Important Role In Bone Repair Research Articles

Experimental Heterotopic Ossification

Publisher Summary Spontaneous heterotopic ossification may occur in almost any connective tissues of the body, but with few definite etiological factors emerging. This chapter describes the heterotopic ossification and the urinary tract, injection of extracts of skeletal tissues, injections of irritants and other traumatic experiments, and implants of devitalized skeletal tissues. The association of both experimentally and spontaneously induced heterotopic bone with proliferating transitional epithelium is well established in several species. Bone and cartilage have also been induced experimentally in many different ways, but general principles are not easily adduced from these results; however, the presence of inductors for bone and cartilage in other tissues and other species has not been conclusively demonstrated. The chapter indicates that until, the presence of inducing agents in bone has been unequivocally established in a number of species, it is required to defer judgment on the many claims that induction plays an important role in bone repair and transplantation.

Studies in the Repair of Bone

Conclusions1. Epiphyseal tissue will regenerate new bone in immature dogs. 2. Cancellous bone will bridge bony defects without the aid of periosteum. 3. Periosteum will hasten callus formation of cancellous bone grafts. 4. Free bone marrow and endosteum will bridge bone defects without the aid of periosteum with a rapid forming callus. 5. The clinical use of bone marrow and endosteum is suggested in bone grafting.The supremacy accorded the periosteum in osteogenesis has led to an almost complete neglect of the role played by other bone elements. Work on epiphyseal tissue has indeed been very scant, but there is both clinical and experimental evidence that cancellous bone plays an important role in bone repair, while the osteogenic properties of bone marrow and endosteum though often mentioned have been little studied.Epiphyseal Tissue Transplants. A set of experiments were carried out on 6 immature dogs. A quarter inch extraperiosteal resection of each fibula was filled on one side with ground epiphyseal ...