Incidence Of Different Types Research Articles

An Epidemiological Survey Conducted on Prevalence and Incidence of Different Types of Cancers in Radiotherapy Department, Government General Hospital, Andhra Pradesh: A Prospective Observational Study

An Epidemiological Survey Conducted on Prevalence and Incidence of Different Types of Cancers in Radiotherapy Department, Government General Hospital, Andhra Pradesh: A Prospective Observational Study

Incidence of different types of dystocia in different seasons of the year and parities in Iranian Holstein dairy cows

Incidence of different types of dystocia in different seasons of the year and parities in Iranian Holstein dairy cows

Analysis of defects in coffee beans compared to biplots for simultaneous tables

ABSTRACT The demand for high quality coffee has become a consolidated criterion to achieve the best prices. Currently, cooperatives evaluate the coffee beans mainly through the particle size and the number of defects in the sample. This evaluation type generates counting data that originates contingency tables from different periods or groups involving the same variables in the row and column and there may be interest in knowing if two tables are related and how much are related. These are the so-called combined tables. Statistical analysis techniques normally employed do not include categorical data in the combined tables. The aim of this study was to evaluate the incidence of different types of defects in samples of large flat coffee beans in two different harvests through the construction of biplots. The decomposition theory in single simultaneous values of double entry contingency tables was used. The results of defect counting in beans of 24 coffee samples from southern Minas Gerais, Brazil, were evaluated in the 2014 and 2015 harvests. Moreover, the association among defect types, considered within different total defect proportions in the sample, was verified based on the percentage in 17/18 sieves. It was also evaluated the relative sums of squares from the similarity and dissimilarity among the harvests. It is concluded that the simultaneous analysis technique allows better visualizing the common behavior and alterations among different harvests, distinguishing the defect types associated with each harvest and among different proportions of large flat beans.

A descriptive study of accidental skeletal injuries and non-accidental skeletal injuries of child maltreatment

BackgroundLack of awareness and recognition of child maltreatment is the major reason behind underreporting. All victims often interact with the health care system for routine or emergency care. In several research works, non-accidental fractures are the second most common injury in maltreated children and it is represented up to one-third of cases. Aim of the studyTo determine the incidence of different types of accidental and non-accidental skeletal injuries among children, estimate the severity of injuries according to the modified injury severity score and to determine the degree of fractures either closed or opened (Gustiloe-Anderson open fracture classification). Moreover, identifying fractures resulting from child abuse and neglect. This aimed for early recognition of non-accidental nature of fractures in child maltreatment that can prevent further morbidity and mortality. Patients and methodA descriptive study was carried out on all children (109) with skeletal injuries who were admitted to both Main Alexandria and El-Hadara Orthopedic and Traumatology University Hospitals during six months. History, physical examination and investigations were done for the patients. A detailed questionnaire was taken to diagnose child abuse and neglect. Gustiloe-Anderson open fracture classification was used to estimate the degree of open fractures. ResultsOut of 109 children, twelve cases (11%) were categorized as child maltreatment. One case was physical abuse, eight cases (7.3%) were child neglect and three cases (2.8%) were labour exploitation. Road traffic accidents (RTA) was the commonest cause of skeletal injuries followed by falling from height. Regarding falls, they included 4 cases of stair falls in neglected children and another four cases of falling from height (balcony/window). The remaining 36 cases of falls were accidental. The skeletal injuries were in the form of fractures in 99 cases, dislocation in two cases, both fracture and/or dislocation in three cases, and bone deformity from brachial plexus injury in five cases. Fractures of the lower limb (42.2%) and both bones of the forearm (35%) represented the highest incidence of skeletal injuries in children. 54.5% of fractures due to neglect were lower limb fractures due to falling from height. Ninety-nine cases were diagnosed as long bone fractures and classified as the following; eighty patients as closed fractures, six patients as open grade I fractures, three patients as open grade II fractures, three patients as open grade IIIA fractures, four patients as open grade IIIB fractures and three patients as open grade IIIC fractures. Conclusion and recommendationCases of neglect and child abuse represented 11% of all the studied cases, where neglect was the main cause. RTA and falling from height represented the most common cause of skeletal injury in children. Most fractures due to neglect were lower limb fractures resulting from falling from height. This demonstrates the need for early detection of neglect and child maltreatment aiming for early initiation of parental educational programs about child care and safety. Misinterpretation of skeletal injuries due to neglect or abuse can be avoided by proper training of orthopedic and traumatology staff on signs of child neglect and abuse.

Assessment of depth of olfactory fossa in pre-functional endoscopic sinus surgery computed tomography scan of paranasal sinuses

<p class="abstract"><strong>Background:</strong> <span lang="EN-GB">To evaluate the olfactory fossae depth according to the Keros' classification on pre functional endoscopic sinus surgery (pre-FESS) and determine the incidence and degree of asymmetry in the height of the ethmoid roof in the population of western Maharashtra</span><span lang="EN-IN">. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-GB">Retrospective analysis of 200 multidetector CT studies (400 sides) of paranasal sinuses performed in between January to August, 2017</span><span lang="EN-IN">. </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-GB">According to the Keros’ classification, the incidence of different types of olfactory fossae was as follows: type I: 18.5%, type II: 74.5% and type III: 7%. Asymmetry in the ethmoid roof height was found in 11.5% of cases</span><span lang="EN-IN">. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-GB">Keros’ type II was the commonest followed by type I and type III. There was asymmetry in the depth of the olfactory fossae in 11.5% cases. There was no significant gender predilection as far as type and asymmetry were considered</span><span lang="EN-IN">.</span></p>

Perinatal and follow-up outcome study of fetal anomalies with multidisciplinary consultation.

SynopsisThe establishment of a multidisciplinary consultation system is necessary for the diagnosis of complicated fetal anomalies.PurposeWe aimed to investigate the incidences of different types of fetal anomalies and the influence of multidisciplinary consultation on fetal prognosis.Patients and methodsMultidisciplinary specialists include obstetricians, pediatricians, pediatric surgeons, and experts of ultrasound department and genetic counseling. Consultation was done if the fetal ultrasound examinations showed abnormality. Follow-up, assistance, and guidance for the fetus were achieved by phone calls.ResultsUltrasound screening showed that the incidences of central nervous system anomaly and genitourinary anomaly were 25.80% (275/1,066) and 22.05% (235/1,066), respectively. The detection rates of fetal anomalies were 5.07% (54/1,066), 36.12% (385/1,066), and 58.82% (627/1,066) in pregnant women with gestational age of <20, 20–28, and >28 weeks, respectively. In addition, the fetal cerebral ventriculomegaly accounted for 40.73% of central nervous system malformation, while 71.43% cases with fetal cerebral ventriculomegaly were alleviated during the follow-up period. The proportion of hydronephrosis in genitourinary anomalies was 50.64%, and the remission rate of hydronephrosis was 67.23% during the follow-up period.ConclusionThe establishment of a multidisciplinary consultation system is necessary for the diagnosis of complicated fetal anomalies. The central nervous system anomaly and genitourinary anomaly are the most common fetal anomalies. In addition, the remission rates of cerebral ventriculomegaly and fetal hydronephrosis are high during the follow-up period.

A clinico-pathological study of posterior triangle neck swelling: a case series

Background: The neck swelling is often surrounded by mystique in arriving at a diagnosis as well as in its management. There are many good approaches to a patient with a swelling in the neck.Methods: This study was done in Dr. D. Y. Patil Medical College Hospital and Research Centre, Pune. In this study, we have taken 30 cases in study group. Only posterior triangle neck swellings were considered during the study. Clinico-pathological co-relation was done during the study.Results: In the present study group of 30 patients we found 10 patients to be having Lymphadenitis which includes both tuberculous and non-tuberculous, 8 patients to be having lipoma, 4 patients to be having neck secondaries, 2 patients of cystic hygroma and 6 nonspecific causes like cavernous haemangioma, madelung disease, Kikuchi Fujimoto disease. Further histological co-relation was done.Conclusions: Incidence of different types of neck swellings were found and rare diseases like Madelung’s disease and Kikuchi fujimoto’s disease.

Adverse drug reactions of antihypertensive agents at tertiary care hospital in central Nepal

Background &amp; Objectives: Acute Hypertension is the most common condition seen in primary care and leads to myocardial infarction, stroke, renal failure, and death if not detected early and treated appropriately. The study was conducted with the objective to examine the incidence of different types of adverse drug reactions in drug treated hypertensive patients.Materials &amp; Methods: Patients (n=382) who received antihypertensive agents were selected and interviewed using a standardized questionnaire. The Naranjo Algorithm, which categorizes the causality relationship into definite, probable, possible and doubtful, was used for the assessment of the exact nature of Adverse drug reaction (ADR).Results: Calcium channel blockers (CCBs) were the drug class with highest number (22 or 32.84%) of ADRs followed by Angiotensin-converting enzyme Inhibitors (ACEI) in 17 (25.38%), Angiotensin Receptor Blockers (ARB) in 12 (17.91%), diuretics in 10 (14.92%) and beta adrenergic antagonist in six (8.95%). Cardiovascular system (40 or 59.70%) was the most affected followed by central nervous system (16 or 23.88%) and respiratory and dermatological system each in 11 (16.42%) cases. On Naranjo’s probability scale, nine (13.4%) of the ADRs were definite, 39 (58.2%) possible, 16 (23.9%) probable and three (4.5%) doubtful. Conclusion: Calcium channel blockers were mostly associated with ADRs while Cardiovascular system was the most frequently affected.

The efficacy of active drainage for preventing postoperative organ/space surgical site infections in patients with Crohn’s disease

Patients with Crohn's disease (CD) show a higher incidence of surgical site infections (SSIs) after bowel resection in comparison to other patient populations because CD patients commonly suffer from anemia, malnutrition, and immunosuppression. In comparison to conventional passive drainage, active drainage using a closed-suction drain reportedly reduces postoperative wound-related complications in several diseases. In the present study, we aimed to investigate the incidence of SSI and to identify the risk factors for SSI in patients with CD. We retrospectively analyzed the patient characteristics and perioperative data of 106 CD patients who underwent bowel resection at our institution between January 2000 and June 2016. We statistically analyzed the incidence of different types of SSI (overall, incisional, and organ/space) in relation to patient-related and surgery-related risk factors. Overall postoperative SSIs were diagnosed in 19 patients (17.9%), including incisional SSI (n=16; 15.1%), organ/space SSI (n=7; 6.6%), and both (n=4; 3.8%). A long operative time (p=0.036) and colonic involvement (p=0.011) were significantly associated with the overall risk of developing an SSI. Active drainage significantly reduced the incidence of organ/space SSI (p=0.037). Intraabdominal active drainage was more useful than passive drainage for preventing organ/space SSI development.

Study of risk factors among stroke patients in a tertiary hospital of Northern India

Background: Stroke is one of the leading causes of death and disability worldwide. The aim of the study was to find out the incidence of different types of strokes and the associated risk factors and to establish the role of different investigations in patients of stroke.Methods: The study dealt with 100 patients of stroke who were admitted to B. R. D. Medical College, Gorakhpur, India. Each patient was analyzed in detail about clinical presentation and the investigations were aimed to establish the pathologic type of stroke and estimation of risk factors.Results: Stroke incidence was more in males (Male: Female= 1.43:1). Maximum incidence of stroke was in 6th decade (32%) followed by 7th decade (30%). Among modifiable risk factors, history of hypertension was the commonest (51%) followed by smoking (36% patients) exclusively, found in males. Hemiparesis was the most common presentation (95%) followed by altered sensorium (55%). Chest X-ray was abnormal in 16% patients, abnormal ECG was found in 27% patients and abnormal lipid values were found in 54 patients.Conclusions: Apart from control of hypertension and diabetes, abnormal lipid profile remains an important modifiable risk factor for stroke.

ACADEMIC MISCONDUCT: CATEGORIES AND ANTICIPATION PROCEDURES IN PHYSICAL EDUCATION

The aim of the present research is to investigate the impact of anticipation procedures on the incidence of different types of academic misconduct in physical education and sport. Plagiarism is a persistent manifestation and scholastic structures have had to deal with. The used method of this investigation is descriptive, in terms of implementation, it is a survey, and in terms of purpose, it is practical. Figures for this study were collected using a researcher-constructed questionnaire. Its validity was definite by a number of sports management faculty and its reliability calculated 87/0 with Cronbach's alpha. The questionnaire was designed with a Likert scale of 5 values. The participants of the study include physical education students all over the country. Based on geographic regions of the country, five universities selected from the North, South, East, West and center of the country all of which were graduate students of physical education. The statistical sample of the study included graduate. The selection of sample was available by stratified-Stochastic sampling method. Sample size in five colleges determined, based on the number of graduate students of this five faculty and using Morgan table. The findings show the importance of prevention methods, especially the knowledgeable observers and judges at various stages of research in occurring academic misconduct. Article visualizations:

Simulation Models of Misclassification Error for Single Thresholds of High-Sensitivity Cardiac Troponin I Due to Assay Bias and Imprecision.

Clinical outcome studies for cardiac troponins (cTn) are expensive and difficult to design owing to variation in patients, in the assays, and in the incidence of different types of myocardial infarction (MI). To overcome these difficulties, simulation models were used to estimate the rate of misclassification error for MI and risk prediction resulting from assay bias and imprecision. Finite mixture analysis of Abbott high-sensitivity cTnI (hs-cTnI) results at time 0 h in patients presenting early with acute coronary syndrome (ACS) symptoms to the emergency department (ED) [n = 145, Reducing the Time Interval for Identifying New Guideline (RING) study] allowed derivation of a simulation data set (n = 10000). hs-cTnI concentrations were modified by addition of bias or imprecision error. The percentage of all 10000 modified hs-cTnI results that were misclassified for MI at thresholds of 2, 5, 26.2, and 52 ng/L was determined by Monte Carlo simulation. Analyses were replicated with an all-comer emergency department (ED) population (n = 1137) ROMI (Optimum Troponin Cutoffs for ACS in the ED) study. In the RING study, simulation at 26.2-ng/L (99th percentile) and 52-ng/L thresholds were affected by both bias ±2 ng/L and imprecision (10%-20%) and had misclassification rates of 0.4% to 0.6%. Simulations at the 2-ng/L and 5-ng/L thresholds were only affected by bias. Misclassification rates at bias of ±1 ng/L were 10% for the 2-ng/L threshold, and 5% for the 5-ng/L threshold. Simulation models predicted that hs-cTnI results are seldom misclassified (<1% of patients) when interpretative thresholds are near or exceed the overall 99th percentile. However, simulation models also predicted that low hs-cTnI results, as recommended in guidelines, are prone to misclassification of 5%-10% of patients.

Quantitative analysis of the effect of institutional case volume on complications after surgical clipping of unruptured aneurysms.

OBJECTIVE The mechanism by which greater institutional case volume translates into improved outcomes after surgical clipping of unruptured intracranial aneurysms (UIAs) is not well established. The authors thus aimed to assess the effect of case volume on the rate of various types of complications after clipping of UIAs. METHODS Using information on the outcomes of inpatient admissions for surgical clipping of UIAs collected within a national database, the relationship of institutional case volume to the incidence of different types of complications after clipping was investigated. Complications were subdivided into different categories, which included all complications, ischemic stroke, intracerebral hemorrhage, medical complications, infectious complications, complications related to anesthesia, and wound complications. The relationship of case volume to different types of complications was assessed using linear regression analysis. The relationships between case volume and overall complication and stroke rates were fit with both linear and quadratic equations. The numerical cutoff for institutional case volume above and below which the authors found the greatest differences in mean overall complication and stroke rate was determined using classification and regression tree (CART) analysis. RESULTS Between October 2012 and September 2015, 125 health care institutions reported patient outcomes from a total of 6040 cases of clipping of UIAs. On linear regression analysis, increasing case volume was negatively correlated to both overall complications (r2 = 0.046, p = 0.0234) and stroke (r2 = 0.029, p = 0.0557) rate, although the relationship of case volume to the complication (r2 = 0.092) and stroke (r2 = 0.067) rate was better fit with a quadratic equation. On CART analysis, the cutoff for the case number that yielded the greatest difference in overall complications and stroke rate between higher- or lower-volume centers was 6 cases/year and 3 cases/year, respectively. CONCLUSIONS Although the authors confirm that increasing case volume is associated with reduced complications after clipping of UIAs, their results suggest that the relationship between case volume and complications is not necessarily linear. Moreover, these results indicate that the effect of case volume on outcome is most evident between very-low-volume centers relative to centers with a medium-to-high volume.

Incidence of Different Types of Head Injury Patients and their Functional Outcomes-An Experience in a Superspeciality Hospital

Incidence of Different Types of Head Injury Patients and their Functional Outcomes-An Experience in a Superspeciality Hospital

Correlation between the Cernea Classification of External Branch of Superior Laryngeal Nerve in Relation to the Ultrasound-based Volume of Thyroid Gland.

Introductíon:Goiter is a very common problem dealt with by surgeons. Surgical treatment of thyroid requires removal of a part (hemi) or whole of the gland (total thyroidectomy). The external branch of the superior laryngeal nerve (EBSLN) is an important but less researched structure to be preserved during surgery. Various studies have described the incidence of different types of EBSLN, but have not described regarding the relationship between the change in volume of the gland to the nerve.Materials and Methods:A prospective analysis of 100 patients who underwent total thyroidectomy in our department was done. All patients underwent preoperative ultrasonography and the volume of the gland was calculated. Intraoperatively, the EBSLN was identified and preserved prior to ligating the superior thyroid vessels. The nerve was classified as per the Cernea classification. The gland was divided into high and low volume, taking 20 ml as the cutoff. The incidence of Type 2 nerve in a low-volume gland was compared with that of a high-volume gland.Results:In 100 patients (200 nerves), 191 nerves were identified. The nerve was type 1 in 56/200 (28%), Type 2a in 116/200 (58%), and Type 2b in 19/200 (9%) patients. In large-volume glands, Type 2 nerve was more common (87%).Conclusion:Dissection of thyroid gland requires expertise to preserve the EBSLN. Large volume glands pose a more difficult challenge, as the gland is more closer to the nerve.

Potential Anticarcinogenic Effects of Lactic Acid Bacteria and Probiotics in Detoxification of Process-Induced Food Toxicants

Context: Nowadays, it has been proved that there is a relation between dietary habits and incidence of different types of cancers. Consumption of processed foods exposes human to a wide range of toxicants such as heterocyclic aromatic amines, polycyclic aromatic hydrocarbons, acrylamide and nitrosamines that have mutagenic and carcinogenic effects on body and especially induce colon cancer. Under such circumstances, search for antimutagenic agents and helpful strategies have gained interest. Evidence Acquisition: We performed a computerized search of Scopus, Pubmed and google scholar databases with keywords: cancer, food toxicants, lactic acid bacteria, and probiotics. Results: Natural dietary compounds like lactic acid bacteria and probiotics can be beneficial in decline of detrimental effects associated with toxicants formed during food processing. It has been stated that binding ability of lactic acid bacteria and probiotics via their cell wall have prominent roles in detoxifying these toxicants. Also, this capability is influenced by various factors. Conclusions: It can be concluded that probiotics can play a vital role in prevention of colon cancer that is induced by food toxicants and their incorporation into food can be helpful in this respect. Keywords: Anticarcinogenic; Cancer; Food Toxicants; Lactic Acid Bacteria; Probiotics

The incidence of dysrhythmias after administration of the antipsychotic olanzapine

Abstract We evaluated the effect of the antipsychotic olanzapine on electrical activity of rat hearts under conditions of ischemic- reperfusion injury. We focused on the prolongation of the corrected QT interval as a risk factor for the incidence of different types of dysrhythmias. Pretreatment with olanzapine showed prolongation of the corrected QT interval as well as increased incidence of dysrhythmias in following order: ventricular premature beats &gt; bigeminies &gt; trigeminies &gt; salvos. We also observed an increase in the frequency of episodes of ventricular tachycardia of about 64% and the average duration of ventricular tachycardia was more than doubled under the conditions of the ischemic-reperfusion injury.

PREVENTION METHODS AND TYPES OF ACADEMIC MISCONDUCT

Purpose and Background: The purpose of the present study is to examine the influence of prevention methods on the incidence of different types of academic misconduct. Plagiarism is a pervasive occurrence and educational systems have had to deal with it and paid a lot because of it for a long time. Methodology: The method of this study is descriptive, in terms of implementation, it is a survey, and in terms of purpose, it is practical. Data for this study were collected using a researcher-constructed questionnaire. Its validity was confirmed by a number of sports management faculty and its reliability calculated 87/0 with Cronbach's alpha. The questionnaire was designed with a Likert scale of 5 values. The participants of the study include physical education students all over the country. Based on geographic regions of the country, five universities selected from the North, South, East, West and center of the country all of which were graduate students of physical education. The statistical sample of the study included graduate students of Physical Education in Tehran, Shiraz, Kurdistan, Mazandaran and Mashhad Universities. The selection of sample was available by stratified-Stochastic sampling method. Sample size in five colleges determined, based on the number of graduate students of this five faculty and using Morgan table. Results: The findings show the importance of prevention methods, especially the knowledgeable observers and judges at various stages of research in occurring academic misconduct. Conclusion: In order to deal with all kinds of academic misconduct, the directors of the affair must give special attention to the prevention methods, especially the knowledgeable observers and judges as an affecting factor in the incidence of academic misconducts. Article visualizations:

Efficacy and Safety of Neurokinin-1 Receptor Antagonists for Prevention of Chemotherapy-Induced Nausea and Vomiting: Systematic Review and Meta-analysis of Randomized Controlled Trials

Can addition of neurokinin-1 receptor antagonists (NK1-RAs) be considered as an ideal strategy for the prevention of chemotherapy-induced nausea and vomiting (CINV)? Researchers differ on this question. Electronic databases were searched for randomized control trials (RCTs) that evaluated the effectiveness and safety of NK1-RAs in preventing CINV. The primary end point was complete response (CR) in the acute, delayed, and overall phases after chemotherapy. Subgroup analyses evaluated the types of NK1-RAs, routines of administration, types of malignancies, regimens used in combination with NK1-RAs, and age of patients included in the studies. The incidences of different types of adverse events were also extracted to estimate the safety of NK1-RAs. A total of 38 RCTs involving 13,923 patients were identified. The CR rate of patients receiving NK-RAs was significantly higher than patients in the control groups during overall phase (70.8% vs 56.0%, <0.001), acute phase (85.1% vs 79.6%, <0.001), and delayed phase (71.4% vs 58.2%, <0.001). There were three studies including patients of children or adolescents, the CR rate was also significantly higher in the treatment group (overall phase: OR=2.807, <0.001; acute phase: OR=2.863, P =0.012; delayed phase: OR=2.417, <0.001). For all the other outcomes, patients in the NK1-RAs groups showed improvements compared to the control groups (incidence of nausea: 45.2% vs 45.9%, <0.001; occurrence of vomiting: 22.6% vs 38.9%, <0.001; usage of rescue drugs: 23.5% vs 34.1%, <0.001). The pooled side effects from NK1-RAs did not significantly differ from previous reports and the toxicity rates in patients less than eighteen years old also did not diff between the two groups (P=0.497). However, we found that constipation and insomnia were more common in the patients of control groups, whereas diarrhea and hiccups were more frequently detected in patients receiving NK1-RAs. NK1-RAs improved the CR rate of CINV. They are effective for both adults and children. The use of NK1-RAs might be associated with the appearance of diarrhea and hiccups, while decreasing the possibility of constipation and insomnia.

Direct inhibition of oncogenic KRAS by Bacillus pumilus ribonuclease (binase)

RAS proteins function as molecular switches that transmit signals from cell surface receptors into specific cellular responses via activation of defined signaling pathways (Fang, 2015). Aberrant constitutive RAS activation occurs with high incidence in different types of cancer (Bos, 1989). Thus, inhibition of RAS-mediated signaling is extremely important for therapeutic approaches against cancer. Here we showed that the ribonuclease (RNase) binase, directly interacts with endogenous KRAS. Further, molecular structure models suggested an inhibitory nature of binase-RAS interaction involving regions of RAS that are important for different aspects of its function. Consistent with these models, phosphorylation analysis of effectors of RAS-mediated signaling revealed that binase inhibits the MAPK/ERK signaling pathway. Interestingly, RAS activation assays using a non-hydrolysable GTP analog (GTPγS) demonstrated that binase interferes with the exchange of GDP by GTP. Furthermore, we showed that binase reduced the interaction of RAS with the guanine nucleotide exchange factor (GEF), SOS1. Our data support a model in which binase-KRAS interaction interferes with the function of GEFs and stabilizes the inactive GDP-bound conformation of RAS thereby inhibiting MAPK/ERK signaling. This model plausibly explains the previously reported, antitumor-effect of binase specific towards RAS-transformed cells and suggests the development of anticancer therapies based on this ribonuclease.