Inclusion Data Research Articles

Abstract TMP96: Clear Thrombectomy Score: An Index to Estimate Probability of Good Functional Outcome Following Endovascular Treatment in the Late Window for Anterior Circulation Occlusion

Background: Endovascular thrombectomy (EVT) has established efficacy across a wide range of patient age, radiological findings, and clinical features. However, EVT may be less effective in extreme scenarios (e.g., large established infarction in later treatment windows), where there are currently limited data. Methods: A heterogeneous, multinational observational cohort (CLEAR registry) of consecutive adult patients ≥18 years old who underwent EVT for acute occlusion (2014-2022) of the internal carotid or proximal middle cerebral (M1 or M2) arteries was queried (n=64 sites). A high-fidelity model for predicting good functional outcome at 90 days (return to pre-stroke modified Rankin Scale [mRS] or mRS 0-2 after EVT) was developed using a binary, multivariable logit model with adaptive double lasso adjustment, which was validated using 5-fold cross validation and 1000 bootstrap sampling for confidence intervals. Results: At the time of the analysis, we evaluated 2953 patients from the registry treated with EVT, of which 1855 (63%) had complete covariate data for inclusion. The median National Institutes of Health Stroke Scale (NIHSS) score was 15 (IQR 9-20), with 14.0% having a pre-stroke mRS >2, 8.3% having a NIHSS <6, and 17.8% having an Alberta Stroke Program Early Computed Tomography Scale (ASPECTS) score ≤6. A good functional outcome occurred in 813 (43.8%) patients. Independent predictors of the primary outcome, with points allocated toward the final score, included younger age, higher ASPECTS, lower NIHSS, and time from last known well to arterial puncture. The areas under the curve for derivation and validation cohorts were 0.72 (95% CI 0.70-0.75) and 0.74 (95% CI 0.71-0.80), respectively. Discussion: The CLEAR thrombectomy score provides a simple, validated means of predicting good functional outcome following late-window, anterior circulation thrombectomy using routinely acquired clinical and imaging data. External validation is warranted.

Ethical considerations related to drone use for environment and health research: A scoping review protocol.

The use of drones in environment and health research is a relatively new phenomenon. A principal research activity drones are used for is environmental monitoring, which can raise concerns in local communities. Existing ethical guidance for researchers is often not specific to drone technology and practices vary between research settings. Therefore, this scoping review aims to gather the evidence available on ethical considerations surrounding drone use as perceived by local communities, ethical considerations reported on by researchers implementing drone research, and published ethical guidance related to drone deployment. This scoping review will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews (PRISMA-ScR) and the Joanna Briggs Institute (JBI) guidelines. The literature search will be conducted using academic databases and grey literature sources. After pilot testing the inclusion criteria and data extraction tool, two researchers will double-screen and then chart available evidence independently. A content analysis will be carried out to identify patterns of categories or terms used to describe ethical considerations related to drone usage for environmental monitoring in the literature using the R Package RQDA. Discrepancies in any phase of the project will be solved through consensus between the two reviewers. If consensus cannot be reached, a third arbitrator will be consulted. Ethical approval is not required; only secondary data will be used. This protocol is registered on the Open Science Framework (osf.io/a78et). The results will be disseminated through publication in a scientific journal and will be used to inform drone field campaigns in the Wellcome Trust funded HARMONIZE project. HARMONIZE aims to develop cost-effective and reproducible digital infrastructure for stakeholders in climate change hotspots in Latin America & the Caribbean and will use drone technology to collect data on fine scale landscape changes.

A study of the promotion mechanism of digital inclusive finance for the common prosperity of Chinese rural households

Common prosperity is a social policy goal pursued by the Chinese government and an ideal social status for humanity. On the basis of three theoretical hypotheses, this study involved the analysis of county-level digital inclusive finance data and rural survey data. The Hierarchical Linear Model was employed to empirically analyze the impact and mechanism of digital inclusive finance on the common prosperity of rural households. The results indicate that the county-level digital inclusive finance index, as well as its depth and coverage, can significantly and directly promote common prosperity. Furthermore, it was found that household livelihood strategies are one of the regulatory mechanisms, and digital inclusive finance significantly promotes common prosperity through factors such as opportunities for migrant work, property income, business livelihood models, and agricultural livelihood models. In addition, financing methods are also important adjustment mechanisms, and digital inclusive finance significantly promotes the common prosperity through digital tools and loan availability variables. Our research provides favorable evidence for the cross-level interaction effect of county-level digital inclusive finance on the common prosperity of rural households.

Evaluation of Hydrometeorological Characteristics in the Northern Ethiopia, Gerado Catchment

In Northern Ethiopia, land degradation, together with population pressure foster soil erosion. Soil erosion in turn escalates surface runoff which is a serious challenge to agricultural production and economic growth in the region. Understanding the characteristics and dynamics of hydrometeorological variables are important elements in water resources development projects. Present study was carried out to evaluate hydrometeorological characteristics in the Northern Ethiopia, Gerado Catchment. Long term meteorological data such as precipitation, temperature and other climatic factors were collected from existing meteorological stations. Thornthwaite empirical equation and thornthwaite soil water balance models were employed in estimating potential and actual evapotranspiration. The first approach used air temperature as an index of energy available for evapotranspiration. Similarly, groundwater recharge of the catchment was computed as a difference of between outflow and change in a water storage. The runoff of the area was calculated based on the rainfall coefficient, annual precipitation and aerial coverage. On the other hand, groundwater potential (GWP) of the area was mapped based on important selected controlling factors. The result indicated that the annual potential and actual evapotranspiration of the catchment was found to be 755 mm/year and 723 mm/year respectively. The actual evapotranspiration was evaluated and weighted based on the dominant soil textures, depth root soil, and the respective land uses. As result, high evapotranspiration was observed in moderate deep rooted cereal crops and sandy loam soil texture which accounted 48.5% influence. But, cereal crops with moderate deep rooted and clay loam type have low AET (42.2%). Because of absence of gauging stations in the catchment, the volume runoff was computed using the runoff coefficient method. Accordingly, surface runoff from the catchment was calculated to be 120,581,841 cubic meter (m3) or 326 mm. Whereas, the groundwater recharge of the area was also found to be 52,208,159.5 cubic meter (141.5mm). Thus, out of the given mean annual precipitation, 27.6% and 12% of the mean annual rainfall lost because of runoff and recharge and the rest (60.4%) due to evapotranspiration. Regarding GWP suitability mapping, lithology, liniment density and geomorphology were found the most essential factors affecting groundwater mapping. The suitable GWP areas were lied within lithology and geomorphology class. Moreover, areas with flat slope and low lineament density are also located in most rich groundwater areas. Furthermore, installation of rain gauges at appropriate areas are essential for all inclusive and consistent data availability. 
 Keywords: Hydro-meteorological, Gerdo Catchment, groundwater recharge, runoff, evapotranspiration, GWP

Immune-related adverse events in patients with gastrointestinal cancer undergoing pembrolizumab monotherapy: A systematic review of clinical trials.

744 Background: Pembrolizumab, an immune checkpoint inhibitor targeting programmed death 1 (PD-1), is widely employed in the treatment of various gastrointestinal (GI) cancers. This systematic review aims to assess the spectrum and incidence of immune-related adverse events (irAEs) associated with pembrolizumab monotherapy in GI cancer patients. Methods: A comprehensive search of PubMed/MEDLINE was conducted to identify full-text articles of clinical trials investigating pembrolizumab monotherapy in GI cancer patients. Two independent authors reviewed the articles and extracted data, with discrepancies resolved by consensus. Primary endpoints included the incidence of grade 3 or higher irAEs and the treatment discontinuation rate due to irAEs. Secondary endpoints encompassed the incidence of any-grade irAEs and specific irAEs such as pneumonitis, colitis, hepatitis, myositis, myocarditis, nephritis, pancreatitis, peripheral neuropathy, skin toxicity, endocrine toxicity, infusion reactions, and deaths. Results: After excluding duplicates and articles not meeting inclusion criteria, data extraction and analysis were performed on 25 selected articles. Common reasons for exclusion included concomitant use of chemotherapy or targeted therapy and trials involving non-GI cancer patients. The analysis included 2866 patients with a median age of 62 years, of which 29% were female. Tumor types included colorectal (13%), esophagogastric (46%), hepatocellular carcinoma (25%), and others (16%). The aggregate incidence of grade 3 or higher irAEs was 8.7%, with reported rates ranging from 3% to 41% across different trials. The incidence of any grade irAEs varied from 39% to 98%. The treatment discontinuation rate due to irAEs was 6.8%. The most common grade 3 or higher irAEs were hepatitis (3.6%), pneumonitis (0.8%), and colitis (0.7%). irAE-related deaths were infrequent (0.9%). Detailed irAE data are summarized in the Table. Conclusions: In GI cancer patients receiving pembrolizumab monotherapy, severe irAEs are rare. Treatment discontinuation and deaths attributed to pembrolizumab-related irAEs are infrequent, underscoring the safety profile of this therapy in patients with GI cancer. [Table: see text]

Outcomes of a Parent-Delivered Baby-mCIMT Model for Infants at High Risk of Unilateral Cerebral Palsy Using Remote Coaching in Telerehabilitation.

There is growing evidence of the positive effects of constraint-induced movement therapy (CIMT) for infants at high risk of unilateral cerebral palsy (UCP) when provided by parents with in-person coaching/supervision from occupational therapists during home visits. The aim of this study is to investigate whether Baby-mCIMT (modifiedCIMT) can be as effective if parents are coached/supervised remotely. In this case-control study, we recruited 20 infants and re-used 18 controls, 4-8-month-old infants in both groups at high risk of UCP. The same protocol regarding inclusion criteria, data collection, and training volume was used in both groups. The training was conducted for two 6-week periods, separated by a 6-week break, consisting of daily 30 min sessions conducted by parents, supported by therapist coaching once a week. The primary outcome was measured using the Hand Assessment for Infants (HAI). There was no difference in the change of HAI units (p = 0.803) or that of the affected-hand raw score (p = 0.942) between the two groups. The remote coaching method was well received by parents. In conclusion, this demonstrates that remote coaching/supervision is as effective as the in-person approach, requiring less time and effort for both families and healthcare providers.

Timing of First Set of Pressure Equalization Tubes in Pediatric Patients With Cleft Deformities.

Children with cleft palates often have comorbid eustachian tube dysfunction requiring pressure equalization tubes (PETs). PETs can relieve middle ear effusions that impede hearing. Ideal PET placement timing in this population is controversial. In this study, the audiologic exam passing rates of patients with cleft palate prior to and following PET insertion were assessed. Rates for patients receiving PETs at different ages were compared. It was hypothesized that earlier PET placement may benefit patients with additional months of improved hearing. A retrospective chart review was performed of patients with cleft palate between November 22, 2016 and November 22, 2021 at a tertiary center. Statistical analysis compared passing/normal audiologic exams in patients receiving PETs at different ages. A total of 348 patients had cleft palate diagnoses, received PETs, and had adequate hearing data for inclusion. Those with PETs inserted at 3 months of age or less had an increase in percent of patients passing audiologic exams following versus prior to PET insertion of 13% (1.3 times improvement). Those receiving PETs between 7- and 12-months had the largest rate of improvement (42%) (2.4 times improvement); other groups had changes in passing rates between 31% and 40%. The rate of passing audiologic exams following PET insertion was high across all groups, ranging from 66% to 81%. This is one of the first studies exploring the timing of PET placement in this population and showed that patients receiving PETs at 3 months of age or younger passed subsequent audiologic exams at similar rates relative to those receiving PETs later in life. 3 Laryngoscope, 134:3391-3394, 2024.

Māori data sovereignty: contributions to data cultures in the government sector in New Zealand

ABSTRACT Māori data sovereignty, an extension of Indigenous data sovereignty, is gaining recognition as a vital element of data-related strategy, management, policy, and culture in New Zealand. Driven by the principles of tino-rangatiratanga and Te Tiriti o Waitangi, Māori data sovereignty emphasizes Māori self-determination and control over their data. This article explores the significance of Māori data sovereignty within public and private sector organizations in New Zealand through interviews with data experts. The outcomes of this research highlight the importance of building relationships based on trust (whanaungatanga), asserting the right to self-determination (rangatiratanga), working collectively for the benefit of all (kotahitanga), and promoting learning and capacity building (akoranga) as key principles of Māori data sovereignty. While there is a growing recognition of Māori data sovereignty, power imbalances and the need for greater education and awareness persist. The study emphasizes the need for organizations to embrace a kaupapa Māori lens and tikanga Māori values to foster inclusive data cultures that uphold the rights and aspirations of Māori communities. Collaboration and further research are essential to advance Māori data sovereignty and integrate its principles into information policies and practices across sectors, thus promoting a data culture that respects Indigenous rights and collective well-being.

PT conditions of deformation of the Gol-e-Gohar shear Zone, SW Iran: Insights from analysis of quartz c-axis fabrics, recrystallization mechanisms and syndeformational fluid inclusions

An investigation into the correlation between microstructural characteristics and deformation temperatures of quartz in the middle crust is of utmost importance in yielding substantial knowledge of the nature of deformation zones. Mylonitic rocks from the Gol-e-Gohar Shear Zone were investigated to infer innovative insights into the ductile deformation pressure–temperature (PT) conditions of the Sanandaj–Sirjan metamorphic rocks within the Zagros, southwest Iran. This approach used a multi-method strategy including quartz c-axis fabrics, recrystallization mechanisms and fluid inclusions (Fls) data. Geothermobarometric analysis based on these data highlight deformational PT conditions ranging from ∼400 to ∼500 °C and P < 5 kbar that correspond to ductile deformation with greenschist to lower-amphibolite conditions at depth of ∼ 12–19 km. Measured opening angles of quartz c-axis fabric and dominance of basal < a > slip system indicate crystal plastic deformation occurred in T > 400 °C. Microstructures highlighting the occurrence of Grain Boundary Migration (GBM) confirm temperature of 500–600 °C. The deduced P–T–salinity Fls history of deformation-related fluid inclusions is highlighted by Fls (B-type) with H2O-CO2–rich metamorphic fluids. These fluids were trapped during ductile deformation in temperatures ranging from ∼ 355 to ∼ 535 °C and pressure of P < 5 kbar. The petrofabric analyses show that the mylonitic rock in the Gol-e-Gohar shear zone have undergone metamorphism at the amphibolite facies condition, and then followed by a retrograde greenschist facies metamorphism. These results emphasize the utility of microstructural and fluid inclusion techniques to constrain the history of mylonitic rocks exhumation in the deformation zones.

Genesis of the Supergiant Shuangjianzishan Ag–Pb–Zn Deposit in the Southern Great Xing’an Range, NE China: Constraints from Geochronology, Isotope Geochemistry, and Fluid Inclusion

The supergiant Shuangjianzishan (SJS) Ag–Pb–Zn deposit, located in the southern Great Xing’an Range (SGXR), is the largest Ag deposit in China. The SJS deposit can be divided into two ore blocks: the Shuangjianzishan ore block and the Xinglongshan ore block. Given the importance of the Xinglongshan ore block in the SJS deposit, our work is focused on the Xinglongshan ore block. The vein orebodies in the Xionglongshan ore block mainly occur in the NW-, NNW-, and NNE-trending fault zones, and its mineralization is mainly related to a deep concealed syenogranite. Here, we present new geochronology, isotope geochemistry, and fluid inclusion data for the Xinglongshan ore block and provide additional insights into the metallogenic mechanism of the deposit. The dating results show that the syenogranite related to the mineralization formed at approximately 137 Ma, which is coherent with some previous age determinations in sulfides from the ore deposit. The mineralization of the Xinglongshan ore block can be divided into four stages: sphalerite–arsenopyrite–pyrite–chalcopyrite–quartz stage (stage I), sphalerite–galena–pyrite–silver-bearing mineral–quartz stage (stage II), sphalerite–galena–silver-bearing mineral–quartz–calcite stage (stage III), and weakly mineralized quartz–calcite stage (stage IV). Four types of fluid inclusions (FIs) have been identified within quartz and calcite veins: liquid-rich, gas-rich, pure-liquid, and pure-gas FIs. The homogenization temperatures in the four stages exhibit a gradual decrease, with stage I ranging from 253 to 302 °C, stage II from 203 to 268 °C, stage III from 184 to 222 °C, and stage IV from 153 to 198 °C, respectively. The salinity for stages I, II, III, and IV falls within the ranges of 3.4–6.6 wt% NaCl eqv., 2.6–7.2 wt% NaCl eqv., 2.9–7.0 wt% NaCl eqv., and 1.2–4.8 wt% NaCl eqv., respectively, indicative of a low-salinity ore-forming fluid. The δ18Owater and δD values of the ore-forming fluid span from −13.9‰ to 7.4‰ and −145‰ to −65‰, with δ13CV-PDB values between −11.0‰ and −7.9‰. These values suggest that the ore-forming fluid predominantly originated from a mixture of magmatic and meteoric water. The 206Pb/204Pb, 207Pb/204Pb, and 208Pb/204Pb ratios of sulfides range from 18.278 to 18.361, 15.530 to 15.634, and 38.107 to 38.448, respectively. These ratios imply that the ore-forming material was primarily derived from the Early Cretaceous granitic magma, which resulted from the mixing of depleted mantle- and crustal-derived magmas. The fluid mixing was the dominant mechanism for mineral precipitation. The Xinglongshan ore block belongs to a magmatic-hydrothermal vein-type deposit related to the Early Cretaceous syenogranite, and the Shuangjianzishan ore block belongs to an intermediate sulfidation epithermal deposit related to coeval subvolcanic rocks. The Ag–Pb–Zn mineralization at Shuangjianzishan is genetically related to the Early Cretaceous volcanic–intrusive complex.

The Role of Social Support in Fostering Self-Acceptance Among Mothers of Children with Intellectual Disabilities

This study investigates the relationship between social support and self-acceptance among mothers of children with intellectual disabilities. Utilizing a quantitative correlational design, it examines how perceived social support impacts self-acceptance in a sample of 59 mothers at Rumah Pintar Salatiga. The research employs the Multidimensional Scale of Perceived Social Support and Berger’s Self-Acceptance Scale, revealing that while most mothers receive moderate social support, a significant proportion struggle with self-acceptance. A positive correlation (r = 0.228, p &lt; 0.05) was found between social support and self-acceptance, albeit accounting for only 5.2% of the variance in self-acceptance. This suggests that other factors also significantly influence self-acceptance. The findings align with existing literature, indicating the necessity of comprehensive support systems that address both emotional and practical needs. Methodological limitations include reliance on questionnaires distributed through schools without researcher supervision and the exclusion of digital platforms for data collection. The study emphasizes the need for diverse and inclusive data collection methods in future research and calls for more extensive support mechanisms, including counseling and peer support, to enhance the well-being of this often-overlooked population.

Measuring jet quenching with a Bayesian inference analysis of hadron and jet data by JETSCAPE

The JETSCAPE Collaboration reports the first multi-messenger study of the QGP jet transport parameter q^ using Bayesian inference, incorporating all available hadron and jet inclusive yield and jet substructure data from RHIC and the LHC. The theoretical model utilizes virtuality-dependent in-medium partonic energy loss coupled to a detailed dynamical model of QGP evolution. Tension is observed when constraining q^ for different kinematic cuts of the inclusive hadron data. The addition of substructure data is shown to improve the constraint on q^, without inducing tension with the constraint due to inclusive observables. These studies provide new insight into the mechanisms of jet interactions in matter, and point to next steps in the field for comprehensive understanding of jet quenching as a probe of the QGP.

Visual Health Status and Visual Impairment among Students in Uyo, Akwa Ibom State Nigeria

The purpose of this study was to determine the visual health status, causes of visual impairment and the prevalence of eye disease among students in Uyo metropolis. Five specific objectives and five research questions were formulated to guard the study. A Quesi-experimental research design was used in the study involving two public and one private secondary schools located in Uyo metropolis. Structured questionnaire was used to collect data as well as clinical examination of the eyes of the students who fulfilled the inclusion criteria and data so generated were analyzed using frequency counts and non parametric statistics. The sample for the study was made up of 419 students, 152 were males and 261 were females. The findings of the study indicated that, testing using chi-square analysis revealed a poor visual health status of majority of the students is caused by refractive error and the prevalence of visual impairment is high among the students, therefore there is need to take appropriate steps to mitigate its effect on the academic performance of these students and their in future. It is recommended that teachers should be trained and equipped for vision screening of their students, pre-school regular eye screening of students including a proper referral chain for students so identified with eye problem should form part of the school health programmers.

Within-Respondent Alignment between Single-Choice and Mark-All-That-Apply Survey Measures for Sexual Identity

With the rising disclosure of LGBTQ+ identities, there have been increasing efforts to capture inclusive sexual identity data. Commonly used survey measures are closed ended and single choice (i.e., “select one”) and may be restrictive for sexuality- and gender-diverse respondents. However, more expansive measures may be unwieldy to survey takers and analysts. In this data visualization, the authors compare single-choice and mark-all-that-apply measures for sexual identity. Using survey data ( n = 2,511) fielded in the United States and United Kingdom in 2022, the authors analyze within-respondent alignment of a single-choice measure and an expansive mark-all-that-apply measure for sexual identity. Responses were considered “aligned” when respondents provided identical information across both measures. Overall, alignment was 89 percent in the full sample, with the highest rate of alignment occurring among straight respondents. With the mark-all-that-apply measure, 3 percent of the sample selected multiple identities, and about 2 percent selected identities not found in the commonly used single-choice measure.

Infrared microthermometry of fluid inclusion in sphalerite: A case study of the Xinqiao deposit in the Middle–Lower Yangtze metallogenic belt

Infrared microthermometry allows direct measurement of fluid inclusions hosted in opaque ore minerals and can provide direct constraints on the evolution of ore-forming fluids. This study presents infrared microthermometry of spherite-hosted fluid inclusions from the Xinqiao deposit in the Middle-Lower Yangtze Metallogenic Belt and sheds new light on the ore genesis of the deposit. Considering that infrared light may lead to non-negligible temperature deviations during microthermometry, some tests were first conducted to ensure the accuracy of the microthermometric measurements. The measurement results indicated that using the lowest light intensity of the microscope and inserting an optical filter were effective in minimizing the possible temperature deviations of infrared microthermometry. All sphalerite-hosted fluid inclusions from the Xinqiao deposit were aqueous. They show homogenization temperature ranging from ~200 to 350 °C, but have two separate salinity groups (1.0–10% and 15.1–19.2% NaCl equivalent). The low-salinity group represents sedimentary exhalative (SEDEX)-associated fluids, whereas the high-salinity group results from modification by later magmatic hydrothermal fluids. Combined with published fluid inclusion data, the four-stage fluid evolution of the Xinqiao deposit was depicted. Furthermore, our data suggest that the Xinqiao deposit was formed by two-stage metallogenic events including SEDEX and magmatic-hydrothermal mineralization.

Toward a trustworthy and inclusive data governance policy for the use of artificial intelligence in Africa

Toward a trustworthy and inclusive data governance policy for the use of artificial intelligence in Africa

Race and Ethnicity of Infants Enrolled in Neonatal Clinical Trials

Representativeness of populations within neonatal clinical trials is crucial to moving the field forward. Although racial and ethnic disparities in research inclusion are well documented in other fields, they are poorly described within neonatology. To describe the race and ethnicity of infants included in a sample of recent US neonatal clinical trials and the variability in this reporting. A systematic search of US neonatal clinical trials entered into Cochrane CENTRAL 2017 to 2021 was conducted. Two individuals performed inclusion determination, data extraction, and quality assessment independently with discrepancies adjudicated by consensus. Of 120 studies with 14 479 participants that met the inclusion criteria, 75 (62.5%) included any participant race or ethnicity data. In the studies that reported race and ethnicity, the median (IQR) percentage of participants of each background were 0% (0%-1%) Asian, 26% (9%-42%) Black, 3% (0%-12%) Hispanic, 0% (0%-0%) Indigenous (eg, Alaska Native, American Indian, and Native Hawaiian), 0% (0%-0%) multiple races, 57% (30%-68%) White, and 7% (1%-21%) other race or ethnicity. Asian, Black, Hispanic, and Indigenous participants were underrepresented, while White participants were overrepresented compared with a reference sample of the US clinical neonatal intensive care unit (NICU) population from the Vermont Oxford Network. Many participants were labeled as other race or ethnicity without adequate description. There was substantial variability in terms and methods of reporting race and ethnicity data. Geographic representation was heavily skewed toward the Northeast, with nearly one-quarter of states unrepresented. These findings suggest that neonatal research may perpetuate inequities by underrepresenting Asian, Black, Hispanic, and Indigenous neonates in clinical trials. Studies varied in documentation of race and ethnicity, and there was regional variation in the sites included. Based on these findings, funders and clinical trialists are advised to consider a 3-point targeted approach to address these issues: prioritize identifying ways to increase diversity in neonatal clinical trial participation, agree on a standardized method to report race and ethnicity among neonatal clinical trial participants, and prioritize the inclusion of participants from all regions of the US in neonatal clinical trials.

Recently-discovered Bahçecik Au±Ag mineralization in the Eastern Pontides, Gümüşhane-NE Türkiye: geological and geochemical implications on the intermediate sulfidation epithermal deposit

ABSTRACT Intermediate sulfidation epithermal deposits represent significant reservoirs of precious metals, playing a crucial role in global mining operations. The Anatolian Peninsula, predominantly characterized by relatively young (Tertiary) lithologies, hosts numerous occurrences of epithermal base and precious metal mineralization. Within the realm of research in Northeastern Anatolia, several hydrothermal alteration zones have emerged as indicators of concealed epithermal mineralization, with the Bahçecik mineralization standing out as a recent focal point. The Bahçecik mineralization represents an intermediate sulfidation epithermal Au-Ag system, hosted by Late Cretaceous andesitic rocks, as well as Eocene dacitic lava and tuffs. Employing U-Pb LA-ICP-MS zircon dating of the dacitic host rocks, the mineralization is estimated to have occurred during the Lutetian epoch (43.61 ± 0.35 Ma) or later. The genesis of the Bahçecik deposit is believed to be linked to postcollisional regional extensional tectonics, primarily controlling its structural arrangement. Comprising pyrite, chalcopyrite, low-Fe sphalerite, galena, tetrahedrite/tennantite, enargite-luzonite, and gold-silver minerals, the deposit is accompanied by prominent gangue minerals such as Mn- and Ca-carbonates, quartz, and barite. Microprobe measurements have identified a majority of Au-Ag minerals (krennerite, buckhornite, and nagyagite) closely associated with sulphide minerals. Fluid inclusion data reveal that mineralization and fluid transportation occurred at temperatures ranging from 153 to 327°C, with solutions exhibiting salinity levels consistent with those of intermediate sulfidation deposits (1.7–7.3 wt.% NaCl). This study unequivocally classifies the Bahçecik mineralization as an intermediate sulfidation deposit, contrary to the conclusions drawn in previous research. Moreover, our investigation has unveiled the presence of a substantial ore resource, totalling 7.84 million tons, featuring 1.76 g/t Au and 2.24 g/t Ag. As an intermediate-type deposit, it shares characteristics with other subtypes within the epithermal class, bridging the realms of both high and low sulfidation systems.

Special Issue: 2023 Research Data Access and Preservation (RDAP) Summit

The 2023 Research Data Access and Preservation (RDAP) Summit, Building on Experience: Centering Communities in Data Creation and Access, focused on engagement with and building communities within data environments, including how data is being made more accessible for a wider range of communities. The 2023 RDAP Summit was a natural extension from the prior year’s theme of Envisioning an Inclusive Data Future, which highlighted the ways data service providers tailor their services to address specific needs. A selection of presentations from this year’s Summit were expanded into articles for this special issue covering topics on developing and maintaining communities that address aspects across the research data life cycle.

Chalcophile element degassing at an active continental arc volcano

Arc volcanoes are significant natural sources of trace chalcophile elements to the atmosphere via gas and aerosol plumes. Villarrica volcano, part of the Andean arc, erupts basaltic magmas and is characterised by a persistent volcanic gas plume and therefore presents an opportunity to quantify volcanic chalcophile processing in a subduction zone from slab to surface. Here we present geochemical data for olivine-hosted melt inclusions, as well as for the gas and aerosol plume. We show that melts erupted at Villarrica are enriched (over mid-ocean ridge basalts) in a suite of fluid-mobile elements comprising the large ion lithophiles, including Cs, and chalcophile elements W, Tl, Pb and Sb. Volcanic gas and aerosol samples show that the chalcophile elements, and Cs, are strongly enriched in the gas phase over the silicate melt, 103 to 106 times more so than the non-volatile Rare Earth Elements. Volatilities (the percentage of an element that degasses from a melt on eruption) reach ∼ 45 % for Tl, with Pb, Sn and Mo exhibiting volatilities of up to 0.3 % and Cu up to 0.08 %. Many of the chalcophile elements (e.g. Cu, Ag, Zn) have an affinity for chloride in the gas phase and we observe that the volatility of chloride-speciating trace metals is linked strongly to the availability of chlorine in volcanic plumes globally. Overall, we show that the trace element composition of the volcanic gas—and hence probably also the deeper, denser and more saline fluids in the subsurface—is sensitive to both the availability of chloride in the gas phase and the composition of the melt, which is controlled by the slab flux and may be variable between subduction zones.