Incidence Of Skin Conditions Research Articles

Observational study of first-line therapy, including cetuximab in cases of nonresectable colorectal cancer: CORAL (interim report).

681 Background: Cetuximab (Cmab) + chemotherapy is now indicated in various treatment guidelines as a first-line therapy for non-resectable metastatic colorectal cancer (mCRC). The efficacy of Cmab + FOLFIRI has been demonstrated in CRYSTAL, but its efficacy and safety in combination with other regimens is unclear. There are few reports on Cmab combination therapy as first-line chemotherapy in Japan, and there are no reports of treatment results in the ESMO guideline groups 1, 2, and 3. Therefore an observational study was planned to evaluate the efficacy and safety of first-line therapy including Cmab, and to clarify the treatment results by group. This study received support from the Public Health Research Foundation’s Comprehensive Support Project for Oncology Research (CSPOR). Methods: The subjects were mCRC patients who received Cmab as first-line therapy either as combination therapy or monotherapy. Endpoints were response rate, PFS, and reason for discontinuation of first-line treatment (curative resection, PD, adverse events). To evaluate safety, skin conditions (incidence, degree, previous history) and other adverse events were investigated. Results: Among 579 patients enrolled at 158 institutes from January 2012 until June 2013, 575 were subjected to analysis. Background factors were PS 0/1/2 at 406/143/26, males females at 368/207, median age of 65 (31-88), groups 1/2/3 at 172/229/174, and concomitant drugs were oxaliplatin/irinotecan/others at 377/173/25. Response rate in the evaluable cases was 57%, and in groups 1/2/3 was 65%/54%/53%. The 1-year survival rate in groups 1/2/3 was 93%/61%/78%. In adverse events, the incidence of skin conditions (rash acneform) at 8 weeks/16 weeks was 69%/60% in patients with no history of acne vulgaris (2%/8% at G3 or higher) and 83%/81% in those with a previous history (13%/14% at G3 or higher). Conclusions: We reported treatment results according to ESMO guideline groups on the efficacy and safety of Cmab as first-line therapy in mCRC patients. Response rate and survival were higher in group 1. Survival outcomes after 1 year will be followed up. Clinical trial information: UMIN000007275.

Skin conditions are the commonest new reason people present to general practitioners in England and Wales

Knowledge of the prevalence and incidence of skin conditions is a prerequisite for designing clinical services and providing appropriate training for primary health care professionals. In the U.K. the general practitioner and practice nurse are the first point of medical contact for persons with skin conditions. We aimed to obtain contemporary data in age-, gender- and diagnosis-specific detail on persons presenting to primary care with skin problems. Comparisons were made with similar data for other major disease groups and with similar data from other recent years. We used surveillance data collected in the Weekly Returns Service (WRS) of the Royal College of General Practitioners during 2006 and trend data for subsequent years. The WRS sentinel practices monitor all consultations by clinical diagnosis in a representative population of 950,000 in England and Wales. For conditions included in chapter XII of the International Classification of Diseases Ninth Revision (ICD9), 15% of the population consulted; a further 9% presented with skin problems classified elsewhere in the ICD9, making a total of 24%. There was no evidence of increasing or decreasing trend since 2006. Skin infections were the commonest diagnostic group, while 20% of children < 12 months were diagnosed with atopic eczema. Considered collectively, the incidence of new episodes of skin disorders (including diagnoses outside chapter XII) exceeded incidences for all other major disease groupings. Compared with other major disease groups, skin conditions are the most frequent reason for consultation in general practice. This result emphasizes the need for appropriate education and training for all medical students and particularly for continuing education in dermatology for all primary health care professionals.

Incidence of skin conditions in neonates born at a public hospital associated with some variables in pregnant women at risk.

To verify the incidence of skin diseases in newborns of pregnant women at risk of a public hospital in the city of Santos, Brazil (Hospital Guilherme Alvaro), determining the potential relation between these dermatoses and diseases presented by the mothers. A total of 1,000 neonates were examined in the first 36 hours of life. The examination was repeated daily in each child up to hospital discharge. The paternal and newborn variables were submitted to analysis to detect statistically significant associations. The most frequent skin disorders were: Mongolian spot (69.8%), erythema toxicum neonatorum (19.7%), Port-wine stain (angiomatous naevi) (13.9%), and hypertrichosis lanuginose (10.3%). Minipuberty had a low incidence in neonates of diabetic mothers. The incidence of Mongolian spot was very low among newborns classified as caucasian.

Investigation into the environmental factors associated with the incidence of skin disease following an outbreak of Miliaria rubra at a coal mine.

A retrospective study was undertaken to examine by interactive linear modeling a possible association between environmental conditions and the incidence of skin conditions (excluding athletes foot) in a coal mine following an increase in skin rashes, mainly 'prickly heat' (Miliaria rubra). An increase in the incidence was found with increasing surface temperature and underground air velocity; a decreased incidence with increased underground air quantity (air volume per unit time); whilst the relationship with underground temperature was found to be quadratic with incidence decreasing until 27 degrees C wet bulb (although this is not necessarily the optimum temperature for other purposes) and then increasing. The association between skin incidence and environmental factors was strongest (in terms of variance explained) when the incidence was associated with the environmental conditions of 4 to 8 weeks previously. The constant nature of relative humidity over the period prevented an examination of its relationship with rash incidence. Possible strategies for reducing the incidence of 'prickly heat' are discussed.

AN OUTBREAK OF HALOWAX ACNE ("CABLE RASH") AMONG ELECTRICIANS

The first observations on the development of acnelike lesions among workers in the United States coming in contact with chlornaphthalenes and chlordiphenyls as well as acute yellow atrophy of the liver occurring among such workers were reported1in 1935. Since that time many authors have reported similar observations. Despite the fact that these compounds, if used without proper safety precautions, cause a high incidence of skin conditions and, in certain processes such as coating wires, also entail the serious hazard of acute yellow atrophy of the liver, they are still being used as dielectrics and insulators, because they are waterproof and have excellent heat resisting and flame proof properties. Since our entrance into the war, the speed-up in our shipyards has in many instances resulted in failure to install the proper safety precautions necessary when handling wires insulated with these substances. Reports have been received by the U. S.