Improve Stress Coping Research Articles

Improving stress coping and problem-solving skills of children in disaster-prone area through cooperative physical education and sports lesson

The present study examined the effect of cooperative games in physical education (PE) and sports classes on the stress coping and problem-solving skills, and the relationship between these skills. The fifteen elementary schools in the volcano disaster area were assigned to the intervention and two control groups. The intervention group received PE and sports lessons with cooperative games while the control groups completed PE and sports lessons consistent with each school’s existing curriculum over 28 weeks. The stress coping and problem-solving skills scales, previously developed for use with students, was implemented before and after the program. Two- and one-way analysis of variance and paired sample t-tests were used to compare the three groups, and a Pearson correlation analysis was used to examine the relationship between skills at pre- and post-test. The analysis showed a significant increase in stress coping and problem-solving skills in the intervention group over two control groups and a high positive relationship between these skills was in the post-test of the intervention group. T he PE and sports lessons with cooperative games could effectively promote both students’ stress coping and problem-solving skills.

Pharmacological Modulation of the Psychiatric Risk Factor FKBP51 Alters Efficiency of Common Antidepressant Drugs.

Despite a growing body of research over the last few decades, mental disorders, including anxiety disorders or depression, are still one of the most prevalent and hardest to treat health burdens worldwide. Since pharmacological treatment with a single drug is often rather ineffective, approaches such as co-medication with functionally diverse antidepressants (ADs) have been discussed and tried more recently. Besides classical ADs, there is a growing number of candidate targets identified as potential starting points for new treatment methods. One of these candidates, the FK506 binding protein 51 (FKBP51) is linked to a number of psychiatric disorders in humans. In this study, we used SAFit2—a newly developed modulator of FKBP51, which has shown promising results in rodent models for stress-related disorders delivered in a depot formulation. We combined SAFit2 with the commonly prescribed selective serotonin reuptake inhibitor (SSRI) escitalopram and performed basic behavioral characterization in a mouse model. Remarkably, co-application of SAFit2 lowered the efficacy of escitalopram in anxiety-related tests but improved stress coping behavior. Given the fact that mental diseases such as anxiety disorders or depression can be divided into different sub-categories, some of which more or less prone to stress, SAFit2 could indeed be a highly beneficial co-medication in very specific cases. This study could be a first, promising step towards the use of FKBP51 modulators as potent and specific enhancers of AD efficiency for subclasses of patients in the future.

Programa para mejorar el afrontamiento del estrés de los estudiantes, los docentes y los no docentes de la Facultad de Farmacia y Bioquímica de la Universidad de Buenos Aires

Introduction and aimsPrograms to improve stress coping include a series of techniques such as relaxation training, cognitive restructuring, and time management, among others. Its application has shown its importance in the field of Health Psychology. In the present study we show the beneficial results of a theory-practice pilot training program of stress management for professionals, teachers, non teachers and students of Pharmacy and Biochemistry. Material and methodsA program of 5 sessions was implemented with the objective of improving stress management. To assess efficacy, we used hair cortisol level and anxiety level tests before and after the program. ResultsAfter the program, both hair cortisol and anxiety levels significantly decreased among participants. Hair cortisol significantly increased in the control group. ConclusionsThis type of program was proved to be effective for all participants, helping to reduce stress and improving their quality of life.

Psychosocial student functioning in comprehensive dental clinic education: A qualitative study.

The aims were to describe first-year clinical dental students' psychosocial experiences in a known well-functioning comprehensive clinic teaching group (F+Grp) and a known dysfunctional group (Dys-Grp) and, thus, discover and describe phenomena related to psychosocial functioning of students. These groups were compared and contrasted regarding negative stress symptoms, perfectionism and coping with stress. Eight female dental students (mean 26years old), four in each group, were interviewed after the first clinical year about learning and emotional experiences. The students also rated their perceived stress using a 0-10 scale, where 0 is no stress, and 10 is highest stress. Qualitative analyses involved searching for recurring themes and discovery of categories of clinical and social functioning. All 8 students were revisited as dentists after 8years and filled out a 15-item survey as longitudinal validation of their first-year clinical experiences and to estimate group consensus and informant accuracy. Both groups suffered from negative stress symptoms attributed to lack of time for clinical tasks, worries about work quality with confusion about their own expectations and worries about how others perceived them. Dys-Grp experienced higher negative stress and maladaptive perfectionism and described crying behaviours, withdrawal and unwillingness to cooperate with others. In contrast, students in F+Grp provided rich content about mutual cooperation related to social networking and positive support. The 8 subjects exhibited high internal consistency (α = .98) in their responses to the follow-up survey about their first year of clinic. The comprehensive care teaching clinic environment with students working in groups appeared to provide a possibility for students to support each other for improved stress coping. Unfortunately, the opposite also occurred. Positive, supportive teacher supervision of student challenges related to perfectionism and stress is crucial and requires specific attention.

Clinical characteristics of suicidal behavior in an intensive care unit at a university hospital in Japan: A 7-year observational study.

Suicidal behavior accounts for at least 40,000 admissions per year to emergency departments in Japan; however, little is known about emergency admissions owing to suicidal behavior in metropolitan areas. Therefore, we examined the clinical characteristics of suicidal behavior using psychosocial assessments performed by experienced psychiatrists in an intensive care unit. Participants were 971 patients admitted to a university hospital's intensive care unit for suicidal behavior between July 2006 and June 2013. Physicians and psychiatrists regularly assessed the participants using a standard data extraction form while the participants were in the intensive care unit. As suicidal behavior involving drug overdose is generally less fatal than other methods, we predicted that clinical characteristics would differ between patients with and without overdose. We classified participants into drug overdose or other method groups (ns=732 and 239, respectively) to compare suicide methods. In the overdose group, participants' median age was approximately 5 years lower, and the following proportions were larger: female participants (77%) and participants with borderline personality disorders (21% vs. 10%), no clear suicidal ideation (30% vs. 15%), impulsively attempted self-harm (86% vs. 62%), and interpersonal problems (26% vs. 16%). Ameliorating interpersonal problems and improving stress coping skills would benefit people who attempt suicide via overdose.

Humor and workplace stress: a longitudinal comparison between Australian and Chinese employees

This study investigates how humor usage (including positive and negative humor styles) influences employees' responses to the same stressful events, namely, the auto‐correlation between stress experiences at two time points. Moreover, it examines differences between Australian and Chinese employees in such effects via bicultural comparisons. Results from a two‐wave survey of 109 Australian and 141 Chinese employees indicated that humor usage moderated the StressTime1 – StressTime2 relationship for Australian employees but not for Chinese employees. Specifically, the positive relationship between the two stress measures became weaker for Australians who were higher in humor than those lower in humor. Similarly, Positive humor mitigated the relationship between StressTime1 and StressTime2 only for the Australians but not the Chinese. However, Negative humor exerted no influence on the focal relationship in either sample. Organizations should encourage employees to use humor in effective ways, thereby improving stress coping skills and reducing workplace stress.

A Virtual Hope Box: Randomized Controlled Trial of a Smartphone App for Emotional Regulation and Coping With Distress.

The purpose of this study was to assess the impact of the Virtual Hope Box (VHB), a smartphone app to improve stress coping skills, suicidal ideation, and perceived reasons for living among patients at elevated risk of suicide and self-harm. The authors conducted a parallel-group randomized controlled trial with two groups of U.S. service veterans in active mental health treatment who had recently expressed suicidal ideation. Between March 2014 and April 2015, 118 patients were enrolled in the study. Participants were assigned to use the VHB (N=58) or to a control group that received printed materials about coping with suicidality (N=60) to supplement treatment as usual over a 12-week period. Three measures-the Coping Self-Efficacy Scale, Beck Scale for Suicidal Ideation, and Brief Reasons for Living Inventory-were collected at baseline (before randomization) and three, six, and 12 weeks. Secondary measures-the Interpersonal Needs Questionnaire, Perceived Stress Scale, and Columbia-Suicide Severity Rating Scale-were collected at baseline and 12 weeks. VHB users reported significantly greater ability to cope with unpleasant emotions and thoughts (Coping Self-Efficacy Scale) at three (b=2.41, 95% confidence interval [CI]=.29-4.55) and 12 weeks (b=2.99, 95% CI=.08-5.90) compared with the control group. No significant advantage was found on other outcome measures for treatment augmented by the VHB. The VHB is a demonstrably useful accessory to treatment-an easily accessible tool that can increase stress coping skills. Because the app is easily disseminated across a large population, it is likely to have broad, positive utility in behavioral health care.

Mindfulness, stress coping and everyday resilience among emerging youth in a university setting: a mixed methods approach

Mindfulness is defined as non-judgmental awareness in the present lived experience. Researchers find that mindfulness training has benefits such as enhanced positive emotions, reduced stress and increased well-being. However, empirical research on the effectiveness of mindfulness curricula on emerging adults in educational settings is sparse. The present study takes a step towards filling this gap by examining The role of mindfulness communication in improving stress coping among young people. Specifically, this study used a mixed methods approach combining qualitative journaling with a pre-test post-test experiment to understand how a mindfulness-based communication course improves everyday resilience for first-year college students. Preliminary findings suggest that participants exposed to mindfulness communication training experience more positive emotions and report lesser perceived stress. Further research is needed to better understand the relationships among mindfulness communication, stress coping and academic buoyancy.

Patient Perspectives on Participation in Cognitive Functional Therapy for Chronic Low Back Pain.

Cognitive functional therapy (CFT) has been shown to reduce pain and disability in people with chronic low back pain. The purpose of this study was to investigate participants' experience of CFT by comparing participants who reported differing levels of improvement after participation in CFT, potentially yielding insight into the implementation of this approach. This was a noninterventional, cross-sectional, qualitative study with an interpretive description framework. Individuals who had participated in CFT in 2 physical therapy settings (in Ireland and Australia) were recruited through purposive sampling based on disability outcomes postintervention (n=9), and theoretical sampling (n=5). This sampling strategy was used to capture a range of participant experiences but was not used to define the final qualitative groupings. Semistructured interviews were conducted 3 to 6 months postintervention. Three groups emerged from the qualitative analysis: large improvers, small improvers, and unchanged. Two themes encapsulating the key requirements in achieving a successful outcome through CFT were identified: (1) changing pain beliefs and (2) achieving independence. Changing pain beliefs to a more biopsychosocial perspective required a strong therapeutic alliance, development of body awareness, and the experience of control over pain. Independence was achieved by large improvers through newly cultivated problem-solving skills, self-efficacy, decreased fear of pain, and improved stress coping. Residual fear and poor stress coping meant that small improvers were easily distressed and lacked independence. Those who were unchanged continued to feel defined by their pain and retained a biomedical perspective. A successful outcome after CFT is dependent on instilling biopsychosocial pain beliefs and developing independence among participants. Small improvers may require ongoing support to maintain results. Further study is needed to elucidate the optimal approach for those who were unchanged.

Perceived stress, unhealthy eating behaviors, and severe obesity in low-income women.

BackgroundStress has been associated with poor eating behaviors and diet quality, as well as high body mass index (BMI). Low-income women may be particularly vulnerable to stress and severe obesity. Yet it is unknown how stress increases the risk of severe obesity through disordered eating behaviors and poor diet quality or through mechanisms independent of diet.MethodsWe examined cross-sectional data from women (n = 101) with a child enrolled in the Special Supplemental Nutrition Program for Women, Infants, and Children in Cumberland County, North Carolina (spring 2012). We collected measured heights and weights to calculate BMI. Using structural equation modeling, we differentiated pathways from stress to weight status: (1) indirectly through eating behaviors (cognitive restraint, emotional eating, and uncontrolled eating) and diet quality, which we examined with the Healthy Eating Index 2010 and 24-h dietary recalls, and (2) directly through possible unmeasured risk factors independent of diet. The analysis controlled for race/ethnicity, income, age, whether the dietary recall day was typical, and whether the respondent completed one or two 24-h dietary recalls.ResultsPerceived stress was positively associated with uncontrolled eating (β = 0.38, p < 0.001) and emotional eating (β = 0.50, p < 0.001). However, higher stress was not associated with weight status through eating behaviors and diet quality. Independent of eating behaviors and diet quality, stress was positively associated with severe obesity (β = 0.26, p = 0.007).ConclusionsImproving stress coping strategies for low-income women may improve eating behaviors and reduce severe obesity.Electronic supplementary materialThe online version of this article (doi:10.1186/s12937-015-0110-4) contains supplementary material, which is available to authorized users.

The Influence of the Laughing Programs on Self-esteem and Stress Coping Behaviors in Elementary School Student

ABSTRACT Purpose: The purpose of this study is to survey on the influence of the laughing program on elementary school students’ self-esteem and stress coping behaviors. Methods: In total, 43 children (grade 4~6 students) were re-cruited for self administered questionnaire. Questionnaire was composed of general characteristics, self-esteem, and stress coping behaviors. Ten week course of laughing program was scheduled to the Experimental group, meanwhile no program was given to the control group. Results: The median self-esteem scores in the experimental group was increased from 30.05 to 34 (Z=-2.375, p <.05). Meanwhile control group did not show significant change. The median inactive/avoidant coping scores in the experimental group was decreased from 10 to 9 (Z=-2.028, p <.05). Meanwhile control group did not show significant change in any items of stress coping behaviors. Conclusion: Laughing program may be helpful to improve stress coping behaviors through reducing inactive/avoidance coping as well as to strengthen self-esteem, especially among participants who had low self-esteem before the intervention.

Protocol: The Effect of 12 Weeks of Tai Chi Practice on Anxiety in Healthy but Stressed People Compared to Exercise and Wait-list Comparison Groups: A Randomized Controlled Trial

Stress is a major problem in today’s fast-paced society and can lead to serious psychosomatic complications. The ancient Chinese mind–body exercise of Tai Chi may provide an alternative and self-sustaining option to pharmaceutical medication for stressed individuals to improve their coping mechanisms. The protocol of this study is designed to evaluate whether Tai Chi practice is equivalent to standard exercise and whether the Tai Chi group is superior to a wait-list control group in improving stress coping levels. This study is a 6-week, three-arm, parallel, randomized, clinical trial designed to evaluate Tai Chi practice against standard exercise and a Tai Chi group against a nonactive control group over a period of 6 weeks with a 6-week follow-up. A total of 72 healthy adult participants (aged 18–60 years) who are either Tai Chi naïve or have not practiced Tai Chi in the past 12 months will be randomized into a Tai Chi group (n = 24), an exercise group (n = 24) or a wait-list group (n = 24). The primary outcome measure will be the State Trait Anxiety Inventory with secondary outcome measures being the Perceived Stress Scale 14, heart rate variability, blood pressure, Short Form 36 and a visual analog scale. The protocol is reported using the appropriate Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) items.

Prevalence and association of perceived stress, substance use and behavioral addictions: a cross-sectional study among university students in France, 2009-2011.

BackgroundUniversity students face multiple stressors such as academic overload, constant pressure to succeed, competition with peers as well as concerns about the future. Stress should not be considered on its own, but should be associated with potential risk behaviors leading to onset of substance use and related problems heightened during the university period. The aim of this study was to determine the prevalence of main substance use and behavioral addictions among students in higher education in France and to examine the relationship with perceived stress.MethodsA self-administered questionnaire was filled out by university student volunteers from Upper Normandy (France) either by anonymous online questionnaire or by paper questionnaire. Data collected included socio-economic characteristics, Perceived Stress Scale (PSS), substance use (tobacco, alcohol, and cannabis) and hazardous behaviors: alcohol abuse problems, smoking, consumption of cannabis, eating disorders, and cyber addiction.ResultsA total of 1876 students were included. Mean PSS score was 15.9 (standard deviation = 7.2). Highly stressed students (4th quartile) were compared with lesser stressed students (1st quartile). A positive relation was observed between female gender, regular smokers, alcohol abuse problems, risk of cyberaddiction and especially eating disorders (AOR = 5.45, 95% CI = 3.42-8.69), and increasing PSS score. PSS score however, was not significantly related to the curriculum, regular alcohol use, drunkenness or binge drinking even after additional controlling for use of other substances. We found a significant negative association between stress and practice of sport: students with the most physical activity were less likely to report perceived stress (4th quartile: AOR = 0.57, 95% CI = 0.39-0.80).ConclusionsThis cross-sectional study among university students in France revealed that perceived stress was associated not only with known risks such as alcohol misuse, but also with new risks such as eating disorders and cyber addiction. These results could help to develop preventive interventions focussing on these risk behaviors and subsequently improving stress coping capacity in this high-risk population.

Environmental Enrichment and Gut Inflammation Modify Stress-Induced c-Fos Expression in the Mouse Corticolimbic System

Environmental enrichment (EE) has a beneficial effect on rodent behaviour, neuronal plasticity and brain function. Although it may also improve stress coping, it is not known whether EE influences the brain response to an external (psychological) stressor such as water avoidance stress (WAS) or an internal (systemic) stressor such as gastrointestinal inflammation. This study hence explored whether EE modifies WAS-induced activation of the mouse corticolimbic system and whether this stress response is altered by gastritis or colitis. Male C67BL/6N mice were housed under standard or enriched environment for 9 weeks, after which they were subjected to a 1-week treatment with oral iodoacetamide to induce gastritis or oral dextran sulfate sodium to induce colitis. Following exposure to WAS the expression of c-Fos, a marker of neuronal activation, was measured by immunocytochemistry. EE aggravated experimentally induced colitis, but not gastritis, as shown by an increase in the disease activity score and the colonic myeloperoxidase content. In the brain, EE enhanced the WAS-induced activation of the dentate gyrus and unmasked an inhibitory effect of gastritis and colitis on WAS-evoked c-Fos expression within this part of the hippocampus. Conversely, EE inhibited the WAS-evoked activation of the central amygdala and prevented the inhibitory effect of gastritis and colitis on WAS-evoked c-Fos expression in this region. EE, in addition, blunted the WAS-induced activation of the infralimbic cortex and attenuated the inhibitory effect of gastritis and colitis on WAS-evoked c-Fos expression in this area. These data reveal that EE has a region-specific effect on stress-induced c-Fos expression in the corticolimbic system, which is likely to improve stress resilience. The response of the prefrontal cortex – amygdala – hippocampus circuitry to psychological stress is also modified by the systemic stress of gut inflammation, and this interaction between external and internal stressors is modulated by the housing environment.

Limitation of pro- and anti-inflammatory cytokine analysis to discriminate biological stress effects in patients suffering from chronic psychological distress

Background: Research endeavors aiming to evaluate the effect of prolonged psychological distress on the immune system have been pursed over the past decades. Due to the complexity of the two systems involved, the mental and immune status, a large number of questions still remains to be addressed. Aim: In the present study, we aimed to test if chronic distress is associated with pro- and anti-inflammatory cytokine levels in a well-defined study cohort. Methods: We recruited 42 inpatients suffering from post-traumatic embitterment disorder (PTED), a condition that has been demonstrated to cause intense and persistent psychological distress. Study participants completed established questionnaires to evaluate stress perception, depression and quality of life before and after psychotherapy, aiming to improve stress coping. Venous blood samples to detect serum levels of pro- and anti-inflammatory cytokines [interleukin (IL)-2, IL-4, IL-6, IL-10, tumor necrosis factor (TNF)-α, interferon (IFN)-γ] were obtained pre- and post-treatment. Results: The psychological assessments showed an increase of quality of life, a decrease of perceived stress and depressive symptoms, between the two groups. These findings are not associated with significant alterations of the cytokine levels before and after treatment. Conclusions: In our study, the psychological treatment of inpatients suffering from chronic psychological distress does not result in changes in cytokine levels. Further research with a broader analysis of immune markers and enhanced detection methods may be required to unveil psycho-immunological association in PTED patients.

대학생의 자기계발프로그램이 대학생활 적응 및 스트레스 대처방식에 미치는 효과

The purpose of this study is to plan out a university students' self-development program and to verify the effect of the students in adapting themselves to college life and coping with stress from it. The program was developed as the liberal arts course for a semester and comprised 12 sessions. Each secession of a 150 minutes workshop program. The pre-test, post test regarding students adaptation to college and stress coping methods conducts upon each experimental group and each control group. Each group consisted of 50 subjects. As a result of this research, this study could come to the following conclusions. Firstly, it was found that the university students' self-development program has effect on improving students adaptation to college. Secondly, it was found that the university students' self-development program has effect on improving stress coping methods.

Pituitary glucocorticoid receptor deletion reduces vulnerability to chronic stress

The incidence of chronic stress is frequently related to the development of psychiatric disorders like depression. The hypothalamic-pituitary-adrenal (HPA) axis is a major physiological system that mediates the stress response. Tight HPA axis regulation through negative feedback mechanisms is essential for health and environmental adaptation. This feedback regulation acts in part through the glucocorticoid receptor (GR) on several organizational levels, including the pituitary, the hypothalamus and the hippocampus. However, the precise role of the different anatomical structures, specifically the pituitary, in HPA axis regulation is yet largely unknown. Here, we show that a conditional pituitary GR knockout is not necessarily detrimental for the animal's ability to cope with chronic stress situations. Mice with a deletion of the GR at the pituitary (GR(POMCCre)) were subjected to 3 weeks of chronic social defeat stress. We analyzed both the behavioral and neuroendocrine phenotype as well as the central nervous system expression of genes involved in HPA axis function in these animals. Our results show a more resilient phenotype of GR(POMCCre) mice with respect to anxiety-related behavior and neuroendocrine parameters compared to stressed wild type animals. In light of the previously reported high corticosterone levels during postnatal development in GR(POMCCre) mice, our findings suggest that adverse early life events may have beneficial developmental effects on the organism to improve stress coping later in life.

남자 대학 골프 선수들의 스트레스와 스트레스 대처와의 관계

This study intends to provide basic data to improve stress coping skills of male college student golfers by closely examining the relationship between the stress experienced by male college student golfers and stress coping. The subjects of the study are convenience samples of 185 male golfers majoring in golf at K, Y and H university which are members of Korean College Golf Association 2008. Mean age was 20.91 with SD of 1.53, mean golf career was 7,91 with SD of 3.23. Questionnaire(Lee Gae Yoon, 1990) and Stress Coping questionnaire(Yoo Jin, Park Sung Joon 1998) was used to as a measure. To analyze the causal relationship between stress and stress coping, correlation analysis and path analysis was conducted. The conclusions reached using SPSS 15.0 program and AMOS 7.0 with .05 significance level are as follows. The results of this study are as follows. Active coping and passive coping mechanism were used to cope with body figure stress, active coping and detachment coping mechanism were used in interpersonal relationship stress. For career stress, problem-focused, detachment, avoidant mechanism were used, problem-focused and avoidant mechanism were used in discrimination stress. Active coping mechanism was used in performance and injury stress, avoidant mechanism was used to cope with poor facilities and environmental conditions.

Exercise Improves Cognitive Responses to Psychological Stress through Enhancement of Epigenetic Mechanisms and Gene Expression in the Dentate Gyrus

BackgroundWe have shown previously that exercise benefits stress resistance and stress coping capabilities. Furthermore, we reported recently that epigenetic changes related to gene transcription are involved in memory formation of stressful events. In view of the enhanced coping capabilities in exercised subjects we investigated epigenetic, gene expression and behavioral changes in 4-weeks voluntarily exercised rats.Methodology/Principal FindingsExercised and control rats coped differently when exposed to a novel environment. Whereas the control rats explored the new cage for the complete 30-min period, exercised animals only did so during the first 15 min after which they returned to sleeping or resting behavior. Both groups of animals showed similar behavioral responses in the initial forced swim session. When re-tested 24 h later however the exercised rats showed significantly more immobility behavior and less struggling and swimming. If rats were killed at 2 h after novelty or the initial swim test, i.e. at the peak of histone H3 phospho-acetylation and c-Fos induction, then the exercised rats showed a significantly higher number of dentate granule neurons expressing the histone modifications and immediate-early gene induction.Conclusions/SignificanceThus, irrespective of the behavioral response in the novel cage or initial forced swim session, the impact of the event at the dentate gyrus level was greater in exercised rats than in control animals. Furthermore, in view of our concept that the neuronal response in the dentate gyrus after forced swimming is involved in memory formation of the stressful event, the observations in exercised rats of enhanced neuronal responses as well as higher immobility responses in the re-test are consistent with the reportedly improved cognitive performance in these animals. Thus, improved stress coping in exercised subjects seems to involve enhanced cognitive capabilities possibly resulting from distinct epigenetic mechanisms in dentate gyrus neurons.

Reduced anxiety and improved stress coping ability in mice lacking NPY-Y2 receptors.

Neuropeptide Y (NPY) has been implicated in the pathophysiology of certain mood disorders, including depression and anxiety. It is, however, not known which of the five cloned NPY receptors mediate these functions. We investigated the effect of Y2 receptor deletion on anxiety and stress-related behaviours. In the elevated plus maze, Y2 knock out (Y2(-/-)) mice showed a 2.7-fold higher frequency of entering into, and spent 3.8 times more time within, the open arms compared to controls, while entries into the closed arms did not differ. Similarly Y2(-/-) mice entered the central area of the open field 1.7 times more frequently and also spent 1.8 times more time there. In the light/dark test Y2(-/-) mice had a 4.8-fold lower latency to enter the lit area but stayed there 2.6 times longer than control mice. Y2(-/-) mice displayed 3.2-fold less immobility in the forced swim test, indicating improved stress coping ability. Y2 receptors are predominantly located presynaptically where they mediate feedback inhibition of neurotransmitter release. Deletion of these receptors may result in enhanced release of NPY, GABA and/or glutamate in brain areas linked to the manifestation of anxiety, and stress-related behaviour such as the amygdala. Taken together, deletion of the Y2 receptor has revealed an important role of Y2 receptors in the generation of anxiety-related and stress-related behaviours in mice.