Controversy exists over whether to target public- and private-sector programs to female-headed households in developing countries in the attempt to combat poverty and social disadvantage. The issues related to the definition and measurement of female headship and the importance of the concept for development policy are discussed. A systematic review is then presented of the empirical evidence on the relation between female headship and poverty. If female-headed households tend to be poorer on average than other households headship should seriously be considered as a potentially useful criterion for targeting antipoverty interventions especially in developing countries where means testing is not feasible. The authors examine the potential costs and benefits of targeting female headship and review the experience of Chile one of the few countries which has targeted female headship through government intervention and the only one which has evaluation data available. The analysis of the project experience is used along with a review of the empirical evidence to answer the question of the desirability and efficiency of targeting female headship in order to reduce poverty in developing countries.