Inclusion Interaction Research Articles

Effects of replacing wet distillers grains with supplemental SoyPass in forage-based growing cattle diets.

One hundred twenty individually fed steers (initial BW 283 kg ± 32) were utilized in an 84-d growing trial to evaluate the effects of increased metabolizable lysine from non-enzymatically browned soybean meal (SoyPass) in grass hay-based diets containing wet distillers grains plus solubles (WDGS). The treatments were arranged as a 2 × 3 factorial with two levels of protein supplement as 20% (low; DL20) or 35% (high; DL35) of dietary DM using WDGS as the basal protein source, and three increments of SoyPass (SP) replacing 0%, 30%, or 60% of the WDGS DM in the protein supplement yielding six dietary treatments. Average daily gain (ADG), dry matter intake (DMI), gain:feed (G:F), and plasma urea N (PUN) data were analyzed using the MIXED procedure of SAS as a 2 × 3 factorial. Animal was the experimental unit and fixed effects included body weight block, dietary inclusion of distillers grains (DL20, DL35), dietary inclusion of SoyPass (SP) (3 levels), and DL × SP inclusion interactions. Linear and quadratic interactions between DL and SP inclusion were analyzed using covariate regression. No interactions were detected for ADG between SP and DL (P = 0.76). Additionally, SP had no effect on ADG (P = 0.49). However, ADG was increased for steers consuming the DL35 diet compared to DL20 (1.13 vs. 0.86 kg/d, respectively; P < 0.01). A DL × SP interaction was detected for DMI (P = 0.01). As SP replaced WDGS in the DL35 diet, DMI increased linearly from 8.10 to 8.93 kg/d (P = 0.02). In the DL20 diet, DMI was not different as SP replaced WDGS (P ≥ 0.11). Therefore, G:F tended to decrease linearly (P = 0.06) as SP replaced WDGS in the DL35 diet, while no difference (P ≥ 0.11) was detected in the DL20 diet, suggesting SP contained less energy than WDGS but did improve dietary lysine balance. Furthermore, plasma urea nitrogen (PUN) increased linearly as SP replaced WDGS in the DL20 diet (P < 0.01) but was not affected by SP substitution in the DL35 diet (P ≥ 0.19). When WDGS is fed at a low (20% DM) or high (35% DM) inclusion rate in a forage-based diet, replacing the distillers with a source of protected amino acids supplied through heat-treated soybean meal, did not improve performance. A more concentrated or energy-dense form of amino acids may be beneficial in forage-based growing cattle diets containing 20% distillers grains but is not needed in diets with 35% distillers grains.

Ab Initio Computational Study on Fe2NiP Schreibersite: Bulk and Surface Characterization

Phosphorous is ubiquitous in planet Earth and plays a fundamental role in all living systems. Finding a reasonable prebiotic source of phosphorous is not trivial, as common sources where it is present nowadays are in the form of phosphate minerals, which are rather insoluble and non-reactive materials, and, accordingly, unavailable for being readily incorporated in living organisms. A possible source of phosphorous is from the exogenous meteoritic bombardment and, in particular, in iron/nickel phosphites. These materials, by simple interaction with water, produce oxygenated phosphorous compounds, which can easily react with organic molecules, thus forming C-O-P bonds. In the present work, periodic ab-initio simulations at PBE level (inclusive of dispersive interactions) have been carried out on metallic Fe2NiP-schreibersite, as a relative abundant component of metallic meteorites, in order to characterize structural, energetics and vibrational properties of both bulk and surfaces of this material. The aim is to study the relative stability among different surfaces, to characterize both the nanocrystal morphology and the reactivity towards water molecules.

Shear force responsive and fixed-point separated system for targeted treatment of arterial thrombus

Thrombolytic treatment is the primary method for thrombotic diseases. However, uncontrollable bleeding and secondary vascular embolism are prone. Based on the thrombus microenvironment, this project constructed an "on-off " drug depot that can accurately identify thrombus and respond to changes of shear force to solve above problems. The fucoidan (Fuc)-based core-shell NPs were prepared by β-CD host-guest inclusion interaction. The thrombolytic drug urokinase (UK) and antiplatelet drug tirofiban (TI) were loaded into outer shell and inner core, respectively. In vitro and in vivo results proved that UK@Fuc-TI/PPCD was closed under low blood shear force to reduce bleeding risk. Once arriving at thrombus site, UK@Fuc-TI/PPCD can realize precise “homing” by recognizing P-selectin overexpressed by thrombus. Then sharply increased shear force at targeted thrombus broke the core-shell structure to release UK rapidly, realizing site-specific thrombolysis. Subsequently, TI loaded in PPCD core was slowly released at thrombolysis site, preventing re-embolization of blood vessels. Thrombolysis results demonstrated the in vitro thrombolysis rate of UK@Fuc-TI/PPCD pre-treated with 1000 dyne/cm2 shear force was 91.59%. And in vivo, the percentage of residual thrombus in UK@Fuc-TI/PPCD treatment group was only 9.37% with relatively low bleeding risk, suggested this shear fore-responsive detachable system with thrombus targeting ability and sequential drug release profile can realize the efficient recanalization of embolized vessels.

Method of image charges for describing deformation of bounded two-dimensional solids with circular inclusions.

We present a method for predicting the linear response deformation of finite and semi-infinite 2D solid structures with circular holes and inclusions by employing the analogies with image charges and induction in electrostatics. Charges in electrostatics induce image charges near conductive boundaries and an external electric field induces polarization (dipoles, quadrupoles, and other multipoles) of conductive and dielectric objects. Similarly, charges in elasticity induce image charges near boundaries and external stress induces polarization (quadrupoles and other multipoles) inside holes and inclusions. Stresses generated by these induced elastic multipoles as well as stresses generated by their images near boundaries then lead to interactions between holes and inclusions and with their images, which induce additional polarization and thus additional deformation of holes and inclusions. We present a method that expands induced polarization in a series of elastic multipoles, which systematically takes into account the interactions of inclusions and holes with the external field, between them, and with their images. The results of our method for linear deformation of circular holes and inclusions near straight and curved boundaries show good agreement with both linear finite element simulations and experiments.

Creating collaboration for contentious projects on managed aquifer recharge: two cases from Finland

In Finland, community water supply has increasingly relied on natural groundwater and artificially recharged groundwater as the raw water source. Several managed aquifer recharge (MAR) projects have been co-created with involved parties and have proceeded well, while some cases have raised considerable resistance among the stakeholders. It seems that success or failure in MAR cooperation is related to management cultures and the ways in which various interests are taken into account, from the very beginning and throughout the process. Empirically, this paper builds on comparison between two conflictual case studies in Finland: one in the Tampere region and the other in the Turku region. The study analyses the major constraints of these projects through the lens of collaborative rationality, also drawing upon discourse analysis and negotiation theory. The material is gathered through thematic interviews of stakeholders, newspaper articles and a stakeholder workshop. The results indicate that conventional management approaches, drawing from expert-based instrumental rationality, were insufficient in both cases. The collaborative rationality framework suggests that legitimacy for the groundwater projects should be gained through joint knowledge production and inclusive multiparty interaction for creating options for collaboration. Both cases lacked the tools and know-how for authentic dialogue and collaboration. The emerging paradigm emphasizes more collaborative approaches for natural resources management and urban planning. While MAR projects operate inside these areas and are highly complex in nature, it is essential to embrace the emerging paradigm in order to promote MAR systems along with their huge potential.

Formulating diets based on digestible calcium instead of total calcium does not affect growth performance or carcass characteristics, but microbial phytase ameliorates bone resorption caused by low calcium in diets fed to pigs from 11 to 130 kg.

An experiment was conducted to test the hypothesis that the requirement for Ca expressed as a ratio between standardized total tract digestible (STTD) Ca and STTD P obtained in short-term experiments may be applied to pigs fed diets without or with microbial phytase from 11 to 130 kg. In a 5-phase program, 160 pigs (body weight: 11.2 ± 1.8 kg) were randomly allotted to 32 pens and 4 corn-soybean meal-based diets in a 2 × 2 factorial design with 2 diet formulation principles (total Ca or STTD Ca), and 2 phytase inclusion levels (0 or 500 units/kg of feed) assuming phytase released 0.11% STTD P and 0.16% total Ca. The STTD Ca:STTD P ratios were 1.40:1, 1.35:1, 1.25:1, 1.18:1, and 1.10:1 for phases 1 to 5, and STTD P was at the requirement. Weights of pigs and feed left in feeders were recorded at the end of each phase. At the conclusion of phase 1 (day 24), 1 pig per pen was euthanized and a blood sample and the right femur were collected. At the end of phases 2 to 5, a blood sample was collected from the same pig in each pen. At the conclusion of the experiment (day 126), the right femur of 1 pig per pen was collected and carcass characteristics from this pig were measured. No interactions were observed between diet formulation principle and phytase inclusion for growth performance in any phase and no differences among treatments were observed for overall growth performance. Plasma Ca and P and bone ash at the end of phase 1 were also not influenced by dietary treatments. However, on day 126, pigs fed nonphytase diets formulated based on total Ca had greater bone ash than pigs fed STTD Ca-based diets, but if phytase was used, no differences were observed between the 2 formulation principles (interaction P < 0.05). At the end of phases 2 and 3, pigs fed diets without phytase had greater (P < 0.05) plasma P than pigs fed diets with phytase, but no differences were observed at the end of phases 4 and 5. A negative quadratic effect (P < 0.05) of phase (2 to 5) on the concentration of plasma Ca was observed, whereas plasma P increased (quadratic; P < 0.05) from phases 2 to 5. However, there was no interaction or effect of diet formulation principle or phytase inclusion on any carcass characteristics measured. In conclusion, STTD Ca to STTD P ratios can be used in diet formulation for growing-finishing pigs without affecting growth performance or carcass characteristics and phytase inclusion ameliorates bone resorption caused by low dietary Ca and P.

Unveiling interactions of non-metallic inclusions within advanced ultra-high-strength steel: A spectro-microscopic determination and first-principles elucidation

Determining non-metallic inclusions (NMIs) are essential to engineer ultra-high-strength steel as they play decisive role on performance and critical to probe via conventional techniques. Herein, advanced Synchrotron X-ray absorption coupled with photoemission electron microscopy and first-principles calculations are employed to provide the structure, local bonding structure and electronic properties of several NMI model systems and their interaction mechanism within and the steel matrix. B K-, N K-, Ca L2,3- and Ti L2,3-edge spectra show that the additional B prefers to result in h-BN exhibiting strong interaction with Ca2+. Such Ca2+-based phases also stabilize through TiN, revealing the irregular coordination of Ca2+. Observed intriguing no interaction between TiN and BN is further supported with the first-principles calculations, wherein unfavorable combination of TiN and h-BN and stabilization of bigger sized Ca2+-based inclusions have been found. These observations can help to optimize the interaction mechanism among various inclusions as well as steel matrix.

Readiness of public school pedagogues for implementation of inclusive education

This article touches upon the problem of readiness of the modern public school pedagogues for implementation of inclusive education. The author carries out an empirical research, the results of which demonstrate unwillingness of the pedagogues to teach children with health limitations. This is manifests in poor organization of correctional and developmental environment for inclusive education, as well as insufficient pedagogical interaction between all actors of the inclusive process pedagogical interaction between all subjects of the inclusive process; inability to select optimal means to arrange inclusive education and use various resources for the development of all children, etc. The author offers the key strategic directions for administration of public schools aimed at working with the indicated flaws, which for the most part are related to the arrangement of comprehensive interdepartmental interaction of all parties to the educational process. The author obtained the data on the main shortages of public school pedagogies in working with impaired children. Based on the method of self-analysis of pedagogical difficulties, the respondents indicated the reluctance to solve professional tasks in lesson planning, difficulties in communicating with children with health limitations, no methodological support or competence to develop it themselves. The author suggests arranging joint activity between the specialists in the field of correctional work (psychologists, speech-language pathologist, defectologists, tutors) and teachers, organizing methodological support in the educational institution to select techniques for working with children in the conditions of inclusion, tracking the dynamics of their development.

Dynamic Stresses in the Elastic Matrix with One-Periodic Array of Compliant Penny-Shaped Inclusions

We consider a symmetric problem of harmonic wave loading of an infinite elastic matrix with a oneperiodic array of penny-shaped compliant inclusions. By using the periodic Green function, we reduce this problem to a boundary integral equation for a function characterizing a jump of displacements on one representative inclusion. The Green function used to describe the interaction of inclusions is adapted for the efficient determination of its representation in the form of exponentially convergent Fourier integrals. To solve the boundary integral equation, we use the method of collocations. The numerical results are obtained and analyzed for the mode I dynamic stress intensity factor in the vicinity of points of the contour of an inclusion depending on the wave number and the distance between the inclusions.

ЭМПИРИЧЕСКОЕ ИССЛЕДОВАНИЕ ТИПОВ ОБРАЗОВАТЕЛЬНОЙ СРЕДЫ ШКОЛЫ В СИТУАЦИИ ИНКЛЮЗИВНОГО ОБУЧЕНИЯ

The ideas of the article are based on the high social significance of discussing the practices of inclusive interaction in various spheres of life and ensuring the variability of approaches to the integration of children with special educational needs into the general education system. On the basis of the environmental approach in education, presented in the works of domestic and foreign authors, the basic principles are outlined and the general difficulties of the functioning of inclusive practice at the present stage are identified. The strategy of applying the vector approach to the examination and modeling of the environment of inclusive interaction and designing ways to improve it for the organization of psychological and pedagogical support of the educational process in school is justified. On the basis of the generalized results of the survey of teachers who organize the education of children with disabilities in non-specialized classes, the features and the type of relations that are currently developing in the joint education of schoolchildren with different educational needs during their integration into a single educational space are characterized. Using the methodology of psychological and pedagogical expertise of the school environment, the typification of the most characteristic influences exerted at modern schools on a child with a developmental disorder is carried out. The emerging dominant modality of the educational environment, its orientation to the development of relationships between teachers and peers, based on the priority of stimulating the activity of the individual with different degrees of manifestation of its freedom or dependence, is revealed. The article describes potential capabilities of each of the diagnosed types of environment in terms of its resources for ensuring freedom of choice of activities, stimulating activity, developing students' independence, and forming their personal characteristics. The diagnosed priority of creative and career-oriented orientation allowed us to draw conclusions about the currently established approaches to the inclusion of children with deviant development in the environment of normotypic peers.

Inclusion and Charge Transfer Interaction of a Multi-Redox Active 1,3,5-Triazine Derivative by Cucurbit[7,8]urils

The redox active 1,3,5-triazine derivative (MPT) was used as a guest to study host-guest, charge transfer interaction with CB[7,8] in water. The multi-redox active MPT undergoes four chemically and electrochemically reversible one electron redox states in organic media, but in water, the fourth redox state shows an unstable nature. As a guest, the host-guest interaction of MPT was studied with two macrocyclic cucurbit[7,8]uril (CB[7,8]) hosts in water; resulting supramolecular complexes were characterized by NMR, ESI-MS, UV-vis, ITC, and cyclic voltammetric studies.

Enantioseparation of three constitutional isomeric 2-(methylphenyl)propanoic acids by countercurrent chromatography

2-(3-Methylphenyl)propanic acid and 2-(4-methylphenyl)propanoic acid were successfully enantioseparated by countercurrent chromatography using hydroxypropyl-β-cyclodextrin (HP-β-CD) as a chiral selector. 2-(2-Methylphenyl)propanoic acid was also studied to compare the enantioseparation ability of three isomeric 2-(methylphenyl)propanoic acids. Totally 20 mg of 2-(3-methylphenyl)propanic acid and 20mg of 2-(4-methylphenyl)propanic acid were enantioseparated individually by countercurrent chromatography. Recovery for the (±)-2-(3-methylphenyl)propanic acid enantiomer was in the range of 85%-90% with 98.0%-98.8% purity and recovery for the (±)-2-(4-methylphenyl)propanic acid enantiomer was in the range of 80%-83% with 97.0%-98.0% purity. The enantioseparation factor in countercurrent chromatography for 2-(4-methylphenyl)propanic acid and 2-(3-methylphenyl)propanic acid were 1.31 and 1.26, and the peak resolution in HPLC reached 2.2 and 1.4. However, no enantioseparation could be found for 2-(2-methylphenyl)propanic acid. In addition, the inclusion complexes were investigated by UV spectrophotometer. The inclusion formation constant of inclusion complex between 2-(4-methylphenyl)propanic acid, 2-(3-methylphenyl)propanic acid, 2-(2-methylphenyl)propanic acid and HP-β-CD were determined as 121.73 mol/L, 78.12 mol/L and 53.18 mol/L, respectively. The present results showed that enantiorecognition was greatly affected by substituted positions of methyl group on the benzene ring. Combined with our previous results, the steric hindrance had a significant effect on inclusion interaction between HP-β-CD and racemic 2-(substitutedphenyl)propanoic acids. No enantiorecognition could be achieved for 2-(substitutedphenyl)propanoic acids with ortho-substituent group on benzene, while the influence of meta- and para- group on enantiorecognition varies with different substituent groups on benzene ring.

Loop-Mediated Isothermal Amplification (LAMP) as a Rapid, Affordable and Effective Tool to Involve Students in Undergraduate Research.

Undergraduate research (UR) is a high-impact practice (HIP) to engage undergraduate student in science, technology, engineering and mathematics (STEM), especially from underrepresented groups. UR experiences (UREs) can be integrated into the classroom, making authentic research experiences inclusive and available to all students. However, developing UR pedagogy can be challenging for faculty in resource-limited labs, such as community colleges and small liberal arts colleges. Often molecular biology research methods are expensive, time-consuming and need equipment not readily available or affordable in small schools. Polymerase chain reaction (PCR) is one of the most commonly used techniques in research labs and many UREs. We have investigated loop-mediated isothermal amplification (LAMP) as an inexpensive, accessible alternative to PCR for DNA amplification enabling the identification of microorganisms in the context of UREs. LAMP does not require expensive instrumentation or reagents and uses equipment commonly found in teaching labs. By performing the technique, students learn several key scientific skills that will be useful in their undergraduate or graduate STEM careers. We designed guided independent research experiences for several undergraduates that included the use of LAMP. Students successfully applied the technique to culture samples of common environmental bacteria, including Escherichia coli, Salmonella spp., Staphylococcus aureus, and Enterococcus, and were in addition, able to detect both Salmonella and Enterococcus in directly sampled environmental waters. To highlight the accessibility and affordability of this URE, a simple boiling method was used for DNA preparation from environmental samples. Student response data show positive attitudes toward UR when LAMP is utilized as a research tool to tackle relevant biological questions. The feasibility of using simplified LAMP in UREs points to a potential, more expanded application to public engagement with science and broader and more inclusive interactions with the research community.

Numerical Investigation of an Orthotropic Plate with Interactions of Crack, Inclusions and Voids under Uniaxial Tensile Loading by XFEM

This work is focused to investigate the effect of various discontinuities like cracks, inclusions and voids for an orthotropic plate, to evaluate the normalized mixed-mode stress intensity factors (NMMSIFs) by implementing the extended finite element method (XFEM) under uniaxial tensile loading though considering the various numerical examples. The NMMSIFs are investigated with the interaction of crack, single- and multi-inclusions/voids for an orthotropic plate. The effect of NMMSIFs is analyzed for an orthotropic plate with several orthotropy axis orientations by changing the position of single- and multi-inclusions/voids while aligned, above and away with respect to an edge crack of the plate and for the both side inclusions/voids aligned the center crack. It is also investigated for the effect of various shapes of inclusions/voids for an edge crack orthotropic plate under uniaxial tensile loading using XFEM.

Inclusive classroom interaction in lower secondary education

Following the German parliament’s ratification of the UN Convention on the Rights of Persons with Disabilities (CRPD) in 2008, inclusive pedagogy has become increasingly relevant for educational science and educational policy. Empirical studies of classes which combine students with and without visual impairment mainly focus on questions of performance and well-being, while not directly examining classroom interactions. Our research seeks to address this notable lack of in-situ studies, using a selected case as an example and illustrating the potential of such an approach through reconstructing the contradictory expectations of inclusive teaching as a specific conflict of norms. This approach ought to demonstrate the potential insights to be gained by reconstructing and interpreting relevant communicative processes of meaning-construction. Based on transcribed interactions in an inclusive fifth-grade class, we interpret the scene of classroom instruction with regard to the normative conflict between the egalitarian promise of participation and a non-egalitarian focus on performance. Adopting a methodology of second-order observation, as outlined in Systems Theory, allows us to conduct an analysis of normativity in order to understand which norms prevail in interactions with students with and without visual impairment. At the center of the analysis is not only the common discrepancy between an inclusive school’s policy and its interactive implementation. Rather, our interpretations also show how the ableist norm of performance is navigated and negotiated among all participants in classroom communication and how the multitude of norms and expectations surrounding inclusive teaching come into conflict, that is, in the paradoxical structural tension between the operational necessity of establishing a separation between students and the policy imperative of decategorization.

Prevalence of polypharmacy and associated factors among patients living with HIV infection in Spain: The POINT study

PurposeSurvival in people living with HIV (PLWH) has increased and thus people are aging with HIV, increasing the frequency of multimorbidity and polypharmacy. This cross-sectional study was conducted to evaluate the prevalence of polypharmacy among PLWH who were on antiretroviral treatment and were followed in an outpatient setting by the pharmacy department of several hospitals across Spain. In addition, we aimed to evaluate factors associated with polypharmacy and treatment complexity among this population. Material and methodsWe recorded information on demographic data, data on disease control including viral load and CD4 count at the time of inclusion, comorbidities, pharmacologic treatment and drugs interactions. Polypharmacy was defined as the use of 6 or more different drugs, including antiretroviral medication; major polypharmacy was defined as the use of ≥11 different drugs. ResultsOverall, 1225 PLWH were eligible in the study. The median (IQR) age was 49 (40–54). Comorbidities were present in 819 (67%) PLWH and 571 (47%) had two or more comorbidities. Overall, 397 (32.4%, 95% CI 29.8–34.9) PLWH met the criteria for polypharmacy, and 67 (5.5%, 95% CI, 4.2–6.7) had major polypharmacy. Several factors were associated with polypharmacy such as type of antiretroviral treatment, presence of potential interactions, the use of several types of medications and the number of comorbidities. Treatment complexity was also a factor strongly associated with polypharmacy; for each point increase in the medication regimen complexity index (MRCI), the likelihood of polypharmacy increased 2.3-fold. ConclusionsPolypharmacy is frequent among PLWH in Spain and contributes to a relevant extent to treatment complexity.

The Effect of Acute Interpersonal Racial Discrimination on Smoking Motivation and Behavior Among Black Smokers: an Experimental Study.

In comparison to White smokers, Black smokers are likely to report both more discrimination and less success in smoking cessation. No previous study has tested the causal relationship between an experience of racial discrimination and smoking variables associated with cessation. The goal of this study was to test the causal influence of interpersonal racial discrimination on smoking motivation (i.e., the urge to smoke cigarettes, cessation self-efficacy, and smoking behavior) using a controlled experimental design. We used a virtual ball-playing game to create a laboratory model of racial discrimination. A 2 × 2 between-subjects factorial design (inclusion/exclusion vs. ingroup/outgroup) was used to randomly assign participants to one of four groups: (1) included/ingroup, (2) included/outgroup, (3) excluded/ingroup (ostracism), and (4) excluded/outgroup (racial discrimination). Sixty-nine Black smokers were recruited from the community. Participants in the excluded conditions reported lower cessation self-efficacy than those in the included conditions. Participants in the outgroup conditions had reduced latency to smoke compared to those in the ingroup conditions. There were no main effects of social inclusion on cravings or latency to smoke and no statistically significant interactions for social inclusion × group membership. This laboratory simulation of racial discrimination shows a causal relationship between exclusion and low cessation self-efficacy, which contributes to a better understanding of influences upon smoking cessation attempts among Black smokers.

Enantioseparation of ketoconazole and miconazole by capillary electrophoresis and a study on their inclusion interactions with β-cyclodextrin and derivatives.

A chiral separation method coupled with capillary electrophoresis (CE) analysis for ketoconazole and miconazole enantiomers using chiral selectors such as β-cyclodextrin (β-CD) and hydroxypropyl-β-CD (HP-β-CD) was developed in this study, which included the optimisation, validation and application of the method on the antifungal cream samples. The formation of inclusion complex between the hosts (β-CD and HP-β-CD) and guests (ketoconazole and miconazole) were compared and analysed using ultraviolet-visible spectrophotometry, nuclear magnetic resonance (NMR) spectroscopy and molecular docking methods. Results from the study showed that in a concentration that ranged between 0.25 and 50 mg L-1 , the linear calibration curves of each enantiomer had a high coefficient of regression (R2 > 0.999), low limit of detection (0.075 mg L-1 ) and low limit of quantification (0.25 mg L-1 ). The relative standard deviation (RSD) of the intraday and interday analyses ranged from 0.79% to 8.01% and 3.30% to 11.43%, respectively, while the recoveries ranged from 82.0% to 105.7% (RSD < 7%, n = 3). The most probable structure of the inclusion complexes was proposed based on the findings from the molecular docking studies conducted using the PatchDock server.

Dispersion of rigid line inclusions as stiffeners and shear band instability triggers

A dispersion of stiff and thin (‘rigid line’) inclusions (RLIs) in a matrix material may result beneficial for stiffening in the elastic range, but might be detrimental to strength, as material instabilities may be triggered by inclusions when the matrix is brought to a viscoplastic-damaging state. This dual role of RLIs is investigated by means of the embedded reinforcement model. Validated against available analytical predictions, this numerical model is employed to assess the roles of RLIs’ orientation, interaction, volume fraction, and distribution, considering up to 1500 inclusions. When the matrix material deforms inelastically, RLIs produce stress concentrations that promote the nucleation of shear bands. These are characterized at collapse for many distributions of RLIs, showing that their effects range from almost negligible to a disrupting alteration of the dominant failure mechanism. In the latter case, it is shown that the dominant shear bands can be fragmented by RLIs into a mosaic of tiny localization bands. These results offer new insights into energy dissipation mechanisms of reinforced materials, as they are promoted or inhibited by the interactions of rigid line inclusions.

Preparation of 2-hydroxypropyl-β-cyclodextrin polymers crosslinked by poly(acrylic acid) for efficient removal of ibuprofen

In this study, 2-hydroxypropyl-β-cyclodextrin polymers crosslinked by poly(acrylic acid) were prepared through esterification reaction. The obtained polymers were characterized by Fourier transform infrared spectroscopy, X-ray diffraction and X-ray photoelectron spectroscopy, respectively. Results indicated that the 2-hydroxypropyl-β-cyclodextrin polymers were successfully prepared and crosslinked network formed in the polymers. The polymers were employed for removal of ibuprofen from aqueous solutions. The adsorption amount of ibuprofen was pH-dependent, and adsorption capacity of the polymer increased with the concentration of 2-hydroxypropyl-β-cyclodextrin in the feed formulations. The possible adsorption mechanism of the polymer towards ibuprofen involved hydrogen bonding and inclusion interactions. The ibuprofen adsorption behavior followed pseudo-second-order kinetic model and Langmuir isotherm model. Thermodynamic parameters suggested that the adsorption process was spontaneous and endothermic in nature. The polymer could be recycled and reused without any significant loss in the adsorption amount of ibuprofen. These results provided important information for designing novel adsorbents that could be employed for efficient removal of ibuprofen.