Additional Inclusion Research Articles

Trevo 3 Mm and/or AXS Catalyst5 for the Treatment of Medium Distal Vessel Occlusion Stroke-results from the ASSIST Registry.

The effect of endovascular therapy (EVT) on the outcome of stroke patients with amedium distal vessel occlusion (MDVO) is unclear. We report the results of MDVO patients treated with the 3 mm Trevo stent retriever (SR) and/or the AXS Catalyst5 distal access catheter. Data was derived from aprospective, multicenter global registry (ASSIST registry) which enrolled patients treated with operator preferred EVT technique at 71sites from January 2019 to January 2022. Three techniques were assessed: SR classic, direct aspiration, and acombined approach. Additional inclusion criteria were (a)EVT performed with the 3 mm Trevo SR and/or AXS Catalyst5 distal access catheter on the first pass and (b)an occlusion of the M2segment or M3segment of the middle cerebral artery or the A1, A2 or A3segment of the anterior cerebral artery. The primary outcome was achieving an expanded Thrombolysis in Cerebral Infarction (eTICI) score of 2c or 3 on the first pass, with the primary technique as adjudicated by core lab. The primary clinical outcome measure was a90-day modified Rankin Scale (mRS) score of 0-2. Atotal of 155 patients (10.4% of the ASSIST population) were included. Most patients had an M2 occlusion (93.5%). First pass eTICI reperfusion was achieved in 43.1% of the patients. No modifying effect of the frontline technique was found. The rate of mRS 0-2 (overall 65.0%) did not significantly differ between groups. The data suggests that the Trevo 3 mm SR and/or the AXS Catalyst5 may be an option to treat medium distal vessel occlusion, but more data is needed to demonstrate safety and efficacy in this patient cohort. Further improvements are needed regarding materials and techniques to improve reperfusion results in this patient cohort in the future.

Oxidative stress markers in brain and gonads of rabbit bucks fed herbal supplements

BackgroundCurrently, there is an increase in the usage of phytogenic feed additives to help improve animal welfare and productivity, while less emphasis is now placed on metabolic and oxidative stability of neuronal and testicular tissues. This study aims at investigating the effects of Moringa oleifera, Phyllanthus amarus and Viscum album as feed additives on some metabolic indicators and oxidative status of rabbit testis and brain. Isonitrogenous and isocaloric diets were formulated with 5% supplementation of each of the phytogenic additive to 3 treatment groups and basal diet group.ResultsIt was revealed that moringa, mistletoe, and phyllanthus can modulate oxidative status in both the brain and gonads of rabbit bucks through their unique phytochemical compositions, thereby affecting reproductive and cognitive functions. Moringa, rich in crude protein, saponins, glycosides, and steroids, enhances protein and lactate dehydrogenase levels but increases lipid peroxidation in the testis. Mistletoe, with high crude fiber, ash, and antioxidants like flavonoids and tannins, boosts total antioxidant activity in several brain regions and reduces lipid peroxidation, indicating its potential for reducing oxidative stress. Phyllanthus, having the least fiber and ash but effective antioxidant properties, notably affects the oxidative balance in both the testis and brain, with varied impacts on different tissues. The result obtained showed that total antioxidant activity of the left testis was enhanced (p < 0.05) by inclusion of the phytogenic additives, while total antioxidant activity of the right testis in bucks fed on phytogenic additives were similar (p > 0.05) to bucks on basal diet. Bucks fed on moringa and phyllanthus additives had higher (p < 0.05) testicular lipid peroxidation, lowered testicular protein and/or lactate dehydrogenase. Result also shows that lipid peroxidation of hypothalamus, cerebrum, olfactory lobe and cerebellum were lowest in bucks fed on mistletoe, phyllanthus, phyllanthus and phyllanthus, respectively. High catalase activity of optic lobe, olfactory lobe and cerebellum were observed in bucks fed on mistletoe, moringa and mistletoe, respectively, while glutathione peroxidase activity in hypothalamus, cerebrum, olfactory lobe and pineal was enhanced (p < 0.05) in bucks fed on moringa and mistletoe compared to bucks on other treatment.ConclusionM. oleifera, P. amarus and V. album leaves as phytogenic feed additives in rabbit diets have negative effect on the metabolic activity of the testis, enhancing antioxidant activity in the brain.

Features of distribution of electric field strength and current density in the reactor during treatment of liquid media with high-voltage pulse discharges

Purpose. Development and use of a mathematical model of the stages of formation of high-voltage pulse discharges in gas bubbles in the discharge gap «rod-plane» to identify the features of the electric field intensity distribution in the reactor and determine the current density in the load during disinfection and purification of liquid media by high-voltage pulse discharges and find the most rational treatment. Methodology. To achieve this goal, we used computer modeling using the finite element method as a method of numerical analysis. An experimental reactor model was created that takes into account the dynamics of discharges in gas bubbles in water. The equations describing the system include the generalized Ampere equation, the Poisson equation and the electric displacement equation, taking into account the corresponding initial and boundary conditions, as well as the properties of materials. The dependence of the potential of a high-voltage electrode on time has the form of a damped sinusoid, and the specific electrical conductivity in a gas bubble is a function of time. Processes occurring at the front of the voltage pulse from 0 to 20 ns are considered. Results. It is shown that with an increase in conductivity and high-voltage potential to amplitude values in a gas bubble, the electric field strength in the water layer in the reactor reaches 70 kV/cm, and it is in the water layer that there is a strong electric field. The calculations show that already by 19th ns the density of conduction currents in water prevails over that of displacement currents. At the same time, additional inclusions in the water significantly affect the distribution of electric field strength and current density, creating a significant difference in their values at the boundaries of the interface between the bubble, conductive element and water. Originality. A simulation of the dynamics of transient discharge processes in a gas bubble and a layer of water with impurities was carried out, including an analysis of the distribution of the electric field strength and current density in a system with rod-plane electrodes in the phase transition section of a gas bubble-water. This approach allows us to reveal the features of processes in reactors and to investigate the influence of phase transitions on the distribution of electrophysical quantities. Practical value. Computer simulations confirm the prospect of using nanosecond discharges generated in gas bubbles within a volume of water for widespread industrial use and are of great interest for further experimental and theoretical research. References 25, figures 9.

Mathematical modeling of meningioma volume change after radiation treatment

ObjectiveMeningiomas are the most common primary central nervous tumor and are often treated with radiation therapy. This study examines the long-term volumetric changes of intracranial meningiomas in response to radiation therapy. The objective is to analyze and model the volumetric changes following treatment. MethodsData from a retrospective single-institution database (2005–2015) were used, with inclusion criteria being patients with a diagnosis of meningiomas, along with additional inclusion criteria consisting of treatment with radiation, having at least three magnetic resonance imaging (MRI) scans with one or more before and after radiation treatment, and the patients following up for at least eighteen months. Exclusion criteria consisted of patients less than 18 years old, patients receiving surgery and/or adjuvant chemotherapy following radiation, and patients without any available details regarding radiation treatment parameters. Tumor volumes were measured via T1-weighted post-contrast MRI and calculated using the ABC/2 ellipsoidal approximation, a method allowing for the measurement of non-linear growth volume reduction. ResultsOf 48 meningioma patients considered, 10 % experienced post-radiation growth, while 75 % witnessed a ≥50 % decrease in volume over a follow-up period of 0.3–14.9 years. Median decay rate was 0.81, and within 1.17 years, 90 % achieved the predicted volume reduction. Predicted vs. actual volumes showed a mean difference of 0.009 ± 0.347 cc. Initial tumor volumes strongly correlated (Pearson’s R=0.98, R-squared=0.96) with final asymptotic volumes, which had a median of 1.50 cc, with interquartile range (IQR) = [0.39, 3.67]. Conclusion90 % of patients achieved tumor-volume reduction at 1.17 years post-treatment, reaching a non-zero asymptote strongly correlated with initial tumor volume, and 75 % experienced at least a 50 % volume decrease. Individual volume changes for responsive meningiomas can be modeled and predicted using exponential decay curves.

Scalable, Flexible, Magnetic-Field-Guided rULGO Sponge-BN-Cobalt Oxide-Based Supercapacitors: Mechanistic Insights into Multiple Charge Transfer Pathways by the Distribution of Relaxation Times.

Scalable and flexible supercapacitors are in high demand from an application point of view. Through our exploration, we have attained promising performance of electrochemical energy storage under the influence of an external magnetic field for future energy-based applications. In this work, a commercial sponge is used as a template for ultra-large graphene oxide (rULGO) functionalization, followed by the incorporation of Co3O4:BN without the inclusion of binders or conductive additives. The fabricated electrodes, namely, SPG-rULGO and SPG-rULGO-Co3O4:BN, demonstrate superior performance with a potential window of 2.2 V at a magnetic field strength of 13.5 and 28 mT, respectively. A specific capacitance of 218 ± 5% F·g-1 and 312 ± 5% F·g-1, respectively, with retention rates of 80 and 88% over 5000 charge-discharge cycles are achieved. In contrast to the conventional fabrication of the asymmetric device, both electrodes are made using flexible substrates with SPG-rULGO-Co3O4:BN as the positive electrode and SPG-rULGO as the negative electrode eliminating the need to use activated carbon. This configuration yields a specific capacitance of 153 ± 5% F·g-1 at 1 Ag-1, leading to a high energy density of 103 ± 5% W·h·kg-1 at a power density of 1.10 ± 5% kW kg-1 with an 85% retention rate. The charge-discharge mechanism of bare and modified electrodes is probed by the distribution of relaxation time analysis of the coupled electrochemical impedance spectra. The integration of magnetic field with advanced electrode materials opens up other possibilities for optimizing energy storage systems and advancing the field of flexible and mechanically robust supercapacitors.

Additive inclusion in plastic life cycle assessments, part II: Review of additive inventory data trends and availability

AbstractPlastic additives are as essential as polymers to the production and performance of plastic materials. Additive content can vary in composition and functionality depending on the product, producer, application, and production method. Such variation may be a barrier to achieving high‐quality recycling and planning for plastic circular economy futures. Yet, as found in Part I, although there is increasing awareness of the importance of additives in plastics, they are often poorly disclosed or only briefly discussed in life cycle assessments (LCAs). In part II, we focus on the inclusion of additives in plastic processes in the database most used in plastic LCAs to date (Ecoinvent) and find that additives have historically been omitted from plastic granulate data and in production processes in the evaluated database. Thus, many practitioners will need to separately include additives in their models of plastic life cycles. To support practitioners in this endeavor, we then assess the availability of the 13,587 additives identified in the recent UN Chemicals in Plastics Report across the three major LCI databases (CarbonMinds, Ecoinvent, and LCA for Experts [GaBi]). We find that databases currently cover only 1,209 of these additives. Moreover, we assert that transparency regarding additive inclusion in plastics datasets, availability of additive datasets, and additive data completeness are major barriers to additive inclusion in plastic LCAs. Thus, we recommend focusing on the development of additive datasets, and we provide a tool for the identification of additive dataset availability and data gaps to improve the quality of plastic LCAs.

Impact of additives on syntrophic propionate and acetate enrichments under high-ammonia conditions

High ammonia concentrations in anaerobic degradation systems cause volatile fatty acid accumulation and reduced methane yield, which often derive from restricted activity of syntrophic acid-oxidising bacteria and hydrogenotrophic methanogens. Inclusion of additives that facilitate the electron transfer or increase cell proximity of syntrophic species by flocculation can be a suitable strategy to counteract these problems, but its actual impact on syntrophic interactions has yet to be determined. In this study, microbial cultivation and molecular and microscopic analysis were performed to evaluate the impact of conductive (graphene, iron oxide) and non-conductive (zeolite) additives on the degradation rate of acetate and propionate to methane by highly enriched ammonia-tolerant syntrophic cultures derived from a biogas process. All additives had a low impact on the lag phase but resulted in a higher rate of acetate (except graphene) and propionate degradation. The syntrophic bacteria ‘Candidatus Syntrophopropionicum ammoniitolerans’, Syntrophaceticus schinkii and a novel hydrogenotrophic methanogen were found in higher relative abundance and higher gene copy numbers in flocculating communities than in planktonic communities in the cultures, indicating benefits to syntrophs of living in close proximity to their cooperating partner. Microscopy and element analysis showed precipitation of phosphates and biofilm formation in all batches except on the graphene batches, possibly enhancing the rate of acetate and propionate degradation. Overall, the concordance of responses observed in both acetate- and propionate-fed cultures highlight the suitability of the addition of iron oxide or zeolites to enhance acid conversion to methane in high-ammonia biogas processes.Key points• All additives promoted acetate (except graphene) and propionate degradation.• A preference for floc formation by ammonia-tolerant syntrophs was revealed.• Microbes colonised the surfaces of iron oxide and zeolite, but not graphene.Graphical

Prognostic Factors and Incidence for Postictal Agitation After Electroconvulsive Therapy: A Systematic Review and Meta-analysis.

Postictal agitation (PIA) is an adverse effect of electroconvulsive therapy (ECT) and is known to predict other side effects of ECT, but inconsistencies in the literature remain regarding PIA prognostic factors and incidence. Therefore, a systematic review and meta-analysis were conducted (1) to identify prognostic factors for PIA following ECT and (2) to elucidate the diverse incidences of PIA following ECT based on demographic and clinical characteristics. Specifically, electronic databases were searched for retrospective observational studies and randomized controlled trials (RCTs) that objectively reported PIA incidence. Additional inclusion criteria encompassed studies involving patients 18 years or older and allowed for the extraction of PIA prognostic factors. This resulted in the inclusion of 21 articles with 66,047 patients in total. A total of 35 prognostic factors were identified for PIA after ECT, consisting of 8 anesthesia-related, 19 patient-related, and 8 ECT-related prognostic factors. A meta-analysis was conducted for 7 prognostic factors. None of the prognostic factors demonstrated a significant effect on reducing or increasing PIA incidence. Mean PIA was 13.9% (18.0% adjusted) at the patient level and 12.4% (16.5% adjusted) at the session level. Overall risk of bias was generally moderate to low, except in the outcome measurement domain, where 43% of the studies had a high risk of bias. Although none of the prognostic factors in meta-analysis were significant, several other prognostic factors consistently indicated increased or decreased risk, providing direction for future research. A scarcity of (high-quality) data emphasizes the need for additional research on this topic to be conducted.

CHAOS. VIII. Far-ultraviolet Spectra of M101 and the Impact of Wolf–Rayet Stars* ∗Based on observations made with the NASA/ESA Hubble Space Telescope, obtained from the Data Archive at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555.

We investigate the stellar and nebular properties of nine H ii regions in the spiral galaxy M101 with far-ultraviolet (FUV; ∼900–2000 Å) and optical (∼3200–10,000 Å) spectra. We detect significant C iii] λλ1907,1909 nebular emission in seven regions, but O iii] λ1666 only in the lowest-metallicity region. We produce new analytic functions of the carbon ionization correction factors as a function of metallicity in order to perform a preliminary C/O abundance analysis. The FUV spectra also contain numerous stellar emission and P-Cygni features that we fit with luminosity-weighted combinations of single-burst Starburst99 and BPASS models. We find that the best-fit Starburst99 models closely match the observed very-high-ionization P-Cygni features, requiring very hot, young (≲3 Myr), metal-enriched massive stars. The youngest stellar populations are strongly correlated with broad He ii emission, nitrogen Wolf–Rayet (WR) FUV and optical spectral features, and enhanced N/O gas abundances. Thus, the short-lived WR phase may be driving excess emission in several N P-Cygni wind features (λ955, λ991, λ1720) that bias the stellar continuum fits to higher metallicities relative to the gas-phase metallicities. Accurate characterization of these H ii regions requires additional inclusion of WR stars in the stellar population synthesis models. Our FUV spectra demonstrate that the ∼900–1200 Å FUV can provide a strong test bed for future WR atmosphere and evolution models.

Columnar self-assembled heteroatom bay-annulated perylene bisimide as passivating layer for high performance perovskite solar cells

The interfaces within Perovskite solar cells (PSCs) are imperative for regulating defects, managing carrier dynamics, preventing ion migration, optimizing energy band alignment, and controlling morphology. The interfaces amidst the absorber layer and the hole transport layer (HTL) pose challenges related to ineffective charge extraction and charge recombination, necessitating enhancement. Spiro-OMeTAD is commonly utilized as p-type material in the HTL of planar architecture, entailing the inclusion of diverse additives to enhance solar cell efficiency, which can restrict device performance and stability. Herein, we explore the influence of a discotic liquid crystalline (DLCs) based semiconductor, a heteroatom bay-annulated perylene bisimide (PBI-SeO10), which is derived from tri-n-alkoxy anilines. Our study examines the function of PBI-SeO10 as an interfacial passivation layer within the perovskite/Spiro-OMeTAD interface, assessing its effects on both device performance and stability. Our results indicate that integrating PBI-SeO10 as a surface passivation layer not only aids in effective hole extraction from the perovskite layer but also substantially diminishes defects, leading to an improvement in overall device performance by approximately 7 %. Furthermore, PBI-SeO10 passivation also reduces ionic/molecular species diffusion into the device and provides good moisture resistivity leading to improved device stability.

Exploring Sibling Relationship Quality among Latinx Siblings: A Systematic Review.

This systematic review addresses the gap in the literature regarding sibling relationship quality among Latinx families, a topic that has not been comprehensively examined to date. This study aimed to synthesize current research on sibling relationship quality in Latinx families, focusing on the influence of cultural factors, identifying key variables associated with sibling relationship quality, and evaluating the methodological approaches used. This paper is a systematic review based on a recently published evidence and gap map (EGM) that identified and visually presented all published studies investigating sibling relationship quality. Additional inclusion criteria were applied to select articles that specifically examined sibling relationship quality in the United States samples with at least 50% Latinx participants. The review included 12 articles representing 6 distinct studies, revealing significant findings on the roles of familism, simpatía, and gender in shaping sibling dynamics. Results indicated that cultural values such as familism and simpatía positively influence sibling intimacy and warmth, while gender dynamics further moderate these relationships. Methodologically, the articles employed longitudinal and cross-sectional designs, utilizing various quantitative measures. The findings underscore the importance of culturally sensitive approaches in studying sibling relationships and highlight the need for further research to explore these dynamics in diverse Latinx subgroups.

Influence of dietary bitter orange peel powder on growth, body composition, blood parameters, gut morphometry, and thermal tolerance of Nile tilapia (Oreochromis niloticus).

The potential of bitter orange peel powder (BOPP) as a nutritional strategy for fish was investigated in Nile tilapia. A total of 120 juveniles with an average initial weight of 9.8 ± 0.7g were divided into four groups, replicated three times, resulting in 12 experimental units (60 L each) at a stocking density of 1.63g of fish per liter. Productive parameters, whole-body composition, blood biochemistry, erythroid morphometry, intestinal histology, and heat tolerance were assessed in the juveniles subjected to one of the following treatments: non-supplemented basal diet (control group); basal diet with BOPP at 10g/kg (BOPP10 group); basal diet with BOPP at 20g/kg (BOPP20 group); and basal diet with BOPP at 40g/kg (BOPP40 group). The BOPP additive had a positive influence on Nile tilapia growth, as final weight and weight gain were greater in all BOPP-treated fish, despite the reduction in crude protein in BOPP10 and BOPP20 groups. Fish receiving BOPP40 had an increase in total lipids and showed the highest levels of triglycerides and total cholesterol. Villi development was greater in the tilapia given BOPP10. It may be concluded that BOPP presented the most promising results for Nile tilapia juveniles when used at 10g/kg diet. Regarding the erythroid morphometry, there was a general increase in nuclear and cytoplasmic areas in BOPP-fed tilapia; this seems to be the first report on the direct impact of the inclusion of functional additives in fish diet upon such parameters. As concerns the thermal tolerance evaluated at the end of the feeding trial, no differences were registered among the experimental groups. Thus, BOPP represents a feasible alternative ingredient to be explored in fish nutrition, since orange peel is a natural low-cost source of essential nutrients and valuable bioactive compounds.

Parathyroid Adenoma Orientation for Gland Embryologic Origin on Ultrasonography

Accurate preoperative localization is critical to success in targeted parathyroidectomy for primary hyperparathyroidism. To determine if the association between the long axis of a parathyroid adenoma (PTA) candidate and strap musculature on sagittal ultrasonography (US) can be used to predict the embryologic origin of the gland. This diagnostic study was performed using the Stanford Research Repository. Patients 18 years or older with primary hyperparathyroidism who underwent parathyroidectomy between January 2009 and October 2021 were considered. Additional inclusion criteria were having clear sagittal view of the adenoma candidate on US, confirmation of the gland of origin intraoperatively, and confirmation of hypercellular parathyroid on final pathology. Data were analyzed from October 2021 to June 2022. B-mode US and surgical parathyroidectomy. The index test was using US to measure the angle between the long axis of an adenoma candidate and the strap musculature in the sagittal plane. This angle was used to test whether inferior and superior PTAs could be accurately assigned. The hypothesis was formulated prior to data collection. A total of 426 patients (mean [range] age, 61.1 [20-96] years; 316 [74.2%] female) with 442 adenomas met inclusion criteria. Of the 442 adenomas, 314 (71.0%) had measurable angles, of which 204 (46.2%) were assigned a superior origin, 238 (53.8%) were assigned an inferior origin, and 128 (29%) were indeterminate. Of the surgically identified superior PTAs, 144 (70.6%) had a definable angle, and of the surgically identified inferior PTAs, 170 (71.4%) had a definable angle. The receiver operating characteristic analysis found 94° as the optimized angle for differentiating true negatives from true positives, with an overall sensitivity of 74% and specificity of 72%. This supported using 90° as a break point for US review. True positives were considered superior adenomas with an angle greater than 90°; true negatives were inferior adenomas with an angle less than 90°. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of angulation analysis for determining PTA origin were 72.2% (95% CI, 64.9%-79.5%), 73.5% (95% CI, 66.9%-80.1%), 69.8% (95% CI, 62.5%-77.1%), 75.8% (95% CI, 69.3%-82.3%), and 72.9%, respectively. A subgroup analysis of 426 adenomas using the posterior carotid artery border on transverse US as a surrogate for predicting gland origin showed the following for sensitivity, specificity, positive predictive value, negative predictive value, and accuracy: 49.5% (95% CI, 42.6%-56.4%), 82.3% (95% CI, 77.3%-87.3%), 71.4% (95% CI, 63.9%-78.9%), 64.6% (95% CI, 59.1%-70.1%), and 66.9%, respectively. This diagnostic study showed that PTA angulation on sagittal plane US can be used to predict gland of origin and guide surgery. The relationship between adenoma and posterior carotid artery border on transverse US can also be used to predict gland origin. These easy-to-apply US-based tests can be used in conjunction with other imaging modalities to guide targeted parathyroidectomy.

Hygienic assessment of dietary intake of saturated fatty acids and trans isomers of fatty acids

Introduction. An imbalance of the fat component of the diet is one of the most common violations of the population nutrition in developed countries, leading to the risk of occurring nutrition-dependent pathologies due to hyperlipidemia and dyslipoproteinemia. A special role in the formation of risk is played by an excess of medium-chain saturated fatty acids (SFA) and trans isomers of unsaturated fatty acids (TFA). Materials and methods. Actual nutrition was studied by reproduction method with three times 24-hour recall. Based on the research results, the content of SFA and TFA was calculated, and their main sources were determined. Three hundred fourteen students of the I.M. Sechenov First Moscow State Medical University took part in the study. Gender and age groups of respondents were analyzed separately. Results. The intake of SFA at the level of normal physiological needs was registered in only 7.6% of students. At the same time, 80% of respondents had a significant excess of both total fat and SFA; an adequate level of TFA intake was noted in 80% of students, and a significant excess of this indicator was registered only in 13.3% of respondents. A significant quantitative increase in SFAs was noted with the additional inclusion of processed products in the diet, including those with hidden fat. Excessive consumption of TFA is associated with the inclusion of rich confectionery products containing hydrogenated fats in the diet. Limitations. The study has age and regional restrictions: young 18–29 years people living in the Moscow region, as well as restrictions on the analyzed indicators: SFA and TFA supplied with the diet. Conclusions. A significant risk of developing nutrition-dependent non-infectious diseases is observed in 52.9% of respondents with an SFA content in the diet of more than 150% of the norm, and the maximum risk is in 13.3% of students receiving a combined excess of SFA and TFA. The results of the study confirm the need to correct the diets of students in terms of the fat component.

TREATMENT OF CHRONIC PERIODONTITIS WITH THE USE OF PHYTOEXTRACT

Background. Periodontal diseases are one of the most common and complex pathologies of the dental system. Chronic inflammatory diseases of periodontal tissues are second only to caries in terms of prevalence. The aim of the study is to conduct a comprehensive treatment of patients using a phytoextract based on a clinical analysis of the incidence of mild and moderate chronic generalized periodontitis (CGPP). Material and methods. A comprehensive dental examination and treatment was performed on 120 patients diagnosed with mild chronic generalized periodontitis (MGPP LS) and moderate chronic generalized periodontitis (MGPP SS). Results. The results showed that the use of the phytoextract in patients with CGP LS severity contributed to the improvement of the dental status parameters of patients in this group. The course of complex treatment with the additional inclusion of the phytoextract in the OG led to a decrease in GI by 54.13% (p 0.05), with a decrease in the parameter in patients using Metrogyl Denta (GS) - by 26.3% (p 0.05) compared to the initial values. In this case, there is a significant decrease in CI in the MG by 69.2% (p 0.05), with a similar shift in CG patients - by 32.13% (p 0.05), a decrease in PI in the MG - by 52.9% (p 0.05), in CG patients - by 38.9% (p 0.05) compared to the initial values. Discussion. The use of the phytoextract in MG patients contributed to the improvement of the dental status, with a reliable decrease in hygienic indices and contributed to a prolonged effect in the late period, which allowed us to conclude that it has a good anti-inflammatory effect. Conclusion. As a result of the course of treatment and observation in patients with MG with CGP LS and CGP SS: clinical signs of inflammation in the periodontal tissues were relieved, which was accompanied by an improvement in the condition of the oral cavity of patients, the absence of complaints associated with the severity of inflammation (bleeding gums, swelling, pain, exudate release from periodontal pockets and tooth mobility) and is confirmed by the values of periodontal indices.

BEST FOR CAN – bringing empirically supported treatments to children and adolescents after child abuse and neglect: update to the study protocol

ABSTRACT Background: The implementation trial BESTFORCAN aims to evaluate the dissemination of Trauma-Focused Behavioural Therapy (TF-CBT) for children and adolescents in Germany with posttraumatic stress symptoms (PTSS) after child abuse and neglect (CAN) with a focus on supervision. Objective: This update to the study protocol outlines changes made due to practical reasons in the course of the ongoing trial while maintaining methodological quality. Method: The amendments to the original study protocol comprise (1) a more refined operationalisation of the primary outcome sufficiently adherent TF-CBT therapy (SATT), (2) changes in the study sites and (3) additional inclusion of one post-gradual psychotherapy training institute. Discussion: The adaptions to the original study protocol ensured high methodological quality through the transparent presentation of protocol modification: ensuring the recruitment of participating psychotherapists in training by including a further post-gradual training institute as well as an adaption of the measurement of SATT with high external validity. The objectives, diagnostic set, and secondary outcomes remained unimpaired by the amendment. Therefore, we expect the trial to provide evidence for the effect of model-specific trauma-focused supervision on the implementation outcomes of TF-CBT as compared to supervision as usual. Trial registration: German Clinical Trials Register identifier: DRKS00020516..

Dynamic and stability analysis of crescent geometry-possessing textured journal bearing using nanolubricant

PurposeThis study aims to find the dynamic performance parameters of the journal bearing with micro geometries patterning the arc (crescent) shape textures provided in three specific regions of the journal bearing: the full, the second half and the increasing pressure region. The dynamic behavior of textured journal bearings has been analyzed by computing dynamic parameters and linear and non-linear trajectories.Design/methodology/approachThe lubricant flows between the bearing and journal surface are governed by Reynold’s equation, which has been solved by finite the element method. The dynamic performance parameters such as stiffness, damping, threshold speed, critical mass and whirl frequency ratio are examined under various operating conditions by considering various ranges of eccentricity ratios and texture depths. Linear and non-linear equations of motion have been solved with Ranga–Kutta method to get journal motion trajectories. Also, the impact of adding aluminum oxide and copper oxide nanoparticles to the base lubricant in combination with arc-shaped textures is analyzed to further see any enhancement in the performance parameters.FindingsThe findings demonstrated that direct stiffness and damping parameters increased to their maximum level with six textures in the pressure-increasing region when compared with the untextured surface. Also, nanoparticle additives showed improvements above the highest value attained with no inclusion of additives in the same region or quantity of textures.Originality/valueEngineers may design bearings with improved stability and overall performance if they understand how texture form impacts dynamic properties.

Association of Serum Lactate Levels Measured in the Emergency Department with 30-Day Mortality in Older Patients with Unilateral Hip Fractures.

Hip fractures are frequent injuries in older patients and are associated with high mortality rates. This study assessed the association between serum lactate level and 30-day mortality in older patients with unilateral hip fractures and examined the prognostic value of this association on the clinical outcomes of these patients. This retrospective, single-center study included patients aged ≥65 years admitted to the emergency department due to low-energy trauma and diagnosed with unilateral hip fracture upon admission. The additional inclusion criteria were patients with independent ambulation or walker or cane assistance before the injury, with available data on serum lactate levels on venous blood gas analysis, and who underwent surgery. Among the 330 included patients, 30.9% experienced postoperative complications and 10.3% died within 30 days. Using a lactate cut-off value of 2 mmol/L to distinguish between living and deceased patients, the sensitivity and specificity were 41% and 88%, respectively. Multivariate logistic regression analysis revealed that high lactate and low albumin levels and male sex were associated with mortality. Identifying risk factors for mortality in geriatric patients with hip fractures is important. Male sex, low albumin levels, and particularly increased lactate levels were independent predictors of short-term mortality in these patients.

Poster 169: Preliminary Outcomes of Revision UCL Repair With Suture Tape Augmentation for Failure of Primary UCL Reconstruction in Professional and Collegiate Pitchers

Objectives: Injury of the ulnar collateral ligament (UCL) is common in baseball players and pitchers, in particular. The gold standard surgical treatment has been UCL reconstruction with autograft, although, UCL repair with collagen-coated suture tape has shown promise as an alternative recently. The outcomes of UCL reconstruction and UCL repair are well-studied, demonstrating high rates of return to sport and a predictable postoperative course of recovery. However, revision UCL reconstructions with allografts do not demonstrate comparable outcomes when compared with primary procedures. This pilot case series reports on the preliminary outcomes of collegiate and professional pitchers who underwent revision UCL repair with collagen-coated suture tape following failure of primary UCL reconstruction. Methods: We performed a retrospective query of a prospectively collected data repository to identify patients at our institution who had undergone UCL repair with internal brace. Additional inclusion criteria included: 1) prior failed UCL reconstruction with autograft; 2) aged between 15 and 45 years; 3) at least 1-year post-operative. From the included cohort, we collected demographic, clinical, and surgical data from the electronic health record. We further collected patient-reported outcomes data using either a web-based database platform or via telephone, including the American Shoulder and Elbow Surgeons Elbow assessment form (ASES-E; satisfaction, pain, and function subscales), the Kerlan Jobe Orthopaedic Clinic Shoulder and Elbow score (KJOC), Andrews Carson score, and information on return-to-sport timing and success. To evaluate outcomes, we reported the proportions of athletes that were able to successfully return-to-sport at the preinjury level or higher as well as return-to-sport timing and level of competition. Additionally, we reported summary statistics for patient-reported questionnaires evaluated at follow-up (ASES-E, KJOC, and Andrews Carson). Results: A total of 10 patients met inclusion criteria, and all were professional or collegiate pitchers at the time of their revision UCL repair surgery (40% professional and 60% collegiate). The mean follow-up time was 3.0 years (Table 1; range: 1-5 years). Table 1 shows complete return-to-sport data. All patients were able to return-to-sport at the same or higher level, and the mean time from surgery to return-to-sport was 9.3 months. Table 2 shows complete patient-reported outcomes data. Mean scores on elbow-related function questionnaires were high (ASES-E Function = 35.8 out of a maximum best of 36; KJOC = 88.3 out of a maximum best of 100; Andrews Carson = 94.5 out of a maximum best of 100) and mean pain scores were low (ASES-E Pain = 1 out of a maximum worst score of 50). Conclusions: This pilot case series demonstrated promising results of a novel UCL repair approach utilizing collagen-coated suture tape for high-level pitchers with recurrent medial elbow instability following initial UCL reconstruction with autograft. Specifically, we found excellent return-to-sport success and patient-reported outcomes in this preliminary cohort. Further study is warranted with larger sample sizes to further evaluate outcomes following revision of UCL reconstruction with UCL repair utilizing internal bracing.

Возможности использования шлаков в зеленом строительстве в контексте устойчивого развития Арктики

This article explores the potential of using concrete made from a cement mixture with blast furnace slag additives for construction in the Russian Arctic to promote sustainable development in the region. Utilizing industrial waste as recycled raw materials aligns with the principles of green and circular economy. Recent observations have shown local symbiotic effects, such as reduced material costs and mitigated environmental impacts. Replacing clinkers with mineral additives during cement production has been noted to reduce the carbon intensity of the final product. Further reductions in greenhouse gas and pollutant emissions can be achieved due to the long-term preservation of thermal insulating properties and the relatively slow degradation of the structure. Comparative laboratory tests were conducted on concrete samples made from cement with 15% (by weight) mineral slag and cement without additives. The dynamic indicators of density and hardness of the cement samples were assessed under simulated natural conditions. The inclusion of mineral additives alters the chemical reactions during the hardening of the concrete in contact with air and water, without prolonging the process, and increases hardness, even with frequent cycles of freezing/thawing and hydration/dehydration, thereby extending the service life of the structures. The obtained data were extrapolated to evaluate the environmental and economic indicators of construction and maintenance; accessibility, suitability, durability, and resource efficiency were identified as the key characteristics. The study concludes that using cement with mineral additives from blast furnace slag in the Arctic is feasible.