Incidence Of Salivary Gland Tumors Research Articles

Effects of Isoproterenol on Mammary Gland Tumors Induced by <italic>N</italic>-Nitroso-<italic>N</italic>-Methylurea and Salivary Gland Tumors Induced by 7,12-Dimethylbenz[<italic>a</italic>]anthracene<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

The effect of isoproterenol (IPR) (20 mg/kg, twice per wk) on mammary gland tumors induced by N-nitroso-N-methylurea (NMU) (40 or 77 mg/kg, iv) was studied. Within 18 weeks 50--60% of the noninbred female Sprague-Dawley rats that received a single injection of NMU developed carcinomas of the mammary gland. In addition, a malignant lymphoma was observed. There was no change in the incidence of tumors if NMU was administered at the time that DNA synthesis was stimulated in the submandibular glands by two injections of IPR (160 mg/kg, ip) given 24 hours apart. Tumors of unequivocal salivary gland origin were not observed, irrespective of whether NMU was given at the peak of stimulated DNA synthesis or without pretreatment with IPR. However, in 10% of the tumor-bearing rats, tumors were found in the neck region. These tumors could be separated from the salivary glands by dissection and were of mammary gland origin. Chronic treatment with IPR caused marked enlargements of the parotid and submandibular glands with hypertrophy of the acinar cells and degeneration of the duct system. Such a treatment caused a high death rate but no change in the incidence of the tumors. The effect of chronic IPR treatment (10 mg/kg twice per wk or 5 mg/kg three times per wk) on submandibular gland tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) was also studied. With the intraglandular injection of 100 or 200 micrograms of DMBA, the incidences of squamous cell carcinomas in the glands were 6.8 and 38.6%, respectively. Chronic administration of IPR after the instillation of DMBA caused a high death rate but no statistically significant change in the incidence of salivary gland tumors.

Incidence of salivary gland tumours in Scotland: accuracy of national records.

Statistics on discharge diagnoses in Scotland during 1968-74 show the incidence of all tumours of major salivary glands to exceed 40/million population yearly. This is higher than in any other nationality except Canadian Eskimos. Studies in two hospitals showed that numerous errors occurred in reporting these tumours, but the figures were more likely to be too low than too high. Probably eastern Scotland at least has an unusually high incidence, although in other countries using different methods of analysis the reported figures are likely to be low. Statistics based on discharge diagnoses will continue to be neglected in research until the standard of completion of discharge diagnoses improves.

Salivary gland tumors in atomic bomb survivors, Hiroshima, Japan. I. Epidemiologic observations.

An epidemiologic investigation was undertaken in Hiroshima to study the relationship of salivary gland tumors to exposure to ionizing radiation. Two hundred and eleven cases examined between 1953-1971 were confirmed by a review of histologic specimens. Of these, 66 cases occurred in residents of Hiroshima City who were born before the A-bomb: 30 among A-bomb-exposed, and 36 in non-exposed individuals. The incidence of salivary gland tumors among the exposed individuals was significantly higher, 2.6 times greater than that among the nonexposed individuals for all tumors, and 10 times greater for malignant tumors. The incidence increased with proximity to the hypocenter for the directly exposed. An increased incidence was also found among early entrants, particularly those entering the city within 3 days of the A-bomb.

Salivary Gland Tumors in Atomic Bomb Survivors

To the Editor.— I read with considerable interest the article by Belsky et al who reported that salivary gland tumors were found to be increased more than fivefold among survivors of the atomic bomb explosions, who had been exposed to high doses of radiation, as compared with unexposed controls ( 219 :864, 1972). In our experimental studies, carried out in mice, 1 we observed that following total body x-ray irradiation (150 to 200 roentgen (R), four times, at weekly intervals, applied to 6- to 8-week old mice of the C3H strain), 56 out of 116 irradiated mice developed leukemia at 8 1/2 months average age, and two mice developed multicentric parotid gland carcinomas when 6 to 7 months old. None of the 93 untreated controls developed either leukemia or salivary gland tumors. The incidence of salivary gland tumors was increased when thymectomized mice were irradiated: Out of 14 mice that received

Salivary gland tumors in the parotid gland, submandibular gland and the palate region

The relative incidence of the different types of salivary gland tumors and their prognoses has been shown to vary with the location in a study of 2,867 patients with tumors in the parotid gland, submandibular gland, and the palate region. After histologic reexamination and reclassification, 2,513 of the 2,867 tumors were classified as salivary gland tumors. The incidence of salivary gland tumors was strikingly high in the parotid gland, i.e., about twelve times more common in the parotid gland than in the submandibular gland. In all sites there was a striking predominance of pleomorphic adenoma, which altogether comprised 74% of the salivary gland tumors in the present series; the second largest group, mucoepidermoid carcinoma, only comprised 5%. The incidence of malignant salivary gland tumors was twice as high in the submandibular gland than in the parotid gland, but it was highest in the palate region. The prognosis for a given type of malignant tumor was most favorable when the primary tumor was located in the palate region, less favorable when it was in the parotid gland, and least favorable in the submandibular gland.

Salivary gland tumors in the parotid gland, submandibular gland, and the palate region.

The relative incidence of the different types of salivary gland tumors and their prognoses has been shown to vary with the location in a study of 2,867 patients with tumors in the parotid gland, submandibular gland, and the palate region. After histologic reexamination and reclassification, 2,513 of the 2,867 tumors were classified as salivary gland tumors. The incidence of salivary gland tumors was strikingly high in the parotid gland, i.e., about twelve times more common in the parotid gland than in the submandibular gland. In all sites there was a striking predominance of pleomorphic adenoma, which altogether comprised 74% of the salivary gland tumors in the present series; the second largest group, mucoepidermoid carcinoma, only comprised 5%. The incidence of malignant salivary gland tumors was twice as high in the submandibular gland than in the parotid gland, but it was highest in the palate region. The prognosis for a given type of malignant tumor was most favorable when the primary tumor was located in the palate region, less favorable when it was in the parotid gland, and least favorable in the submandibular gland.

Oncogenic Effect of Tissue-Culture Preparations of Polyoma Virus on Fetal Mice

Swiss mice inoculated late in fetal life with tissue-culture preparations of SE polyoma virus died earlier and had a higher incidence of tumors than animals inoculated shortly after birth. No histologic types of tumors were seen in the mice treated in utero that had not been seen previously in mice treated as newborns. Some of the treated mice were the offspring of mothers bred near mice that had been inoculated previously with polyoma-virus preparations. The incidence of salivary-gland tumors and renal lesions was significantly lower in mice from those mothers that had been indirectly exposed to inoculated animals than in mice from unexposed mothers. A comprehensive morphologic analysis of the tumors indicated interrelated patterns of development and behavior which are unique among murine neoplasms. Initially in organs where tumors developed, epithelial cells hypertrophied, formed intranuclear inclusion bodies, and degenerated. The tumors were composed of hyperplastic epithelial elements and proliferating undifferentiated cells that were limited in their capacity to invade adjacent tissues or metastasize. Some tumors regressed, while other caused death of the animal only by local growth in vital organs.