Improvements In Cognitive Abilities Research Articles

Human Dento-Facial Evolution: Cranial Capacity, Facial Expression, Language, Oral Complications and Diseases

Objectives: To review dento-facial evolution based on fossil data, comparative anatomy, developmental biology and genetics. Modern human evolution reveals profound insight into the technical and biological challenges faced by clinicians in daily practice of dentistry. Materials and Methods: An analysis and review of the literature is presented to further explain the evolutionary forces that have shaped hominins. Results: Modern human evolutionary morphological and biological adaptations allowed improvement of cognitive ability, facial expression, smile and language. However, the increased cranial capacity correlates inversely with a decrease in size of the maxillary and mandibular bones, weakening of the muscles and facial shortening, contributing to dento-facial complications. Moreover, the distinctive differences in origin and development of the dento-facial components have further contributed to these maladies. In addition, human lifestyle transition from nomadic to sedentary increased the incidence of oral diseases. Conclusions: Knowledge of human evolutionary patterns can improve the quality of response by clinicians to biological challenges. The limitations in current treatment modalities can be explained, in part, due to the complexity of the life forms that resulted from evolution. Although there are no rules to predict how evolutionary forces will shape modern humans, the evolution of the dento-facial complex reveals profound insight into our connection to other forms of life and nature.

Effectiveness of Montessori Sensorial Training Program for Children with Mild Intellectual Disabilities in Pakistan: A Randomized Control Trial

ABSTRACT Intellectual disability is a serious lifelong disability that places heavy demands on society and the health system. The study was designed to determine the extent to which the intellectually challenged children are capable of improving their cognitive abilities as well as adaptive functioning through the Montessori Sensorial Training program when introduced in a different setting (i.e. special education school system). With randomised control trial (RCT) of pre-and post-testing, 30 children with mild intellectual disabilities were randomly allocated to Montessori Sensorial Training intervention condition (n = 15) and waitlist control condition (n = 15). The intervention group showed significant improvement in cognitive abilities (i.e. classification, seriation, recognition, ordination, and visual and auditory discrimination) as compared to the control group at post-assessment. Children who received training also showed improvement in communication and self-care domain as compared to the control group. This study provides evidence that Montessori Sensorial Training is not only effective for children going to mainstream schools but also for children with intellectual disabilities. Despite some limitations, the results of the study are encouraging and suggesting that Montessori Sensorial Training is an effective intervention to facilitate self-based learning, independence, and decision-making skills in children with mild intellectual disabilities.

Combination of dasatinib and quercetin improves cognitive abilities in aged male Wistar rats, alleviates inflammation and changes hippocampal synaptic plasticity and histone H3 methylation profile.

Aging is associated with cognitive decline and accumulation of senescent cells in various tissues and organs. Senolytic agents such as dasatinib and quercetin (D+Q) in combination have been shown to target senescent cells and ameliorate symptoms of aging-related disorders in mouse models. However, the mechanisms by which senolytics improve cognitive impairments have not been fully elucidated particularly in species other than mice. To study the effect of senolytics on aging-related multifactorial cognitive dysfunctions we tested the spatial memory of male Wistar rats in an active allothetic place avoidance task. Here we report that 8 weeks treatment with D+Q alleviated learning deficits and memory impairment observed in aged animals. Furthermore, treatment with D+Q resulted in a reduction of the peripheral inflammation measured by the levels of serum inflammatory mediators (including members of senescent cell secretome) in aged rats. Significant improvements in cognitive abilities observed in aged rats upon treatment with D+Q were associated with changes in the dendritic spine morphology of the apical dendritic tree from the hippocampal CA1 neurons and changes in the level of histone H3 trimethylation at lysine 9 and 27 in the hippocampus. The beneficial effects of D+Q on learning and memory in aged rats were long-lasting and persisted at least 5 weeks after the cessation of the drugs administration. Our results expand and provide new insights to the existing knowledge associated with effects of senolytics on alleviating age-related associated cognitive dysfunctions.

Goldberg Shprintzen Syndrome: The Novel Association with Congenital Unilateral Anorchia (Monorchism)

Background: Goldberg Shprintzen syndrome is a very rare autosomal recessive mental-growth retardation syndrome associated with characteristic facial dysmorphism, Hirschsprung disease, and a variety of neurological abnormalities, and abnormalities on brain imaging studies. However, the association of the syndrome with congenital unilateral absence of the testis (monorchism) has not been reported before. We have previously reported the thirty fourth and thirty fifth cases of the syndrome which occurred in Iraqi brothers, and described a novel therapeutic approach which was used to treat the younger brother. The aim of this paper is to report the novel association of Goldberg Shprintzen syndrome with congenital right monorchism. Patients and methods: T.A.S, the younger of two brothers with Goldberg Shprintzen syndrome was first seen at the age of four years and 10 months at the pediatric neuro-psychiatric clinic on the 29th of August, 2019. He had spastic right hemiparesis and was unable to walk alone, and was not saying any word and had characteristic facial features including hypertelorism, narrow palpebral fissures, open mouth, and laterally lifted ear. He also had neonatal intestinal obstruction which was attributed to Hirschsprung disease, and was treated surgically with resection and colostomy. The boy was treated successfully with novel therapeutic approach and experienced improvement in cognitive abilities, speech, and motor function, and after treatment was able to walk alone. Results: During July, 2021, the family reminded us that the child had single testis in the scrotum, and during early infancy an MRI study failed to find any second testis anywhere. An ultrasound was performed and showed normal left testis. However, the right testis could not found in the right hemi-scrotal sac nor with the right inguinal canal or within the abdomen. Thus, the ultrasound confirmed the earlier MRI findings which suggested congenital absence of the right testis (monorchism). Conclusion: This paper reported the novel association of Goldberg Shprintzen syndrome with monorchism, and this case represented the third case of congenital syndromic monorchism in the world.

Transcranial photobiomodulation (laser) therapy for cognitive impairment: A review of molecular mechanisms and potential application to canine cognitive dysfunction (CCD).

Alzheimer’s disease (AD) is a common degenerative brain disorder of aging people which shares many clinical and pathological features with canine cognitive dysfunction (CCD). CCD is considered a naturally occurring model of human AD. Transcranial photobiomodulation therapy (tPBMT), also known as transcranial laser therapy, entails delivering photons of near infrared to infrared light from the skin surface of the scalp to the underlying brain. Specific molecular cellular receptors, called chromophores, absorb this energy, and use it to initiate biological reactions with potential therapeutic benefit. Improvement in cognitive ability using tPBMT has been documented in rodent AD models and human clinical trials. The purposes of this review are to provide an overview of the suspected molecular mechanisms of action of tPBMT for the treatment of cognitive decline and to propose potential application of this treatment modality for dogs affected by CCD.

Anti-LINGO-1 antibody ameliorates cognitive impairment, promotes adult hippocampal neurogenesis, and increases the abundance of CB1R-rich CCK-GABAergic interneurons in AD mice

In view of the negative regulatory effect of leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO-1) on neurons, an antibody against LINGO-1 (anti-LINGO-1 antibody) was herein administered to 10-month-old APP/PS1 transgenic Alzheimer's disease (AD) mice for 2 months as an experimental intervention. Behavioral, stereology, immunohistochemistry and immunofluorescence analyses revealed that the anti-LINGO-1 antibody significantly improved the cognitive abilities, promoted adult hippocampal neurogenesis (AHN), decreased the amyloid beta (Aβ) deposition, enlarged the hippocampal volume, and increased the numbers of total neurons and GABAergic interneurons, including GABAergic and CCK-GABAergic interneurons rich in cannabinoid type 1 receptor (CB1R), in the hippocampus of AD mice. In contrast, this intervention significantly reduced the number of GABAergic interneurons expressing LINGO-1 and CB1R in the hippocampus of AD mice. More importantly, we also found a negative correlation between LINGO-1 and CB1R on GABAergic interneurons in the hippocampus of AD mice, while the anti-LINGO-1 antibody reversed this relationship. These results indicated that LINGO-1 plays an important role in the process of hippocampal neuron loss in AD mice and that antagonizing LINGO-1 can effectively prevent hippocampal neuron loss and promote AHN. The improvement in cognitive abilities may be attributed to the improvement in AHN, and in the numbers of GABAergic interneurons and CCK-GABAergic interneurons rich in CB1Rs in the hippocampus of AD mice induced by the anti-LINGO-1 antibody. Collectively, the double target effect (LINGO-1 and CB1R) initiated by the anti-LINGO-1 antibody may provide an important basis for the study of drugs for the prevention and treatment of AD in the future.

Mindfulness in face recognition: Embedding mindfulness instructions in the face‐composite construction process

SummaryMeditative mindfulness practices, promoting sustained attention and reducing mind‐wandering, have been associated with improvements in cognitive abilities and memory. The present study explored whether a non‐meditative practice could be successfully applied in a forensic application; specifically, whether mindfulness instructions can be embedded in the face‐composite construction process to facilitate identification. Twenty participants, who were not football fans, were asked to memorise an unfamiliar footballer's face and return 24 hr later to construct a face using the self‐administered EvoFIT facial composite system. In the experimental condition, mindfulness instructions were embedded in the EvoFIT system, encouraging witnesses to focus on the target face and the process; in the control condition, participants constructed the face using the standard EvoFIT system. Naming of the composites was attempted by 24 football fans, who each viewed 10 composites, five from each condition, and then the target footballer images to ensure they were familiar with the identities. Results showed significantly higher levels of correct naming for composites constructed using EvoFIT with mindfulness instructions compared to using the standard EvoFIT. These findings indicate the potential for non‐meditative mindfulness instructions to assist face‐composite construction, improving correct naming of ensuing composites.

Improvement in Cognitive Abilities, Mental and Emotional Wellbeing of Teenagers following a Meditation Retreat: An Open-Trial Pilot Study

Background: Today’s teenagers face several challenges that result in poor mental health, depression and anxiety. Several studies in the past decade have explored meditation as adjunctive therapy for mental illness however, the long-term residual benefits of meditation have rarely been studied. Objective: The aim of the study was to investigate the benefits of a four day meditation retreat on cognitive abilities, mental and emotional well-being of teenagers. Methods: 303 teenagers participated in this study. Cognitive abilities of the students were measured using the Six letter cancellation test (SLCT). Mental and emotional well-being was measured using World Health Organization Well-being index (WHO-5) and Strength and Difficulties questionnaire (SDQ), respectively. Data analysis was performed using paired sample t-test and repeated measure ANOVA. Results: Teenagers demonstrated a 33% increase in average accuracy for SLCT post intervention. WHO-5 mental well-being index scores also increased significantly (p<0.001). The participants experienced a significant reduction in emotional problems and hyperactivity as measured by SDQ. The benefits of the retreat continued to persist, when measured after 40 days of the intervention. Conclusion: A well-structured meditation retreat has significant and long-term benefits on teenagers’ mental well-being, emotional stability and cognitive capacity.

Effects of Exercise Interventions on Cognitive Adaptations for Older Adults with Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

PURPOSE: Old adults with mild cognitive impairment (MCI) are at high risk for developing dementia. Exercise is a promising intervention for cognitive decline. This study evaluated the effects of exercise interventions on cognitive adaptation for older adults with MCI and attempted to identify which specific modality of exercise is more effective.METHODS: National Assembly library, Research information sharing service, Google scholar databases from 1 January 2010 to 31 Oct 2020 were utilized for searching articles related to research purpose. Meta-analysis was conducted with Comprehensive Meta-Analysis 2.0 using the fixed-effect model for the available data without significant heterogeneity, or the random-effect model was used if appropriate.RESULTS:Through meta-analysis in 13 studies, the combination of aerobic and resistance movements significantly improved cognitive ability and showed that intervention in a particular week and time is of paramount importance to improving cognitive function.CONCLUSIONS: The Combination of aerobic and resistance exercise led to an improvement in cognitive ability and had a positive effect with a middle effect size on cognitive function in older adults with MCI.

Improvement of cognitive ability of English language learners through writing skills.

This paper explores the interrelation between the cognitive linguistic skills that are necessary for children to write on both words and texts. Three types of cognitive-linguistic abilities, which were considered to be more specifically interested in the text writing research, were transcriptional skills, ideation and syntax. The first two emerged out of a simplistic writing view (Berninger, 2010) while the predicted value of syntactic skills was based on an "extended triangle model" (Bishop & Snowling, 2011). The transcription skills in the present research have been operationalized to generate strokes in line with the proper order of stroke. With respect to the ideation, we tested the capacity of children to create orally sentences on such subjects and the requirements for grading are close to the criteria of text composition. Although good handwriting enhances student reading, improves skills, the process of abandoning handwriting has already started in a number of countries. This study paper reveals that handwriting is not only meant for
 primary school students, but also in high school education with regard to some important studies.

Measuring the Impacts of Virtual Reality Games on Cognitive Ability Using EEG Signals and Game Performance Data

Gamification has been widely used in training and enhancing cognitive ability, such as working memory and attention. For example, 3D games can enhance participants’ working memory, thereby improving their learning efficiency, and the powerful immersion of VR games can improve the attention of patients with ADHD. However, previous works have not elaborated to what extent the two different game modes can affect cognitive ability respectively, nor have they determined which game mode has a greater effect on the cognitive level. Exploring the impact of different game modes on cognitive ability can help better apply gamification to the training and improvement of cognitive ability, and quantifying cognitive ability through human physiological signals such as brain electrical activity level (EEG) can help evaluate the changes of cognitive ability in different game modes more accurately. Therefore, different from previous studies, we used EEG signals and game performance data (such as game scores and time to complete the game) to calculate participants’ cognitive level quantitatively, and did comparative experiments to study cognitive abilities in different game modes and the temporal characteristics of cognitive ability changes. We also explored whether gender would affect cognitive ability. Our research has the following findings. First, compared with the 3D mode, participants get better game scores and higher EEG scores in the VR mode, the time to complete the game task is shorter, and the time to reach the best state of working memory is shorter. Second, participants’ gender has no significant effect on working memory, but there is a significant difference in attention in the VR game mode, it takes less time for males to reach the peak of attention than for females. Our conclusion indicates that VR games have greater potential in the field of training and enhancing cognitive ability than 3D games.

High-dose Vitamin D Supplementation and Improvement in Cognitive Abilities, Insomnia, and Daytime Sleepiness in Adolescent Girls.

Introduction:Vitamin D may affect the modulation of signaling pathways in the central nervous system. We aimed to evaluate the effect of high-dose vitamin D supplementation on neuropsychological functions in female adolescents.Methods:We studied the effects of 9 weeks of vitamin D supplementation (50000 IU vitamin D3 [cholecalciferol]/week) on cognitive abilities and sleep disorders in 940 adolescent girls.Results:Oral vitamin D supplementation improved cognitive abilities, including memory, inhibitory control, selective attention, decision making, planning, sustained attention, and cognitive flexibility in healthy adolescent girls (P<0.001). The prevalence of subjects with insomnia after intervention fell from 15.0% to 11.3%. Similar results were also found for the prevalence of sleepiness (15.6% reduced to 14.7%), or cases with both insomnia and sleepiness (8.0% reduced to 6.1%; P<0.05).Conclusion:High dose of vitamin D can improve cognitive abilities and alleviate insomnia and daytime sleepiness in adolescent girls. Further investigations are required on different population groups (age and gender) to determine the sustainability of these effects. The value of vitamin D therapy in other neurological disorders would also be of research interest.

Effects of Cognitive Training in Mild Cognitive Impairmentmeasured by Resting State Functional Imaging.

Mild cognitive impairment (MCI) is defined as an intermediate state of cognitive alteration between normal aging and dementia. In this study, we performed a functional network connectivity analysis using resting-state functional magnetic resonance imaging to investigate the association between changes in functional connectivity in the brain and the improvement in cognitive abilities after cognitive training. A computerized cognitive training program was used to improve the abilities of fifteen participants with MCI. The cognitive training program (Comcog), which consists of three weekly sessions totaling 90 min, was conducted with all participants over six weeks. The cognitive abilities before (pre-Comcog) and after (post-Comcog) the cognitive training process were measured using a neurocognitive function test. After the Comcog, the participants enhanced their visual and verbal memories, attention, and visuo-motor coordination. The functional connectivity between cingulo-opercular (CON) and default mode (DMN) showed significant improvements after Comcog training. Therefore, our study suggests that cognitive training may improve the cognitive abilities of participants. This improvement was associated with an increase in the functional connectivity between DMN and CON. The increase in functional connectivity after cognitive training was specifically associated with overall cognitive functions, including executive, memory, decision-making, and motivational functions.

Integrative and Complementary Health Practices Building a New Health Paradigm

Abstract This work arose from the need to broaden the therapeutic approach and offer a differentiated health intervention proposal based on the understanding that the illness process has repercussions on all integrated systems of Being. Since 2019, the Health Center for the Elderly in Blumenau (SC-Brasil), specialized multi-professional service, offering support for biopsychoenergetic transformation with the practice of Yoga and Meditation, through a holistic and comprehensive view of health. It begins with the Multidimensional Assessment of the Elderly, with a guideline in welcoming and qualified listening, which considers the subject and all subjectivity. From there, the expanded diagnosis and the Singular Therapeutic Project are built and the consultations with the team and the 'Re-Conhecer group' begin. The activity is weekly, aimed at the elderly and their family, takes place in an appropriate place and lasts two hours. Welcoming, pranayama, mantras, kriyas and meditation are made, as well as reflections on free themes. The professionals who conduct the practice are the dentist, trained in yoga, and the social worker, the welcoming process continues individually after the activity. Due to subjectivity, results are routinely collected in a qualitative way from the participants' report. There is a perception on the part of the participants, therapists and members of the multidisciplinary team that this work provides improvement in cognitive abilities, self-care, well-being, self-confidence, creativity, improved sleep, autonomy, balance, strengthening bonds, joy, vitality. Key messages This initiative builds new models of health care, transcending the traditional biomedical model, according to the operational guideline for comprehensiveness, universal access and equity. Provokes reflections and builds a new perspective of life with quality and participation of the elderly as subjects of their health.

A-034 Improvement in Cognitive Functioning Post Cardiovascular Event—A Case Study

Abstract Objective To evaluate changes in cognitive functioning over time following a cardiovascular event evidenced by a series of neuropsychological evaluations. This data adds to the limited research on episodes of vascular induced dementia and demonstrates how a patient that suffers a cardiovascular event can show improvements in cognitive abilities over time. Methods Patient A is a 78-year-old, right-handed, Caucasian, male, with a medical history significant for congestive heart failure with subsequent cognitive, emotional, and behavioral changes. Comprehensive neuropsychological evaluations were performed two weeks, three weeks and seven months post cardiovascular event to monitor changes in cognitive functioning. All background information was obtained from a clinical interview with Patient A and his daughter, as well as a review of available medical records. Results The initial evaluation revealed cognitive deficits across domains, whereas the most recent evaluation showed improvements in all domains except for isolated declines in areas of memory and visual planning and organization. The most recent results evidenced his memory performance was notable for greater encoding deficits for both verbal information and visual information. Attention, executive functioning, language, and visual acuity remained stable or improved from previous evaluations. Conclusions The series of evaluations showed a general improvement in Patient A’s cognitive functioning, however, isolated declines were noted in memory and visual planning and organization. This data suggests that following a cardiovascular event, an individual’s functioning may improve over time and allow clinicians to see the isolated areas of decline to provide a more accurate and thorough diagnosis.

The Result of Second Field Test of Cellulose Degrading Bacteria from Mangrove Soil Microbiology Handout

Learning media is one of the most important component in a learning process, both inside or outside a classroom. In order to provide proper learning for students based on the researcher’s prior research, at least, three different field tests are needed. This research is a quasi-experiment, which is provide result of the second field test of cellulose degrading bacteria from mangrove soil microbiology handout both in cognitive and psychomotor ability. The research aims are to describe effect of this microbiology handout on student’s cognitive achievement and gain data about inappropriate laboratory written instruction in this handout. Data gained by conducting learning activities using developed handout which were 2 times in class theory and three times of practical activity using instuctions written in the handout. In the end of class theory activity, students did a posttest to confirm their improvement of cognitive ability while their practical ability was observed using observation sheet along with their activities. Results showed that handout which being tested could improve student cognitive at average level (n gain 0,419). In contrast, several parts of laboratory written instruction need to be fixed to make better microbiology handout.

Ginsenoside Rb1 Improves Cognitive Impairment Induced by Insulin Resistance through Cdk5/p35-NMDAR-IDE Pathway.

The relationship between diabetes mellitus (DM) and Alzheimer's disease (AD) has attracted wide attention. Studies have reported that ginsenoside Rb1 can improve human cognitive ability and glucose tolerance during the development of diabetes. The mechanism behind the improvement in cognitive ability and glucose tolerance still remains unclear. In this study, streptozotocin- (STZ-) injected mice were used as models to explore the mechanisms behind the cognitive improvement of ginsenoside Rb1. According to the results of behavioral tests, ginsenoside Rb1 improved memory and cognitive ability of STZ-lesioned mice. In addition to that, ginsenoside Rb1 also relieved glucose intolerance induced by STZ injection by enhancing insulin sensitivity. These beneficial effects of ginsenoside Rb1 is most likely mediated by upregulating the expression of NMDAR1 and IDE in the hippocampus through inhibiting the activity of Cdk5/p35. This work will be of great importance in illustrating the mechanisms of ginsenoside Rb1 for improving cognitive ability, as well as revealing the relationship between diabetes and AD.

Investigation of cognitive changes in cerebral palsy children employing different integrated sensing techniques

Background and purposeCognitive impairment is one of the biggest challenges for cerebral palsy (CP) survivors. Cognition is a mental process, of acquiring knowledge and understanding the thoughts, experiences, and senses. It encompasses processes such as attention, knowledge, working memory, judgment and logical reasoning. The purpose of this study was to determine the most effective therapy for understanding the cognitive changes in children with CP from different available rehabilitation therapies being employed. Materials and methodsA total of sixty participants divided into the four groups namely A, B, C and D (n = 15) were recruited for the study. Groups A, B, C, and D received usual standard therapy (ST), repetitive transcranial magnetic stimulation (r-TMS), neurofeedback (NFB) and cognitive brain training exercises respectively for 20 days. Outcome measures such as Vineland Social Maturity Scale (VSMS) and raw EEG data were recorded before and after the completion of 20 days (5 days a week for 4 weeks) therapy as pre and post assessment data of these different groups, for statistical data analysis. ResultsThe results suggested that r-TMS largely resulted in oriented therapy for cognitive enhancement in all selected therapy groups. Cognitive brain training exercises were found to be the second most effective as well as cost-effective therapy for cognitive enhancement in brain-damaged children. It showed 1.17% improvement in cognitive abilities as compared with r-TMS (1.28%) therapy. ConclusionAll therapies showed some degree of significant improvement in cognitive enhancement, however, r-TMS and cognitive exercises were found to be the best among the studied rehabilitation therapies in different groups for cognitive enhancement in CP children. This one of the first study to the best of our knowledge using different intervention techniques such as rTMS, NFB and CE for understanding the changes in the cognitive development in the CP children.

The influence of scientific creativity and critical worksheets (SCCW) on creative thinking skills and critical scientific as well as students’ cognitive abilities on project-based learning work and energy concepts

This study describes the influence of scientific creativity and critical worksheet (SCCW) to the creative thinking and scientific critical as well as students’ cognitive ability of Work and Energy concept. The aim of this study was to find out the improvement of cognitive ability, creative thinking skill and critically scientific students with applied model of project-based learning integrated with SCCW and conventional student worksheet (CSW). This study is based on one of the 21st Century Partnership Learning Framework which contains the skills that must be possessed by learners in the 21st century, which is focused on scientific creative thinking skills and critical scientific thinking skills. The research method used is pre-experimental research with randomized control group pretest-postest design. Implementation of SCCW on project-based learning can improve creative thinking skills and critical scientific and cognitive abilities of students with greater improvement than the application of SCW on project-based learning.

A Comparison Study of the Auditory P300 Results of Elderly Patients with Sensorineural Hearing Loss

Objective: The purpose of this study was to compare the auditory P300 results of elderly patients with sensorineural hearing loss (SNHL) before and after hearing aid use. Material and Methods: A cross-sectional study was conducted from July, 2016 to April, 2017 at the Hearing Aid Clinic of Ramathibodi Hospital. Twenty-six elderly patients aged ≥60 with bilateral symmetrical SNHL who were referred for unilateral hearing aid fitting by otolaryngologist were included. The auditory P300 was recorded before and 2 months after hearing aid fitting. Results: The P300 waveforms, with a mean latency of 374.48 milliseconds and mean amplitude of 6.68 microvolts (µV), could be recorded in only 21 participants. At 2 months after hearing aid use, the mean P3 latency was 376.83 ms and mean amplitude was 8.77 µV. There was a statistically significant difference in amplitude of P300 2 months after hearing aid fitting (p-value=0.004). Conclusion: The auditory P300 results indicate an improvement in cognitive ability with higher amplitude. Thus, the P300 may be used to evaluate improvements in cognitive function after using a hearing aid. It can also be used as a guideline for explaining the benefits of hearing aid use to patients who initially rejected a hearing aid.