Incidence Of Sickle Cell Disease Research Articles

Re: Osteoporosis among male Saudi Arabs: a pilot study

lettersRe: Osteoporosis among male Saudi Arabs: a pilot study Mohammed Shaker Mohammed Shaker Search for more papers by this author Published Online::5 Apr 2007https://doi.org/10.5144/0256-4947.2007.131SectionsPDF ToolsAdd to favoritesDownload citationTrack citations ShareShare onFacebookTwitterLinked InRedditEmail AboutIntroductionTo the Editor: I read with great interest the article by Mir Sadat Ali, et al “Osteoporosis Among Male Saudi Arabs: Pilot Study” published in November–December 2006 issue of the Annals of Saudi Medicine. I have few concerns about some aspects of this article.Firstly, issues with the sample, being too small, the subjects were recruited from one geographic area, which is not a true representation of the “male Saudi Arab”. An example of this concern is the fact that the Eastern province is known to have a higher incidence of sickle cell disease, which can give low bone mass and be a potential cause of bias. Moreover, the subjects were “male attending outpatient orthopedic and internal medicine clinic”. That means this is a hospital-based population utilizing “sick” patients to represent a healthy population. This might be accepted in some situations in which the variable is not affected by the health status of the subjects studied, which is not the case in this study. BMD can be significantly affected by other diseases these patients might have, or even by their ambulatory status which might be jeopardized by their diseases.Secondly, the work-up mentioned did not include 25-hydroxy-vitamin D. Hypovitaminosis D is common in Saudi Arabia and might lead to low bone mass, which is frequently misinterpreted as osteoporosis. Another important cause of secondary osteoporosis is primary idiopathic hypercalcuria. I could not find any effort to detect this entity in the article.Thirdly, there are a couple of actual DNA scans of the lumbar spine shown in the article, while no scans are shown for the femoral neck. We need to see an example of the femoral neck scan to ensure the appropriate technique. Previous article Next article FiguresReferencesRelatedDetails Volume 27, Issue 2March-April 2007 Metrics History Published online5 April 2007 InformationCopyright © 2007, Annals of Saudi MedicineThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.PDF download

Pregnancy outcome in women with sickle cell - A five year review

To evaluate the cases of sickle cell anaemia in obstetric practice, and to highlight their problems in pregnancy as well as their contribution to maternal and foetal outcome in Nigeria. We believe that the findings would be useful for designing interventions to reduce the obstetric burden of sickle cell disease. The service delivery record of 42 pregnancies in 39 patients with sickle cell disease was retrospectively reviewed at the University of Benin Teaching Hospital (UBTH) between January 2000 and December 2004. The incidence of sickle cell disease in the study was 8.7/1000 deliveries. Nearly 62% of the patients were aged 25-34 years, while 76.2% were either nulliparous (Para O) or primiparous (Para 1). There was one grandmultipara (2.38%). Anaemia (95.25%), Malaria (33.33%), Bone pain crisis (23.81%), and pneumonia (19.05%) in that order of frequency were the most common complications of pregnancy. The perinatal mortality rate was 250 per 1000 births while the maternal mortality rate was 47.6 per 1000 pregnancies. At delivery, 20% of cases had caesarean section (5% elective and 15% emergency) and the instrumental interventions include 12.5% vacuum and 27.5% forceps respectively. Early booking, good antenatal care and supervised hospital delivery produced a better obstetric outcome.

Cribado neonatal de hemoglobinopatías y déficit de glucosa-6-fosfato deshidrogenasa en Cataluña. Estudio piloto en población anónima no relacionada

This was a preliminary study on the prevalence of the HbS gene, associated with sickle cell disease, other hemoglobinopathies and G6PD deficiency of immigrant and non-immigrant population of Catalonia. A total of 3,189 blood samples from the Catalan Neonatal Screening Program for Metabolic Diseases (CNSPMD) including 1,620 from immigrant population were screened for haemoglobinopathies and G6PD deficiency. For screening of hemoglobinopathies the high performance liquid chromatography (HPLC) method was used and for the screening of G6PD deficiency, we used the fluorescent spot test as described by ICSH. 1. Hemoglobinopathies: in 47 samples from immigrant population 2 cases of sickle cell anemia (phenotypes FS and FSC) were detected as well as 45 cases of heterozygote carriers of different pathological hemoglobins (HbS, HbC, HbD and HbE). 2. G6PD deficiency: in 29 samples, 3 cases of G6PD deficiency belonging to local (non-immigrant) population of G6PD were detected. The incidence of sickle cell disease in the risk population of Catalonia is 1 case out of 810 samples. This value is significantly higher than that reported for any of the metabolic diseases included in the CNSPMD. Despite it is a preliminary study, the results obtained give further support to the convenience of incorporating a neonatal screening of hemoglobinopathies, at least in the risk population, to the official programs of newborn screening. Due to its feasibility and low cost, a similar criterion might be adopted for the neonatal screening of G6PD deficiency.

Septic arthritis in childhood

We studied retrospectively the pattern of septic arthritis in childhood at a major municipal hospital during a ten-year period. Hemophilus influenzae was the most common organism in septic arthritis in patients less than two years old and was associated with upper respiratory tract infections in nine of 12 patients (75%). Staphylococcus aureus was seen in seven of eight (87.5%) children above the age of five and was associated with history of trauma. All patients were black. Despite the high incidence of sickle cell disease in our hospital population, not one patient had sickle cell disease.

The Inheritance of the Sickling Phenomenon, with Particular Reference to Sickle Cell Disease

Abstract1. The manner of inheritance of the sickling phenomenon has been investigated in 75 kindreds, with hematologic observations on 465 persons.2. Data are presented to support the contention that with a possible rare exception, the differential diagnosis between the sickle cell trait and sickle cell anemia is readily made.3. The hematologic findings pertinent to a decision as to the mode of heredity of the sickle cell trait and sickle cell disease are as follows:a. Out of a total of 94 parents of children with sickle cell disease, 93 have shown the sickle cell trait.b. The incidence of sickle cell disease in segregating sibships would appear to lie between 0.18 and 0.26.c. In sibships segregating for sickle cell disease, the ratio of sickle cell trait to normal is approximately 2:1, but in sibships resulting from the marriage of a normal person with an individual with the sickle cell trait, the ratio of sickle cell trait to normal is significantly less than 1:1.d. Of the 4 children in this series who have a parent with sickle cell disease, all have the sickle cell trait.4. The most reasonable hypothesis which will render the above data intelligible is that the sickling phenomenon is due to a gene which in single dose (heterozygous condition) produces only the sickle cell trait, and in double dose (homozygous condition), sickle cell disease. The chief and only discrepancy between theory and fact at the present time appears to lie in a deficiency of individuals with the sickle cell trait in certain types of matings.5. No clear cut differences between normal and sickle cell trait were observed with respect to erythrocyte number, hemoglobin level, hematocrit, the cell constants, the leukocyte number or the differential count.6. Certain minor hematologic abnormalities encountered in the kindreds under study and not obviously related to the sickling phenomenon are described.