This research aimed to know the influence of financial compensation and work motivation on employee performance with work discipline as an intervening variable in BLUD employees at Siti Fatimah Hospital, South Sumatra Province. The population in this research are all BLUD employees of Siti Fatimah Regional Hospital consisting of 138 employees and and census method was implemented to consider the number of respondents. The data analysis technique in this research uses Structural Equation Modeling (SEM) using SmartPLS software. The results of the research show that financial compensation and work motivation have a positive and significant effect on employee performance, financial compensation and work motivation have a positive and significant effect on work discipline, work discipline has a positive and significant effect on employee performance, work discipline can mediate the relationship between financial compensation and work motivation on employee performance. The implication of this research is the importance of organizational units to provide additional rewards for employees who participate in additional work, provide motivation for each BLUD employee, and improve work discipline within the Siti Fatimah Regional Hospital, South Sumatra Province.