Impulsive Personality Research Articles

Eveningness and Impulsivity in Euthymic Mood States Adversely Affect the Quality of Life of Major Depression and Bipolar Disorder Patients

Objective: Chronotype and impulsivity are important features to be examined in mood disorder patients; these characteristics precede mood disorder onset and persist between mood episodes. Moreover, quality of life is an important outcome in psychiatric patients. This study investigated the interaction between these features and its effect on mood disorder patient’s quality of life.Methods: Early-onset major depressive disorder (MDD), bipolar disorder I (BD I), and bipolar disorder II (BD II) patients were recruited. Excluding 18 patients who were missing data on main variables and 5 patients who were classified as severely ill, a total of 472 euthymic patients (MDD=167, BD I=133, BD II= 172) were assessed on their chronotype, trait impulsivity, and quality of life using self-reports.Results: Both impulsivity and eveningness were negatively associated with quality of life. Regression results showed that there was a significant interaction effect between eveningness and impulsivity on quality of life. This indicates that the higher the level of impulsivity in mood disorder patients, the negative effect of eveningness on quality of life increased.Conclusion: The current study suggests that examination of impulsive personality in relation to chronotype may be important in further understanding the effects of these features on mood disorder patients’ lives.

Impulsive Personality Traits Predicted Weight Loss in Individuals with Type 2 Diabetes after 3 Years of Lifestyle Interventions.

Impulsivity has been associated with type 2 diabetes (T2D) and may negatively impact its management. This study aimed to investigate impulsive personality traits in an older adult population with T2D and their predicting role in long-term weight control and glycemic management, through glycated hemoglobin (HbA1c), following 3 years of intervention with a Mediterranean diet. The Impulsive Behavior Scale (UPPS-P) was administered as a measure of impulsive traits at baseline. Results showed higher total baseline scores of UPPS-P, and higher positive urgency in individuals with T2D, compared with those without T2D. The regression analysis in patients with T2D showed that sensation seeking and lack of perseverance predicted weight loss at follow-up. By contrast, impulsive traits did not predict follow-up levels of HbA1c. In conclusion, the present findings suggest that higher impulsive traits in individuals with T2D seem to affect long-term weight control, but not glycemic control.

Aripiprazol and Hypersexuality: when partial is to much

IntroductionA growing number of published cases has showed that hypersexual behavior may arise with treatment with second-generation antipsychotics, including aripiprazole and olanzapine. Aripiprazole is a second-generation antipsychotic commonly used to treat schizophrenia and bipolar disorder. It has a unique pharmacologic profile acting as a partial agonist of the dopamine D2 receptor, as a partial agonist at the 5-HT1A receptor, and as an antagonist at the 5-HT2A receptor. Literature shows that medication with partial dopaminergic agonistic activity can cause compulsive behaviors, such as pathological gambling, compulsive eating, compulsive shopping, and hypersexuality. Although it is difficult to predict who would develop these behaviors, the literature suggests that patients at a higher risk of developing impulsive behaviors include those with a personal or family history of obsessive-compulsive disorder, impulse control disorder, bipolar disorder, impulsive personality, alcoholism, drug abuse, or other addictive behaviors.ObjectivesHere, we present a case of a 32-year-old male who developed hypersexuality symptoms after receiving aripiprazole as treatment for bipolar disorder.MethodsWe have done a literature review using the MeSH terms Aripiprazole and hypersexuality in the “PubMed”.ResultsAfter switching Aripiprazole to Risperidone the hypersexuality symptoms started to decrease and got almost complete relief after 2 weeks.ConclusionsThis case highlights the rare hypersexuality side effect that can arise in patients receiving aripiprazole for bipolar disorder treatment. Clinicians should be aware of the increased risk of hypersexuality and other impulsive behaviors as they can significantly impair a patient’s daily functioning.DisclosureNo significant relationships.

Tattooing and piercing are associated with symptoms of ADHD: A cross-sectional study of non-clinical adults

IntroductionPrevious studies suggest that individuals with tattoos and piercings exhibit higher impulsive personality traits compared to peers without body modifications. No studies on body modifications and core-symptoms of ADHD are available.ObjectivesThis study aimed to compare self-reported ADHD symptoms between non-clinical adults with and without body modifications.MethodsA non-clinical adult Swedish population (n=815) completed the Adult ADHD self-report scale (ASRS-v1.1) and answered questions concerning body modification. ADHD diagnosis served as exclusion criterion. Three grouping variables were analysed separately; tattoo status, piercing status and a combination of having both tattoo and piercing. Linear regression compared mean ASRS total- and subscale scores between individuals with and without body modification according to each grouping variable, while adjusting for candidate covariates age and sex.ResultsThe prevalence of each body modification variable was; 30% for tattoo, 18% for piercing other than earlobe and 12% for combination of tattoo and piercing. Any combination of body modification was associated with significantly higher ASRS total- and subscale scores compared to no body modification. The most pronounced differences between groups were for the combination of tattoo and piercing, and on the hyperactivity/impulsivity (HI) subscale; revealing adjusted mean differences of 4.3 points (range 0-72) on the ASRS-total score (p <0.001) and 2.6 points (range 0-36) on the ASRS HI subscale (p <0.001).ConclusionsBody modification was associated with more pronounced ADHD core symptoms amongst non-clinical adults. Although statistically significant, the clinical significance is uncertain. The prevalence rates of body modifications in our cohort indicate that they are becoming cultural normal.DisclosureNo significant relationships.

Relationship between smoking, narcissism, and impulsiveness among young women

Although the connection between smoking and individual differences has been recently recognized, the relationship between narcissistic personality traits and cigarette smoking has received less attention. The notion that personality traits can be associated with addictive behavior is influential in clinical practice. However, questions remain about specific interactions between smoking and personality characteristics that need empirical support to substantiate this hypothesis. This study thus identifies narcissistic and impulsive personality traits as precursors of smoking in a sample of tattooed individuals. In a cross-sectional study (N = 120), personality traits were assessed in young women (aged 18–35 years) using the narcissistic personality inventory and the Barratt Impulsivity Scale (BIS-11). The current study, using the regression analysis, has clearly demonstrated that young women who smoke have different personality characteristics as compared with women who do not smoke.

Network Analysis of Eating Disorders Symptoms Co-occurring With Impulsive Personality Traits and Negative Mood States in Patients With Bulimia Nervosa

BackgroundBulimia nervosa (BN) is characterized by recurrent episodes of eating large amounts of food without control. Studies have found positive correlations of BN symptoms with impulsive traits and negative affect. However, the network relationship supporting BN symptoms is unclear.MethodsThe study participants included female BN patients (146) and healthy controls (HCs, 146). The participants were matched for age. All participants completed the Eating Disorder Examination Questionnaire 6.0, Barratt Impulsiveness Scale-11, Beck Anxiety Inventory, and Beck Depression Inventory. We characterized the centrality parameters of BN, impulsiveness, and anxiety and depression symptoms of BN patients compared with HCs.ResultsAmong all symptoms in the constructed BN group network, Shape dissatisfaction had the highest strength. In the BN group network, three clusters of symptoms (“ED-specific symptoms,” “impulsivity,” and “anxiety and depression”) were linked to each other by several symptoms. Compared to the HC network, impulsiveness was strongly associated with Concerns about Others Seeing One Eat in the BN network.ConclusionThis study shows that ED-specific symptoms, i.e., Shape dissatisfaction, play a key role in BN. The cognition of “shape dissatisfaction” is a basis, and impulsivity and emotional symptoms are maintaining factors that may lead to BN development.

Structure and mechanism of addictive impulsivity based on the interaction between drive and control

<p id="p00005">Impulsivity, consisted of driving forces and controlling forces, is an endophenotypic feature which predicts addiction. The driving force is the factor that determines the impulsivity of addiction, while inhibitory control plays the role of regulating the driving force. The addicts of different types all tend to act at a low level of inhibitory control and an abnormally high level of driving force. The imbalance of the two forces can result in drug abuse and relapse. <br/>Reward effect of substance is the main driving force of addiction. Besides, the stimulus-response association triggered by conditional learning, and the personality traits of addicts such as sensation seeking and negative urgency, are all factors associated with driving force. These psychological phenomena can trigger significant impulsivity and evoke habitual and compulsive drug use when inhibitory control is low. <br/>The controlling force mainly includes: the response inhibition characteristic that related to impulsivity personality trait, the cognitive control defect (waiting impulsivity) that cannot delay gratification. Behavioral and neurophysiological studies showed that addicts do possess the traits of low inhibitory control, including at least high sensation seeking and low response inhibition. Rooted in the unusual neurophysiological mechanism, these characteristics may result in the innate susceptibility to drug use and weak inhibitory control among individuals with addition. Waiting impulsivity based on ventral striatum - prefrontal lobe function may also relate to inherited personality traits. <br/> For individuals with addiction, response inhibition and executive control functions that regulate their impulsivity level are influenced by genetic factors and may deteriorate along the course of drug use. The inhibitory and executive control of addicts cannot regulate the tendency of drug use caused by driving forces, thus resulting in impulsive drug use in different stages of addiction.Empirical studies have found that inhibitory control functions remain largely unchanged after short-term abstinence. Moreover, the psychological phenomenon of impulsive personality, which is hereditary, is difficult to be changed within a short time. That is to say, even after a long-term abstinence, it is hardly possible for addicts to elevate the inhibitory control fundamentally. Therefore, one potential way to decrease impulsivity is to alleviate the driving force. Through reducing the reward effect, eliminating the S-R connection or reducing the appearance of related stimulus, the driving force can be decreased, thereby mitigating the impulsivity of drug use. This method might be effective in the treatment of addiction and the prevention of relapse with strong practicability and applicability.

The profile of amphetamine users in a substance abuse treatment center in Mexico

Introduction: in Mexico, amphetamine use is a public health problem. Objective: to describe the profile of consumers of amphetamines. Method: it was retrospective and cross-sectional study. The medical records of those admitted to the state Cúspide substance abuse treatment center, during the period 2016-2018, were reviewed. Results: 112 patients (89 men, 23 women) were analyzed. The profile included a patient with high school (40.2%), coming from an unstructured (67.9%) and dysfunctional family (93.8%) with poor parental affective relationship, alcoholism in the family nucleus (55.3%), early onset of sexual activity, alcohol and tobacco consumption; impulsive personality, suicide attempts (35.7%), and injuries to third parties and theft (73.2%). Discussion and conclusions: amphetamine use and rising prevalence behavior are a reality; the problem goes beyond the field of health and becomes a social problem that potentially involves the entire population to a greater or lesser extent. Knowing the epidemiological profile of the amphetamine consumer is a reference for implementing health policies and establishing preventive and therapeutic measures in order to solve the problem.

Lower Emotion Regulation Competencies Mediate the Association between Impulsivity and Craving during Alcohol Withdrawal Treatment

There is evidence that craving mediates the relationship between Impulsive Personality Traits (IPTs) and relapse during the treatment of an Alcohol Use Disorder (AUD). To provide tailored interventions, a deeper understanding of the relation between IPTs and craving, namely mediating processes, is important. Based on previous literature, we proposed that lower emotion regulation competencies mediate the relation between attentional as well as non-planning IPTs and craving. To investigate these interrelations, we used data from the baseline assessment (n = 320) of the SmartAssistEntz project (pre-registered in the German Clinical Trials Register [DRKS00017700]). Inpatients with a primary AUD diagnosis were interviewed using standardized self-report measures (IPTs: BIS-15, emotion regulation competencies: ERSQ, craving: OCDS-G short version) during their withdrawal treatment. Indirect effects were calculated using the SPSS macro PROCESS v3.5. Attentional as well as non-planning, but not motor, IPTs were associated with craving. Emotion regulation competencies mediated the relationship between attentional as well as non-planning IPTs and craving. Given their mediating role in the present study, it is interesting to investigate if addressing emotion regulation competencies can mitigate the negative influences of attentional and non-planning IPTs. The direct effect of attentional IPTs implicates alternate mediating processes, which should also be investigated in future research.

Multidimensional Impulsive Personality Traits Mediate the Effect of Parent Substance Use Disorder on Adolescent Alcohol and Cannabis Use.

Theory suggests that behavioral undercontrol mediates the effect of parental substance disorder on offspring substance use, but no studies have tested multidimensional impulsive personality traits as mechanisms of risk. Adolescents (N = 392; 48% female) from a multigenerational study of familial alcohol disorder self-reported impulsive personality traits via the UPPS-P (Mage = 16.09; Range = 13-19) and alcohol/cannabis frequency one year later. The UPPS-P assesses negative and positive urgency (i.e., rash action in a negative or positive mood state), lack of premeditation (i.e., lack of planning/forethought), lack of perseverance (i.e., inability to finish tedious/boring tasks), and sensation seeking (i.e., thrill seeking/risk taking). Parent substance disorder was assessed via diagnostic interviews. Two-part hurdle models tested predictors of any substance use (i.e., binary part) and frequency of use (i.e., continuous part). Parent substance disorder was indirectly associated with any alcohol/cannabis use (binary part) and higher cannabis frequency (continuous part) through negative urgency. Parental substance disorder was associated with higher alcohol frequency through a lack of premeditation. Sensation seeking was associated with any alcohol/cannabis use but unrelated to parental substance disorder. Despite indirect effects, strong effects of parental substance disorder on substance use remained. The findings are discussed in terms of theory and public health implications.

Associations between impulsive personality traits and HIV-related knowledge, beliefs and behaviours among college students in Chengdu, China: a cross-sectional study.

Impulsive personality traits (IPTs) are key predictors of individuals' engagement in sexual risk behaviours. This study investigated the associations between IPTs and HIV-related knowledge, beliefs and behaviours among Chinese college students. A sample of 1062 freshmen (first year) and sophomore (second year) students was obtained through stratified random sampling from 11 universities and colleges in Chengdu, China. The sociodemographic information, and HIV-related knowledge, beliefs and behaviours were investigated. A 20-item Short UPPS-P Impulsive Behaviour Scale (S-UPPS-P) was employed to estimate IPTs. Contingency table analyses (χ 2 ) and adjusted logistic regression were used to analyse the association between IPTs and HIV-related knowledge, beliefs and behaviours. The S-UPPS-P scale measure of IPTs yielded scores among college students ranging from 26 to 70. Students with a greater level of IPTs were more likely to have a high level of HIV stigma (aOR=1.46, 95% CI: 1.13-1.89), and a low level of HIV knowledge (aOR=1.41, 95% CI: 1.11-1.80) and HIV prevention beliefs (aOR=1.40, 95% CI: 1.09-1.80). All variables of HIV-related behaviours were not significantly associated with IPTs (all P >0.05). Future campus health education should provide HIV education without neglect of early identification of students' IPTs.

Relationship between impulsivity and aggressiveness with mental disorders and suicide risk in cocaine/crack users

the purpose of this study was to determine the correlation between impulsivity/aggressivity traits and mental disorders in cocaine/crack users. A non-probabilistic sample of the 106 subjects from an out-patient center for homeless people and three therapeutics communities in Northeast Brazil was investigated. The version of the Mini International Neuropsychiatric Interview 5.0 was used to assess lifetime psychiatric disorder. Impulsivity and aggressiveness were used in the Barratt Impulsivity Scale (BIS-11) and Buss–Perry Aggression Questionnaire (BPAQ), respectively. Individuals in cocaine/crack use report heightened levels impulsive and aggressive behavior. Linear regression results showed a positive correlation between total impulsivity and abuse of alcohol in our population. Considering impulsivity subscores, low levels of motor impulsivity, suicide risk, generalized anxiety disorder and antisocial personality disorder were negatively correlated. Past hypomanic episode was correlated positively with high non-planning impulsivity scores. These findings highlight the need for a continual investigation of mental disorder and its link with aggressive and impulsive personality traits in the cocaine/crack patients and these data can contribute to stratification for continuity treatment for these patients. Aggressiveness was correlated inversely with suicide risk, psychotic, mood and anxiety disorders. These findings highlight the need for a continual investigation of mental disorder and its link with aggressive and impulsive personality traits in the cocaine/crack patients and these data can contribute to stratification for continuity treatment for these patients.

Characterizing Clinical Heterogeneity in a Large Inpatient Addiction Treatment Sample: Confirmatory Latent Profile Analysis and Differential Levels of Craving and Impulsivity.

Individuals with substance use disorders (SUDs) have highly heterogeneous presentations and identifying more homogeneous subgroups may foster more personalized treatment. This study used SUD and other psychiatric indicators to characterize latent subgroups of patients in a large inpatient addiction treatment program. The resulting subgroups were then analyzed with respect to differences on clinically informative motivational mechanisms. Patients (n = 803) were assessed for severity of SUD (ie, alcohol use disorder, drug use disorder), post-traumatic stress disorder, anxiety disorders, and major depressive disorder. Confirmatory latent profile analysis (CLPA) was used to identify latent subgroups, hypothesizing 4 subgroups. Subgroups were then characterized with respect to multiple indicators of impulsivity (ie, delay discounting and impulsive personality traits via the UPPS-P) and craving. The CLPA confirmed the hypothesized 4-profile solution according to all indicators (eg, entropy = 0.90, all posterior probabilities ⩾.92). Profile 1 (n = 229 [32.2%], 24.9% female, median age in range of 45-49) reflected individuals with high alcohol severity and low psychiatric severity (HAlc/LPsy). Profile 2 (n = 193 [27.1%], 29.3% female, median age in range of 35-39) reflected individuals with high drug and psychiatric severity (HDrug/HPsy). Profile 3 (n = 160 [22.5%], 37.6% female, median age in range of 45-49) reflected individuals with high alcohol severity and psychiatric severity (HAlc/HPsy). Profile 4 (n = 130 [18.3%], 19.4% female, median age in range of 35-39) reflected individuals with high drug severity and low psychiatric severity (HDrug/LPsy). Both high comorbid psychiatric severity subgroups exhibited significantly higher craving and facets of impulsivity. The results provide further evidence of 4 latent subgroups among inpatients receiving addiction treatment, varying by alcohol versus other drugs and low versus high psychiatric comorbidity. Furthermore, they reveal the highest craving and impulsivity in the high psychiatric comorbidity groups, suggesting targets for more intensive clinical intervention in these patients.

Mental Disorders in Individuals With Exercise Addiction-A Cross-Sectional Study.

Background and Aims: Exercise addiction has not yet been designated as an addictive disorder in the DSM-5 due to a lack of detailed research. In particular, associations with other psychiatric diagnoses have received little attention. In this study, individuals with a possible exercise addiction are clinically assessed, in order to establish a profile of co-occurring psychiatric disorders in individuals with exercise addiction.Methods: One hundred and fifty-six individuals who reported exercising more than 10 h a week, and continued to do so despite illness or injury, were recruited for the study. Those who met the cut-off of the Exercise Dependence Scale (n = 32) were invited to participate in a screening with the Structured Clinical Interview for DSM-5 (SCID-5-CV) and personality disorders (SCID-5-PD). Additionally, an interview based on the DSM-5 criteria of non-substance-related addictive disorders was conducted to explore the severity of exercise addiction symptoms.Results: 75% of participants fulfilled the criteria for at least one psychiatric disorder. Depressive disorders (56.3%), personality disorders (46.9%) and obsessive-compulsive disorders (31.3%) were the most common disorders. Moreover, there was a significant positive correlation between the number of psychiatric disorders and the severity of exercise addiction (r = 0.549, p = 0.002).Discussion: The results showed a variety of mental disorders in individuals with exercise addiction and a correlation between the co-occurrence of mental disorders and the severity of exercise addiction. Exercise addiction differs from other addictive und substance use disorders, as obsessive-compulsive (Cluster C), rather than impulsive (Cluster B) personality traits were most commonly identified.Conclusions: Our results underscore the importance of clinical diagnostics, and indicate that treatment options for individuals with exercise addiction are required. However, the natural history and specific challenges of exercise addiction must be studied in more detail.

The Dickman Impulsivity Inventory: Validation and measurement invariance among Portuguese young adults.

The Dickman Impulsivity Inventory (DII) measures impulsive personality related to both negative and positive behaviors and characteristics. The main aim of the present study was to examine the psychometric properties of the DII among a Southern-European sample of Portuguese young adults. Our convenience sample (N = 429, M = 22.11 years, SD = 3.35, range = 18–42), composed of women (n = 237, M = 22.08 years, SD = 3.35, age range = 18–42) and men (n = 192, M = 22.14 years, SD = 3.34, range = 18–35), was collected from a university context. The two-factor latent structure of the DII composed of functional and dysfunctional impulsivity was supported, although three items had to be removed due to low standardized loadings, and strong cross-gender measurement invariance was established. Our analyses of the DII also provided evidence of criterion-related validity, known-groups validity, and internal consistency/reliability. Our findings support the use of the DII among Portuguese young adults.

The network structure of impulsive personality and temporal discounting

Impulsivity is an ill-defined umbrella term. Therefore, in addition to factor-analytic models, network models that characterize the relative positions of their components can offer novel insights. Here, we investigated the structure of impulsivity in 1000 participants using the Short UPPS-P Impulsive Behavior Scale and a temporal discounting task. Our results revealed an acceptable fit of a five-factor solution of the Short UPPS-P but question the separability of Positive and Negative Urgency. Additionally, Lack of Premeditation showed high closeness centrality and was – like Positive and Negative Urgency – significantly yet weakly related to temporal discounting. It remains to be investigated further to what extent Lack of Premeditation is a common cause or consequence of other impulsivity components.

The predictive role of working memory and impulsivity in internet addiction, an investigation about the mediating role of time perception

The association between impulsivity and time perception is well established; however, this relationship has not been examined in Internet addiction disorders (IAD). Research on the role of human working memory and IAD suggests paradoxical findings. The working memory is a critical component in Scalar Expectancy Theory (SET). In the present study, self-reported measures on Internet addiction and impulsivity, as well as behavioral tasks on working memory and time perception were administered among 262 students, aged 15–32, to investigate whether time perception mediated the relations between impulsivity, working memory, and Internet addiction in the sample. Impulsivity predicted IAD positively, and working memory negatively predicted IAD and positively predicted time perception. Meanwhile, there were no significant indirect effects in the model, indicating only significant direct relations. Therefore, this study suggests that in short intervals (below five seconds), there was no relationship between impulsivity and time perception in IAD. Impulsive personalities and impaired cognitive functions may increase the risk of problematic Internet use. Such findings might have relevant implications on various prevention and treatment plans.

Food Addiction and Its Relationship to Weight- and Addiction-Related Psychological Parameters in Individuals With Overweight and Obesity.

Background and Aims: It is assumed that a relevant subgroup of individuals experiences an addiction-like eating behaviour (Food Addiction), characterized by an impaired control over eating behaviour, emotional eating and food craving. Individuals experiencing Food Addiction partially share common symptomatology with Binge-Eating-Disorder and Bulimia Nervosa. The aim of this study was to investigate the prevalence of Food Addiction, general psychopathology, and associations with weight- and addiction-related constructs in individuals with overweight and obesity, who did not suffer from Binge-Eating-Disorder or Bulimia Nervosa.Methods:N=213 (67.1% female; MBMI=33.35kg/m2, SDBMI=3.79kg/m2) participants who were included in a weight loss program (I-GENDO project) reported BMI and completed questionnaires before the start of the treatment. Food Addiction severity, depressive symptoms, alcohol use disorder, internet use disorder, psychological distress, impulsivity personality trait, impulsive and emotional eating behaviour, food related inhibitory control, weight bias internalization, and self-efficacy were assessed.Results: The prevalence of Food Addiction was 15% with higher, although not statistically significant, prevalence in female (18.2%) compared to male (8.6%) participants. Food Addiction was associated with higher BMI at baseline assessment, low self-esteem, impulsive and emotional eating behaviour, weight bias internalization, and deficits in food-related inhibitory control. In addition, correlations were found between Food Addiction and severity of depressive symptoms, internet use disorder, and psychological distress.Conclusion: A relevant subgroup of participants experiences Food Addiction even when controlling for Binge-Eating-Disorder and Bulimia Nervosa. Future studies are warranted that investigate whether Food Addiction affects treatment success.

Drinking less on cannabis use days: The moderating role of UPPS-P impulsive personality traits.

Objective: Several studies suggest that alcohol and cannabis co-users are heavier drinkers and experience more alcohol-related consequences. However, day-level associations between co-use and drinking levels are mixed. One reason may be that individual characteristics moderate the daily impact of using alcohol alone or in conjunction with cannabis. The theory would suggest that highly impulsive individuals may drink more on co-use days, yet this assertion remains untested. Therefore, the current study tested whether impulsivity moderated the effect of co-use on same-day drinking quantity within veterans, a high-risk sample for substance use and impulsivity. Method: In a longitudinal observational study, co-using veterans (N = 139) completed three semi-annual assessments reporting on their daily drinking quantity and cannabis use via Timeline Followback (Observations = 19,245) and impulsivity via the UPPS-P. Mixed effect modeling was used to test hypotheses that co-use (compared to alcohol-only) days would be associated with heavier drinking for those high (but not low) in positive and negative urgency. Results: Significant interactions were found for positive urgency (PU) and lack of perseverance (LP), such that individuals at mean and low levels of PU and LP drank less on co-use (compared to alcohol-only) days. There were no significant interactions for other UPPS-P impulsivity facets. Conclusion: Findings are consistent with a substitution/compensatory effect for individuals at mean and low levels of both UPPS-P facets, and may be a byproduct of frequent cannabis use in veterans. In contrast, findings suggest that co-use and alcohol-only days may be characterized by similarly high levels of drinking for highly impulsive individuals. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Cocaine cue-induced mesocorticolimbic activation in cocaine users: Effects of personality traits, lifetime drug use, and acute stimulant ingestion.

Stimulant drug-paired cues can acquire the ability to activate mesocorticolimbic pathways and lead to new bouts of drug use. Studies in laboratory animals suggest that these effects are augmented by progressively greater drug use histories, impulsive personality traits, and acute drug ingestion. As a preliminary test of these hypotheses in humans, we exposed cocaine users (n = 14) and healthy volunteers (n = 10) to cocaine-related videos during two functional magnetic resonance imaging (fMRI) sessions, once following acute administration of placebo and once following d-amphetamine (0.3 mg/kg, p.o.). Across sessions, cocaine users showed larger cocaine cue-induced responses than healthy controls in the associative striatum and midbrain. Among the cocaine users, larger drug cue-induced responses during the placebo session were correlated with higher Barratt Impulsiveness Scale (BIS-11) nonplanning scores (associative striatum) and greater lifetime use of stimulant drugs (limbic, associative, and sensorimotor striatum). The administration of d-amphetamine did not augment the cue-induced activations, but, in cocaine users, drug cue-induced striatal activations were more widespread following prolonged cocaine cue exposure. Together, these effects of past and present drug use might aggravate the risk for stimulant drug use problems.