Deformation anisotropy and re-orientation for α phase during isothermal compression of TC17 alloy with basketweave microstructure were investigated systematically by quantitative analysis the influence of tilt angle between compression axis and c-axis on LABs density, rotate factor and ratio of activated slip system. The test results revealed that the tilt angle between compression axis and c-axis affects the deformability of α grain by affecting the rotation tendency and the number of activated slip systems. It results in the different prone of lamellar α with different orientation to globularization. Therein, the variation of the rotation factor with tilt angle conforms to the quadratic function, reaching a maximum value around 45°. When the rotation factor is small, the ratio of (01–11) [1–210] slip system with small Burgers vector at the phase boundary is large, the rotation tendency is poor, and the intragranular dislocation slip replaces the grain rotation as the strain accommodation mechanism, the lamella is more prone to globularization. And when the tilt angles are between 0°–13°, 13°–35°, 35°–78° and 78°–90°, the most easily activated slip systems are pyramidal <a+c> slip, basal <a> slip, pyramidal <a> slip and prismatic <a> slip, respectively. The more slip systems may be activated, the lamella is more prone to globularization. In addition, isothermal compression destroys the initial preferred orientations of the α grains and causes the lamellar α to rotate towards the direction that forms (0 0 0 1) plane texture, which is formed due to the activation of the prismatic <a> slip. Then, the (0 0 0 1) plane texture will be weakened due to a large number of randomly oriented grains generated by recrystallization under larger height reduction.