This article reviews new data presented at the recent European Society for Photodynamic Therapy (Euro-PDT) Annual Congress 2018. The role of topical photodynamic therapy (PDT) in the treatment of actinic keratoses (AK), among other therapies, was reviewed, along with updates on rising incidence of nonmelanoma skin cancer (NMSC), awareness of skin cancer risk in outdoor workers, and the potential of PDT as a treatment for prevention of AK and NMSC. A novel scoring method for AK and potential biomarkers for skin cancer, as well as those predictive of PDT response, were presented. Several studies highlighted real-world use of daylight (DL)-PDT across Europe and of its use in novel indications, including acral AK, application following organ transplant, and the option for home-based DL-PDT. New data on PDT combined with other therapies, as well as using novel light sources, will broaden the appeal of PDT to patients and practitioners. Optimisation of PDT using pretreatments and improving the tolerability of the treatment will boost efficacy and patient preference for this therapy. Evidence for off-label use of PDT presented at the congress included antimicrobial and aesthetic indications.