Objective To discuss the relationship between pregnant outcomes and increased fetal nuchal translucency (NT),and to predict adverse outcomes of fetus with NT.Methods One thousand eight hundred and thirty-nine women who had their antenatal visits in the First Affiliated Hospital of Kunming Medical University from February 13,2009 to May 16,2010 were admitted into the study.Crown rump length (CRL) and NT of fetus were measured following the guideline of Fetal Medicine Foundation.Pregnant outcomes were followed-up.The cut-off points of high risk of adverse pregnant outcome were set as NT≥2.0 mm,2.5 mm,3.0 mm,3.5 mm or 4.5 mm.Receiver operating characteristics (ROC) curve was drawn at different cut-off points to estimate the value of NT to predict adverse pregnancy outcomes.Differences between sensitivity and false positive rate were analyzed by Chi-square test or Fisher's exact test.Results The adverse outcome rate in this population was 2.7% (49/1839).The positive likelihood ratios of NT≥2.0 mm,2.5 mm,3.0 mm,3.5 mm and 4.5 mm for adverse outcomes were 1.6,3.4,12.4,51.0 and 92.0,respectively; and the incidences of adverse outcomes were 2.7%,1.0%,4.0%,17.0% and 75.0%,which rose with the increase of NT.Area under ROC curve for adverse outcomes was 0.647 with 95%CI of 0.561-0.732.Conclusions NT increase is related to adverse pregnant outcomes.The predictive value of different NT for the incidence of adverse outcomes might provide evidence for clinical consultation.NT is applicable in predicting adverse outcomes. Key words: Nuchal translucency measurement; Uitrasonography, prenatal; Pregnacy outcome; ROC curve