Introduction: Despite the lower incidence of cardiac arrest in women, their rates of survival to hospital discharge are poorer compared to men. To further examine this disparity in outcomes following cardiac arrest, we assessed the differences in outcomes among patients hospitalized after successful resuscitation. We utilized data from the National Inpatient Sample Database (NIS) for this evaluation. Methods: We conducted a query of the NIS spanning the years 2015 to 2019 to identify patients who experienced cardiac arrest. Subsequently, we categorized the sample based on gender. The primary outcome measured was in-hospital mortality. To calculate the adjusted odds ratios (aOR) of in-hospital outcomes, we employed multi-logistic regression analysis using STATA v.17. Results: Among the 874,745 weighted hospitalizations related to cardiac arrest, 56.91% were men and 43.09% were women. After adjusting for confounding factors, we observed that women who were successfully resuscitated from cardiac arrest had significantly higher rates of adverse outcomes compared to men. These outcomes included in-hospital mortality (aOR 1.092, 95% CI 1.07-1.10, p<0.001), stroke (aOR 1.19, 95% CI 1.14-1.24, p<0.001), pericardial effusion (aOR 1.14, 95% CI 1.09-1.18, p<0.001), and pacemaker placement (aOR 1.20, 95% CI 1.15-1.25, p<0.001). However, major bleeding occurred less frequently in women (aOR 0.93, 95% CI 0.90-0.96, p<0.001). Although the total cost of hospitalization was higher for men ($172,021 ± 267,161 vs $149,718 ± 241,244), the length of stay was similar for both groups. Conclusions: Our study highlights significant gender-based disparities in post-cardiac arrest patients, with women experiencing poorer overall outcomes. Future qualitative studies should focus on identifying risk factors and improving post-resuscitation care specifically for women, with the aim of reducing gender-based differences in clinical outcomes.