Abstract In the digital world of remarkable technological advancements, the detection of cervical cancer at early stages is of important clinical significance as it can vastly improve the survival rate during treatment. Cervical cytopathology, often known as a Pap test is the frequently adopted screening method for cervical cancer. However, the test seems to be effective but investigation of images containing Pap smear with the help of a microscope is a difficult as well as laborious exercise. The procedure for the same demands an expert in the area and is often time-consuming. The serious pitfalls in subjective clinical evaluation evoke the need of developing an automated system for more reliable cervical cancer diagnosis. Therefore, the goal of this study primarily focuses on designing a Deep learning model to process the Pap smear images and correctly classify the cervical cells. For this purpose, firstly, a publically available dataset namely SIPaKMeD is utilized. Then, different data pre-processing methods are applied to intensify the data quality for effective analysis. Next, a novel stacking model is proposed that leverages a Support Vector Classifier (SVC) as a Meta model over a combination of different Transfer Learning Models including VGG16, ResNet101, InceptionV3, Xception, DenseNet169, and Inception ResNet. Furthermore, the dense layers are added to tune the underlying base transfer learning models to learn fine-tuned adaptive weights. The results obtained from experimental evaluation demonstrate the efficacy of the proposed stacking model by yielding the highest accuracy rate of 95.66% in comparison to other employed methods and existing state-of-the-art techniques.
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