Kenya's healthcare sector plays a crucial role in economic growth and the realization of Vision 2030. Mission hospitals in Kiambu County, however, face sustainability challenges, including inadequate financial resources, staff turnover, weak health systems, and patient non-payment. This study investigated how strategic innovation affects the sustainability of these hospitals, focusing on business models, services, processes, and technological innovations. The research involved 100 managers from seven mission hospitals, using a census approach and a cross-sectional descriptive design. Data were analysed using SPSS, with multiple linear regression to determine relationships between variables. The study found that adopting innovative business models, aligning with market trends, improving service quality, and implementing technological solutions like telemedicine and electronic health systems significantly enhanced operational efficiency, patient satisfaction, and financial stability. The study recommended that mission hospitals regularly review and adapt their value propositions, while the government should support innovation through policies to ensure healthcare sustainability.
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