Incidence Of Tuberculosis Research Articles

Spatial Analysis of Pulmonary Tuberculosis Incidence in Kupang City in 2019-2021

Abstract Introduction: Pulmonary tuberculosis has a fairly high number of cases in several regions of Indonesia, including Kupang City. In 2019, tuberculosis cases in Kupang City amounted to 667 cases, in 2020 it increased to 693 cases and in 2021 it decreased to 419 cases. This study aims to analyze the factors that influence the incidence of pulmonary tuberculosis which are studied in a spatial analysis model.Methods : This research is a quantitative research with an analytical observational design using an approach to Geographic Information Systems (GIS). This study aims to see the autocorrelation of population density, poor families, and healthy homes with the incidence of pulmonary tuberculosis and to see the pattern of relationships that are formed.The data used in this research is secondary data taken from related agencies. The samples in this study were 11 community health centers in Kupang City, namely Naioni Health Center, Alak Health Center, Manutapen Health Center, Sikumana Health Center, Penfui Health Center, Bakunase Health Center, Oebobo Health Center, Oepoi Health Center, Pasir Panjang Health Center, Kupang City Health Center, and Oesapa Community Health Center. Spatial analysis uses computer programs, namely the QGIS and GeoDa applications. QGIS was used to produce a map of the distribution of pulmonary tuberculosis cases in 11 health centers in Kupang City in 2019-2021 and the GeoDa application was used to see the pattern of TB distribution in Kupang City in 2019-2021, in general or globally through the LISA (Local Indicators Spatial Autocorrelation) tests.Results: Based on the results of the LISA (Local Indicators Spatial Autocorrelation) bivariate test, it shows that population density, poor families, and healthy housing coverage have no relationship with the incidence of TB in Kupang City (p-value > 0.05) and show a random pattern of case distribution (Morans Index ' I is smaller than E[I] = -0.1000). However, in 2019-2020, the Morans I Index value covering healthy homes was greater than E[I] = -0.1000, which shows a clustered pattern of case distribution.Conclusion: It was concluded that there was no positive spatial autocorrelation between population density, poor families, and healthy homes with the incidence of pulmonary tuberculosis in Kupang City in 2019-2021

Determinant of Pulmonary Tuberculosis in Outpatients at Daya Hospital, Makassar City

Indonesia ranks third with the highest number of TB patients in the world after India and China. Initial data collection conducted at Daya Kota Makassar Regional General Hospital revealed that Pulmonary Tuberculosis is among the top 10 diseases in both outpatient and inpatient cases. The incidence of Pulmonary TB in outpatient cases was 783 in 2019, 210 in 2020, and 238 in 2021. The objective of this research is to determine the determinants of pulmonary tuberculosis incidence in outpatient patients at Daya Kota Makassar Regional General Hospital. The research method employed is quantitative research with a cross-sectional design. The population for the study includes all outpatient patients in the Pulmonary Clinic of Daya Kota Makassar Regional General Hospital, totaling 142 individuals, with a subject of 49 subjekts selected using purposive sampling technique. Bivariate analysis uses Chi-square, and multivariate analysis employs logistic regression. The research results indicate a correlation between knowledge (p-value=0,004), smoking behavior (p-value=0,003), and nutritional status (p-value=0,019) with the incidence of Pulmonary Tuberculosis. However, there is no socio-economic relationship with Pulmonary Tuberculosis incidence (p-value=0,169) at Daya Kota Makassar Regional General Hospital. It is recommended that the community participate in the socialization activities for preventing the risk of Pulmonary Tuberculosis provided by health cadres to reduce the incidence of Pulmonary Tuberculosis.

Evaluation Of The Level Of Compliance Of Tuberculosis Patients To The Use Of Anti-Tuberculosis Drugs In Puskesmas Lima Puluh In 2023

The incidence of Tuberculosis (TBC) is still a priority health problem, especially in the working area of the Puskesmas Lima Puluh . The Puskesmas Lima Puluh is a health center in the Fifty District which has a high incidence of TB, where the number of TB cases in 2022 has increased from the previous year. Patient compliance with treatment is one of the factors that determine the success of therapy. This study aims to describe the level of adherence of TB patients to the use of OAT and determine the factors that influence the level of adherence to taking OAT at the Puskesmas Lima Puluh . After the selection was carried out, 40 patients were obtained, then the probably sampling method was carried out so that 29 respondents were obtained. Data collection through direct interviews using questionnaires, bivariate and univariate data analysis. The results of statistical tests using the Chi Test showed a significant relationship with several variables including last education (p = 0.001), knowledge (p = 0.003), family support (p = 0.018) and distance traveled to health services (0.010) with adherence taking OAT in TB patients.

EMPOWERMENT OF HOUSEWIVES IN EARLY DETECTION OF CHILDREN'S PULMONARY TB IN THE RW 8 AREA, PUTAT JAYA DISTRICT SURABAYA

Tuberculosis (TB) in Indonesia has been detected to be increasing in recent years. Community involvement in tackling TB disease is very necessary. Child TB cases are not clearly visible if the family does not understand the signs and symptoms they cause. There is a need for knowledge regarding early detection of pulmonary TB in children through TB ​​screening. In an effort to reduce the increase in children's TB, the participation of the family is needed, especially the mother who is currently the closest to the child. The aim of this community service is to increase the knowledge of housewives in early detection of TB disease in children. Community service activities include counseling, presentation of material, simulations and applying TB screening tests directly to children. This activity is carried out by 20 housewives from each RT, represented by 2 people. The activity lasts for 2 days. Empowerment and education through counseling proven to be able to increase the knowledge of housewives in carrying out TB screening in children in the area. It was found that the number screened was 152 children, consisting of cases without risk, 111 children, at risk/exposed: 26 people at risk, 15 people. It is hoped that this empowerment of housewives can continue optimally and sustainably so that the results of the discovery of suspected TB cases in children can be followed up by health workers at Community Health Centers in an effort to prevent and reduce the incidence of TB in children.

Retrospective Analysis of Tuberculosis Epidemiology in Okara, Pakistan

Tuberculosis, commonly called T.B., is a persistent bacterial illness attributed to Mycobacterium tuberculosis. Tuberculosis (T.B.) is a prevalent infectious disease that results in millions of deaths each year, particularly in low-income countries. A retrospective study was conducted between December 1, 2022, and April 30, 2023. Sputum smear microscopy was performed on all individuals suspected of having the T.B. condition. Out of the entire pool of 711 cases under suspicion, 227 cases, which accounts for 31.93% of the total, were confirmed positive for Tuberculosis. The male population is more susceptible to T.B. infection than their female counterparts, with a distribution of 59.47% and 40.53%, respectively. The age group of 30-44 years exhibited the highest rate of pulmonary tuberculosis cases at 24.67%, whereas the age group of 60-74 years recorded the highest percentage of cases at 25.56%. Based on our research, it was determined that the incidence of Tuberculosis exhibited a statistically significant increase within the overall populace of Okara District. The objective of the present study was to examine the Prevalence of Tuberculosis (T.B.) infection and raise awareness among the population regarding T.B. infection in the Okara district of Punjab, Pakistan. Effective disease control and elimination require appropriate management, diagnosis, treatment, and public consciousness.

Subclinical tuberculosis: a meta-analysis of prevalence and scoping review of definitions, prevalence and clinical characteristics.

This scoping review aimed to characterise definitions used to describe subclinical tuberculosis (TB), estimate the prevalence in different populations and describe the clinical characteristics and treatment outcomes in the scientific literature. A systematic literature search was conducted using PubMed. We included studies published in English between January 1990 and August 2022 that defined "subclinical" or "asymptomatic" pulmonary TB disease, regardless of age, HIV status and comorbidities. We estimated the weighted pooled proportions of subclinical TB using a random-effects model by World Health Organization reported TB incidence, populations and settings. We also pooled the proportion of subclinical TB according to definitions described in published prevalence surveys. We identified 29 prevalence surveys and 71 other studies. Prevalence survey data (2002-2022) using "absence of cough of any duration" criteria reported higher subclinical TB prevalence than those using the stricter "completely asymptomatic" threshold. Prevalence estimates overlap in studies using other symptoms and cough duration. Subclinical TB in studies was commonly defined as asymptomatic TB disease. Higher prevalence was reported in high TB burden areas, community settings and immunocompetent populations. People with subclinical TB showed less extensive radiographic abnormalities, higher treatment success rates and lower mortality, although studies were few. A substantial proportion of TB is subclinical. However, prevalence estimates were highly heterogeneous between settings. Most published studies incompletely characterised the phenotype of people with subclinical TB. Standardised definitions and diagnostic criteria are needed to characterise this phenotype. Further research is required to enhance case finding, screening, diagnostics and treatment options for subclinical TB.

THE RELATIONSHIP BETWEEN THE PHYSICAL CONDITION OF THE HOME ENVIRONMENT AND HISTORY OF DISEASE WITH THE INCIDENCE OF TUBERCULOSIS IN THE WORKING AREA OF THE RANGKASBITUNG HEALTH CENTER IN 2023

This study aims to determine the relationship between the physical condition of the home environment and history of disease with the incidence of tuberculosis or pulmonary tuberculosis in the work area of the Rangkasbitung Health Center in 2023. This study is a descriptive correlation study with cross sectional design, which is research that explores the relationship between the physical condition of the house and the behavior of residents towards the incidence of tuberculosis. The type of data used is primary data, from the results of questionnaires and secondary data obtained from recording and reporting TB patient visit data at the Rangkasbitung Health Center. Data analysis in the study, using univariate analysis with positive TB incidence results (69.2%); Bivariate analysis showed a relationship between home air circulation and the incidence of tuberculosis (P<0.028), occupancy density (P<0.011), lighting (P<0.015), humidity (P<0.020), education (P<0.002), employment (P<0.006), and smoking (P<0.009); and humidity factor being the dominant factor with the largest OR (OR=28.579). The results of the cross-sectional test in the study, showed a significant relationship between the physical condition of the home environment and the history of disease with the incidence of tuberculosis in the work area of the Rangkasbitung Health Center. Suggestions in this study are the need for education related to environmental factors and behaviors that cause tuberculosis, such as counseling about healthy homes with qualified ventilation, good lighting, good humidity, occupancy in an adequate place, and reducing cigarette use habits. Other factors that need to be improved, in order to support the reduction in TB prevalence rates, namely education and employment factors. Patients with pulmonary tuberculosis must also be given understanding, related must always be tried to be in a place that has adequate air ventilation and good humidity, in order to reduce the risk of the severity of TB disease which can lead to death or the duration of the treatment process.

Incidence and risk factors of active tuberculosis among older individuals with latent tuberculosis infection: a cohort study in two high-epidemic sites in eastern China.

The influencing factors of the process from latent tuberculosis infection (LTBI) to the onset of active tuberculosis (TB) remain unknown among different population groups, especially among older individuals in high-incidence areas. This study aimed to investigate the development of active TB among older adults with LTBI and identify groups in greatest need of improved prevention and control strategies for TB. In 2021, we implemented an investigation among older individuals (≥ 65 years old) in two towns in Zhejiang Province with the highest incidence of TB. All participants underwent assessment using standardized questionnaires, physical examinations, interferon-gamma release assays, and chest radiography. All the participants with suspected TB based on the clinical symptoms or abnormal chest radiography results, as well as those with LTBI, were referred for diagnostic investigation in accordance with the national guidelines. Those with an initial diagnosis of TB were then excluded, whereas those with LTBI were included in a follow-up at baseline. Incident patients with active TB were identified from the Chinese Tuberculosis Management Information System, and a multivariate Cox regression model was used to estimate the incidence and risk of TB among those with LTBI. In total, 667 participants with LTBI were followed up for 1,315.3 person-years, revealing a disease density of 1,292.5 individuals/100,000 person-years (17/1,315.3). For those with LTBI, chest radiograph abnormalities had adjusted hazard ratios for active TB of 4.9 (1.6-15.3). The presence of abnormal chest radiography findings increased the risk of active TB among older individuals with LTBI in high-epidemic sites in eastern China.

Prevalence and incidence rates of tuberculosis in people with HIV during the coronavirus 2019 pandemic: a single center retrospective analysis

Background Tuberculosis (TB) poses a significant risk to people with HIV (PWH), with heightened incidence and prevalence rates, especially in countries with a high TB burden. This study assesses the prevalence and incidence rates of TB among PWH during the COVID-19 pandemic, and on treatment outcomes in TB-HIV co-infections. Methods A retrospective study was conducted at Suddhavej Hospital, Faculty of Medicine, Mahasarakham University, Maha Sarakham, Thailand, from January 2020 to September 2023, involving newly diagnosed adult PWH. Data were collected on TB prevalence and incidence rates, with TB cases categorized as definite or possible. The primary outcomes were TB prevalence and incidence rates per 100,000 person-years of follow-up. Results Among 171 newly diagnosed PWH, the prevalence of TB was 5.85%, with an incidence rate of 4,568.71 per 100,000 person-years. All but one TB cases were diagnosed before antiretroviral therapy (ART) initiation. There was no incident TB during the follow-up period during ART. Nearly half of the TB cases required therapeutic trials without microbiological confirmation. Conclusions The study revealed a high prevalence and incidence rate of TB among PWH during the COVID-19 pandemic, comparable to pre-pandemic rates in Thailand. The findings highlight the necessity of comprehensive TB screening prior to ART initiation and the cautious implementation of universal TB preventive therapy. The use of molecular diagnostics, in addition to symptom screening, can enhance TB diagnosis among PWH, though accessibility remains an issue in many regions.

Active Tuberculosis Risk Associated with Malignancies: A 4-Year Retrospective Study in a Tertiary Care Hospital

Background Tuberculosis (TB) remains an important public health problem worldwide. Risk of acquiring TB in patients diagnosed with cancers remains high and can result due to reactivation or reinfection. We share the experience in a large tertiary care hospital. Materials and Methods Clinical samples from presumptive TB patients while on cancer therapy were tested by smear Ziehl–Neelsen (ZN) staining, GeneXpert MTB/RIF (Gx), TB polymerase chain reaction (PCR), and liquid culture (MGIT 960) from January 1, 2019, to December 31, 2022. Statistical Analysis Stata 14.0 software was used for statistical analysis. The p-value calculation was done by Pearson's chi-square test. Results Of 906 patients investigated, 42 (4.64%) tested positive for TB. Seven (1.37%) tested positive by ZN staining, 10 patients (6%) had culture positive by MGIT, 20 (10.53%) and 5 (13.51%) samples were positive by Gx and PCR, respectively. Maximum number of TB-positive patients were found to be suffering from carcinoma lung (28%) followed by leukemia (25%), gastrointestinal cancer (13%), and genitourinary cancer (13%), respectively. Seven of the 42 patients succumbed to the disease; the cases belonged to Hodgkin's lymphoma (75% mortality), leukemia (30% mortality), and genitourinary cancer (20% mortality). Conclusion The incidence of active TB is high in cancer patients, especially lung cancer, leukemia, gastrointestinal, and genitourinary cancers. Mortality was high in Hodgkin's lymphoma patients who developed TB. Screening for TB at the time of diagnosis of a high TB risk cancer would help initiate early treatment. We recommend targeted screening for TB in patients with these high-risk cancers, at the time of diagnosis and periodically through cancer treatment.

The Relationship between House Conditions and the Household Contacts with the Incidence of Children's Pulmonary Tuberculosis

Tuberculosis (TB) is a high risk in vulnerable groups with low immunity, such as children. Environmental factors and household contacts influence the high incidence of tuberculosis. This study aimed to analyze the relationship between housing conditions and the presence of household contacts with the incidence of pulmonary tuberculosis in children. This study used a case-control design. This study used a case-control design at the Puskesmas Kedaton Bandar Lampung from December 2023 to January 2024. The total sample was 58 children (29 cases and 29 controls), selected using Simple Random Sampling. The variables of this study were residential density, humidity, lighting, floor type, ventilation area, and the presence of household contacts. This study used univariate analysis, bivariate analysis with chi-square, and multivariate with multiple logistic regression. This study shows that there is a relationship between lighting (p=0,008), ventilation area (p=0,032), and the presence of household contacts (p<0,001) with the incidence of pulmonary TB in children. The factor most associated with the incidence of pulmonary TB in children was lighting (OR=6.061; 95% CI=1.768-20.777), which means children with home lighting that doesn't meet the requirements have a 6.061 times higher risk of experiencing childhood pulmonary TB than those who meet the lighting requirements.

Impact of COVID-19 Pandemic on Tuberculosis and Latent Tuberculosis Infection Diagnosis in Healthcare Workers.

The aim of the study is to compare the prevalence of latent tuberculosis infection and tuberculosis (TB) in the prepandemic period (2017-2019) with the pandemic period (2020-2022), in a group of healthcare workers (HCWs). This is a retrospective study. Data on TB diagnosis was retrieved from the hospital information system database. All HCWs who underwent tuberculin skin test (TST) from January 2017 to December 2022 were included in the study. In the prepandemic period (2017-2019), 163 HCWs out of 710 were TST positive (22.9%), and in the pandemic period (2020-2022), 85 HCWs out of 449 were TST positive (18.9%) ( P = 0.11). There were 10 HCWs diagnosed with TB in the prepandemic period (incidence: 41.7/100,000) and 2 in the pandemic period (incidence: 8.3/100,000) ( P < 0.0001). This study showed that TB incidence was reduced during the pandemic period in HCWs. TST positivity was also reduced, though not statistically significant.

A Mathematical Model for the Impact of 3HP and Social Programme Implementation on the Incidence and Mortality of Tuberculosis: Study in Brazil.

In this paper, we presented a mathematical model for tuberculosis with treatment for latent tuberculosis cases and incorporated social implementations based on the impact they will have on tuberculosis incidence, cure, and recovery. We incorporated two variables containing the accumulated deaths and active cases into the model in order to study the incidence and mortality rate per year with the data reported by the model. Our objective is to study the impact of social program implementations and therapies on latent tuberculosis in particular the use of once-weekly isoniazid-rifapentine for 12 weeks (3HP). The computational experimentation was performed with data from Brazil and for model calibration, we used the Markov Chain Monte Carlo method (MCMC) with a Bayesian approach. We studied the effect of increasing the coverage of social programs, the Bolsa Familia Programme (BFP) and the Family Health Strategy (FHS) and the implementation of the 3HP as a substitution therapy for two rates of diagnosis and treatment of latent at 1% and 5%. Based of the data obtained by the model in the period 2023-2035, the FHS reported better results than BFP in the case of social implementations and 3HP with a higher rate of diagnosis and treatment of latent in the reduction of incidence and mortality rate and in cases and deaths avoided. With the objective of linking the social and biomedical implementations, we constructed two different scenarios with the rate of diagnosis and treatment. We verified with results reported by the model that with the social implementations studied and the 3HP with the highest rate of diagnosis and treatment of latent, the best results were obtained in comparison with the other independent and joint implementations. A reduction of the incidence by 36.54% with respect to the model with the current strategies and coverage was achieved, and a greater number of cases and deaths from tuberculosis was avoided.

Risk factors for Tuberculosis in children at labuang baji hospital and center for community pulmonary health Makassar in 2023

Efforts to achieve the Sustainable Development Goals (SDGs) include eradicating the global tuberculosis (TB) epidemic by 2030. In 2020, the global TB incidence rate stood at 121 per 100,000 people, with 1.1 million children succumbing to the disease worldwide. Indonesia alone recorded 42,187 pediatric TB cases in 2021, emphasizing the urgency of addressing this public health concern.A recent observational study in Makassar City focused on children aged 0-14, revealing 380 cases in 2022, notably concentrated in Labuang Baji Regional Hospital, Tajuddin Chalid Hospital, and Community Center for Lung Health Makassar. Developing countries, where children under 15 constitute 40-50% of the population, witness around 500,000 pediatric TB cases annually, leading to severe morbidity and mortality, especially in those under 14. May to July 2023, researchers conducted a case-control study involving 114 children. The study revealed that malnutrition (with an odds ratio of 2.614 and a 95% confidence interval of 1.133-6.085) and a history of TB contact (with an odds ratio of 7.84 and a 95% confidence interval of 2.932-22.319) emerged as noteworthy risk factors for pediatric TB. Notably, economic status, residential density, BCG vaccination status, and exposure to smokers showed no significant impact on the prevalence of the disease.The study advocates consistent screening of adult TB patients' family contacts to trace potential cases in children. Future research should explore the feasibility of TB transmission among children. Tackling malnutrition and strengthening contact tracing initiatives are imperative to curbing pediatric TB, aligning with global goals for a TB-free world by 2030.

Extra-pulmonary tuberculosis frequency and the risk factors influence (case of the PHE-Batna regional unit) (2017-2022)

Context: Tuberculosis is an infectious disease that is endemic in developing countries. The causal agent is Mycobacterium tuberculosis. Extra-pulmonary tuberculosis (EPTB) is receiving renewed attention due to an unexplained increase in its relative frequency. The aim of this study was to carry out a retrospective descriptive survey to assess the frequency of extra-pulmonary tuberculosis in an eastern Algeria population range. Methods: this study took place at the regional tuberculosis Batna’s Public hospitalian establishment unit; over a period of 64 months (2017-2022). 2405 files were studied through the collection of information recorded at laboratory level. Results: Out of 2405 samples, 102 were positive (4.24%). There was a clear predominance of females (64.70%) and males (35.29%), giving a sex ratio of 1.8. The age group most affected was 11 to 49. Pus was the most common specimen with a percentage of 44.12%, followed by urine (28.43%), CSF (14.70%). The incidence of extra pulmonary tuberculosis in patients in Batna’s Department and neighbouring Departments is 4.24%, with adult women being the most affected. Conclusion: Extrapulmonary tuberculosis is common and should not be neglected; it is no longer a pathology of the past but still remains relevant today.

Incidence, Outcomes, and Risk Factors for Isoniazid-Resistant Tuberculosis from 2012 to 2022 in Eastern China.

Isoniazid-resistant, rifampicin-susceptible tuberculosis (Hr-TB) is the most frequent drug-resistant tuberculosis (DR-TB) in the world, and unfavorable outcomes of Hr-TB are more common compared to drug-susceptible TB. Considering there is no optimal regimen accepted worldwide, we undertook a retrospective cohort study in eastern China to estimate incidence trends and risk factors associated with unfavorable outcomes of Hr-TB. Between January 2012 and December 2022, all Hr-TB patients' information was extracted from the Tuberculosis Information Management System (TIMS), which is a national electronic information platform, to record TB patients' clinical information in this study. The incidence of Hr-TB was determined by the mid-year population according to census data published by the government. We categorized treatment regimens depending on fluoroquinolone (FQ) use, and potential risk factors were analyzed using multivariable logistic regression. A total of 3116 Hr-TB patients fulfilled the inclusion criteria and were enrolled in this study. The average annual rate of Hr-TB in the 11 years under investigation was 0.34 per 100,000 and increased to 0.53 per 100,000 until 2019. In total, six different treatment regimens were utilized in the study sites, and less than 1% of regimens adopted FQ. There was no difference in the unfavorable outcomes between the FQ-included and FQ-excluded groups (p = 0.22). The average treatment duration was 7.06 months, and the longest treatment was 26 months. Approximately 20% (637/3116) of Hr-TB patients had unfavorable outcomes, and 60.13% (383/637) of them proceeded to multidrug-resistant tuberculosis (MDR-TB). Treatment duration and a positive smear at the end of the 5th month were significantly associated with unfavorable outcomes (p < 0.001). The unfavorable treatment outcomes of Hr-TB are still high in eastern China, and the efficacy of FQ-containing regimens needs to be validated for Hr-TB treatment.

Pulmonary tuberculosis epidemiology and genetics in Kazakhstan.

Tuberculosis (TB) is a major public health emergency in many countries, including Kazakhstan. Despite the decline in the incidence rate and having one of the highest treatment effectiveness in the world, the incidence rate of TB remains high in Kazakhstan. Social and environmental factors along with host genetics contribute to pulmonary tuberculosis (PTB) incidence. Due to the high incidence rate of TB in Kazakhstan, our research aimed to study the epidemiology and genetics of PTB in Kazakhstan. 1,555 participants were recruited to the case-control study. The epidemiology data was taken during an interview. Polymorphisms of selected genes were determined by real-time PCR using pre-designed TaqMan probes. Epidemiological risk factors like diabetes (χ2 = 57.71, p < 0.001), unemployment (χ2 = 81.1, p < 0.001), and underweight-ranged BMI (<18.49, χ2 = 206.39, p < 0.001) were significantly associated with PTB. VDR FokI (rs2228570) and VDR BsmI (rs1544410) polymorphisms were associated with an increased risk of PTB. A/A genotype of the TLR8 gene (rs3764880) showed a significant association with an increased risk of PTB in Asians and Asian males. The G allele of the rs2278589 polymorphism of the MARCO gene increases PTB susceptibility in Asians and Asian females. VDR BsmI (rs1544410) polymorphism was significantly associated with PTB in Asian females. A significant association between VDR ApaI polymorphism and PTB susceptibility in the Caucasian population of Kazakhstan was found. This is the first study that evaluated the epidemiology and genetics of PTB in Kazakhstan on a relatively large cohort. Social and environmental risk factors play a crucial role in TB incidence in Kazakhstan. Underweight BMI (<18.49 kg/m2), diabetes, and unemployment showed a statistically significant association with PTB in our study group. FokI (rs2228570) and BsmI (rs1544410) polymorphisms of the VDR gene can be used as possible biomarkers of PTB in Asian males. rs2278589 polymorphism of the MARCO gene may act as a potential biomarker of PTB in Kazakhs. BsmI polymorphism of the VDR gene and rs2278589 polymorphism of the MARCO gene can be used as possible biomarkers of PTB risk in Asian females as well as VDR ApaI polymorphism in Caucasians.

Correlation Of Neutrophil Lymphocyte Ratio (NLR) Value With Incidence Of Tuberculosis Disease In Patients With Diabetes Mellitus

Diabetes mellitus is a non-communicable disease (PTM) that is chronic and can weaken the immune system so that sufferers are 3 times more likely to suffer from pulmonary TB. In chronic infection there is continuous inflammation which is characterized by the presence of neutrophils themselves and will be followed by low lymphocyte values due to immune system pathways that do not work perfectly. The purpose of this study was to determine the correlation between the Neutrophil Lymphocyte Ratio (NLR) and the incidence of Tuberculosis in Diabetes Mellitus patients at the Jorongan Health Center, Probolinggo Regency. This research is a correlative analytic study with a cross sectional approach. A total of 30 samples of diabetes mellitus patients at the Jorongan Health Center from January to April 2023. The NLR examination method was with a hematology analyzer and tuberculosis patients were examined using Molecular Rapid Test. The statistical test uses Spearman's nonparametric test. The results showed that there was a correlation between NLR values and the incidence of tuberculosis in diabetes mellitus patients at the Jorongan Health Center, p = 0.003 and r = 0.521. Further research needs to be carried out involving larger samples and other laboratory tests related to the immune system in patients with diabetes mellitus.

Prevalence of pulmonary tuberculosis and HIV infections and risk factors associated to tuberculosis in detained persons in Antananarivo, Madagascar

The incidence rate of tuberculosis in prisons is estimated to be 8 times greater than that in the general population in Madagascar. Our objectives were to estimate the prevalence of pulmonary tuberculosis and HIV infection among prisoners and to identify risk factors associated with tuberculosis. We conducted a cross-sectional study at the central prison of Antananarivo from March to July 2021. Individual male and female inmates aged ≥ 13 years who had lived in the prison for at least three months prior to the study period were included as participants. Acid-fast bacilli detection by microscopy and/or culture, an intradermal tuberculin test, a chest X-ray, and a rapid diagnostic orientation test for HIV were performed. Among 748 participants, 4 (0.5%) were confirmed to have pulmonary tuberculosis. Overall, 14 (1.9%) patients had “confirmed” or “probable” tuberculosis [0.90–2.84, 95% CI]. The proportion of participants with latent tuberculosis infection was 69.6% (517/743) based on a positive tuberculin test without clinical symptoms or radiography images indicating tuberculosis. Out of 745 HIV screening tests, three showed reactive results (0.4%). Age (OR = 4.4, 95% CI [1.4–14.0]) and prior tuberculosis treatment (or episodes) were found to be associated with confirmed and probable tuberculosis.

Magnetic Resonance Imaging (MRI) Images in Tuberculosis Spondylitis Patients at the Central General Hospital Prof. Dr. I.G.N.G. Ngoerah Year 2021-2023

Background: Tuberculous spondylitis is extrapulmonary tuberculosis that attacks the spine. The incidence of tuberculosis has decreased. However, the prevalence of deaths due to tuberculosis is still high, so it requires appropriate management. Method: This study used a cross-sectional descriptive method, the research population was tuberculous spondylitis patients diagnosed at RSUP Prof. Dr. I.G.N.G Ngoerah 2021-2023. The research data source is PACS MRI data, with a sample size of 25. This research uses a consecutive sampling technique. Data analysis uses univariate analysis. Result: The research results showed that 25 samples met the inclusion criteria. Patients in the largest age group were 19 – 39 (36%) years and 40 – 59 years (36%) and the largest sex was female (56%). The most common location of vertebral MR Imaging was found in the thoracic (36%), intervertebral disc involvement was (52%) with normal discs and (48%) with disc destruction, there was endplate defect and paravertebral abscess in all samples (100%), the presence of gibbus deformity As many as (88%) of the sample, spinal cord compression was (96%), the most destruction of the corpus vertebral was on the anterior side (64%), and the most change in intensity of the interverbal disc was without contrast enhancement (60%). Conclusion: There are more women than men. The largest age groups are 19 - 39 years and 40 - 59 years with the most MR Imaging, namely in the thoracic location, normal intervertebral discs, endplatedefect, and paravertebral abscesses in all samples, gibbus deformity, spinal cord compression, anterior corpus vertebral destruction, and changes in intensity, intervertebral disc without contrast enhancement. Keywords: Tuberculous spondylitis, MRI, Bali