Objective: Comparative evaluation of Tweed's analyses in Class I, Class II, and Class III participants of Central India in two different age groups. Materials and Methods: Sample size comprised 240 participants belonged to Central India. Participants were divided into two main groups: Group I comprised 120 young children in the age group of 12–16 years and Group II comprised 120 young adults in the age group of 18–22 years. Tweed's analysis was performed from the collected sample. Results: The lower incisor inclination (incisor-mandibular plane angle [IMPA]) in Central India participants was higher (100.13°) compared to the original Tweed norm of IMPA 90°. Statistically higher value of IMPA was found in young male children compared to young female children in Class II div 1 and Class II div 2 participants and opposite trend was seen in Class III young adults. The Frankfort-mandibular plane angle was found to be significantly more in young adult females (24.93°) than males (18.07°) in Class III participants. Angle IMPA was found to be significantly higher in Class I compared to Class III participants and significantly higher in Class III compared to Class II div 2 participants. Conclusion: The differences of Tweed's parameters in this pilot study indicate that Caucasian norms cannot be truly adhered to Central India participants during orthodontic treatment. Lower incisors were normally more proclined in Central Indian participants and their over retraction during orthodontic treatment would cause prominent chin. Proclination of lower incisor was more in young male children compared to young female children in Class II div 1 and Class II div 2 participants and opposite trend was seen in Class III young adults. Class III female adults show tendency toward vertical growth pattern compared to males. Proclination of lower incisor was found to be more in Class I compared to Class III participants and more in Class III compared to Class II div 2 participants.
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