Incidence Of Somnolence Research Articles

Clinical evaluation of sustained-release antihistamine (chlorprophenpyridamine) in hay fever

One hundred twenty-eight patients with allergic disorders, predominantly hay fever, were treated with chlorprophenpyridamine maleate in each of three dosage forms: tablets, enteric-coated tablets, and sustained-release capsules. Patients greatly preferred the capsules because of their superior effectiveness and their long action, which eliminates the need for frequent doses throughout the day. Except for drowsiness, side effects were minimal. The incidence of drowsiness was essentially the same with tablets and capsules, 16 and 12 per cent, respectively; however, the degree of drowsiness was less with the capsules.