Incidence Of Anticardiolipin Antibodies Research Articles

Incidence of arteriovenous thrombosis and the role of anticardiolipin antibodies in hemodialysis patients.

Fistula thrombosis in patients on maintenance hemodialysis is an important morbidity factor. Arterial or venous thrombotic events have been described as complications in patients on regular hemodialysis and positive titers of anticardiolipin antibodies (ACLA). This study was designed to evaluate the prevalence of ACLA in hemodialysis patients and it's relation to arteriovenous fistula (AVF) thrombosis. 218 patients with AVF on maintenance hemodialysis were studied prospectively during a period of 14 months for any episode of AVF thrombosis (AVFT), after ACLA was assayed by ELISA in 171 ones. Other risk factors for thrombosis such as presence of diabetes, hypotension during dialysis, using of erythropoietin (rEpo), fistula site, gender, age, dialysis duration, and type of dialyser membrane were accessed. 56% of the patients had IgG ACLA = 10 GPL which was significantly correlated with dialysis duration (23.18 +/- 24.56 months in patients with ACLA = 10 GPL vs 37.73 +/- 36.35 months in patients with 20 = IgG ACLA < 40 GPL). Within 14 months follow up, 39 episodes of AVFT occurred in 34 patients (15.8%). Dialysis duration prior to start of study was 29.16 +/- 22.04 months. In our patients radiocephalic AVFs showed more thrombosis than brachiocephalic ones (23% vs 10%, p = 0.01 by Chi-square). Age more than 50 years old was a risk factor for AVFT (p = 0.034 by Chi-square). Also erythropoietin use (p = 0.011 by chi-square) and ultrafiltration more than 3 liters (average value of 14 months) were correlated with AVFT (p = 0.042 by Chi-square), but there wasn't any correlation between diabetes, presence of ACLA, hypotension during dialysis, gender, and dialysis membranes with AVFT. Ultimately, logistic regression analysis of factors associated with thrombosis was done and only fistula site (p = 0.015, O.R. = 2.87), and Eprex use (p = 0.031, O.R. = 4.05) showed significant correlation with AVFT. Although incidence of anticardiolipin antibodies was high in our patients, we found no correlation between IgG ACLA and AVFT. Instead, we found that radiocephalic fistulas and Eprex injection were risk factors for AVFT.

Young Women With Advanced Aortoiliac Occlusive Disease: New Insights

We identified a group of 24 young (less than 50 years of age) women with isolated, premature atherosclerotic aortoiliac occlusive disease and attempted to identify distinguishing hemostatic characteristics. Most of these patients (62%) presented with acute thromboembolic events (blue toe syndrome, n = 6; macroemboli, n = 6; or aortoiliac thrombosis, n = 3). Aortoiliac reconstruction (aortoiliac endarterectomy, n = 10, aortobifurcation bypass grafts, n = 6; and percutaneous angioplasty, n = 4) was complicated by early thrombosis in 6 of 20 cases (30%), (1 of 10 endarterectomies, 4 of 6 bypass grafts, and 1 of 4 angioplasties). Fresh thrombus overlying an atherosclerotic plaque was a common finding at surgery. This observation and the relatively high incidence of thromboembolic events led us to hypothesize that a characteristic hemostatic profile might underlie the remarkably similar clinical presentations of these women. Levels of antiphospholipid antibodies (anticardiolipin antibodies and lupus anticoagulant), plasminogen activator inhibitor-1, fibrinogen, antithrombin III, protein C, protein S, plasminogen, prothrombin fragment F1 + 2, and D-dimer were determined for these young women and for 21 age-matched white female control subjects without vascular disease and nine white male patients with aortoiliac occlusive disease (mean 61 years, range 43 to 74 years). The incidence of anticardiolipin antibodies was 42% (8 of 19) in the female patients, which was significantly elevated (p = 0.028). The female (62.5%) and male (100%) patients had significantly elevated D-dimer levels (p < 0.001). Deficiencies of antithrombin III, protein C, and protein S were rare. A unique pattern of premature aortoiliac atherosclerosis exists in some young women. Intra-arterial thromboembolic events are common at presentation and complicate surgical management. The role of antiphospholipid antibodies remains uncertain.

Anticardiolipin antibodies in Behçet's syndrome: a predictor of a more severe disease.

A high incidence of anticardiolipin antibodies were detected in 7 of 20 patients (35%) with Behçet's Syndrome. Three patients had IgG-ab, three had IgM-ab and one had both IgG and IgM antibodies. IgG-ACA was detected mainly in patients with ocular disease (30%) and one of them also has cerebral vascular disease. A lower incidence of ACA was found in the patients taking steroids compared with the ones taking other drugs. This work draws attention to the more severe disease present in patients with ACA and also the possibility of such tests become negative in patients taking immunosuppressive drugs.