You have accessJournal of UrologyCME1 Apr 2023MP46-06 DOES PERIOPERATIVE BLOOD TRANSFUSION INCREASE THE RISK OF VENOUS THROMBOEMBOLISM AFTER RADICAL CYSTECTOMY? Kays Chaker, Yassine Ouanes, Anouar Madani, Nizar Cherni, Boutheina Mosabhi, Rania Cherif, Mokhtar Bibi, Nouha Harouni, Moez Rahoui, Kheireddine Mrad Dali, Karem Abid, Ahmed Sellami, Adel Ammous, and Yassine Nouira Kays ChakerKays Chaker More articles by this author , Yassine OuanesYassine Ouanes More articles by this author , Anouar MadaniAnouar Madani More articles by this author , Nizar CherniNizar Cherni More articles by this author , Boutheina MosabhiBoutheina Mosabhi More articles by this author , Rania CherifRania Cherif More articles by this author , Mokhtar BibiMokhtar Bibi More articles by this author , Nouha HarouniNouha Harouni More articles by this author , Moez RahouiMoez Rahoui More articles by this author , Kheireddine Mrad DaliKheireddine Mrad Dali More articles by this author , Karem AbidKarem Abid More articles by this author , Ahmed SellamiAhmed Sellami More articles by this author , Adel AmmousAdel Ammous More articles by this author , and Yassine NouiraYassine Nouira More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003292.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Radical cystectomy (RC) is associated with significant morbidity including perioperative blood transfusion. The aim of this study was to develop a model that would provide information on the relationship between perioperative blood transfusion and the development of venous thromboembolism (VTE) after RC. METHODS: All patients who underwent open RC between between january 2006 and december 2021 at our institution were reviewed retrospectively. Patient with a history of prior VTE, those taking anticoagulation prior to surgery, patients with metastatic bladder cancer or with missing data were excluded. A venous thromboembolism was defined as either a deep venous thrombosis or pulmonary embolism. Patients who developed a VTE within 90 days after surgery were compared to those who did not. Logistic regression was performed to assess the association between covariates and the probability of VTE within 90 days after surgery. RESULTS: A total of 372 cases were enrolled in this study. Almost 224 patients (60.21%) received a perioperative blood transfusion, with a median of 1 (IQR: 0-4) unit transfused. Forty-two patients (11.29%) of whom developed a VTE within 90 days after surgery. There was no significant difference in age, sex, race, Charlson score, clinical stay, BMI. Patient who developed a VTE experienced a longer mean operative time (367.84 vs 311.5 minutes, p=0.01), had adverse pathology (≥pT3 or node positive) (p=0.005) and received a greater mean number of transfused units of blood during their stay (2.42 vs 1.26, p=0.02). The variables included in the model were selected based on the univariate analysis and on an a priori basis and included blood transfusion, age, BMI, Charlson score, smoking status, pathologic tumor stage, pathologic nodal stage and operative time. On multivariable logistic regression, each unit of transfused blood given during a patient's hospital stay was significantly associated with development of VTE (OR 1.22, 95% CI 1.12-1.44), as was operative time (OR 1.47, 95% CI 1.16-1.88). CONCLUSIONS: The incidence of perioperative blood transfusion is significant at the time of radical cystectomy. This study demonstrates that blood transfusion was associated with an increased risk for developing the VTE. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e632 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Kays Chaker More articles by this author Yassine Ouanes More articles by this author Anouar Madani More articles by this author Nizar Cherni More articles by this author Boutheina Mosabhi More articles by this author Rania Cherif More articles by this author Mokhtar Bibi More articles by this author Nouha Harouni More articles by this author Moez Rahoui More articles by this author Kheireddine Mrad Dali More articles by this author Karem Abid More articles by this author Ahmed Sellami More articles by this author Adel Ammous More articles by this author Yassine Nouira More articles by this author Expand All Advertisement PDF downloadLoading ...