As maternal opioid exposure increased fourfold over a recent 15 year span,1 the incidence of neonatal abstinence syndrome (NAS) grew from 1.6 cases per 1000 live births in 2004 to 8.8 in 2016.2 Given this growing number of affected infants, optimization and standardization of care for opioid exposed newborns (OENs) has great potential for impact. The Eat, Sleep, Console (ESC) assessment strategy is a relatively new approach focusing on the infant’s ability to feed, sleep, and be consoled in a timely manner.3 ESC is often used in conjunction with nonpharmacologic methods of management for infants with NAS. Evaluating the implementation and outcomes of the ESC strategy is an important and active area of research.4,5 Although infants with NAS are more likely to be White, NAS affects infants from all demographic groups; in 2016, 5.8% of infants diagnosed with NAS were Hispanic.2 Disparities in quality of care and outcomes have been found in Hispanic populations of newborns treated in the NICU6,7; however, approaches to care that directly seek to address such gaps have been more limited. Therefore, evaluation of how outcomes resulting from interventions like ESC differ by race and ethnicity is a critically important area of inquiry. Before the study by Weikel et al8 in this issue of Hospital Pediatrics , little was known about differences in NAS management and outcomes in Hispanic and non-Hispanic populations. This study describes important factors about the care of patients with NAS and highlights equity factors warranting increased consideration in quality improvement (QI) projects more generally. This includes equity-oriented data collection and clear recognition of and approaches to mitigate ill effects of racism, ethnocentrism, and immigration status. Equity provides a lens through which to view opportunities for improved design and implementation of …