Stress is a feeling of emotional or physical tension. It can come from any event or thought that makes you feel frustrated, angry or nervous stress in your body’s reaction to a challenge or demand. In short burst, stress can be positive, such as when it helps you avoid danger or meet a deadline but when stress last for a long time it may harm your health. In Ayurveda Ojakshaya can be correlated with Stress. Ayurveda is reported to have several combinations and approaches effective for STRESS with the help of Panchakarma like Shirodhara and Shaman chikitsa with Manasmitra Vatak. Aim and Objective: To study the effect of Manasmitra vatak and Bramhi tail Shirodhara in management of Stress. Material and Method: The 38 years old female patient, suffering from Stress since last one year and having complaints of Insomnia, Inability to concentrate, anxious, constant worry, anger, feeling overwhelmed, constipation, frequent cold. These symptoms increases day by day since last six months. She was approached to our OPD and prescribed Manasmitra avatak once a day for one month and Bramhi tail Shirodhana 5 days in every month for 3 months. Observation and Results: Patient was assessed on the basis of Perceived Stress scale score which was 30 before treatment; it would be consider high perceived stress. After administration of Manasmitra vatak once a day for one months and Bramhi tail Shirodhara 5 days in every month for 3 months. There is significant relief seen and the perceived stress score reduced up to 10 after treatment. Manasmitra Vatak and Shirodhara helps in improving brain functions and reduced stress. Conclusion: 1. Manasmitra vatak and Bramhi tail Shirodhara showed significant improvement in this case. 2. No adverse effects were observed.