Background and Aim: Knowledge management and job involvement are critical requirements for today's organizations that this can be developed in the light of professional ethics. By understanding these issues, present study aims to evaluate the relationship between professional ethics with knowledge management and job involvement. Materials and Methods: The research method was descriptive-correlative. Statistical population was all female teachers of Zahedan high school in the academic years 1394-95 (175 people). By stratified random method, 120 high school female teachers through three questionnaires professional ethics (Gregory, 1990), knowledge management (Bhatt, 2001) and job involvement ( Lodahl & Kejnar, 1965) were studied.To analyze the data, from the Pearson correlation coefficient and multiple regression were used with the help SPSS21 software. Findings: The correlation coefficients of professional ethics and its components: dependable, ambitious, considerate, cooperative respectively with knowledge management were 0/346, 0/395, 0/234, 0/219 and 0/216. The results also showed that 18/2 percent of the variance in knowledge management professional ethics explain that the only component dependable between the components of professional ethics to do with the amount of β (0/51) of the predictive power of knowledge management. Other findings showed that the correlation coefficients of professional ethics and its components: dependable, ambitious, considerate, cooperative respectively with job involvement were 0/497, 0/519, 0/412, 0/292 and 0/31 respectively. The results also showed that 29/3 percent of the variance in job involvement of professional ethics explains that the only component dependable of professional ethics to do with the amount of β (0/486) had the power to predict job engagement. Conclusion: According to the findings to your school administrators recommended that efforts to establish ethical work environment and encourage teachers to focus on their business activities .So that in this way we hoped teachers to improve knowledge management and job involvement. Please cite this article as: Shojayifar Z, Marzieh A, Nastiezaie N. The Relationship between Professional Ethics with Knowledge Management and Job Involvement. Iran J Bioethics 2017; 7(23): 17-28.