Previous dehydration studies have emphasized almost exclusively acute dehydration in white rats or larger laboratory mammals. There is little information on rodents smaller than rats, or on the effects of chronic dehydration on any sized mammal. In order to study dehydration uncomplicated by other changes, such as starvation, it may be necessary to cause water loss quickly— by forced diuresis (see Brokaw, 1949) or forced extrarenal loss by exposure to heat (Adolph, 1947). But, as pointed out by Brokaw, an animal's response to and toleration of a rapidly developing dehydration may be quite different from that of a slowly occurring water loss. There are fairly numerous reports of casual, limited observations of the general effects of water deficiency on small wild rodents (see review by Schmidt-Nielsen, 1952), but there have been few serious studies. The latter include studies of survival time on reduced water rations (Lindeborg, 1952), measurement of energy metabolism and water exchanges on extremely reduced water intakes (Chew, 1951), and measurement of water balance and kidney function in rodents on air-dry diets (Schmidt-Nielsen, 1952). Changes in the blood and in the water compartments of mice on restricted water intakes is an unexplored field. The physiological effects of inadequate water intake or excessive water loss are varied: starvation (Adolph, 1947; Brokaw, 1949), reduction in blood volume, with edema (Dicker, 1949) or without edema (Adolph, 1947), failure of renal responsiveness to water load (Dicker, 1949), concentration of body fluids (Black et al. , 1944), and cell dehydration (Winkler et al. , 1944). Death that may occur during dehydration has been attributed to circulatory collapse (Adolph, 1947; Brokaw, 1949) and cell dehydration (Black et al. , 1944; and others), but not to starvation, although starvation has been mentioned as a complication. The object of the present study has …
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