Background: Considering the growing awareness of the population regarding the importance of engaging in physical activity, the utilization of supplements, such as creatine monohydrate, is also expanding in search of the attributed benefits of these substances. This study describes and analyzes the relationship between supplementation with creatine monohydrate and the improvement in the athletic performance of athletes from various disciplines and training levels, as well as non-athletes. Material and methods: A systematic review of clinical trials that address the use of creatine monohydrate in various sports contexts was conducted, followed by an analysis of the results based on body composition, jump capacity, and strength performance to determine points of correlation between the data presented in each publication. Results: A significant improvement in body composition, jump capacity, and strength performance was observed among participants who used supplementation, although in many cases, the results were heterogeneous. Conclusion: Creatine monohydrate supplementation positively influences body composition and physical performance, but further research is needed to understand its effects in specific populations.
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