Objective: To study the effect of organochlorine pollution on the incidence of male infertility. Materials and methods: 1036 dispensary records of males from rural areas suffering from infertility were analyzed. The incidence rate of male infertility per 100, 000 population was calculated by conventional techniques. All patients were allocated into 5 groups. Concentration levels of organochlorine pesticides (OCPs) in soil were measured by gas-liquid chromatography. Results: Group I consisted of men living in mountainous uncontaminated areas. The local population is mainly engaged in cattle breeding. The incidence rate of male infertility per 100, 000 male population was 5.5. Group II comprised men who were engaged in cattle breeding and cultivation of grain legumes. Small amounts of OCPs were used for pest control in the area. The incidence rate in Group II was 20.55. Group ??? consisted of men living in mountainous areas where DDT had been used during the period 1980-1982 for pest control. The incidence rate - 29.19. Group ?V group comprised men living in the areas which were used for tobacco growing. The incidence rate - 24.96. Group V consisted of men from the areas used for rice growing. The incidence rate -31.55. Group V? comprised men from the areas which were used for cotton growing and where OCPs had been used for control of cotton pests. The incidence rate of male infertility ranged from 44.63 to 50.89 per 100, 000 population. Our studies showed that males living in the vicinity of the former pesticides warehouses and airstrips and who are engaged in cultivation of fruit and vegetables are 7-10 times more likely to develop infertility than those from the same areas but living far from the pesticide warehouses. Investigation of soil showed the concentration level of OCPs at the sites of former pesticide warehouses to be 1.2 g/kg. Thus, the incidence rate of male infertility under conditions of Osh Province of Kyrgyzstan depends on the pollution rate.