Abstract: Ayurveda, an ancient medical system, highlights the significance of Ahara (diet) in maintaining health and preventing disease. A core aspect of Ayurvedic theory is the concept of Viruddhahara, which refers to incompatible food combinations that are believed to disrupt the equilibrium of the body's Doshas, potentially leading to various health complications. This review examines the concept of Viruddhahara and its implications for contemporary lifestyle-related disorders such as hypertension, diabetes, obesity, and cardiovascular diseases. In the current fast-paced environment, improper eating habits and the proliferation of fast food have led to widespread consumption of Viruddhahara, contributing to metabolic disturbances and chronic conditions. Ayurveda categorizes Viruddhahara into several types, including incompatibilities based on properties, timing, and combinations. For instance, the pairing of fish with milk or the consumption of heated honey serves as examples of how such food combinations can negatively impact health. The review emphasizes the importance of adhering to dietary guidelines to prevent disturbances in Dosha and the degradation of body tissues, which are essential for preserving health. With the rising incidence of lifestyle-related disorders, it is crucial to understand the scientific underpinnings of Viruddhahara and its role in disease etiology. This research aims to enhance awareness about the adverse effects of incompatible diets and to advocate for the incorporation of Ayurvedic principles into contemporary dietary practices. By conducting a thorough review of classical Ayurvedic texts alongside modern research, this study seeks to establish a framework for integrating Ayurvedic dietary principles into modern lifestyles, offering a comprehensive approach to the prevention and management of lifestyle-related diseases.