AbstractWith the development of health consciousness and growing of the aging population, the healthcare demand becomes more and more important. At the same time, recent rapid growth in mobile computing technologies enables telemedicine applications operations on mobile devices. The technologies and demands accelerated different kinds of home-based devices for the aged healthcare and medical treatment. Our focus is on the design of an information system for in-home healthcare, and a new household acquisition terminal device which integrated electrocardiogram (ECG), blood oxygen, blood pressure and body temperature acquirement functions. A set-top box based manipulation method was adopted for operators, the physiological data could be acquired by the corresponding detectors. The parameters were collected and transmitted by set-top box and were received by the data server and sent to the medical staff of a hospital or healthcare center, professional healthcare advice or clinical diagnosis would be provided. Simultaneously, the collected parameters and the feedback clinic advice was stored on the servers which could be accessed by long distance clients such as a mobile smart phone user. The proposed system involved multiple physiologic parameters which led to great potential for universality, and in the terminal side the set-top box and IPTV screen shared scenario brought ease of use. Further progresses were made in the product upgrade because the shared IPTV screen was employed, which might be improved with the family demand. The acquirement instrument got a certification of China State Food and Drug Administration. The entire system was built for commercial achievements and the acquired data had great potential in disease screening and public hygiene research.