Improvement In Skin Condition Research Articles

Robust skin microrelief depth estimation using a mobile stereo system.

The skin surface becomes wrinkled and rough due to various internal and external factors. A three-dimensional (3D) analysis of the skin is required to improve skin conditions. Stereophotogrammetry, a noninvasive 3D analysis method, is easy to install and use, but most stereo systems have a fixed baseline and scale. Previous stereo systems are not suitable for observing micro-range skin features. Therefore, we suggest the optimal conditions and methods for the 3D analysis of skin microrelief using a multi-conditioned stereo system. We constructed a nonconvergence model using a mobile device and acquired stereo images under multiscale and multi-baseline conditions. We extracted 3D information of the skin through our process: preprocessing, skin feature extraction, feature matching, and actual depth mapping. We improved the accuracy of the 3D analysis of the skin by using disparity values instead of disparity maps. We compared and analyzed the performances of six local feature detector and descriptor algorithms. In addition, we suggested depth-mapping formulas to estimate the actual depth of the skin microrelief. We confirmed that stereo images with a working distance of 70-75mm and a baseline of 4-8mm are effective for the 3D analysis of skin microrelief. In addition, accelerated KAZE exhibited the best performance for features extraction and stereo matching. Finally, the extracted 3D information was converted to the actual depth, and the performance of the 3D analysis was verified. The proposed system and method that provide texture information are effective for 3D skin disease analysis and evaluation.

33249 Novel high-emollient hand sanitizer improves skin condition without compromising antiseptic efficacy

The impact of frequent hand hygiene practices on the skin condition of health care workers has been studied extensively, however, there are little data available on normal consumer usage of hand sanitizers on skin health and the skin barrier. The objective of this research was to understand the impact to skin hydration, irritation, and barrier integrity between different marketed hand sanitizers in conjunction with normal handwashing hygiene. Participants provided informed consent to participate in a balanced, randomized, IRB-approved, double-blind 4-cell 2-week clinical study, with approximately 20 participants per cell. A new high emollient and 2 leading marketed alcohol-based hand sanitizers were included with instructions to use a minimum of 6 times daily, as well as a control cell of liquid handwash alone. The control liquid handwash was also used in each sanitizer cell to replace handwash products. Objective measurements of hydration and transepidermal water loss (TEWL) were obtained as well as expert visual assessment of dryness and erythema, and 3D imaging of texture with Antera measurements. When added to a routine of handwashing with a marketed liquid handwash, the high emollient sanitizer ameliorated the dryness evident from hand washing alone. Both handwashing alone and in combination with 2 leading marketed hand sanitizers resulted in increased skin dryness and markedly greater sensory irritation. The high-emollient sanitizer product also mitigated the damaging effects of liquid handwash, as demonstrated by TEWL. The results indicate that when deploying normal consumer hand hygiene practices, selection of hand sanitizers does matter for maintaining skin barrier health.

Does weight loss lead to improvement of dermatological conditions: what is the evidence?

Obese and overweight individuals may have a wide spectrum of cutaneous features and can have more severe manifestations of multiple dermatological conditions. There have been multiple expert opinions on the role of weight loss, in the improvement of skin conditions. There have been few studies over the past decade evaluating the effects of exercise and other modes of weight reduction on various dermatoses such as psoriasis, acne vulgaris, hidradenitis suppurativa and acanthosis nigricans. In this review, we have attempted to provide a summary of the beneficial effects of weight loss on various dermatological conditions.

Potential Effect of Black Cumin Honey on Skin Wrinkles, Pores, Moisture, and Sebum

Acne vulgaris is a chronic inflammation of the polysebaceous follicles with the presence of blackheads, papules, pustules, and cysts in predilection areas. The new drug development to provide more effective therapy of topical cream containing bioactive compounds has emerged. The properties possessed by black cumin and honey can be combined as a new anti-acne drug. This research aims to provide the skin evaluation data of modified topical cream of black cumin honey by following the guidelines of good manufacturing practice (GGMP). The organoleptic, pH, homogeneity, scatter power, cream type, and stability of combination cream have been tested. The the effectiveness of cream was evaluated based on the number of skin wrinkles, skin moisture content, number of skin pores, and sebum. Results showed that a combination cream of 5% extract has met the good standard of preparation. The topical application involving 40 volunteers within two weeks showed a significant effect on increasing the skin moisture and also reducing the skin wrinkles, pores, and sebum. This research showed the black cumin honey cream could improve skin conditions and potentially be used for topical antiacne treatment soon.

Ameliorating Effect of Crassocephalum rabens (Asteraceae) Extract on Skin Aging: A Randomized, Parallel, Double-Blind, and Placebo-Controlled Study.

Crassocephalum rabens (Asteraceae) is a common herb used in Taiwanese folk medicine to treat inflammation-related syndromes. Pharmacological studies have revealed that galactolipids exhibit anti-oxidative, anti-inflammatory, and anti-hyaluronidase activities and improve skin wrinkles, moisture, and elasticity in healthy subjects. However, the anti-aging effects of C. rabens and its primary active compound, 1,2-di-O-linolenoyl-3-O-β-galactopyranosyl-sn-glycerol (dLGG), remain elusive. Here, we investigated whether C. rabens can improve skin conditions in healthy individuals using a double-blind approach. Forty enrolled volunteers were randomly and equally assigned to the control or treatment group and were required to take either a placebo or a C. rabens extract capsule daily for one month. Skin parameters were measured before and after the study. The results showed significant differences in skin elasticity, wrinkles, collagen content, brightness, and hydration between the baseline and week 4 in the treatment group. Particularly, compared with those in the placebo group, skin wrinkles (p < 0.05), brightness (p < 0.001), collagen content (p < 0.01), and UV spots (p < 0.05) were notably improved after treatment with the C. rabens extract. Our study successfully demonstrated the application of C. rabens in preventing skin aging. Further investigations will be conducted to study the underlying anti-aging mechanism of dLGG.

Utilization of Aloe vera Plants as a Raw Materials for Cosmetics: A Narrative Review

One of the plants that can be used as natural ingredients in cosmetics is aloe vera (Aloe vera). Aloe vera is very easy to get and has also been widely cultivated in Indonesia. The benefits of aloe vera are very diverse, including as an antibiotic, antiseptic, antibacterial, antiviral, anti-infective, anti-inflammatory, and anti-swelling. Aloe vera is effective in replacing damaged cells and improving skin conditions because there are polysaccharides that work together with essential amino acids and protein-breaking enzymes. Other aloe vera content in vitamins A, B12, E, inositol, and folic acid. The mineral content includes calcium (Ca), magnesium (Mg), potassium (K), sodium (Na), iron (Fe), zinc (Zn), and chromium (Cr). Aloe vera can be used as cosmetic preparations in the form of hair tonic, lotion, lip balm, shampoo, creambath, and liquid soap.

Extracellular Vesicles in Facial Aesthetics: A Review.

Facial aesthetics involve the application of non-invasive or minimally invasive techniques to improve facial appearance. Currently, extracellular vesicles (EVs) are attracting much interest as nanocarriers in facial aesthetics due to their lipid bilayer membrane, nanosized dimensions, biological origin, intercellular communication ability, and capability to modulate the molecular activities of recipient cells that play important roles in skin rejuvenation. Therefore, EVs have been suggested to have therapeutic potential in improving skin conditions, and these highlighted the potential to develop EV-based cosmetic products. This review summarizes EVs’ latest research, reporting applications in facial aesthetics, including scar removal, facial rejuvenation, anti-aging, and anti-pigmentation. This review also discussed the advanced delivery strategy of EVs, the therapeutic potential of plant EVs, and clinical studies using EVs to improve skin conditions. In summary, EV therapy reduces scarring, rejuvenates aging skin, and reduces pigmentation. These observations warrant the development of EV-based cosmetic products. However, more efforts are needed to establish a large-scale EV production platform that can consistently produce functional EVs and understand EVs’ underlying mechanism of action to improve their efficacy.

The effects of wearing a face mask and of subsequent moisturizer use on the characteristics of sensitive skin.

BackgroundCOVID‐19 is a serious respiratory disease, and wearing masks has become essential in daily life. Nevertheless, the number of people complaining of skin problems caused by wearing masks is increasing. Therefore, we investigated the characteristics of changes in sensitive skin caused by wearing a mask.Materials and methodsTwenty healthy Korean women with sensitive skin participated in this study. To determine any skin‐related changes caused by mask‐wearing, we evaluated redness, hydration, transepidermal water loss (TEWL), and moisture at 2.5 mm below the surface before and 4 h after wearing a Korea Filter 94 mask. In addition, we tested whether applying a moisturizer for 30 min after mask removal could reverse any mask‐induced changes.ResultsSkin redness and TEWL were significantly increased at 4 h after wearing a mask (p < 0.05), otherwise skin hydration and the 2.5 mm moisture were significantly decreased (p < 0.05). After applying the moisturizer, skin redness and TEWL were significantly decreased compared to their values 4 h after wearing masks (p < 0.05), whereas skin hydration and the 2.5 mm moisture were significantly increased (p < 0.05). Moreover, after applying the moisturizer, skin redness and TEWL were significantly reduced compared to the pre‐masking baseline (p < 0.05), whereas skin hydration was significantly increased (p < 0.05); the 2.5 mm moisture showed no significant change.ConclusionWe observed that wearing masks causes physiological changes in sensitive skin, whereas applying a moisturizer after removing the mask improved skin conditions.

Collagen Peptide Combined with Annona Muricata Fermentation, Snow Lotus and Rosa Rugosa Improve Skin Condition and Anti-Inflammation

Skin aging is a complex and continuous process that affects skin functions and appearance

Peptide-pro complex serum: Investigating effects on aged skin.

Effective anti-aging treatments are an unmet consumer need. Ex vivoand clinical tests have evaluated the efficacy of a topical facial serum containing a proprietary blend of neuropeptides, proteins, amino acids, and marine extracts on aged skin. In the ex vivo study the facial serum was compared to a commercially marketed face serum and to an untreated control on skin explants using microrelief, smoothness, and epidermal thickness endpoints. The 12weeks monadic clinical study was designed for the test product to be used on the whole face. Subjects functioned as their own control; evaluating change from baseline. Skin was evaluated clinically by a Dermatologist for tolerability and for efficacy. Also part of the product assessment was skin hydration measurements, imaging, and a subject questionnaire. The facial serum improved skin condition by significant reductions in skin surface area occupied by microfolds and in skin roughness. Additionally, it increased epidermal thickness as compared to the untreated control as well as the commercially marketed face serum. The facial serum provided a statistically increased skin moisturization compared to pretreatment values. Dermatological evaluation of the skin concluded that there were statistically and clinically significant improvements in skin smoothness, wrinkles severity, fine lines visibility and lifting, and tightening effects at crow's feet area, forehead, and upper lip. A facial serum, containing a proprietary blend of neuropeptides, proteins, amino acids, and marine extracts, has been shown to improve the overall quality of aged skin in a series of ex vivo and clinical tests.

Role of Phytochemicals in Skin Photoprotection via Regulation of Nrf2

Ethnopharmacological studies have become increasingly valuable in the development of botanical products and their bioactive phytochemicals as novel and effective preventive and therapeutic strategies for various diseases including skin photoaging and photodamage-related skin problems including abnormal pigmentation and inflammation. Exploring the roles of phytochemicals in mitigating ultraviolet radiation (UVR)-induced skin damage is thus of importance to offer insights into medicinal and ethnopharmacological potential for development of novel and effective photoprotective agents. UVR plays a role in the skin premature aging (or photoaging) or impaired skin integrity and function through triggering various biological responses of skin cells including apoptosis, oxidative stress, DNA damage and inflammation. In addition, melanin produced by epidermal melanocytes play a protective role against UVR-induced skin damage and therefore hyperpigmentation mediated by UV irradiation could reflect a sign of defensive response of the skin to stress. However, alteration in melanin synthesis may be implicated in skin damage, particularly in individuals with fair skin. Oxidative stress induced by UVR contributes to the process of skin aging and inflammation through the activation of related signaling pathways such as the mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1), the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), the nuclear factor kappa B (NF-κB) and the signal transducer and activator of transcription (STAT) in epidermal keratinocytes and dermal fibroblasts. ROS formation induced by UVR also plays a role in regulation of melanogenesis in melanocytes via modulating MAPK, PI3K/Akt and the melanocortin 1 receptor (MC1R)-microphthalmia-associated transcription factor (MITF) signaling cascades. Additionally, nuclear factor erythroid 2-related factor 2 (Nrf2)-regulated antioxidant defenses can affect the major signaling pathways involved in regulation of photoaging, inflammation associated with skin barrier dysfunction and melanogenesis. This review thus highlights the roles of phytochemicals potentially acting as Nrf2 inducers in improving photoaging, inflammation and hyperpigmentation via regulation of cellular homeostasis involved in skin integrity and function. Taken together, understanding the role of phytochemicals targeting Nrf2 in photoprotection could provide an insight into potential development of natural products as a promising strategy to delay skin photoaging and improve skin conditions.

Effects of ozonation and foam fractionation on rainbow trout condition and physiology in a small-scale freshwater recirculation aquaculture system

The combined use of ozonation and foam fractionation significantly improves the water quality in freshwater recirculating aquaculture systems (RAS). In a recent study, numbers and total volume of suspended particles were reduced by 89% and 76%, respectively, water turbidity was improved by 79% and bacterial activity was reduced by 90% compared to control RAS. In the current study, we assessed the effects of those improvements in water quality on the welfare status of the rainbow trout juveniles present in the RAS. Ozone and foam fractionation were applied separately or in combination in a two-by-two factorial design with triplicated individual RAS. The trial was 8-week long and the welfare of the fish was assessed on week 4 (mid-term) and on week 8 (final). Fish welfare was assessed by using a combination of variables related to physiological stress, oxidative stress, growth performance, energy metabolism and external damage. Feed amounts were kept constant during the study to maintain homogeneous water quality conditions through the study, resulting in a decreasing specific feeding ration during the experiment. Restrictive feeding affected a number of variables related to the metabolic condition of the fish, but those effects were similar for all treatments. Effects of ozonation, foam fractionation and their combination on fish welfare were modest. Both ozone and foam fractionation led to improved skin condition of the fish, and seemed to act complementarily when applied together. Furthermore, foam fractionation had a small significant effect in improving the fish condition factor with respect to the fish in the RAS without foam fractionation. While the size of the described effects was small, they were the result of short-term exposure to the improved water quality. Further studies should focus in investigating the long-term effects of ozonation and foam fractionation on fish welfare in RAS-based aquaculture.

The use of hydrogen purification and mixture of cosmetics acids, and the influence on acne skin parameters: a case report.

Background: Acne vulgaris is a common disease which causes physical and mental ailments that are associated with a significantly reduced quality of life. Contemporary cosmetology is looking for innovative and effective methods of treating acne vulgaris. The synergistic action of acids and hydrogen purification has a positive effect on the reduction of sebum secretion and thus the amount of skin eruptions. The aim of the study : To check the effectiveness of hydrogen purification treatment combined with topical acids for the treatment of acne vulgaris. Case report: The participant of this study is a 20-year-old female, struggling with acne vulgaris for 5 years. She has a problem with large sebum secretion and numerous eruptions on her skin. Before and 30 days after a series of treatments the sebum secretion was measured with Derma Unit SCC 3Courage + Khazaka electronic GmbH, which characterizes the hydrolipidic film of the skin. The severity of acne vulgaris was measured using the GAGS scale. Conclusions: There was a significant improvement in skin condition after a series of treatments. Hydrogen purification combined with phytic, pyruvic, lactic and ferulic acids 40% (pH 1.4) was found to be safe and effective.

The Efficacy and Safety Evaluations of a Formulation SIDAI® on the Improvement of Skin Conditions: Results of a Clinical Study

The Efficacy and Safety Evaluations of a Formulation SIDAI® on the Improvement of Skin Conditions: Results of a Clinical Study

Novel Hydrolyzed Porcine and Fish Collagen Beverage Improved Collagen, Elasticity, Moisture, Spots: A Randomized, Double-blind, Placebo-controlled Trial

Background: As the population ages, oral hydrolyzed collagen supplements are gaining traction. However, few clinical studies on the skin health of hydrolyzed porcine collagen combined with fish collagen. Objective: This study investigates whether TripleUp collagen beverage has skincare and anti-inflammatory effects. Methods: Using collagen beverage to treat epidermal keratinocytes and examine ROS, HA, inflammatory factor, and moisturizing-related gene expressions (Tgm1, Krt14, FLG-F, GBA, HAS3). Fifty subjects were recruited into a placebo and collagen beverage group for four weeks and then examined skin condition at 0, 2, 4 weeks. Results: TripleUp collagen beverage decreased IL-8 and ROS expression and increased moisturizing-related gene expressions. In addition, collagen beverages increase skin collagen, elasticity, moisture, and decreased spots. Conclusions: Thus, TripleUp collagen beverage included hydrolyzed porcine, and fish collagen and vitamin C can improve skin condition.

Skin biophysical properties including impaired skin barrier function determine ultraviolet sensitivity.

The levels of burning susceptibility to ultraviolet (UV) radiations are affected by various factors, including Fitzpatrick skin types, skin color, sex, and ethnicity. However, studies on the relationship between skin biophysical properties and erythemal responses to UV radiations are rare. This study aimed to investigate biophysical properties of the skin that determined individual skin sensitivity to UV radiation. As an indicator of skin sensitivity to UV radiation, Korean women were subjected to minimal erythema dose (MED) testing. The skin biophysical properties, such as skin hydration, transepidermal water loss (TEWL), were measured. MED were also evaluated in further variations in the skin, including barrier disruption. A significant negative correlation was observed between TEWL and MED. With an increase in TEWL, that represents reduced skin barrier function, skin UV sensitivity also increased. Artificial alteration of skin conditions also changed erythemal response to UV radiation. When the skin barrier was disrupted, MED significantly decreased, indicating increased skin UV sensitivity. It is hypothesized that the altered penetration of UV radiation into the stratum corneum under the respective skin conditions caused different erythema reactions. For the first time in a clinical study, the skin biophysical properties, including skin barrier function, were found to have significant effects on skin sensitivity to UV radiation. This finding could help predict individual susceptibility to UV damage. Therefore, skincare products that improve skin conditions associated with UV sensitivity, as well as sunscreen are important for protection against the hazards of UV radiation.

Assessment of Circadian-based Antioxidants Plus a Comprehensive Brightener in Skin of Color Patients With Hyperpigmentation.

Hyperpigmentation disorders disproportionately affect individuals with skin of color. There is an unmet need for safe and effective topical treatments for this population. The efficacy and tolerability of LYT2 in combination with LVS were assessed in skin of color patients with moderate to severe facial hyperpigmentation. A single-arm study was performed in Asian, Hispanic, or African American patients (Fitzpatrick phototypes III&ndash;VI). Subjects applied LYT2 and LVS daily, in addition to a basic skincare regimen, for 12 weeks. Overall hyperpigmentation, skin-tone evenness, and radiance were evaluated by the investigator, and subjects completed questionnaires regarding self-perceived efficacy. After 12 weeks, the combination of LYT2 and LVS produced a 23% improvement in overall hyperpigmentation, a 33% increase in skin-tone evenness, and a 51% increase in radiance compared to baseline. At the study conclusion, all patients noted at least a slight improvement in skin condition, and 70% reported good or excellent satisfaction. One subject (8%) experienced a treatment-related adverse event. The combination of LYT2 and LVS was well-tolerated and improved the appearance of hyperpigmentation and overall quality in skin of color. J Drugs Dermatol. 2022;21(4):376-380. doi:10.36849/JDD.6687.

The Beneficial Effect of Cannabis sativa Seed Oil on the Epidermis

Background: Cannabis Sativa seed oil has become more and more popular in cosmetic industry mainly due to the high content of antioxidants and unsaturated fatty acids that are desirable in formulations because they prevent moisture loss and reduce the occurrence of dry skin. Objective: The aim of this study was to determine the effect of Cannabis Sativa seed oil on skin parameters such as hydration and transepidermal water loss. Methods: The in vivo tests on volunteers with combination skin were performed by using corneometer and tewameter. Results: The obtained results proved that Cannabis Sativa seed oil improved skin condition. The transepidermal water loss decreased because the lipophilic components of the oil formulation tend to form an occlusive layer on the epidermis surface. The highest increase in skin hydration was observed after one week of treatment. Conclusion: These results confirmed that Cannabis Sativa seed oil has strong moisturizing properties and can be recommended as a natural-based skin conditioning agent.

The Effect of Adult Women s Lifestyle on the Use of the Beauty Information on Social Media and Skin Care Related Purchase Motivation for the Skin Health Protection

Purpose: Personal hygiene become important due to the Covid-19 outbreak after 2019. An interest in skin health care has received attention to protect facial skin from wearing a protective mask on every day basis. This study has researched on an effect of lifestyle of female adult on searching beauty information through social network service (social media) and motivation to invest on skincare service. Method: Survey method was used to gather information from 20s~50s of female. The survey consists of life-style, a usage of beauty information through social media, the motivation to purchase skincare service, and de-mographic variables. To characterize subjects, percentage, average, and frequency were calculated. Pearson Corre-lation has been applied to analyze the relationship between lifestyle, the usage of beauty information through social media and the motivation to purchase skincare service. Multiple regression analysis was performed to find cause-and-effect relationship. Results: First, achievement seeking types and trend seeking types were outcomes as lifestyle. Information spread, sharing latest information, a use of information was obtained as a result of use of beauty information through social media. Aims of purchase of skincare were for relaxing, improving skin condition, and external stimulation based on this study. Second, among the lifestyles, achievement seeking types were found to use the latest variety of social media beauty information for purpose of rests, and trend seeking types were found to be active in using various skin care related purchase motivations and social media beauty information. Conclusion: These studies confirmed that depending on types of lifestyles, an influence of use of beauty infor-mation on social media is different on skin care related purchase motivation. This study can be a baseline for marketing in the skin care industry by identifying lifestyle characteristics and use of beauty information on social media characteristics.

Oral intake of Bioactive Collagen Peptides in the improvement of skin and hair: clinical studies by instrumental measurements

The effect of collagen peptides on various aspects of skin and hair physiology is known but needs further studies. Thus, the objective of this study was to evaluate the clinical changes in skin and hair after 90 days of treatment with oral supplementation of 5 g/day of collagen peptides. For this, 60 healthy female participants were enrolled, aged 45 to 60 years old, with the primary objective of evaluating the effect of the ingestion of a bioactive collagen peptides-based supplementation in the cutaneous microrelief, reduction of wrinkles, thickness, and echogenicity of the dermis, as well as in the mechanical properties of the hair using biophysical and skin imaging techniques. The present study showed important benefits in relevant skin visual parameters, dermis density, and hair strength with the obtained data. In addition, considering that the aging process affects the hair's mechanical resistance due to hair fiber thinner, the proposed treatment was effective for aged hair. In conclusion, the collagen peptides oral supplementation is essential not only for improving skin conditions but also for hair care once it significantly increases the mechanical hair resistance evaluated by objective measurements. Keywords: Collagen peptides, skin aging, skin imaging techniques, hair mechanical properties, clinical study