Children from economically disadvantaged families have few opportunities to engage in shared storybook reading activities, and thus are disadvantaged in the area of vocabulary development. In today’s classroom, many children’s e-books provide audio narration support to facilitate comprehension for children with no adult support. Yet, in this digital age, we still know little about how to effectively use e-books to support these children. To rectify this gap, this study investigates the effects of e-book reading with audio narration and some recorded word explanation on the novel vocabulary learning of first grade students from low-achieving elementary schools (mean age = 6.5, SD = 0.50). Employing a within-subject design, students read two e-books and their performances on seven explained words were compared to the seven unexplained control words. As a whole, results indicated that recorded word explanation resulted in greater word learning than when word explanation was not provided. Additionally, e-book reading lead to incidental word learning, and three subgroups of readers showed different patterns of word learning across the e-book with and without the recorded word explanation and the control conditions. Findings suggest that children from low-income families can increase vocabulary from reading an e-book when a short recorded word explanation precedes the e-book reading activity.