Objective To investigate the current situation of road traffic injuries (RTI) among the population in Shenzhen from 2010 to 2018, and to provide references and suggestions for improving road traffic safety related policies and traffic injures prevention in Shenzhen. Methods Retrospective analysis was performed on the RTI data accepted by the Emergency Comprehensive Information Query Platform of Shenzhen Emergency Center from 2010 to 2018, and statistics were made on the overall situation, population characteristics, time, regional distribution and severity of RTI in Shenzhen. Results From 2010 to 2018, there were 79 369 cases of RTI in Shenzhen, and the ratio of injuries to instant deaths was 79.66∶1. The incidence of RTI in Shenzhen Emergency Center was generally decreasing (χtrend2=8.200, P=0.004), and the on-site death rate was also showed a decreasing (χtrend2=4.604, P=0.032) trend. The incidence rate of male was 478.90 per 100 000, which was higher than that of female (223.92 per 100 000, χ2=92.823, P Conclusion According to the epidemiological characters from 2010 to 2018, the key points to preventing and controlling RTI would be: improving the road traffic management system; improving the traffic safety awareness of the key crowds; strengthening the roads regulation during the rush hours; deploying the emergency resources more rationally; shorting the emergency response time; improving the first aid system and service mode; and developing scientific precautionary measures.