: Assessment of Technological Quality and Oxidative Stability.

In the present work, incorporating low molecular weight chitosan (LMWCH) (0, 0.5, 1, and 2%) as a fat replacer into low-fat beef burgers and technological, textural, and oxidative stability were investigated. The weight loss and shrinkage of samples decreased with the increase of LMWCH concentration. In contrast, the water-holding capacity and color of burgers were enhanced by the addition of LMWCH. The instrumental TPA results indicated an increase in the LMWCH levels, significantly increasing the hardness, springiness, and gumminess but decreasing the cohesiveness of low-fat beef burgers. The TBARS and peroxide values and free fatty acid content in the burgers supplemented with LMWCH increase slower than the control sample during refrigerated storage.

The Development and Characterization of a Cotton-Chitosan Composite for Lead Removal from Water.

Heavy metals in water are a serious environmental problem due to their accumulation and toxicity; there are several processes we can use to address this issue, but adsorption is the most popular due to its simplicity and efficiency. Polysaccharides such as cellulose have received attention as adsorbents for heavy metals, and cotton–chitosan composites (CCs) were developed here with nontoxic reagents such as carboxylic acids as crosslinkers and NaH2PO4 as a catalyst to achieve chitosan covalent crosslinkage into oxidized cotton textiles with H2O2. The composites were characterized by fourier-transform infrared spectroscopy (FTIR), elemental analysis (EA), X-ray photoelectron spectroscopy (XPS), atomic-force and scanning electron microscopy (AFM and SEM), and tensile strength; the adsorption of lead ions (Pb) was evaluated with cotton–chitosan composites and quantified by microwave plasma atomic emission spectroscopy (MP-AES). The composites showed a maximum incorporation of chitosan of 27.62 mg per gram of cotton textile. A tensile strength analysis of the composite showed a Young’s modulus approximately 1 MPa higher than that of cotton textile. The adsorption of lead ions with composites in an aqueous solution at pH 5 and 25 °C was circa 74% after 6 h of contact, as determined by MP-AES. This work is an approach to demonstrate the potential of these polysaccharides, modified by “green” procedures to remove pollutants from water.

Effect of the Incorporation of Chitosan and TiO2 Nanoparticles on the Shear Bond Strength of an Orthodontic Adhesive: An In Vitro Study

Aim: This in vitro study was aimed to evaluate the effect of adding different concentrations of chitosan nanoparticles (NPs) and TiO2 NPs on the shear bond strength (SBS) of an orthodontic adhesive. Materials and Methods: In this in vitro study, 72 extracted human premolars were embedded in an acrylic resin and randomly allocated into four groups of 18 specimens. In group 1 (control), brackets were bonded to the tooth with the Transbond XT orthodontic adhesive. In groups 2, 3, and 4, 0.5% chitosan NPs and 0.5% TiO2 NPs, 1% chitosan NPs and 1% TiO2 NPs, and 1.5% chitosan NPs and 1.5% TiO2 NPs were added to Transbond XT, respectively. Then, the brackets were bonded by the modified adhesive. The SBS and adhesive remnant index (ARI) of each group were assessed with a universal testing machine. The SBS test results were analyzed using one-way analysis of variance followed by the posthoc Tukey’s honestly significant difference (HSD) test. The Kruskal–Wallis test was also applied to evaluate the ARI scores. Results: The results showed no statistically significant difference between groups 1, 2, and 3, but SBS decreased significantly in group 4. With increasing the concentration of NPs up to 1% chitosan NPs and 1% TiO2 NPs, SBS did not change significantly. However, in 1.5% chitosan NPs and 1.5% TiO2 NPs, SBS decreased compared to the other three groups. No significant differences were found between the groups in terms of ARI scores. Conclusion: It is concluded that the orthodontic composite containing 1% chitosan NPs and 1% TiO2 NPs has adequate SBS for use in the clinical setting.

Hierarchically hybrid biocoatings on Ti implants for enhanced antibacterial activity and osteogenesis

Titanium (Ti) is widely applied as bone-anchoring implants in dental and orthopedic applications owing to its superior mechanical characteristics, high corrosion resistance, and excellent biocompatibility. Nevertheless, Ti-based implants with the deficiencies of insufficient osteoinduction and associated infections can result in implant failure, which significantly limits its applications in some cases. In this work, hierarchically hybrid biocoatings on Ti implants are developed by gradual incorporation of polydopamine (PDA), ZnO nanoparticles (nZnO), and chitosan (CS)/nanocrystal hydroxyapatite (nHA) via oxidative self-polymerization, nanoparticle deposition, solvent casting and evaporation methods for enhancing their antibacterial activity and osteogenesis. The modification of PDA on porous reticular Ti substrates greatly reduces the surface roughness, wettability, protein adsorption, and provides high adhesion to the deposited nZnO. Further, incorporating nZnO on PDA-coated Ti surfaces affects the surface structure and wettability, significantly inhibits the growth of both Staphylococcus aureus and Escherichia coli. Moreover, the CS/nHA-doped coating on the nZnO-modified Ti surfaces remarkably improves cytocompatibility and enhances the osteogenic differentiation of MC3T3-E1 cells by upregulating the protein expression of alkaline phosphatase. This work offers a promising alternative for developing Ti implants with long-lifetime bioactivity to achieve strong antibacterial ability and enhanced bone formation for potential dental/orthopedic applications.

Effect of cellulose nanofiber-based coating with chitosan and trans-cinnamaldehyde on the microbiological safety and quality of cantaloupe rind and fresh-cut pulp. Part 2: Quality attributes

The quality characteristics of fruits and vegetables can be protected with coatings. The presented study aimed to evaluate the effect of cellulose nanofiber (CNF) based coatings with chitosan (CHI) and trans-cinnamaldehyde (TC) on the quality attributes, including weight loss, total soluble solid (TSS) content, firmness, and color of whole and fresh-cut cantaloupe during storage at 22 °C and 4 °C, respectively. Results showed that CNF-based coating was effective in protecting whole cantaloupes from firmness reduction and color change in redness/greenness (a*) and yellowness/blueness (b*) during room-temperature storage for up to 11 days. Coating containing only CNF was not able to prevent the quality changes of fresh-cut cantaloupe during the cold storage, but CNF + CHI/CNF + CHI + TC significantly decreased the weight loss, decelerated the firmness increase and maintained the lightness (L*) of fresh-cut cantaloupe for up to 7 days. The incorporation of chitosan (1%, w/w) improved the protection effect of CNF-based coatings against quality changes during storage for both whole and fresh-cut cantaloupes, but TC (1%, w/w) did not show significant enhancement on the protection effects of coatings for most quality attributes. This study indicates that the CNF-based coatings have the potential to maintain quality attributes of whole and fresh-cut fruits during storage and distribution.

A novel approach for efficient fabrication of chitosan nanoparticles-embedded bacterial nanocellulose conduits

Incorporation of chitosan (CS) into Bacterial nanocellulose (BNC) matrix is of great interests in biomedical field due to the advantageous properties of each material. However, the conventional strategies result in poor composite effect with low efficiency. In this study, the three-dimensional fibrillar network of BNC was utilized as a template for the first time to homogeneously disperse CS to form nanoparticles (CSNPs) in BNC matrix via ionic gelation method, to develop chitosan nanoparticles-embedded bacterial nanocellulose (CSNPs-BNC) composites. This composite method is simple and efficient, without introducing dispersants and crosslinking agents, while retaining the mechanical properties and native 3D network structure of BNC. The CSNPs-BNC composites had excellent antibacterial activity to support potential clinical application. The CSNPs-BNC composites could promote the adhesion and proliferation of Schwann cells, and demonstrate good biocompatibility both in vitro and in vivo. The results indicated that CSNPs-BNC can provide a promising candidate for biomedical applications.

Incorporation of Dual-Stimuli Responsive Microgels in Nanofibrous Membranes for Cancer Treatment by Magnetic Hyperthermia.

The delivery of multiple anti-cancer agents holds great promise for better treatments. The present work focuses on developing multifunctional materials for simultaneous and local combinatory treatment: Chemotherapy and hyperthermia. We first produced hybrid microgels (MG), synthesized by surfactant-free emulsion polymerization, consisting of Poly (N-isopropyl acrylamide) (PNIPAAm), chitosan (40 wt.%), and iron oxide nanoparticles (NPs) (5 wt.%) as the inorganic component. PNIPAAm MGs with a hydrodynamic diameter of about 1 μm (in their swollen state) were successfully synthesized. With the incorporation of chitosan and NPs in PNIPAAm MG, a decrease in MG diameter and swelling capacity was observed, without affecting their thermosensitivity. We then sought to produce biocompatible and mechanically robust membranes containing these dual-responsive MG. To achieve this, MG were incorporated in poly (vinyl pyrrolidone) (PVP) fibers through colloidal electrospinning. The presence of NPs in MG decreases the membrane swelling ratio from 10 to values between 6 and 7, and increases the material stiffness, raising its Young modulus from 20 to 35 MPa. Furthermore, magnetic hyperthermia assay shows that PVP-MG-NP composites perform better than any other formulation, with a temperature variation of about 1 °C. The present work demonstrates the potential of using multifunctional colloidal membranes for magnetic hyperthermia and may in the future be used as an alternative treatment for cancer.

Sequestration of cadmium ions from aqueous phase using magnetic chitosan composite

Present communication reports on the synthesis, characterization and application of Fe3O4-chitosan composite (MCC). The magnetic chitosan composite are crafted by mixing Fe3O4 nanoparticles solution to chitosan solution. Fe3O4 nanoparticles have been synthesized by co-precipitation method. The synthesized composite have been extensively characterized using various techniques such as FTIR, TEM, XRD and BET analysis. The surface area analysis suggested that the materials synthesized is mesoporous in nature. Incorporation of chitosan crosslinked actively with Fe3O4 nanoparticles that results in reduction of surface area and narrower pore size distribution of the composite than pure Fe3O4 nanoparticles. TEM study demonstrated that Fe3O4 nanoparticles were found in the range of 20–25 nm. The synthesized composite is able to capture more than 89% Cd(II) from synthetic Cd(II) solution within 80 min of contact time. The adsorption equilibrium data better conformed with the Langmuir isotherm. The maximum capacity determined from Langmuir isotherm was 149.92 mg/g at 323 K. Adsorption kinetics of cadmium on MCC could be well analyzed with pseudo-second-order kinetic model. Thermodynamics investigation reveals that with the increase of solution temperature 303 K, 313 K and 323 K the ΔGo values decreases correspondingly to −87.76, −90.36 and -93.36 KJ/mol, suggesting endothermic nature of the adsorption process. The adsorbent could be successfully reused for more than five cycles. Thus, MCC can be serves as a reliable and sustainable material for efficient sequestration of Cd(II) species from aqueous environment.

Preparation, and physicochemical and biological evaluation of chitosan-Arthrospira platensis polysaccharide active films for food packaging.

Active films from chitosan incorporated with Arthrospira platensis polysaccharide (APP) of various ratios (0.0%, 0.5%, and 1.0%, w/v) were developed by solution casting. The effect of APP on the structural, physicochemical, mechanical, antimicrobial, and antioxidant properties of the chitosan-APP films (CA-film) was investigated. Fourier transform infrared spectra (FTIR) confirmed successful incorporation of chitosan and APP. The compact structure of the films was observed clearly in scanning electron microscopy (SEM) and atomic force microscopy (AFM) images. X-ray diffraction (XRD) patterns suggest the semi-crystalline structure was increased upon addition of APP. The composite films showed an improved water resistance and vapor barrier properties, and reduced by at least 27.4% and 32.1% in swelling degree (Sd ) and water vapor permeability (WVP) compared with chitosan film (C-film), respectively. However, the transparency decreased slightly, which may be due to the shrinkage of the spacing of the polymer interchain. The composite films also displayed enhanced the mechanical properties. The antimicrobial activity of the CA-film showed an increase of at least of 0.41-fold in inhibition zone diameter for E. coli. At a concentration of 1.2mg/mL, the antioxidant activity of CA-film was enhanced by more than threefold compared with C-film. Therefore, CA-films have good potential as sources of active packaging material for the food industry.

Facile synthesis of reusable graphene oxide composite magnetic beads for removal of arsenic (III)

AbstractConsumption of As(III) in drinking water is a severe problem, and more than 180 million people are suffering worldwide. Therefore, developing an affordable technique to remove As(III) from drinking water is essential to protect human health. In this work, we report chitosan‐iron oxide‐graphene oxide composite beads (GO‐BDs) for the removal of As(III) from the drinking water. The incorporation of chitosan and graphene oxide (GO) provides better physical strength and stability to the GO‐BDs. Prepared GO‐BDs were characterized using different characterization techniques. X‐Ray diffraction (XRD) spectra show the iron oxide nanoparticles were successfully linked with graphene oxide. The size of the beads confirmed by scanning electron microscopy (SEM) and found to be ~1 mm. Elemental mapping of beads show the uniform dispersion of GO/iron oxide on the surface of the beads. The adsorption of As(III) occurs rapidly and attain equilibrium condition in <6 h after removing As(III) from the water within the permissible limit. Effect of water pH, time, temperature, adsorbent dosage, and concentration of the dose have been studied in detail for arsenic removal. Coexisting ions show negligible influence on As(III) removal. Langmuir and Freundlich isotherms were also examined. This study provides the application of GO‐BDs for As(III) removal from contaminated drinking water.

Incorporation of chitosan into a universal adhesive system: Physicochemical characteristics, gelatinolytic activity, bond strength and interface micromorphology analyses

This study evaluated the physicochemical characteristics (particle size, zeta potential and polydispersity index) of a universal adhesive system (Scotchbond Universal/3 M ESPE) containing 0.5% chitosan (Ch), used as a self-etching (SE) or a total-etching (TE) strategy, and the effects of this chitosan-incorporated adhesive on microtensile bond strength stability to dentin, dentin-restoration interface, and gelatinolytic activity by in situ zymography. Dentin surfaces received treatments applying adhesive systems with or without Ch, and were used with an SE or a TE strategy. Composite resin blocks were built, and sticks were obtained and separated for microtensile bond strength tests (n = 10). Assessments were made after 24-h and 6-month storage, and the dentin/resin interface was evaluated by scanning electron microscopy (SEM) and zymography analyses (n = 4). Particle size and polydispersity index increased significantly, whereas zeta potential increased and decreased significantly over time. Microtensile bond strength for the SE (without Ch) and TE (with Ch) strategies decreased significantly after 6 months (p < 0.0001). At 6 months, the TE strategy had significantly higher microtensile bond strength than SE. SE and TE strategies (both with Ch) provided higher collagenolytic activity than SE and TE (without Ch) (p = 0.0007). Addition of 0.5% chitosan promoted solution instability. Both the TE strategy and the Ch incorporation affected microtensile bond strength negatively. There was higher collagenolytic activity when Ch was incorporated into the adhesive, regardless of the application strategy.

Green approach for fabrication of bacterial cellulose-chitosan composites in the solutions of carbonic acid under high pressure CO2

The functionalization of the bacterial cellulose (BC) surface with a chitosan biopolymer to expand the areas of possible applications of the modified BC is an important scientific task. The creation of such composites in the carbonic acid solutions that were performed in this work has several advantages in terms of being biocompatible and eco-friendly. Quantitative analysis of chitosan content in the composite was conducted by tritium-labeled chitosan radioactivity detection method and this showed three times increased chitosan loading. Different physicochemical methods showed successful incorporation of chitosan into the BC matrix and interaction with it through hydrogen bonds. Microscopy results showed that the chitosan coating with a thickness of around 10 nm was formed in the bulk of BC, covering each microfibril. It was found that the inner specific surface area increased 1.5 times on deposition of chitosan from the solutions in carbonic acid.

Impact of succinylation on pea protein-curcumin interaction, polyelectrolyte complexation with chitosan, and gastrointestinal release of curcumin in loaded-biopolymer nano-complexes

The influence of pea protein succinylation on the nature and strength of interaction with curcumin for a potential role in encapsulation and gastrointestinal delivery was investigated. Succinylation neutralized the positive charge on lysine residue and increased the effective negative charge on the protein from −34.4 ± 0.2 to −59.9 ± 0.9 mV with corresponding decrease in surface hydrophobicity and binding with curcumin. The binding constants (K) of 6.9 (± 0.21) × 104 M−1 and 4.2 (±0.05) × 104 M−1 were obtained for the native protein-curcumin (CUR/PPI) and succinylated protein-curcumin (CUR/SPPI) interactions, respectively. These values increased to 14.5 (± 0.64) × 104 M−1 and 187.9 (± 12.40) × 104 M−1 for curcumin-native pea protein-chitosan (CUR/PPI/CHI) and curcumin-succinylated protein-chitosan complexes (CUR/SPPI/CHI), respectively. Incorporation of chitosan to the protein-curcumin complex favoured static interaction. Transmission electron microscopy and dynamic light scattering confirmed the formation of spherical nano-complexes within the size range of 100–194.5 nm. FTIR showed that curcumin was stabilized more in the native protein complex than in the succinylated form. Polyelectrolyte complexation with chitosan by electrostatic interaction stabilized the succinylated protein-curcumin complex. The encapsulation efficiency decreased with a decrease in protein hydrophobicity and binding as a result of succinylation, from 34.65 ± 0.10% in CUR/PPI to 24.92 ± 0.03% in CUR/SPPI and from 85.01 ± 1.43 in CUR/PPI/CHI to 62.05 ± 2.95% in CUR/SPPI/CHI nano-complex. Although polyelectrolyte biopolymers enhance curcumin-loaded complex stability at the gastric phase, the release profile demonstrated that pea protein isolate effectively encapsulated and released curcumin without protein modification or incorporation of chitosan.

Some Significant Advances in Antibacterial Treatment of Textile Materials

The article reviews some significant trends in the antibacterial treatment of textile materials. Jute-cotton blended denim is a new diversified product for the fashion and clothing sector. Chitosan was incorporated in this blend in order to improve its antimicrobial property. The incorporation of chitosan to the blended apparel was confirmed by Fourier transform infrared spectroscopy. Two microorganisms were used to create individual bacterial medium; one is the gram-positive Staphylococcus aureus and the other is the gram-negative Escherichia coli. Functional cotton with high and durable antibacterial activity by in situ formation of Ag nanoparticles (NPs) onto cotton fabric derived from phytic acid-Ag complex. The route can be divided into two simple steps, adsorption of silver ions onto cellulose matrix with phytic acid as a capture agent and subsequent reduction of Agþ to Ag NPs by sodium borohydride

What happens when chitosan meets bentonite under microwave-assisted conditions? Clay-based hybrid nanocomposites for dye adsorption

In this study, bionanocomposites were prepared with bentonite and chitosan in proportions of 50, 100, 200, and 300 % of the cation exchange capacity (CEC) of the bentonite using microwave heating at 50 °C for 15 and 30 min. The X-ray diffraction patterns indicated basal spacings in the range of 1.48–2.10 and 1.57–1.98 nm for nanocomposites obtained at 15 and 30 min of heating, respectively, suggesting the intercalation of chitosan in the interlayer space of montmorillonite. Fourier transform infrared spectra confirmed the incorporation of chitosan in bentonite. The results of the elemental analysis suggested a higher chitosan content for the nanocomposites prepared with 200 and 300 % of the CEC after 30 min of irradiation. Chitosan–bentonite nanocomposites obtained after 30 min of heating successfully adsorbed the Reactive Violet 5R dye from aqueous solutions. The influence of several factors such as the pH, adsorbent dosage, contact time, and initial dye concentration was investigated. The optimal adsorption conditions were a pH of 1.0 and a contact time of 20 min. The adsorption capacity reached 98.00, 207.71, 250.00, and 282.01 mg g−1 for nanocomposites prepared with 50, 100, 200, and 300 % of the CEC, respectively. In was demonstrated that the prepared bentonite–chitosan nanocomposites were good dye adsorbents.

The potential use of curcumin-β-cyclodextrin inclusion complex/chitosan-loaded cellulose sponges for the treatment of chronic wound

In this research, the cellulose sponges with curcumin-β-cyclodextrin inclusion complex (CMx) and chitosan (CS) were fabricated for use as wound dressings. 1-Allyl-3-methylimidazolium chloride (AMIMCl) ionic liquid as a green solvent was used for the fabrication of cellulose sponges. Due to the low aqueous solubility and low bioavailability of curcumin, cyclodextrins (CDs) were applied and complexed with curcumin to obtain CMx. In addition, CS was incorporated in the cellulose sponges to improve the antibacterial activity of sponges. Attenuated total reflection-Fourier transform infrared (ATR-FTIR) analysis, morphological appearances, mechanical properties, water retention and weight loss, release behaviors, antibacterial activity, indirect cytotoxicity, cell attachment, and cell proliferation of the CMx/CS-loaded cellulose sponges were investigated. From the results, the cellulose sponges showed a porous structure. The incorporation of CMx and CS improved the mechanical properties when compared to the neat cellulose sponges. Moreover, the addition of CS into the cellulose sponges exhibited antibacterial activity against E. coli and S. aureus. Furthermore, the indirect cytotoxicity of the CMx/CS-loaded cellulose sponges was non-toxic and compatible with NCTC L929 and NHDF cells. Consequently, the CMx/CS-loaded cellulose sponges might be good candidates for use as wound dressing materials for the treatment of wound, especially chronic wound.