The goaf volume in the vacancy method of hard rock mines is significantly larger than the filling capacity, forming layered and inclined planes during the large-scale filling process. This results in unclear mechanical impact mechanisms on the backfill. To investigate the effect of interface inclination angle on the mechanical behavior of backfill, a set of cemented tailings composite backfill (CTCB) samples with interface inclination angles of 15°, 30°, and 45° are prepared. Uniaxial compression tests and digital image correlation techniques are used to investigate the influence of various interface inclination angles on the strength, deformation behavior, and failure mode of the CTCB. The results show that: (1) The uniaxial compressive strength (UCS) of the CTCB weakens with increasing interface inclination angle but consistently shows exponential growth with curing age (CA) regardless of the interface inclination angle. (2) The interface inclination angle controls the behavior and classification characteristics of the stress-strain curve of CTCB samples, and the increase of interface inclination angle weakens the elastic modulus. (3) The interface inclination angle significantly influences the failure mode and classification characteristics of the samples compared to CA and tailing-to-cement ratio (TCR), with shear slip failure induced by the former and axial splitting failure induced by the latter. The research provides a theoretical basis for understanding the mechanical behavior and stability control of inclined CTCB in underground mining.