Length of stay (LOS) is a quality metric used for pathway development to improve hospital efficiency. We sought to define the predictors of prolonged LOS in patients undergoing thoracic endovascular aortic repair (TEVAR) for dissection or aneurysm by comparing demographic, operative, and postoperative factors in the National Surgical Quality Improvement Program (NSQIP). Patients undergoing TEVAR from 2005 to 2015 in the NSQIP were separated into dissection and aneurysm populations using International Classification of Diseases-Ninth Revision diagnosis codes. Groups were compared with χ2 analysis and t-tests. Prolonged LOS was defined as those patients at or above the 75th percentile for LOS (≥11 days). Univariate and multivariate logistic regression identified factors associated with prolonged LOS. There were 3021 patients undergoing TEVAR identified: 858 (28.4%) for dissection, and 2163 (71.6%) for aneurysm. Aneurysm patients were older (71.2 ± 11.7 vs 63.1 ± 13.6 years; P < .001), more Caucasian (76.8% vs 61.8%; P < .001), and had higher rates of chronic comorbidities (chronic obstructive pulmonary disease, cardiac history, diabetes, peripheral vascular disease, transient ischemia attack; P < .001). In contrast, dissection patients had higher American Society of Anesthesiologists classifications (P < .001), lower preoperative hematocrit (34.9 ± 5.4 vs 36.8 ± 5.8; P < .001), more emergent cases (32.4% vs 15.4%; P < .001), extended ventilator courses (11.7% vs 9.0%; P = .028), and longer hospital LOS (10.2 ± 10.8 vs 8.5 ± 10.3 days; P < .001). Multivariable analysis identified low hematocrit (odds ratio [OR], 0.92; 95% confidence interval [CI], 0.88-0.96; P < .001; OR, 0.90; 95% CI, 0.87-0.93; P < .001), postoperative stroke (OR, 4.02; 95% CI, 1.57-10.26; P = .004; OR, 2.67; 95% CI, 1.27-5.62; P = .01), extended ventilator course (OR, 4.21; 95% CI, 2.05-8.66; P < .001; OR, 4.72, 95% CI, 2.55-8.73; P < .001), postoperative pneumonia (OR, 3.33, 95% CI, 1.13-9.84; P = .029; OR, 6.69; 95% CI, 3.18-14.08; P < .001), and reoperation (OR, 2.28; 95% CI, 1.25-4.13; P = .007; OR, 2.18; 95% CI, 1.36-3.5; P = .001) as significant predictors of prolonged LOS in both dissection and aneurysm patients, respectively (Table). In the aneurysm population, chronic obstructive pulmonary disease (OR, 1.53; 95% CI, 1.04-2.26; P = .033), low preoperative albumin (OR, 0.64; 95% CI, 0.48-0.84; P = .002), dependent functional status (OR, 1.84; 95% CI, 1.15-2.96; P = .011), and postoperative urinary tract infection (OR, 2.18; 95% CI, 1.32-4.92; P = .006) additionally predicted longer LOS. In evaluating trends in LOS over time, emergent patients had greater LOS compared to nonemergent patients, with nonemergent dissection patients staying longer than nonemergent aneurysm patients (P < .001, Fig). These results reflect the differing populations of patients in the application of TEVAR. Aneurysm patients had more medical comorbidities, while dissection patients were more often operated on in an emergent fashion. Not surprisingly, both groups displayed prolonged LOS with postoperative complications as well as emergent status. Indication for TEVAR should be taken into account in devising hospital pathways to reduce LOS.TableMultivariable logistic regression of prolonged length of stay (LOS) in dissection vs aneurysm patientsVariableDissectionThoracic aortic aneurysmOR (95% CI)P valueOR (95% CI)P valuePreoperative ASA class1.38 (0.97-1.96).0741.09 (0.81-1.46).588 Diabetes0.98 (0.4-2.39).9561.11 (0.64-1.93).715 Dialysis0.95 (0.29-3.1).9271.24 (0.47-3.26).657 Emergency surgery0.69 (0.43-1.1).1191.2 (0.77-1.87).413 Dependent functional status1.15 (0.67-1.98).6191.84 (1.15-2.96).011 Cardiac history……1.44 (0.99-2.08).055 COPD……1.53 (1.04-2.26).033 Albumin0.75 (0.53-1.06).0990.64 (0.48-0.84).002 Creatinine1.09 (0.9-1.33).3671.08 (0.9-1.3).421 Hematocrit0.92 (0.88-0.96)<.0010.9 (0.87-0.93)<.001 WBC1.05 (1-1.1).0740.99 (0.95-1.02).495 Sex……0.94 (0.67-1.3).693Postoperative Stroke/TIA4.02 (1.57-10.26).0042.67 (1.27-5.62)0.01 Fail to wean >48 hours4.21 (2.05-8.66)<.0014.72 (2.55-8.73)<.001 Number of MI events……0.91 (0.3-2.75).865 Number of AKI events1.49 (0.44-5).5190.61 (0.23-1.64).326 Number of DVT events2.41 (0.54-10.67).2462.7 (0.74-9.76).131 Number of sepsis events12.3 (2.35-64.5).0031.42 (0.55-3.66).473 Number of UTI events1.83 (0.54-6.22).3332.54 (1.32-4.92).006 Operation time1 (1-1).151 (1-1).006 Bleeding requiring transfusion0.85 (0.5-1.45).5561.18 (0.79-1.75).427 Sepsis1.22 (0.24-6.31).8120.69 (0.25-1.89).465 Pneumonia3.33 (1.13-9.84).0296.69 (3.18-14.08)<.001 Reintubation1.32 (0.6-2.9).4841.76 (0.95-3.27).072 AKI4.31 (0.34-53.91).2581.91 (0.46-8.01).375 Reoperation2.28 (1.25-4.13).0072.18 (1.36-3.5).001AKI, Acute kidney injury; ASA, American Society of Anesthesiologists; CI, confidence interval; COPD, chronic obstructive pulmonary disease; DVT, deep vein thrombosis; MI, myocardial infarction; OR, odds ratio; TIA, transient ischemic attack; UTI, urinary tract infection; WBC, white blood cells. 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