Incidence Of Lesions In Patients Research Articles

Incidence of thyroid nodules in early stage autosomal polycystic kidney disease

BackgroundAutosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease. Defect in cilia-mediated signaling activity is a crucial factor leading to cyst formation. Hence, ADPKD is regarded as a systemic disorder with multiple extrarenal complications, including cysts in other organs, for instance, the liver, pancreas, spleen, or ovaries. Interestingly, loss-of-function of primary cilia has been recently found to contribute to a malignant transformation from degenerated thyroid follicles. However, the increased incidence of thyroid nodules in ADPKD patients has not yet been fully confirmed.ObjectivesTo determine the incidence of thyroid lesions in patients with ADPKD in comparison to previous population studies. Moreover, we aimed to investigate if the pace of the disease progression is associated with a higher prevalence of thyroid lesions.Material and methodsIn 49 early-stage ADPKD patients recruited from our center, we performed ultrasonography of the thyroid glands, and laboratory evaluation of thyroids function. We compared the results with population studies.ResultsTwenty-three individuals had solid, cystic-solid, or cystic lesions revealed in the ultrasonography and 2 patients had a positive past medical history for thyroidectomy due to nodular goiter. In 10 patients out of the 23, only minor cysts with no clinical significance were found and 13 out of the 23 patients had solid or cystic-solid lesions, which occurred to be benign based on three years of follow-up or the biopsy of the nodule.ConclusionsWe found no increased incidence of thyroid gland lesions in early ADPKD patients in comparison to previous population studies. Plausibly, mechanisms other than defective cilia signaling are involved in the risk for focal thyroid lesions formation. Moreover, the rate of progression of kidney function decline seems to be not accompanied by the higher incidence of thyroid pathology.

Incidence of Oral Mucosal Lesions in Patients Visiting A Private Dental Institution

Incidence of Oral Mucosal Lesions in Patients Visiting A Private Dental Institution

Cytomorphological study of lymph node lesions

Lymph nodes are important components of peripheral or secondary lymphoid organs which play a huge role in immune response. To study cytomorphological features and incidence of various lymph node lesions in patients ≤18 years. The data has taken from 100 patients of ≤18 years having lymph node lesion presented at central clinical laboratory for Fine Needle Aspiration cytology examination. FNAC was done in all cases & correlated with their clinical data. Interpretation of their cytology examination is showing that in our tertiary care centre most common lymph node lesion in patient ≤18 year is granulomatous lymphadenitis(44%) followed by reactive lymphadenitis (37%), Acute inflammation(06%), Abscess formation (05%), Cystic lesion (03%), and Leukemic infiltration (02%). Most affected age is 6 to 10 years. Granulomatous & Reactive lymphadenitis are common causes of lymphadenitisin ≤18 years age group. Among this study 6-10 years are more affected age group. These result can be obtain by Fine Needle Aspiration cytology examination.

Effect of Immunomodulatory Supplements Based on Echinacea Angustifolia and Echinacea Purpurea on the Posttreatment Relapse Incidence of Genital Condylomatosis: A Prospective Randomized Study.

Introduction. HPV infection is a highly infectious disease; about 65% of partners of individuals with genital warts will develop genital condylomatosis. Only in 20-30% it regresses spontaneously and relapse rates range deeply (9-80%). Echinacea extracts possess antiviral and immunomodulator activities. The aim of this study was to evaluate the efficacy of the therapy, using a formulation based on HPVADL18® (on dry extracts of 200 mg Echinacea Purpurea (EP) roots plus E. Angustifolia (EA)), on the posttreatment relapse incidence of genital condylomatosis. Materials and Methods. It is a prospective single-arm study. Patients with a satisfactory and positive vulvoscopy, colposcopy, or peniscopy for genital condylomatosis were divided into two random groups and subjected to destructive therapy with Co2 Laser. Group A (N=64) immediately after the laser therapy started a 4-month treatment with oral HPVADL18®; Group B (N=61) did not undergo any additional therapy. Patients were subjected to a follow-up after 1, 6, and 12 months. Differences in relapse incidence between the two groups during follow-up controls were evaluated by χ2-test; the groups were stratified by age, gender, and condylomatosis extension degree. Results and Discussion. Gender, age, and condyloma lesions' extension degree showed no statistically significant differences between the two trial groups. The relapse incidence differs statistically between the two studied groups and progressively decreases during the 12 months after treatment in both groups. Statistically significant reduction of relapse rates has been shown in Group A in patients over 25 years old. This difference is significant for both men and women. The relapse incidence is superior in case of extended condylomatosis. Conclusions. In conclusion, the presence of a latent infection causes condylomatosis relapse; in order to reduce the relapse risk an induction of a protective immune response seems to be essential to allow rapid viral clearance from genital areas surrounding lesion and treatment zones. Echinacea promotes this process. EP and EA dry root extracts seem to be a valid adjuvant therapy in reducing relapse incidence of lesions in patients treated for genital condylomatosis.

Incidence of esophageal lesions in patients undergoing ablation for atrial fibrillation with multipolar pulmonary vein ablation catheter (PVAC-GOLD®)

Incidence of esophageal lesions in patients undergoing ablation for atrial fibrillation with multipolar pulmonary vein ablation catheter (PVAC-GOLD®)

387 Ischemic Preconditioning Reduces the Incidence of Postoperative Ischemic Lesions in Patients Undergoing Surgical Resection of Brain Tumors

Abstract INTRODUCTION Postoperative ischemia is a frequent phenomenon in patients with brain tumors and is associated with postoperative neurological deficits and impaired overall survival. Previous clinical and experimental studies have shown that the application of a brief ischemic stimulus not only in the target organ but also in a remote tissue can prevent ischemia. We hypothesized that remote ischemic preconditioning (rIPC) in patients with brain tumors undergoing elective surgical resection reduces the incidence of postoperative ischemic tissue damage and its consequences. METHODS Sixty patients were randomly assigned to two groups, with 1:1 allocation, stratified after tumor type (glioma or metastasis) and previous treatment with radiotherapy. Remote ischemic preconditioning was induced by inflating a blood pressure cuff placed on the upper arm three times for 5 minutes at 200 mmHg in the treatment group after induction of anesthesia. Between the cycles, the blood pressure cuff was released to allow reperfusion. In the control group no preconditioning was performed. Early postoperative MR images were evaluated blinded to randomization for the presence of ischemia and its volume. RESULTS >Fifty-eight of the 60 patients were assessed for occurrence of postoperative ischemia. Of these 58 patients, 44 (75.9%) had new postoperative ischemic lesions. The incidence of new postoperative ischemic lesions was significantly higher in the control group (87.1%) (27/31) than in the rIPC group (63.0%) (17/27) (P = 0.03). The median infarct volume was 0.36 cm3 (IR: 0.0- 2.35) in the rIPC group compared with 1.30 cm3 (IR: 0.29- 3.66) in the control group (P = 0.09). CONCLUSION Application of rIPC significantly reduced the incidence of postoperative ischemic tissue damage in patients undergoing elective brain tumor surgery. This is the first study indicating a benefit of rIPC in brain tumor surgery.

Incidence of Tubal Pre Cancerous Lesions in Patients Undergoing Benign Gynecological Procedures

Incidence of Tubal Pre Cancerous Lesions in Patients Undergoing Benign Gynecological Procedures

An observational study of nasal cavity toxicity in cancer patients treated with bevacizumab

Background: The nasal cavity is a vulnerable zone which may be damaged by vascular disorders. We systematically assessed the frequency and severity of nasal cavity alterations during bevacizumab treatment, to determine its clinical relevance and factors contributing to its onset.Patients and methods: We conducted a hospital-based cohort study in 47 consecutive patients with advanced cancers who were on treatment with chemotherapy and bevacizumab at different doses. All patients underwent otolaryngology (ENT) examination at the time of study initiation.Results: The mean number of cycles at first ENT examination was 16 (standard deviation = 14). A total of 45 patients (96%) showed nose mucosal lesions, of whom 30% had erosions and 62% had grade 1 – 2 epistaxis. One patient had septal perforation. Grades 1 – 4 sinus disorders were noted in 60%. There was a significant trend to a higher risk of grade ≥ 2 nasal events for bevacizumab doses > 7.5 mg/kg, concomitant taxane use and digital nasal self-manipulation.Conclusions: We found a high incidence of nasal cavity lesions in patients receiving bevacizumab, with evidence for a dose-related effect. Most cases were low grade and manageable without drug interruption, but severe toxicity may rarely occur. Oncologists should be aware of this unusual event.

Incidence of Spinal Cord Lesions in Patients With Intractable Constipation

Incidence of Spinal Cord Lesions in Patients With Intractable Constipation

Effective program designed for long-term surveillance following colonoscopic polypectomy of adenomas.

Eighty-six patients who had adenoma and underwent colonoscopic polypectomy were examined by colonoscopy over a long period (mean follow-up time: 5 years) to establish an effective long-term surveillance program. The incidence of neogenetic lesions in patients with a large monoadenoma (diameter 0.5 cm; LA 69.7%) and polyadenoma (PA 74.2%) was higher than in those with a small monoadenoma (diameter <0.5 cm; SA 27.3%). We found 4 and 2 carcinomas in patients with LA and PA, respectively. The high incidence of neogenetic lesions in patients with LA (40.7%) and PA (50.0%) did not decrease with the passage of time. Long-term surveillance with total colonoscopy should be performed every two years in patients with large monoadenoma or polyadenoma for effective detection of neogenetic lesions.

Advances in transesophageal echocardiography for the evaluation of atherosclerotic lesions in thoracic aorta--the effects of hypertension, hypercholesterolemia, and aging on atherosclerotic lesions.

We assessed atherosclerotic lesions in the thoracic aorta in 166 consecutive patients (aged 56 +/- 13 years) by transesophageal echocardiography, and investigated the influences of hypertension, hypercholesterolemia and age on the prevalence of such lesions. Satisfactory images were obtained of all the thoracic aorta, except for a small part of the ascending aorta, by use of a biplane transesophageal probe. We defined atherosclerotic lesions as increased echogenicity of the intima (intimal thickening), raised plaque, calcification, ulceration, or aneurysms. Lesions were observed in 97 patients (58%). The incidence of lesions in patients with hypertension (81%) or hypercholesterolemia (80%) was significantly greater than in those without both conditions (37%, p less than 0.005). The incidence of lesions was significantly increased among patients over 60 years old compared with that in patients under 60 (76% vs 42%, p less than 0.005). Patients without either hypertension or hypercholesterolemia showed a marked increase in the incidence of lesions with age (16% at less than 60 yrs vs. 67% at greater than 60 yrs), and no significant influence of these conditions on the incidence of lesions was found in patients over 60. We conclude that hypertension and hypercholesterolemia might be important risk factors for the development of atherosclerotic lesions in the thoracic aorta in relatively younger patients. Age appears to become a more important determinant of such lesions in Japanese patients over 60 years old irrespective of blood pressure and serum cholesterol levels.

Incidence of arteriosclerotic lesions of the carotid arteries in chronic peripheral arterial disease and myocardial infarction.

Arteriosclerotic lesions in the carotid arteries are the main cause of ischemic cerebral infarction. Only a few studies of the incidence of carotid lesions in patients with chronic peripheral arterial disease (CPAD) and myocardial infarction (MI) have been made. Thus the aim of this study was to investigate the pathoanatomy of the carotid arteries in a representative number of patients suffering from CPAD or MI by using highly sensitive and specific noninvasive methods. RESULTS by other authors are discussed. The authors' own study of cerebrovascular disease (CD), which covers epidemiologic aspects, is presented. "duplex scanning" and continuous-wave Doppler ultrasound. myocardial infarction, N = 73; chronic peripheral arterial disease, N = 112; cerebrovascular disease, N = 73. MI: stenosis greater than 50% N = 31 (42.4% of cases) - in the case of recurring infarction 67.8% of cases; CPAD: stenosis greater than 50% N = 54 (48.2%); CD: stenosis greater than 50% N = 35 (48%).

Incidence of gastric lesions in patients with rheumatoid arthritis and osteoarthritis on chronic aspirin therapy

Incidence of gastric lesions in patients with rheumatoid arthritis and osteoarthritis on chronic aspirin therapy

Incidence of gastric lesions in patients with rheumatic diseases on chronic anti-inflammatory therapy

Incidence of gastric lesions in patients with rheumatic diseases on chronic anti-inflammatory therapy