Injection of polymer solutions has been recognized as an effective means to improve oil recovery. Prior to full-scale implementation, an extensive numerical simulation is essential to provide evaluation and development of the optimum design of polymer flood process. This article presents numerical investigations of a two-well model in a five-spot pattern operating under polymer flood process. A three-dimensional numerical model for fluid flow and mass transport is used to analyze the performance of the reservoir. The model includes the effects of polymer concentration-dependent viscosities, shear-thinning rheology of the polymer solution, shear degradation, polymer adsorption onto the reservoir rock, and inaccessible pore volume. The design variables include polymer concentration, slug size, and water salinity. For different parameters of the system, performances were compared in terms of cumulative recovery and water-oil ratio at the production well and pressure drop at the injection well. Properties of polymer bank such as concentration and size are shown to impact the predicted recovery. But salinity of the make-up water has a minimal effect on the performance of the process.